Dsg4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dsg4
Entrez Gene ID	291754
Full Name	desmoglein 4
General protein information	Preferred Names desmoglein 4 Names desmoglein-4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p12
Summary	cell adhesion molecule; involved in providing mechanical integrity and stability to epithelial cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_199490.1	NP_955784.1	desmoglein-4 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DSG4	XP_002697734.1
Xenopus tropicalis (tropical clawed frog)	dsg4	XP_002934178.2
Homo sapiens (human)	DSG4	NP_817123.1
Rattus norvegicus (Norway rat)	Dsg4	NP_955784.1
Macaca mulatta (Rhesus monkey)	DSG4	XP_001102180.1
Canis lupus familiaris (dog)	DSG4	XP_005623044.1
Gallus gallus (chicken)	DSG4	XP_426082.4
Mus musculus (house mouse)	Dsg4	NP_853543.1
Pan troglodytes (chimpanzee)	DSG4	XP_003953318.1

Gene Ontology
Bibliography

Related articles in PubMed

Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation.
Bazzi H, Demehri S, Potter CS, Barber AG, Awgulewitsch A, Kopan R, Christiano AM
Differentiation; research in biological diversity78(5)292-300(2009 Dec)

Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity.
Owens P, Bazzi H, Engelking E, Han G, Christiano AM, Wang XJ
Developmental biology322(1)156-66(2008 Oct)

Desmoglein 4 mutations underlie localized autosomal recessive hypotrichosis in humans, mice, and rats.
Bazzi H, Martinez-Mir A, Kljuic A, Christiano AM
The journal of investigative dermatology. Symposium proceedings10(3)222-4(2005 Dec)

A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model.
Meyer B, Bazzi H, Zidek V, Musilova A, Pravenec M, Kurtz TW, Nurnberg P, Christiano AM
Differentiation; research in biological diversity72(9-10)541-7(2004 Dec)

Intragenic deletion in the Desmoglein 4 gene underlies the skin phenotype in the Iffa Credo "hairless" rat.
Bazzi H, Kljuic A, Christiano AM, Christiano AM, Panteleyev AA
Differentiation; research in biological diversity72(8)450-64(2004 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dsg4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dsg4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42713	NM_199490.1 Latest version!	Rattus norvegicus desmoglein 4 (Dsg4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dsg4 ( NM_199490.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_955784.1 Rattus norvegicus desmoglein 4 (Dsg4), mRNA.

Price & Availability↑

CloneID	ORa42713
Clone ID Related Accession (Same CDS sequence)	NM_199490.1
Accession Version	NM_199490.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3123bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571241600000
Organism	Rattus norvegicus(Norway rat)
Product	desmoglein-4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY314982.1. On Jan 23, 2004 this sequence version replaced XM_226115.2. ##Evidence-Data-START## Transcript exon combination :: AY314982.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689602, SAMEA2689605 [ECO:0000350] ##Evidence-Data-END##

ATGGACTGGC TTCTCTTCAG AAATATTTGC CTTCTGATCC TATTTATGGT GGTCCTAGGA 
GTGAACAGTG AATTTATCGT TGAGGTAAAA GAATTAGACA TAGAAAACGG CACCACAACC 
TGGCAGACTG TCAGGAGGCA GAAGCGAGAG TGGATCAAGT TTGCAGCGGC CTGTCGGGAG 
GGCGAGGACA ACTCCAAGAG GAATCCGATT GCCAGAATTA GATCAGACTG TGAAGTGAGC 
CAGAGGATCA CTTATCGAAT CTCTGGAGCG GGGATTGATC GGCCGCCTTA TGGAGTGTTC 
ACCATCAACC CTCGGACTGG AGAAATCAAC ATTACCTCAG TAGTGGACAG AGAGATAACC 
CCACTGTTCC TGATCCATTG CCGAGCTCTC AACTCGAGAG GAGAAGACCT GGAGAGACCG 
CTGGAGCTCA GAGTGAAAGT CATGGATGTA AATGACAACC CTCCAGTCTT CACTCAGAAC 
GTGTACACAG CCAACATTGA AGAAAACAGT GATGCAAATG CACTGGTGGT GAAGTTAAGT 
GCCACGGATG CAGATGAAGA CAATCACTTG AATTCTAAAA TTGCTTACAA GATCATCTCC 
CAGGAGCCTG CTGGTGCACC CATGTTCATG GTGAACAGGT ACACTGGAGA AGTCCGCACG 
ATGTCCAACT TCCTTGACAG AGAGCAACAC AGTATGTACA ATCTCCTGGT GAGGGGCTCA 
GATCGGGATG GAGCCACAGA TGGGCTGTCC TCTGAATGTG ACTGCAGAAT CAAGATTTTG 
GATGTCAATG ATAATTTCCC CATCTTGGAG AAAACCTCAT ACTCAGCAAG TATTGAAGAA 
AACTGTTTGA GCTCAGAACT GATACGACTG CAAGCAATCG ATCTCGATGA GGAAGGCACT 
GATAACTGGC TGGCCCAATA CTCCATCCTC TCTGGCAATG ATGGGAACTG GTTTGAAATC 
CAAACAGATC CAAAAACCAA CGAAGGCATT TTGAAATTGG TCAAGATGCT GGACTATGAA 
CAGGAACCTA ACATTTACCT CAGCATTGGA GTTAGAAACC AAGCTGAGTT TCACCATTCA 
GTGGCATCTC AATTCCAAAT GCACTCCACT CCCGTGAGAA TCCAGGTTAT TAACGTGCGG 
GAAGGACCAA CCTTTCGCCC AAGTTCCATG ACATTTAGTC TACGAGGAGG AATGAGGGGA 
GACTCCTTAA TGAACTATGT GCTTGGCACA TACACAGCCA TAGATATGGA CACGGGGAGC 
CCTGCAACAA ACGTCAGGTA TGTCATAGGG CACGATGCAG GCAGCTGGCT AAAAGTTGAT 
TCAAGGACTG GTGAGATACA GTTTTCTAGG GAATTTGACA CGAAGTCAAA ATATATTACG 
GATGGGATGT ATGCAGCAGA GATCCTGGCT ATAGATGATG GCTCTGGGAG AACAGCTACG 
GGAACCATAT GCATTGAGGT TCCTGATGCC AATGATTACT GTCCCGTCAT TTATGCCGAA 
AGTAGAAGTG TCTGCACCCA TGCTTCGTCT GTCAGGATCT ACGTCAACGA CCATTCTTTC 
GGGGCTCCCT TTACCTTTTG TGTGGTTGAC GAGTCGCCAG ACACAGCTGA CATATGGGAT 
ATCAGGTCCA TCAATGGAAC TTCTGCAATC CTTATGACTG AGCAGACCTT GTCTCCAGGA 
CCCTACCAAA TCCCCATCCT CGTGAAGGAC AGTCACAACA GAGCATGTGA ATTGCCACAG 
ACTGTACTGT TAGACGCCTG CTTGTGTGAC GACTACCATG TGTGCTTGCA CTCCAGCACC 
ACAGGCATCT ACACTGGGGA CACCATCTGG GTGACCGATG ACATGGGGAC GGTCACTGAT 
GATGGACTTA GGCAGTCAAA CGTCGGACTT GGCCCAGCGG GGATTGGCAT GATTATTTTG 
GGTCTCTTGC TGCTGTTCTT GTCACCCCTT TTACTGCTCA TGTGCTGCTG CAAGAGGAGA 
CAGCCAGAAG GCCTGGGGAC AAGGTTTGCC CCTGTGCCTG AGGGAGGCGA AGGAGTGATG 
CAGCCCTGGA GAATCGAGGG GGCTCATCCG GAAGACAGGG ATGTATCAAA TATATGTGTG 
CCCATGACAG CCTCTAACAC CCAAGATCGC ATTGATTCCT CTGAAATCTA CACCAACACT 
TATGCTGGTG GAGGAACAGT GGAAGGGGGT GTGTCAGGAG TGGAGCTCAA TACAGGTGTT 
GGGACAGCTG CAGGCATAGC AGCTGGAGGA GCAACAGGGA CCCTGAGAAA GAGGAGTTCA 
ACTATAGGGA CTCTTCGGGA ATACCAAGAC ACCGGCATGA ACATGGCCTT CCTGGACAGC 
TACTTCTCTG AGAAAGCGTA TGCGTATGCA GATGAAGATG AAGGCCGTCC AGCCAATGAT 
TGCCTGCTCA TTTATGACCA TGAAGGAACT GGCTCACCCG TGGGCTCCAT TGGCTGCTGC 
AGTTGGATTG TGGATGACTT AGATGAGAGC TACATGGAGA CTTTAGATCC AAAGTTCAGG 
ACTCTAGCTG AAATCTGCTT GGACACAGAG ATTGAACCAT TCCCCTCACA CCAGGCCTGT 
ATACCAATAA GCACTGACCT CCCTCTGCTG GGGCCTAATT ACTTTGTCAA TGAATCTTCA 
GGAATGACTC TCTCGGAGGC TGAATTCCAA GCAGAAATGG CAGCAGCCTC TGAACCCATG 
ATTCATGGGG ACATCATAGT GACTGAAACT TACACTGCCA CTGACCCATG TGTACAACCC 
ACGACGATTG TCTTTGACTC TCAGCTTCCA CCCAATGTAG TCGTGACCGA AACCGTGATG 
GCACCTGTCT ATGATGTTCA AGGGAACATC TGTGTGCCTG CCGAGATAGC CAACACACAC 
AATGTATACT ACGCTGAGAG AGTGGTGGCT AGCCCTGGTG TGCCTGACAT GGGCAACGGT 
AACATAGGTG ATACATGTAT AGGACCAGTG ATGAGTGGTG GTATTTTGGT AGGGCCAGAA 
ATTCAAGTGA CACAAATGAT GAGCCCAGAC ATTCACATAA GCCAAACCAC ACGCTCTACC 
TCCCCAATGA CGTCTCAACA CCGAGTAACC AGATACAGCA ACATACACTA CTCCCGACAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955784.1
CDS	1..3123
Translation	MDWLLFRNICLLILFMVVLGVNSEFIVEVKELDIENGTTTWQTVRRQKREWIKFAAACREGEDNSKRNPIARIRSDCEVSQRITYRISGAGIDRPPYGVFTINPRTGEINITSVVDREITPLFLIHCRALNSRGEDLERPLELRVKVMDVNDNPPVFTQNVYTANIEENSDANALVVKLSATDADEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDREQHSMYNLLVRGSDRDGATDGLSSECDCRIKILDVNDNFPILEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYSILSGNDGNWFEIQTDPKTNEGILKLVKMLDYEQEPNIYLSIGVRNQAEFHHSVASQFQMHSTPVRIQVINVREGPTFRPSSMTFSLRGGMRGDSLMNYVLGTYTAIDMDTGSPATNVRYVIGHDAGSWLKVDSRTGEIQFSREFDTKSKYITDGMYAAEILAIDDGSGRTATGTICIEVPDANDYCPVIYAESRSVCTHASSVRIYVNDHSFGAPFTFCVVDESPDTADIWDIRSINGTSAILMTEQTLSPGPYQIPILVKDSHNRACELPQTVLLDACLCDDYHVCLHSSTTGIYTGDTIWVTDDMGTVTDDGLRQSNVGLGPAGIGMIILGLLLLFLSPLLLLMCCCKRRQPEGLGTRFAPVPEGGEGVMQPWRIEGAHPEDRDVSNICVPMTASNTQDRIDSSEIYTNTYAGGGTVEGGVSGVELNTGVGTAAGIAAGGATGTLRKRSSTIGTLREYQDTGMNMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGTGSPVGSIGCCSWIVDDLDESYMETLDPKFRTLAEICLDTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGMTLSEAEFQAEMAAASEPMIHGDIIVTETYTATDPCVQPTTIVFDSQLPPNVVVTETVMAPVYDVQGNICVPAEIANTHNVYYAERVVASPGVPDMGNGNIGDTCIGPVMSGGILVGPEIQVTQMMSPDIHISQTTRSTSPMTSQHRVTRYSNIHYSRQ

Target ORF information:

RefSeq Version	NM_199490.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus desmoglein 4 (Dsg4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199490.1

ORF Insert Sequence:

ATGGACTGGC TTCTCTTCAG AAATATTTGC CTTCTGATCC TATTTATGGT GGTCCTAGGA 
GTGAACAGTG AATTTATCGT TGAGGTAAAA GAATTAGACA TAGAAAACGG CACCACAACC 
TGGCAGACTG TCAGGAGGCA GAAGCGAGAG TGGATCAAGT TTGCAGCGGC CTGTCGGGAG 
GGCGAGGACA ACTCCAAGAG GAATCCGATT GCCAGAATTA GATCAGACTG TGAAGTGAGC 
CAGAGGATCA CTTATCGAAT CTCTGGAGCG GGGATTGATC GGCCGCCTTA TGGAGTGTTC 
ACCATCAACC CTCGGACTGG AGAAATCAAC ATTACCTCAG TAGTGGACAG AGAGATAACC 
CCACTGTTCC TGATCCATTG CCGAGCTCTC AACTCGAGAG GAGAAGACCT GGAGAGACCG 
CTGGAGCTCA GAGTGAAAGT CATGGATGTA AATGACAACC CTCCAGTCTT CACTCAGAAC 
GTGTACACAG CCAACATTGA AGAAAACAGT GATGCAAATG CACTGGTGGT GAAGTTAAGT 
GCCACGGATG CAGATGAAGA CAATCACTTG AATTCTAAAA TTGCTTACAA GATCATCTCC 
CAGGAGCCTG CTGGTGCACC CATGTTCATG GTGAACAGGT ACACTGGAGA AGTCCGCACG 
ATGTCCAACT TCCTTGACAG AGAGCAACAC AGTATGTACA ATCTCCTGGT GAGGGGCTCA 
GATCGGGATG GAGCCACAGA TGGGCTGTCC TCTGAATGTG ACTGCAGAAT CAAGATTTTG 
GATGTCAATG ATAATTTCCC CATCTTGGAG AAAACCTCAT ACTCAGCAAG TATTGAAGAA 
AACTGTTTGA GCTCAGAACT GATACGACTG CAAGCAATCG ATCTCGATGA GGAAGGCACT 
GATAACTGGC TGGCCCAATA CTCCATCCTC TCTGGCAATG ATGGGAACTG GTTTGAAATC 
CAAACAGATC CAAAAACCAA CGAAGGCATT TTGAAATTGG TCAAGATGCT GGACTATGAA 
CAGGAACCTA ACATTTACCT CAGCATTGGA GTTAGAAACC AAGCTGAGTT TCACCATTCA 
GTGGCATCTC AATTCCAAAT GCACTCCACT CCCGTGAGAA TCCAGGTTAT TAACGTGCGG 
GAAGGACCAA CCTTTCGCCC AAGTTCCATG ACATTTAGTC TACGAGGAGG AATGAGGGGA 
GACTCCTTAA TGAACTATGT GCTTGGCACA TACACAGCCA TAGATATGGA CACGGGGAGC 
CCTGCAACAA ACGTCAGGTA TGTCATAGGG CACGATGCAG GCAGCTGGCT AAAAGTTGAT 
TCAAGGACTG GTGAGATACA GTTTTCTAGG GAATTTGACA CGAAGTCAAA ATATATTACG 
GATGGGATGT ATGCAGCAGA GATCCTGGCT ATAGATGATG GCTCTGGGAG AACAGCTACG 
GGAACCATAT GCATTGAGGT TCCTGATGCC AATGATTACT GTCCCGTCAT TTATGCCGAA 
AGTAGAAGTG TCTGCACCCA TGCTTCGTCT GTCAGGATCT ACGTCAACGA CCATTCTTTC 
GGGGCTCCCT TTACCTTTTG TGTGGTTGAC GAGTCGCCAG ACACAGCTGA CATATGGGAT 
ATCAGGTCCA TCAATGGAAC TTCTGCAATC CTTATGACTG AGCAGACCTT GTCTCCAGGA 
CCCTACCAAA TCCCCATCCT CGTGAAGGAC AGTCACAACA GAGCATGTGA ATTGCCACAG 
ACTGTACTGT TAGACGCCTG CTTGTGTGAC GACTACCATG TGTGCTTGCA CTCCAGCACC 
ACAGGCATCT ACACTGGGGA CACCATCTGG GTGACCGATG ACATGGGGAC GGTCACTGAT 
GATGGACTTA GGCAGTCAAA CGTCGGACTT GGCCCAGCGG GGATTGGCAT GATTATTTTG 
GGTCTCTTGC TGCTGTTCTT GTCACCCCTT TTACTGCTCA TGTGCTGCTG CAAGAGGAGA 
CAGCCAGAAG GCCTGGGGAC AAGGTTTGCC CCTGTGCCTG AGGGAGGCGA AGGAGTGATG 
CAGCCCTGGA GAATCGAGGG GGCTCATCCG GAAGACAGGG ATGTATCAAA TATATGTGTG 
CCCATGACAG CCTCTAACAC CCAAGATCGC ATTGATTCCT CTGAAATCTA CACCAACACT 
TATGCTGGTG GAGGAACAGT GGAAGGGGGT GTGTCAGGAG TGGAGCTCAA TACAGGTGTT 
GGGACAGCTG CAGGCATAGC AGCTGGAGGA GCAACAGGGA CCCTGAGAAA GAGGAGTTCA 
ACTATAGGGA CTCTTCGGGA ATACCAAGAC ACCGGCATGA ACATGGCCTT CCTGGACAGC 
TACTTCTCTG AGAAAGCGTA TGCGTATGCA GATGAAGATG AAGGCCGTCC AGCCAATGAT 
TGCCTGCTCA TTTATGACCA TGAAGGAACT GGCTCACCCG TGGGCTCCAT TGGCTGCTGC 
AGTTGGATTG TGGATGACTT AGATGAGAGC TACATGGAGA CTTTAGATCC AAAGTTCAGG 
ACTCTAGCTG AAATCTGCTT GGACACAGAG ATTGAACCAT TCCCCTCACA CCAGGCCTGT 
ATACCAATAA GCACTGACCT CCCTCTGCTG GGGCCTAATT ACTTTGTCAA TGAATCTTCA 
GGAATGACTC TCTCGGAGGC TGAATTCCAA GCAGAAATGG CAGCAGCCTC TGAACCCATG 
ATTCATGGGG ACATCATAGT GACTGAAACT TACACTGCCA CTGACCCATG TGTACAACCC 
ACGACGATTG TCTTTGACTC TCAGCTTCCA CCCAATGTAG TCGTGACCGA AACCGTGATG 
GCACCTGTCT ATGATGTTCA AGGGAACATC TGTGTGCCTG CCGAGATAGC CAACACACAC 
AATGTATACT ACGCTGAGAG AGTGGTGGCT AGCCCTGGTG TGCCTGACAT GGGCAACGGT 
AACATAGGTG ATACATGTAT AGGACCAGTG ATGAGTGGTG GTATTTTGGT AGGGCCAGAA 
ATTCAAGTGA CACAAATGAT GAGCCCAGAC ATTCACATAA GCCAAACCAC ACGCTCTACC 
TCCCCAATGA CGTCTCAACA CCGAGTAACC AGATACAGCA ACATACACTA CTCCCGACAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation.
Differentiation; research in biological diversity78(5)292-300(2009 Dec)
Bazzi H,Demehri S,Potter CS,Barber AG,Awgulewitsch A,Kopan R,Christiano AM

Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity.
Developmental biology322(1)156-66(2008 Oct)
Owens P,Bazzi H,Engelking E,Han G,Christiano AM,Wang XJ

Desmoglein 4 mutations underlie localized autosomal recessive hypotrichosis in humans, mice, and rats.
The journal of investigative dermatology. Symposium proceedings10(3)222-4(2005 Dec)
Bazzi H,Martinez-Mir A,Kljuic A,Christiano AM

A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model.
Differentiation; research in biological diversity72(9-10)541-7(2004 Dec)
Meyer B,Bazzi H,Zidek V,Musilova A,Pravenec M,Kurtz TW,Nurnberg P,Christiano AM

Intragenic deletion in the Desmoglein 4 gene underlies the skin phenotype in the Iffa Credo "hairless" rat.
Differentiation; research in biological diversity72(8)450-64(2004 Oct)
Bazzi H,Kljuic A,Christiano AM,Christiano AM,Panteleyev AA

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Dsg4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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