Tbc1d24 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tbc1d24
Entrez Gene ID	287110
Full Name	TBC1 domain family, member 24
Synonyms	RGD1306143
General protein information	Preferred Names TBC1 domain family, member 24 Names TBC1 domain family member 24
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597064.1	XP_017452553.1	TBC1 domain family member 24 isoform X1
NM_001105769.1	NP_001099239.1	TBC1 domain family member 24
XM_006245926.2	XP_006245988.1	TBC1 domain family member 24 isoform X1

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010235	XP_319423.3
Pan troglodytes (chimpanzee)	TBC1D24	XP_523268.2
Bos taurus (cattle)	TBC1D24	NP_001039761.1
Mus musculus (house mouse)	Tbc1d24	NP_001157321.1
Rattus norvegicus (Norway rat)	Tbc1d24	NP_001099239.1
Macaca mulatta (Rhesus monkey)	TBC1D24	XP_001085929.1
Drosophila melanogaster (fruit fly)	sky	NP_724302.1
Xenopus tropicalis (tropical clawed frog)	tbc1d24.1	NP_001072701.1
Gallus gallus (chicken)	TBC1D24	NP_001244200.1
Danio rerio (zebrafish)	LOC100536073	XP_003201409.2
Homo sapiens (human)	TBC1D24	NP_001186036.1
Canis lupus familiaris (dog)	TBC1D24	XP_851962.1
Caenorhabditis elegans (roundworm)	tbc-7	NP_741778.1

Gene Ontology
Bibliography

Related articles in PubMed

The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons.
Finelli MJ, Aprile D, Castroflorio E, Jeans A, Moschetta M, Chessum L, Degiacomi MT, Grasegger J, Lupien-Meilleur A, Bassett A, Rossignol E, Campeau PM, Bowl MR, Benfenati F, Fassio A, Oliver PL
Human molecular genetics28(4)584-597(2019 02)

The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress.
Finelli MJ, Sanchez-Pulido L, Liu KX, Davies KE, Oliver PL
The Journal of biological chemistry291(6)2751-63(2016 Feb)

Homozygous TBC1D24 mutation in two siblings with familial infantile myoclonic epilepsy (FIME) and moderate intellectual disability.
Poulat AL, Ville D, de Bellescize J, André-Obadia N, Cacciagli P, Milh M, Villard L, Lesca G
Epilepsy research11172-7(2015 Mar)

Recessive TBC1D24 Mutations Are Frequent in Moroccan Non-Syndromic Hearing Loss Pedigrees.
Bakhchane A, Charif M, Salime S, Boulouiz R, Nahili H, Roky R, Lenaers G, Barakat A
PloS one10(9)e0138072(2015)

TBC1D24 mutation causes autosomal-dominant nonsyndromic hearing loss.
Azaiez H, Booth KT, Bu F, Huygen P, Shibata SB, Shearer AE, Kolbe D, Meyer N, Black-Ziegelbein EA, Smith RJ
Human mutation35(7)819-23(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Tbc1d24 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tbc1d24 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13526	NM_001105769.1 Latest version!	Rattus norvegicus TBC1 domain family, member 24 (Tbc1d24), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa32847	XM_006245926.2 Latest version!	Rattus norvegicus TBC1 domain family, member 24 (Tbc1d24), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa32847	XM_017597064.1 Latest version!	Rattus norvegicus TBC1 domain family, member 24 (Tbc1d24), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tbc1d24 ( NM_001105769.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099239.1 Rattus norvegicus TBC1 domain family, member 24 (Tbc1d24), mRNA.

Price & Availability↑

CloneID	ORa13526
Clone ID Related Accession (Same CDS sequence)	NM_001105769.1
Accession Version	NM_001105769.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1671bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570550400000
Organism	Rattus norvegicus(Norway rat)
Product	TBC1 domain family member 24
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On or before Oct 3, 2007 this sequence version replaced XM_001057264.1, XM_220245.4. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01906354 [ECO:0000348] ##Evidence-Data-END##

ATGGACTCCC CAGGGTACAA TTGCTTTGTG GATAAGGACA AGATGGACGC GTCCATCCAG 
GACCTGGGGC CAAAGGAGCT GAACTACACC GAGCTACAGG AGCTGAAGCA GCTGGCGCGG 
CAGGGTTACT GGGCTCAGAG CCACGCCCTG CGGGGGAAAG TGTACCAGCG TCTGATCCGG 
GACATCCCCT GCCGCACGGT CACACCCGAC GCCAGCGTGT ACAGCGACAT CGTGGGGAAG 
ATTGTGGGCA AGCACAGCAG CAGTAGCTTG CCCCTGCCTG AGTTTGTAGA CAACACTCAG 
GTGCCCACCT ACTGCCTGAA CCCGCGGGGT GAGGGGGCCG TGCGCAAGAT CCTCCTGTGC 
ATCGCCAACC AGTTCCCCGA CATCTCCTTC TGCCCTGCCC TGCCCGCGGT GGTGGCCTTG 
CTGCTACACT ACAGCATTGA CGAGGCCGAG TGCTTTGAAA AGGCCTGCCG CATCTTGTCC 
TGCAACGACC CCGGCAAGAA GCTCATTGAC CAGAGCTTCC TGGCCTTCGA GTCTTCCTGT 
ATGACGTTTG GAGACCTGGT GAACAAGTAC TGCCAGGCAG CCCACAAACT GATGGTGGCC 
GTGTCAGAGG ACGTTCTGCA GGTCTACTCT GACTGGCAGA GATGGCTCTT TGGGGAGCTG 
CCCCTCAACT ACTTTGCCCG CGTTTTCGAC GTCTTCCTTG TAGAAGGCTA CAAGGTACTG 
TACCGAGTCG CTCTGGCCAT CCTCAAGTTC TTCCACAAGG TGAGAGCAGG ACAGCCCCTT 
GAGTCAGACA ATGTAAAGCA AGACATCCGG ATGTTTGTCA AGGACATTGC CAAGACAGTG 
TCCCCTGAGA AACTACTAGA GAAGGCCTTT GCCATCCGCC TGTTTTCCCG CAAGGAGATT 
CAGCTCTTGC AAATGGCCAA TGAGAAAGCC CTGAGGCAGA AGGGTATTAC TGTCAAACAG 
AAGAGGCAGT TTGTACACTT GGCTGTCCAT GCAGAGAACT TCCGCTCAGA GATTGTCAGT 
GTGAAGGAGA TGAGAGACAT TTGGTCCTGG ATCCCTGAGC GCTTCGCCCT CTGCCAACCC 
CTCCTGCTCT TCTCGTCGCT GCAGCATGGG TACAGCCTAA GCAGGTTCTA TTTCCAGTGC 
GAAGGACATG AGCCCACACT CCTGCTCATC AAGACCACTC AAAAGGAGGT TTGTGGGGCT 
TACCTGTCAA CAGACTGGAG TGAGCGGAAT AAGTTCGGAG GCAAGCTGAG CTTCTTTGGG 
ACTGGAGAAT GCTTTGTTTT TAGGCTGCAG CCGGAGGTGC AGCGCTATGA GTGGGTGGTC 
ATCAAGCACC CAGAACTGAC CAAGGCAGCA TCCTTCAAGT CCTCAGAGGC TGCAGCCAAT 
CCTTGCCTCA TCAGCCACTC CGTCTCTTCA GACCCTGCCG ACCGGCTCTC TCCTTTCCTG 
GCTGCCCGGC ACTTCAACCT GCCCTCCAAG ACCGAGTCCA TGTTCATGGC TGGGGGCAAC 
GACTGCCTCA TCATTGGGGG AGGAGGTGGC CAAGCACTCT ACATCGATGG GGATCTGAAC 
CGAGGGCGCA CCGGACACTG TGACACGTTC AACAACCAGC CCCTGTGCTC GGAGAGCTTC 
CTCATCGCGG CCGTGGAGGC TTGGGGCTTC CAAGACCCCG ACACCCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099239.1
CDS	279..1949
Translation	MDSPGYNCFVDKDKMDASIQDLGPKELNYTELQELKQLARQGYWAQSHALRGKVYQRLIRDIPCRTVTPDASVYSDIVGKIVGKHSSSSLPLPEFVDNTQVPTYCLNPRGEGAVRKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILSCNDPGKKLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYSDWQRWLFGELPLNYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESDNVKQDIRMFVKDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALRQKGITVKQKRQFVHLAVHAENFRSEIVSVKEMRDIWSWIPERFALCQPLLLFSSLQHGYSLSRFYFQCEGHEPTLLLIKTTQKEVCGAYLSTDWSERNKFGGKLSFFGTGECFVFRLQPEVQRYEWVVIKHPELTKAASFKSSEAAANPCLISHSVSSDPADRLSPFLAARHFNLPSKTESMFMAGGNDCLIIGGGGGQALYIDGDLNRGRTGHCDTFNNQPLCSESFLIAAVEAWGFQDPDTQ

Target ORF information:

RefSeq Version	NM_001105769.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TBC1 domain family, member 24 (Tbc1d24), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105769.1

ORF Insert Sequence:

ATGGACTCCC CAGGGTACAA TTGCTTTGTG GATAAGGACA AGATGGACGC GTCCATCCAG 
GACCTGGGGC CAAAGGAGCT GAACTACACC GAGCTACAGG AGCTGAAGCA GCTGGCGCGG 
CAGGGTTACT GGGCTCAGAG CCACGCCCTG CGGGGGAAAG TGTACCAGCG TCTGATCCGG 
GACATCCCCT GCCGCACGGT CACACCCGAC GCCAGCGTGT ACAGCGACAT CGTGGGGAAG 
ATTGTGGGCA AGCACAGCAG CAGTAGCTTG CCCCTGCCTG AGTTTGTAGA CAACACTCAG 
GTGCCCACCT ACTGCCTGAA CCCGCGGGGT GAGGGGGCCG TGCGCAAGAT CCTCCTGTGC 
ATCGCCAACC AGTTCCCCGA CATCTCCTTC TGCCCTGCCC TGCCCGCGGT GGTGGCCTTG 
CTGCTACACT ACAGCATTGA CGAGGCCGAG TGCTTTGAAA AGGCCTGCCG CATCTTGTCC 
TGCAACGACC CCGGCAAGAA GCTCATTGAC CAGAGCTTCC TGGCCTTCGA GTCTTCCTGT 
ATGACGTTTG GAGACCTGGT GAACAAGTAC TGCCAGGCAG CCCACAAACT GATGGTGGCC 
GTGTCAGAGG ACGTTCTGCA GGTCTACTCT GACTGGCAGA GATGGCTCTT TGGGGAGCTG 
CCCCTCAACT ACTTTGCCCG CGTTTTCGAC GTCTTCCTTG TAGAAGGCTA CAAGGTACTG 
TACCGAGTCG CTCTGGCCAT CCTCAAGTTC TTCCACAAGG TGAGAGCAGG ACAGCCCCTT 
GAGTCAGACA ATGTAAAGCA AGACATCCGG ATGTTTGTCA AGGACATTGC CAAGACAGTG 
TCCCCTGAGA AACTACTAGA GAAGGCCTTT GCCATCCGCC TGTTTTCCCG CAAGGAGATT 
CAGCTCTTGC AAATGGCCAA TGAGAAAGCC CTGAGGCAGA AGGGTATTAC TGTCAAACAG 
AAGAGGCAGT TTGTACACTT GGCTGTCCAT GCAGAGAACT TCCGCTCAGA GATTGTCAGT 
GTGAAGGAGA TGAGAGACAT TTGGTCCTGG ATCCCTGAGC GCTTCGCCCT CTGCCAACCC 
CTCCTGCTCT TCTCGTCGCT GCAGCATGGG TACAGCCTAA GCAGGTTCTA TTTCCAGTGC 
GAAGGACATG AGCCCACACT CCTGCTCATC AAGACCACTC AAAAGGAGGT TTGTGGGGCT 
TACCTGTCAA CAGACTGGAG TGAGCGGAAT AAGTTCGGAG GCAAGCTGAG CTTCTTTGGG 
ACTGGAGAAT GCTTTGTTTT TAGGCTGCAG CCGGAGGTGC AGCGCTATGA GTGGGTGGTC 
ATCAAGCACC CAGAACTGAC CAAGGCAGCA TCCTTCAAGT CCTCAGAGGC TGCAGCCAAT 
CCTTGCCTCA TCAGCCACTC CGTCTCTTCA GACCCTGCCG ACCGGCTCTC TCCTTTCCTG 
GCTGCCCGGC ACTTCAACCT GCCCTCCAAG ACCGAGTCCA TGTTCATGGC TGGGGGCAAC 
GACTGCCTCA TCATTGGGGG AGGAGGTGGC CAAGCACTCT ACATCGATGG GGATCTGAAC 
CGAGGGCGCA CCGGACACTG TGACACGTTC AACAACCAGC CCCTGTGCTC GGAGAGCTTC 
CTCATCGCGG CCGTGGAGGC TTGGGGCTTC CAAGACCCCG ACACCCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tbc1d24 ( XM_017597064.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452553.1 Rattus norvegicus TBC1 domain family, member 24 (Tbc1d24), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa32847
Clone ID Related Accession (Same CDS sequence)	XM_017597064.1 , XM_006245926.2
Accession Version	XM_017597064.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1689bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	TBC1 domain family member 24 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTCCC CAGGGTACAA TTGCTTTGTG GATAAGGACA AGATGGACGC GTCCATCCAG 
GACCTGGGGC CAAAGGAGCT GAACTACACC GAGCTACAGG AGCTGAAGCA GCTGGCGCGG 
CAGGGTTACT GGGCTCAGAG CCACGCCCTG CGGGGGAAAG TGTACCAGCG TCTGATCCGG 
GACATCCCCT GCCGCACGGT CACACCCGAC GCCAGCGTGT ACAGCGACAT CGTGGGGAAG 
ATTGTGGGCA AGCACAGCAG CAGTAGCTTG CCCCTGCCTG AGTTTGTAGA CAACACTCAG 
GTGCCCACCT ACTGCCTGAA CCCGCGGGGT GAGGGGGCCG TGCGCAAGAT CCTCCTGTGC 
ATCGCCAACC AGTTCCCCGA CATCTCCTTC TGCCCTGCCC TGCCCGCGGT GGTGGCCTTG 
CTGCTACACT ACAGCATTGA CGAGGCCGAG TGCTTTGAAA AGGCCTGCCG CATCTTGTCC 
TGCAACGACC CCGGCAAGAA GCTCATTGAC CAGAGCTTCC TGGCCTTCGA GTCTTCCTGT 
ATGACGTTTG GAGACCTGGT GAACAAGTAC TGCCAGGCAG CCCACAAACT GATGGTGGCC 
GTGTCAGAGG ACGTTCTGCA GGTCTACTCT GACTGGCAGA GATGGCTCTT TGGGGAGCTG 
CCCCTCAACT ACTTTGCCCG CGTTTTCGAC GTCTTCCTTG TAGAAGGCTA CAAGGTACTG 
TACCGAGTCG CTCTGGCCAT CCTCAAGTTC TTCCACAAGG TGAGAGCAGG ACAGCCCCTT 
GAGTCAGACA ATGTAAAGCA AGACATCCGG ATGTTTGTCA AGGACATTGC CAAGACAGTG 
TCCCCTGAGA AACTACTAGA GAAGGCCTTT GCCATCCGCC TGTTTTCCCG CAAGGAGATT 
CAGCTCTTGC AAATGGCCAA TGAGAAAGCC CTGAGGCAGA AGGGTATTAC TGTCAAACAG 
AAGAGTGTCT CACTTTCTAA AAGGCAGTTT GTACACTTGG CTGTCCATGC AGAGAACTTC 
CGCTCAGAGA TTGTCAGTGT GAAGGAGATG AGAGACATTT GGTCCTGGAT CCCTGAGCGC 
TTCGCCCTCT GCCAACCCCT CCTGCTCTTC TCGTCGCTGC AGCATGGGTA CAGCCTAAGC 
AGGTTCTATT TCCAGTGCGA AGGACATGAG CCCACACTCC TGCTCATCAA GACCACTCAA 
AAGGAGGTTT GTGGGGCTTA CCTGTCAACA GACTGGAGTG AGCGGAATAA GTTCGGAGGC 
AAGCTGAGCT TCTTTGGGAC TGGAGAATGC TTTGTTTTTA GGCTGCAGCC GGAGGTGCAG 
CGCTATGAGT GGGTGGTCAT CAAGCACCCA GAACTGACCA AGGCAGCATC CTTCAAGTCC 
TCAGAGGCTG CAGCCAATCC TTGCCTCATC AGCCACTCCG TCTCTTCAGA CCCTGCCGAC 
CGGCTCTCTC CTTTCCTGGC TGCCCGGCAC TTCAACCTGC CCTCCAAGAC CGAGTCCATG 
TTCATGGCTG GGGGCAACGA CTGCCTCATC ATTGGGGGAG GAGGTGGCCA AGCACTCTAC 
ATCGATGGGG ATCTGAACCG AGGGCGCACC GGACACTGTG ACACGTTCAA CAACCAGCCC 
CTGTGCTCGG AGAGCTTCCT CATCGCGGCC GTGGAGGCTT GGGGCTTCCA AGACCCCGAC 
ACCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452553.1
CDS	25..1713
Translation	MDSPGYNCFVDKDKMDASIQDLGPKELNYTELQELKQLARQGYWAQSHALRGKVYQRLIRDIPCRTVTPDASVYSDIVGKIVGKHSSSSLPLPEFVDNTQVPTYCLNPRGEGAVRKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILSCNDPGKKLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYSDWQRWLFGELPLNYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESDNVKQDIRMFVKDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALRQKGITVKQKSVSLSKRQFVHLAVHAENFRSEIVSVKEMRDIWSWIPERFALCQPLLLFSSLQHGYSLSRFYFQCEGHEPTLLLIKTTQKEVCGAYLSTDWSERNKFGGKLSFFGTGECFVFRLQPEVQRYEWVVIKHPELTKAASFKSSEAAANPCLISHSVSSDPADRLSPFLAARHFNLPSKTESMFMAGGNDCLIIGGGGGQALYIDGDLNRGRTGHCDTFNNQPLCSESFLIAAVEAWGFQDPDTQ

Target ORF information:

RefSeq Version	XM_017597064.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TBC1 domain family, member 24 (Tbc1d24), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597064.1

ORF Insert Sequence:

ATGGACTCCC CAGGGTACAA TTGCTTTGTG GATAAGGACA AGATGGACGC GTCCATCCAG 
GACCTGGGGC CAAAGGAGCT GAACTACACC GAGCTACAGG AGCTGAAGCA GCTGGCGCGG 
CAGGGTTACT GGGCTCAGAG CCACGCCCTG CGGGGGAAAG TGTACCAGCG TCTGATCCGG 
GACATCCCCT GCCGCACGGT CACACCCGAC GCCAGCGTGT ACAGCGACAT CGTGGGGAAG 
ATTGTGGGCA AGCACAGCAG CAGTAGCTTG CCCCTGCCTG AGTTTGTAGA CAACACTCAG 
GTGCCCACCT ACTGCCTGAA CCCGCGGGGT GAGGGGGCCG TGCGCAAGAT CCTCCTGTGC 
ATCGCCAACC AGTTCCCCGA CATCTCCTTC TGCCCTGCCC TGCCCGCGGT GGTGGCCTTG 
CTGCTACACT ACAGCATTGA CGAGGCCGAG TGCTTTGAAA AGGCCTGCCG CATCTTGTCC 
TGCAACGACC CCGGCAAGAA GCTCATTGAC CAGAGCTTCC TGGCCTTCGA GTCTTCCTGT 
ATGACGTTTG GAGACCTGGT GAACAAGTAC TGCCAGGCAG CCCACAAACT GATGGTGGCC 
GTGTCAGAGG ACGTTCTGCA GGTCTACTCT GACTGGCAGA GATGGCTCTT TGGGGAGCTG 
CCCCTCAACT ACTTTGCCCG CGTTTTCGAC GTCTTCCTTG TAGAAGGCTA CAAGGTACTG 
TACCGAGTCG CTCTGGCCAT CCTCAAGTTC TTCCACAAGG TGAGAGCAGG ACAGCCCCTT 
GAGTCAGACA ATGTAAAGCA AGACATCCGG ATGTTTGTCA AGGACATTGC CAAGACAGTG 
TCCCCTGAGA AACTACTAGA GAAGGCCTTT GCCATCCGCC TGTTTTCCCG CAAGGAGATT 
CAGCTCTTGC AAATGGCCAA TGAGAAAGCC CTGAGGCAGA AGGGTATTAC TGTCAAACAG 
AAGAGTGTCT CACTTTCTAA AAGGCAGTTT GTACACTTGG CTGTCCATGC AGAGAACTTC 
CGCTCAGAGA TTGTCAGTGT GAAGGAGATG AGAGACATTT GGTCCTGGAT CCCTGAGCGC 
TTCGCCCTCT GCCAACCCCT CCTGCTCTTC TCGTCGCTGC AGCATGGGTA CAGCCTAAGC 
AGGTTCTATT TCCAGTGCGA AGGACATGAG CCCACACTCC TGCTCATCAA GACCACTCAA 
AAGGAGGTTT GTGGGGCTTA CCTGTCAACA GACTGGAGTG AGCGGAATAA GTTCGGAGGC 
AAGCTGAGCT TCTTTGGGAC TGGAGAATGC TTTGTTTTTA GGCTGCAGCC GGAGGTGCAG 
CGCTATGAGT GGGTGGTCAT CAAGCACCCA GAACTGACCA AGGCAGCATC CTTCAAGTCC 
TCAGAGGCTG CAGCCAATCC TTGCCTCATC AGCCACTCCG TCTCTTCAGA CCCTGCCGAC 
CGGCTCTCTC CTTTCCTGGC TGCCCGGCAC TTCAACCTGC CCTCCAAGAC CGAGTCCATG 
TTCATGGCTG GGGGCAACGA CTGCCTCATC ATTGGGGGAG GAGGTGGCCA AGCACTCTAC 
ATCGATGGGG ATCTGAACCG AGGGCGCACC GGACACTGTG ACACGTTCAA CAACCAGCCC 
CTGTGCTCGG AGAGCTTCCT CATCGCGGCC GTGGAGGCTT GGGGCTTCCA AGACCCCGAC 
ACCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tbc1d24 ( XM_006245926.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006245988.1 Rattus norvegicus TBC1 domain family, member 24 (Tbc1d24), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa32847
Clone ID Related Accession (Same CDS sequence)	XM_017597064.1 , XM_006245926.2
Accession Version	XM_006245926.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1689bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	TBC1 domain family member 24 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006245926.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTCCC CAGGGTACAA TTGCTTTGTG GATAAGGACA AGATGGACGC GTCCATCCAG 
GACCTGGGGC CAAAGGAGCT GAACTACACC GAGCTACAGG AGCTGAAGCA GCTGGCGCGG 
CAGGGTTACT GGGCTCAGAG CCACGCCCTG CGGGGGAAAG TGTACCAGCG TCTGATCCGG 
GACATCCCCT GCCGCACGGT CACACCCGAC GCCAGCGTGT ACAGCGACAT CGTGGGGAAG 
ATTGTGGGCA AGCACAGCAG CAGTAGCTTG CCCCTGCCTG AGTTTGTAGA CAACACTCAG 
GTGCCCACCT ACTGCCTGAA CCCGCGGGGT GAGGGGGCCG TGCGCAAGAT CCTCCTGTGC 
ATCGCCAACC AGTTCCCCGA CATCTCCTTC TGCCCTGCCC TGCCCGCGGT GGTGGCCTTG 
CTGCTACACT ACAGCATTGA CGAGGCCGAG TGCTTTGAAA AGGCCTGCCG CATCTTGTCC 
TGCAACGACC CCGGCAAGAA GCTCATTGAC CAGAGCTTCC TGGCCTTCGA GTCTTCCTGT 
ATGACGTTTG GAGACCTGGT GAACAAGTAC TGCCAGGCAG CCCACAAACT GATGGTGGCC 
GTGTCAGAGG ACGTTCTGCA GGTCTACTCT GACTGGCAGA GATGGCTCTT TGGGGAGCTG 
CCCCTCAACT ACTTTGCCCG CGTTTTCGAC GTCTTCCTTG TAGAAGGCTA CAAGGTACTG 
TACCGAGTCG CTCTGGCCAT CCTCAAGTTC TTCCACAAGG TGAGAGCAGG ACAGCCCCTT 
GAGTCAGACA ATGTAAAGCA AGACATCCGG ATGTTTGTCA AGGACATTGC CAAGACAGTG 
TCCCCTGAGA AACTACTAGA GAAGGCCTTT GCCATCCGCC TGTTTTCCCG CAAGGAGATT 
CAGCTCTTGC AAATGGCCAA TGAGAAAGCC CTGAGGCAGA AGGGTATTAC TGTCAAACAG 
AAGAGTGTCT CACTTTCTAA AAGGCAGTTT GTACACTTGG CTGTCCATGC AGAGAACTTC 
CGCTCAGAGA TTGTCAGTGT GAAGGAGATG AGAGACATTT GGTCCTGGAT CCCTGAGCGC 
TTCGCCCTCT GCCAACCCCT CCTGCTCTTC TCGTCGCTGC AGCATGGGTA CAGCCTAAGC 
AGGTTCTATT TCCAGTGCGA AGGACATGAG CCCACACTCC TGCTCATCAA GACCACTCAA 
AAGGAGGTTT GTGGGGCTTA CCTGTCAACA GACTGGAGTG AGCGGAATAA GTTCGGAGGC 
AAGCTGAGCT TCTTTGGGAC TGGAGAATGC TTTGTTTTTA GGCTGCAGCC GGAGGTGCAG 
CGCTATGAGT GGGTGGTCAT CAAGCACCCA GAACTGACCA AGGCAGCATC CTTCAAGTCC 
TCAGAGGCTG CAGCCAATCC TTGCCTCATC AGCCACTCCG TCTCTTCAGA CCCTGCCGAC 
CGGCTCTCTC CTTTCCTGGC TGCCCGGCAC TTCAACCTGC CCTCCAAGAC CGAGTCCATG 
TTCATGGCTG GGGGCAACGA CTGCCTCATC ATTGGGGGAG GAGGTGGCCA AGCACTCTAC 
ATCGATGGGG ATCTGAACCG AGGGCGCACC GGACACTGTG ACACGTTCAA CAACCAGCCC 
CTGTGCTCGG AGAGCTTCCT CATCGCGGCC GTGGAGGCTT GGGGCTTCCA AGACCCCGAC 
ACCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006245988.1
CDS	25..1713
Translation	MDSPGYNCFVDKDKMDASIQDLGPKELNYTELQELKQLARQGYWAQSHALRGKVYQRLIRDIPCRTVTPDASVYSDIVGKIVGKHSSSSLPLPEFVDNTQVPTYCLNPRGEGAVRKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILSCNDPGKKLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYSDWQRWLFGELPLNYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESDNVKQDIRMFVKDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALRQKGITVKQKSVSLSKRQFVHLAVHAENFRSEIVSVKEMRDIWSWIPERFALCQPLLLFSSLQHGYSLSRFYFQCEGHEPTLLLIKTTQKEVCGAYLSTDWSERNKFGGKLSFFGTGECFVFRLQPEVQRYEWVVIKHPELTKAASFKSSEAAANPCLISHSVSSDPADRLSPFLAARHFNLPSKTESMFMAGGNDCLIIGGGGGQALYIDGDLNRGRTGHCDTFNNQPLCSESFLIAAVEAWGFQDPDTQ

Target ORF information:

RefSeq Version	XM_006245926.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TBC1 domain family, member 24 (Tbc1d24), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006245926.2

ORF Insert Sequence:

ATGGACTCCC CAGGGTACAA TTGCTTTGTG GATAAGGACA AGATGGACGC GTCCATCCAG 
GACCTGGGGC CAAAGGAGCT GAACTACACC GAGCTACAGG AGCTGAAGCA GCTGGCGCGG 
CAGGGTTACT GGGCTCAGAG CCACGCCCTG CGGGGGAAAG TGTACCAGCG TCTGATCCGG 
GACATCCCCT GCCGCACGGT CACACCCGAC GCCAGCGTGT ACAGCGACAT CGTGGGGAAG 
ATTGTGGGCA AGCACAGCAG CAGTAGCTTG CCCCTGCCTG AGTTTGTAGA CAACACTCAG 
GTGCCCACCT ACTGCCTGAA CCCGCGGGGT GAGGGGGCCG TGCGCAAGAT CCTCCTGTGC 
ATCGCCAACC AGTTCCCCGA CATCTCCTTC TGCCCTGCCC TGCCCGCGGT GGTGGCCTTG 
CTGCTACACT ACAGCATTGA CGAGGCCGAG TGCTTTGAAA AGGCCTGCCG CATCTTGTCC 
TGCAACGACC CCGGCAAGAA GCTCATTGAC CAGAGCTTCC TGGCCTTCGA GTCTTCCTGT 
ATGACGTTTG GAGACCTGGT GAACAAGTAC TGCCAGGCAG CCCACAAACT GATGGTGGCC 
GTGTCAGAGG ACGTTCTGCA GGTCTACTCT GACTGGCAGA GATGGCTCTT TGGGGAGCTG 
CCCCTCAACT ACTTTGCCCG CGTTTTCGAC GTCTTCCTTG TAGAAGGCTA CAAGGTACTG 
TACCGAGTCG CTCTGGCCAT CCTCAAGTTC TTCCACAAGG TGAGAGCAGG ACAGCCCCTT 
GAGTCAGACA ATGTAAAGCA AGACATCCGG ATGTTTGTCA AGGACATTGC CAAGACAGTG 
TCCCCTGAGA AACTACTAGA GAAGGCCTTT GCCATCCGCC TGTTTTCCCG CAAGGAGATT 
CAGCTCTTGC AAATGGCCAA TGAGAAAGCC CTGAGGCAGA AGGGTATTAC TGTCAAACAG 
AAGAGTGTCT CACTTTCTAA AAGGCAGTTT GTACACTTGG CTGTCCATGC AGAGAACTTC 
CGCTCAGAGA TTGTCAGTGT GAAGGAGATG AGAGACATTT GGTCCTGGAT CCCTGAGCGC 
TTCGCCCTCT GCCAACCCCT CCTGCTCTTC TCGTCGCTGC AGCATGGGTA CAGCCTAAGC 
AGGTTCTATT TCCAGTGCGA AGGACATGAG CCCACACTCC TGCTCATCAA GACCACTCAA 
AAGGAGGTTT GTGGGGCTTA CCTGTCAACA GACTGGAGTG AGCGGAATAA GTTCGGAGGC 
AAGCTGAGCT TCTTTGGGAC TGGAGAATGC TTTGTTTTTA GGCTGCAGCC GGAGGTGCAG 
CGCTATGAGT GGGTGGTCAT CAAGCACCCA GAACTGACCA AGGCAGCATC CTTCAAGTCC 
TCAGAGGCTG CAGCCAATCC TTGCCTCATC AGCCACTCCG TCTCTTCAGA CCCTGCCGAC 
CGGCTCTCTC CTTTCCTGGC TGCCCGGCAC TTCAACCTGC CCTCCAAGAC CGAGTCCATG 
TTCATGGCTG GGGGCAACGA CTGCCTCATC ATTGGGGGAG GAGGTGGCCA AGCACTCTAC 
ATCGATGGGG ATCTGAACCG AGGGCGCACC GGACACTGTG ACACGTTCAA CAACCAGCCC 
CTGTGCTCGG AGAGCTTCCT CATCGCGGCC GTGGAGGCTT GGGGCTTCCA AGACCCCGAC 
ACCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons.
Human molecular genetics28(4)584-597(2019 02)
Finelli MJ,Aprile D,Castroflorio E,Jeans A,Moschetta M,Chessum L,Degiacomi MT,Grasegger J,Lupien-Meilleur A,Bassett A,Rossignol E,Campeau PM,Bowl MR,Benfenati F,Fassio A,Oliver PL

The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress.
The Journal of biological chemistry291(6)2751-63(2016 Feb)
Finelli MJ,Sanchez-Pulido L,Liu KX,Davies KE,Oliver PL

Homozygous TBC1D24 mutation in two siblings with familial infantile myoclonic epilepsy (FIME) and moderate intellectual disability.
Epilepsy research11172-7(2015 Mar)
Poulat AL,Ville D,de Bellescize J,André-Obadia N,Cacciagli P,Milh M,Villard L,Lesca G

Recessive TBC1D24 Mutations Are Frequent in Moroccan Non-Syndromic Hearing Loss Pedigrees.
PloS one10(9)e0138072(2015)
Bakhchane A,Charif M,Salime S,Boulouiz R,Nahili H,Roky R,Lenaers G,Barakat A

TBC1D24 mutation causes autosomal-dominant nonsyndromic hearing loss.
Human mutation35(7)819-23(2014 Jul)
Azaiez H,Booth KT,Bu F,Huygen P,Shibata SB,Shearer AE,Kolbe D,Meyer N,Black-Ziegelbein EA,Smith RJ

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Tbc1d24 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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