Cd74 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd74
Entrez Gene ID	25599
Full Name	CD74 molecule
Synonyms	INVG34
General protein information	Preferred Names CD74 molecule Names H-2 class II histocompatibility antigen gamma chain Cd74 molecule, major histocompatibility complex, class II invariant chain MHC class II-associated invariant chain ia antigen-associated invariant chain ii
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q12.1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006254761.3	XP_006254823.1	H-2 class II histocompatibility antigen gamma chain isoform X1
NM_013069.2	NP_037201.1	H-2 class II histocompatibility antigen gamma chain

Pathways from BioSystems

Homologies

Homo sapiens (human)	CD74	NP_001020330.1
Pan troglodytes (chimpanzee)	CD74	NP_001138308.1
Mus musculus (house mouse)	Cd74	NP_001036070.1
Macaca mulatta (Rhesus monkey)	CD74	XP_001099491.2
Canis lupus familiaris (dog)	CD74	XP_536468.5
Rattus norvegicus (Norway rat)	Cd74	NP_037201.1
Gallus gallus (chicken)	CD74	NP_001001613.1
Xenopus tropicalis (tropical clawed frog)	cd74	NP_001184039.1

Gene Ontology
Bibliography

Related articles in PubMed

Macrophage migration inhibitory factor activates inflammatory responses of astrocytes through interaction with CD74 receptor.
Su Y, Wang Y, Zhou Y, Zhu Z, Zhang Q, Zhang X, Wang W, Gu X, Guo A, Wang Y
Oncotarget8(2)2719-2730(2017 Jan)

CD74 indicates microglial activation in experimental diabetic retinopathy and exogenous methylglyoxal mimics the response in normoglycemic retina.
Wang J, Lin J, Schlotterer A, Wu L, Fleming T, Busch S, Dietrich N, Hammes HP
Acta diabetologica51(5)813-21(2014 Oct)

CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.
Zhen A, Krutzik SR, Levin BR, Kasparian S, Zack JA, Kitchen SG
Journal of virology88(17)9934-46(2014 Sep)

Migration inhibitory factor enhances inflammation via CD74 in cartilage end plates with Modic type 1 changes on MRI.
Xiong C, Huang B, Cun Y, Aghdasi BG, Zhou Y
Clinical orthopaedics and related research472(6)1943-54(2014 Jun)

Porcine CD74 is involved in the inflammatory response activated by nuclear factor kappa B during porcine circovirus type 2 (PCV-2) infection.
Zhang H, Liu C, Cheng S, Wang X, Li W, Charreyre C, Audonnet JC, He Q
Archives of virology158(11)2285-95(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cd74 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd74 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01847	NM_013069.2 Latest version!	Rattus norvegicus CD74 molecule (Cd74), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa38412	XM_006254761.3 Latest version!	Rattus norvegicus CD74 molecule (Cd74), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd74 ( NM_013069.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037201.1 Rattus norvegicus CD74 molecule (Cd74), mRNA.

Price & Availability↑

CloneID	ORa01847
Clone ID Related Accession (Same CDS sequence)	NM_013069.2
Accession Version	NM_013069.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570550400000
Organism	Rattus norvegicus(Norway rat)
Product	H-2 class II histocompatibility antigen gamma chain
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB696567.1, BC059152.1 and CB611598.1. On Oct 26, 2005 this sequence version replaced NM_013069.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ231756.1, FQ232412.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGATGACC AGCGCGACCT CATCTCTAAC CATGAGCAGC TGCCCATCCT GGGCCAGCGT 
GCTAGAGCCC CAGAAAGCAA TTGCAACCGT GGAGTCCTGT ACACCAGTGT CTCTGTCCTG 
GTGGCTCTGC TCTTGGCTGG GCAGGCCACC ACTGCTTACT TCCTGTACCA GCAGCAGGGC 
CGCCTGGACA AGCTGACCGT CACCTCCCAG AACCTGCAAC TGGAGAACCT TCGCATGAAG 
CTTCCGAAAT CTGCCAAACC TGTGAGCCCG ATGCGCATGG CTACTCCCTT GCTGATGCGC 
CCACTGTCCA TGGATAACAT GCTCCAAGCG CCCGTGAAGA ATGTTACCAA GTATGGCAAC 
ATGACCCAGG ACCACGTGAT GCACCTGCTT ACGAAGTCTG GACCCGTGAA CTACCCACAG 
CTGAAGGGGA GCTTCCCGGA GAATCTGAAG CACCTTAAGA ACTCTATGAA TGGTCTGGAC 
TGGAAGGTCT TTGAGAGCTG GATGAAACAG TGGCTGTTGT TTGAAATGAG CAAGAACTCC 
CTGGAGGAGA AGCAGCCCAC CCAGACTCCA CCTAAAGAGC CACTGGACAT GGAAGACCCA 
TCTTCTGGCC TGGGAGTGAC CAAGCAGGAT ATGGGCCAAA TGTTCTTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037201.1
CDS	97..747
Translation	MDDQRDLISNHEQLPILGQRARAPESNCNRGVLYTSVSVLVALLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKSAKPVSPMRMATPLLMRPLSMDNMLQAPVKNVTKYGNMTQDHVMHLLTKSGPVNYPQLKGSFPENLKHLKNSMNGLDWKVFESWMKQWLLFEMSKNSLEEKQPTQTPPKEPLDMEDPSSGLGVTKQDMGQMFL

Target ORF information:

RefSeq Version	NM_013069.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CD74 molecule (Cd74), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013069.2

ORF Insert Sequence:

ATGGATGACC AGCGCGACCT CATCTCTAAC CATGAGCAGC TGCCCATCCT GGGCCAGCGT 
GCTAGAGCCC CAGAAAGCAA TTGCAACCGT GGAGTCCTGT ACACCAGTGT CTCTGTCCTG 
GTGGCTCTGC TCTTGGCTGG GCAGGCCACC ACTGCTTACT TCCTGTACCA GCAGCAGGGC 
CGCCTGGACA AGCTGACCGT CACCTCCCAG AACCTGCAAC TGGAGAACCT TCGCATGAAG 
CTTCCGAAAT CTGCCAAACC TGTGAGCCCG ATGCGCATGG CTACTCCCTT GCTGATGCGC 
CCACTGTCCA TGGATAACAT GCTCCAAGCG CCCGTGAAGA ATGTTACCAA GTATGGCAAC 
ATGACCCAGG ACCACGTGAT GCACCTGCTT ACGAAGTCTG GACCCGTGAA CTACCCACAG 
CTGAAGGGGA GCTTCCCGGA GAATCTGAAG CACCTTAAGA ACTCTATGAA TGGTCTGGAC 
TGGAAGGTCT TTGAGAGCTG GATGAAACAG TGGCTGTTGT TTGAAATGAG CAAGAACTCC 
CTGGAGGAGA AGCAGCCCAC CCAGACTCCA CCTAAAGAGC CACTGGACAT GGAAGACCCA 
TCTTCTGGCC TGGGAGTGAC CAAGCAGGAT ATGGGCCAAA TGTTCTTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cd74 ( XM_006254761.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254823.1 Rattus norvegicus CD74 molecule (Cd74), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa38412
Clone ID Related Accession (Same CDS sequence)	XM_006254761.3
Accession Version	XM_006254761.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	H-2 class II histocompatibility antigen gamma chain isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254761.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGACC AGCGCGACCT CATCTCTAAC CATGAGCAGC TGCCCATCCT GGGCCAGCGT 
GCTAGAGCCC CAGAAAGCAA TTGCAACCGT GGAGTCCTGT ACACCAGTGT CTCTGTCCTG 
GTGGCTCTGC TCTTGGCTGG GCAGGCCACC ACTGCTTACT TCCTGTACCA GCAGCAGGGC 
CGCCTGGACA AGCTGACCGT CACCTCCCAG AACCTGCAAC TGGAGAACCT TCGCATGAAG 
CTTCCGAAAT CTGCCAAACC TGTGAGCCCG ATGCGCATGG CTACTCCCTT GCTGATGCGC 
CCACTGTCCA TGGATAACAT GCTCCAAGCG CCCGTGAAGA ATGTTACCAA GTATGGCAAC 
ATGACCCAGG ACCACGTGAT GCACCTGCTT ACGAAGTCTG GACCCGTGAA CTACCCACAG 
CTGAAGGGGA GCTTCCCGGA GAATCTGAAG CACCTTAAGA ACTCTATGAA TGGTCTGGAC 
TGGAAGGTCT TTGAGAGCTG GATGAAACAG TGGCTGTTGT TTGAAATGAG CAAGAACTCC 
CTGGAGGAGA AGCAGCCCAC CCAGACTCCA CCTAAAGTAT TGACCAAGTG CCAGGAAGAA 
GTCAGCCACA TCCCTGATGT CCACCCGGGG GCGTTCCGTC CCAAGTGTGA TGAGAACGGT 
AACTATATGC CACTCCAGTG CCATGGGAGC ACTGGCTACT GCTGGTGTGT GTTCCCCAAC 
GGCACTGAGG TCCCTCACAC CAAGAGCCGC GGGCGCCATA ACTGCAGTGA GCCACTGGAC 
ATGGAAGACC CATCTTCTGG CCTGGGAGTG ACCAAGCAGG ATATGGGCCA AATGTTCTTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254823.1
CDS	155..997
Translation	MDDQRDLISNHEQLPILGQRARAPESNCNRGVLYTSVSVLVALLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKSAKPVSPMRMATPLLMRPLSMDNMLQAPVKNVTKYGNMTQDHVMHLLTKSGPVNYPQLKGSFPENLKHLKNSMNGLDWKVFESWMKQWLLFEMSKNSLEEKQPTQTPPKVLTKCQEEVSHIPDVHPGAFRPKCDENGNYMPLQCHGSTGYCWCVFPNGTEVPHTKSRGRHNCSEPLDMEDPSSGLGVTKQDMGQMFL

Target ORF information:

RefSeq Version	XM_006254761.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CD74 molecule (Cd74), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254761.3

ORF Insert Sequence:

ATGGATGACC AGCGCGACCT CATCTCTAAC CATGAGCAGC TGCCCATCCT GGGCCAGCGT 
GCTAGAGCCC CAGAAAGCAA TTGCAACCGT GGAGTCCTGT ACACCAGTGT CTCTGTCCTG 
GTGGCTCTGC TCTTGGCTGG GCAGGCCACC ACTGCTTACT TCCTGTACCA GCAGCAGGGC 
CGCCTGGACA AGCTGACCGT CACCTCCCAG AACCTGCAAC TGGAGAACCT TCGCATGAAG 
CTTCCGAAAT CTGCCAAACC TGTGAGCCCG ATGCGCATGG CTACTCCCTT GCTGATGCGC 
CCACTGTCCA TGGATAACAT GCTCCAAGCG CCCGTGAAGA ATGTTACCAA GTATGGCAAC 
ATGACCCAGG ACCACGTGAT GCACCTGCTT ACGAAGTCTG GACCCGTGAA CTACCCACAG 
CTGAAGGGGA GCTTCCCGGA GAATCTGAAG CACCTTAAGA ACTCTATGAA TGGTCTGGAC 
TGGAAGGTCT TTGAGAGCTG GATGAAACAG TGGCTGTTGT TTGAAATGAG CAAGAACTCC 
CTGGAGGAGA AGCAGCCCAC CCAGACTCCA CCTAAAGTAT TGACCAAGTG CCAGGAAGAA 
GTCAGCCACA TCCCTGATGT CCACCCGGGG GCGTTCCGTC CCAAGTGTGA TGAGAACGGT 
AACTATATGC CACTCCAGTG CCATGGGAGC ACTGGCTACT GCTGGTGTGT GTTCCCCAAC 
GGCACTGAGG TCCCTCACAC CAAGAGCCGC GGGCGCCATA ACTGCAGTGA GCCACTGGAC 
ATGGAAGACC CATCTTCTGG CCTGGGAGTG ACCAAGCAGG ATATGGGCCA AATGTTCTTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Macrophage migration inhibitory factor activates inflammatory responses of astrocytes through interaction with CD74 receptor.
Oncotarget8(2)2719-2730(2017 Jan)
Su Y,Wang Y,Zhou Y,Zhu Z,Zhang Q,Zhang X,Wang W,Gu X,Guo A,Wang Y

CD74 indicates microglial activation in experimental diabetic retinopathy and exogenous methylglyoxal mimics the response in normoglycemic retina.
Acta diabetologica51(5)813-21(2014 Oct)
Wang J,Lin J,Schlotterer A,Wu L,Fleming T,Busch S,Dietrich N,Hammes HP

CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.
Journal of virology88(17)9934-46(2014 Sep)
Zhen A,Krutzik SR,Levin BR,Kasparian S,Zack JA,Kitchen SG

Migration inhibitory factor enhances inflammation via CD74 in cartilage end plates with Modic type 1 changes on MRI.
Clinical orthopaedics and related research472(6)1943-54(2014 Jun)
Xiong C,Huang B,Cun Y,Aghdasi BG,Zhou Y

Porcine CD74 is involved in the inflammatory response activated by nuclear factor kappa B during porcine circovirus type 2 (PCV-2) infection.
Archives of virology158(11)2285-95(2013 Nov)
Zhang H,Liu C,Cheng S,Wang X,Li W,Charreyre C,Audonnet JC,He Q