Cd74 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd74
Entrez Gene ID	16149
Full Name	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
Synonyms	CLIP,DHLAG,HLADG,Ia-GAMMA,Ii
General protein information	Preferred Names CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) Names H-2 class II histocompatibility antigen gamma chain HLA-DR-GAMMA Ia-associated invariant chain MHC class II-associated invariant chain class II-associated invariant chain peptide dinucleotide microsatellite histocompatibility: class II antigens, gamma chain of ia antigen-associated invariant chain invariant polypeptide of major histocompatibility complex, class II antigen-associated
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18 E1\|18 34.41 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001042605.1	NP_001036070.1	H-2 class II histocompatibility antigen gamma chain isoform 1
NM_010545.3	NP_034675.1	H-2 class II histocompatibility antigen gamma chain isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	CD74	NP_001020330.1
Pan troglodytes (chimpanzee)	CD74	NP_001138308.1
Mus musculus (house mouse)	Cd74	NP_001036070.1
Macaca mulatta (Rhesus monkey)	CD74	XP_001099491.2
Canis lupus familiaris (dog)	CD74	XP_536468.5
Rattus norvegicus (Norway rat)	Cd74	NP_037201.1
Gallus gallus (chicken)	CD74	NP_001001613.1
Xenopus tropicalis (tropical clawed frog)	cd74	NP_001184039.1

Gene Ontology
Bibliography

Related articles in PubMed

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.
Masuda T, Sankowski R, Staszewski O, Böttcher C, Amann L, Sagar, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Grün D, Priller J, Stadelmann C, Prinz M
Nature566(7744)388-392(2019 02)

Invariant chain p41 mediates production of soluble MHC class II molecules.
Shishido T, Kohyama M, Nakai W, Matsumoto M, Miyata H, Suenaga T, Arase H
Biochemical and biophysical research communications509(1)216-221(2019 01)

Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development.
Su X, Wu C, Ye X, Zeng M, Zhang Z, Che Y, Zhang Y, Liu L, Lin Y, Yang R
Cell death & disease9(3)302(2018 02)

TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells.
Valiño-Rivas L, Cuarental L, Grana O, Bucala R, Leng L, Sanz A, Gomez G, Ortiz A, Sanchez-Niño MD
PloS one13(6)e0199391(2018)

T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP.
Radomir L, Cohen S, Kramer MP, Bakos E, Lewinsky H, Barak A, Porat Z, Bucala R, Stepensky P, Becker-Herman S, Shachar I
Journal of immunology (Baltimore, Md. : 1950)199(8)2745-2757(2017 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cd74 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd74 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21682	NM_010545.3 Latest version!	Mus musculus CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu21811	NM_001042605.1 Latest version!	Mus musculus CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00

ORF Online Only Promotion

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1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd74 ( NM_010545.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034675.1 Mus musculus CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu21682
Clone ID Related Accession (Same CDS sequence)	NM_010545.3
Accession Version	NM_010545.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Mus musculus(house mouse)
Product	H-2 class II histocompatibility antigen gamma chain isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK002232.1 and AW123644.1. On Jul 22, 2006 this sequence version replaced NM_010545.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC096435.1, AK020607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGACC AACGCGACCT CATCTCTAAC CATGAACAGT TGCCCATACT GGGCAACCGC 
CCTAGAGAGC CAGAAAGGTG CAGCCGTGGA GCTCTGTACA CCGGTGTCTC TGTCCTGGTG 
GCTCTGCTCT TGGCTGGGCA GGCCACCACT GCTTACTTCC TGTACCAGCA ACAGGGCCGC 
CTAGACAAGC TGACCATCAC CTCCCAGAAC CTGCAACTGG AGAGCCTTCG CATGAAGCTT 
CCGAAATCTG CCAAACCTGT GAGCCAGATG CGGATGGCTA CTCCCTTGCT GATGCGTCCA 
ATGTCCATGG ATAACATGCT CCTTGGGCCT GTGAAGAACG TTACCAAGTA CGGCAACATG 
ACCCAGGACC ATGTGATGCA TCTGCTCACG AGGTCTGGAC CCCTGGAGTA CCCGCAGCTG 
AAGGGGACCT TCCCAGAGAA TCTGAAGCAT CTTAAGAACT CCATGGATGG CGTGAACTGG 
AAGATCTTCG AGAGCTGGAT GAAGCAGTGG CTCTTGTTTG AGATGAGCAA GAACTCCCTG 
GAGGAGAAGA AGCCCACCGA GGCTCCACCT AAAGAGCCAC TGGACATGGA AGACCTATCT 
TCTGGCCTGG GAGTGACCAG GCAGGAACTG GGTCAAGTCA CCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034675.1
CDS	86..733
Translation	MDDQRDLISNHEQLPILGNRPREPERCSRGALYTGVSVLVALLLAGQATTAYFLYQQQGRLDKLTITSQNLQLESLRMKLPKSAKPVSQMRMATPLLMRPMSMDNMLLGPVKNVTKYGNMTQDHVMHLLTRSGPLEYPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKKPTEAPPKEPLDMEDLSSGLGVTRQELGQVTL

Target ORF information:

RefSeq Version	NM_010545.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010545.3

ORF Insert Sequence:

ATGGATGACC AACGCGACCT CATCTCTAAC CATGAACAGT TGCCCATACT GGGCAACCGC 
CCTAGAGAGC CAGAAAGGTG CAGCCGTGGA GCTCTGTACA CCGGTGTCTC TGTCCTGGTG 
GCTCTGCTCT TGGCTGGGCA GGCCACCACT GCTTACTTCC TGTACCAGCA ACAGGGCCGC 
CTAGACAAGC TGACCATCAC CTCCCAGAAC CTGCAACTGG AGAGCCTTCG CATGAAGCTT 
CCGAAATCTG CCAAACCTGT GAGCCAGATG CGGATGGCTA CTCCCTTGCT GATGCGTCCA 
ATGTCCATGG ATAACATGCT CCTTGGGCCT GTGAAGAACG TTACCAAGTA CGGCAACATG 
ACCCAGGACC ATGTGATGCA TCTGCTCACG AGGTCTGGAC CCCTGGAGTA CCCGCAGCTG 
AAGGGGACCT TCCCAGAGAA TCTGAAGCAT CTTAAGAACT CCATGGATGG CGTGAACTGG 
AAGATCTTCG AGAGCTGGAT GAAGCAGTGG CTCTTGTTTG AGATGAGCAA GAACTCCCTG 
GAGGAGAAGA AGCCCACCGA GGCTCCACCT AAAGAGCCAC TGGACATGGA AGACCTATCT 
TCTGGCCTGG GAGTGACCAG GCAGGAACTG GGTCAAGTCA CCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cd74 ( NM_001042605.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001036070.1 Mus musculus CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu21811
Clone ID Related Accession (Same CDS sequence)	NM_001042605.1
Accession Version	NM_001042605.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Mus musculus(house mouse)
Product	H-2 class II histocompatibility antigen gamma chain isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK002232.1, BG148172.1 and AW123644.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK154096.1, BC003476.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGACC AACGCGACCT CATCTCTAAC CATGAACAGT TGCCCATACT GGGCAACCGC 
CCTAGAGAGC CAGAAAGGTG CAGCCGTGGA GCTCTGTACA CCGGTGTCTC TGTCCTGGTG 
GCTCTGCTCT TGGCTGGGCA GGCCACCACT GCTTACTTCC TGTACCAGCA ACAGGGCCGC 
CTAGACAAGC TGACCATCAC CTCCCAGAAC CTGCAACTGG AGAGCCTTCG CATGAAGCTT 
CCGAAATCTG CCAAACCTGT GAGCCAGATG CGGATGGCTA CTCCCTTGCT GATGCGTCCA 
ATGTCCATGG ATAACATGCT CCTTGGGCCT GTGAAGAACG TTACCAAGTA CGGCAACATG 
ACCCAGGACC ATGTGATGCA TCTGCTCACG AGGTCTGGAC CCCTGGAGTA CCCGCAGCTG 
AAGGGGACCT TCCCAGAGAA TCTGAAGCAT CTTAAGAACT CCATGGATGG CGTGAACTGG 
AAGATCTTCG AGAGCTGGAT GAAGCAGTGG CTCTTGTTTG AGATGAGCAA GAACTCCCTG 
GAGGAGAAGA AGCCCACCGA GGCTCCACCT AAAGTACTGA CCAAGTGCCA GGAAGAAGTC 
AGCCACATCC CTGCCGTCTA CCCGGGTGCG TTCCGTCCCA AGTGCGACGA GAACGGTAAC 
TATTTGCCAC TCCAGTGCCA CGGGAGCACT GGCTACTGCT GGTGTGTGTT CCCCAACGGC 
ACTGAGGTTC CTCACACCAA GAGCCGCGGG CGCCATAACT GCAGTGAGCC ACTGGACATG 
GAAGACCTAT CTTCTGGCCT GGGAGTGACC AGGCAGGAAC TGGGTCAAGT CACCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001036070.1
CDS	86..925
Translation	MDDQRDLISNHEQLPILGNRPREPERCSRGALYTGVSVLVALLLAGQATTAYFLYQQQGRLDKLTITSQNLQLESLRMKLPKSAKPVSQMRMATPLLMRPMSMDNMLLGPVKNVTKYGNMTQDHVMHLLTRSGPLEYPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKKPTEAPPKVLTKCQEEVSHIPAVYPGAFRPKCDENGNYLPLQCHGSTGYCWCVFPNGTEVPHTKSRGRHNCSEPLDMEDLSSGLGVTRQELGQVTL

Target ORF information:

RefSeq Version	NM_001042605.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042605.1

ORF Insert Sequence:

ATGGATGACC AACGCGACCT CATCTCTAAC CATGAACAGT TGCCCATACT GGGCAACCGC 
CCTAGAGAGC CAGAAAGGTG CAGCCGTGGA GCTCTGTACA CCGGTGTCTC TGTCCTGGTG 
GCTCTGCTCT TGGCTGGGCA GGCCACCACT GCTTACTTCC TGTACCAGCA ACAGGGCCGC 
CTAGACAAGC TGACCATCAC CTCCCAGAAC CTGCAACTGG AGAGCCTTCG CATGAAGCTT 
CCGAAATCTG CCAAACCTGT GAGCCAGATG CGGATGGCTA CTCCCTTGCT GATGCGTCCA 
ATGTCCATGG ATAACATGCT CCTTGGGCCT GTGAAGAACG TTACCAAGTA CGGCAACATG 
ACCCAGGACC ATGTGATGCA TCTGCTCACG AGGTCTGGAC CCCTGGAGTA CCCGCAGCTG 
AAGGGGACCT TCCCAGAGAA TCTGAAGCAT CTTAAGAACT CCATGGATGG CGTGAACTGG 
AAGATCTTCG AGAGCTGGAT GAAGCAGTGG CTCTTGTTTG AGATGAGCAA GAACTCCCTG 
GAGGAGAAGA AGCCCACCGA GGCTCCACCT AAAGTACTGA CCAAGTGCCA GGAAGAAGTC 
AGCCACATCC CTGCCGTCTA CCCGGGTGCG TTCCGTCCCA AGTGCGACGA GAACGGTAAC 
TATTTGCCAC TCCAGTGCCA CGGGAGCACT GGCTACTGCT GGTGTGTGTT CCCCAACGGC 
ACTGAGGTTC CTCACACCAA GAGCCGCGGG CGCCATAACT GCAGTGAGCC ACTGGACATG 
GAAGACCTAT CTTCTGGCCT GGGAGTGACC AGGCAGGAAC TGGGTCAAGT CACCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.
Nature566(7744)388-392(2019 02)
Masuda T,Sankowski R,Staszewski O,Böttcher C,Amann L,Sagar,Scheiwe C,Nessler S,Kunz P,van Loo G,Coenen VA,Reinacher PC,Michel A,Sure U,Gold R,Grün D,Priller J,Stadelmann C,Prinz M

Invariant chain p41 mediates production of soluble MHC class II molecules.
Biochemical and biophysical research communications509(1)216-221(2019 01)
Shishido T,Kohyama M,Nakai W,Matsumoto M,Miyata H,Suenaga T,Arase H

Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development.
Cell death & disease9(3)302(2018 02)
Su X,Wu C,Ye X,Zeng M,Zhang Z,Che Y,Zhang Y,Liu L,Lin Y,Yang R

TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells.
PloS one13(6)e0199391(2018)
Valiño-Rivas L,Cuarental L,Grana O,Bucala R,Leng L,Sanz A,Gomez G,Ortiz A,Sanchez-Niño MD

T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP.
Journal of immunology (Baltimore, Md. : 1950)199(8)2745-2757(2017 10)
Radomir L,Cohen S,Kramer MP,Bakos E,Lewinsky H,Barak A,Porat Z,Bucala R,Stepensky P,Becker-Herman S,Shachar I

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Cd74 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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