Lipa cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lipa
Entrez Gene ID	25055
Full Name	lipase A, lysosomal acid type
Synonyms	Chole,Chole2,LAL,Lip1
General protein information	Preferred Names lipase A, lysosomal acid type Names lysosomal acid lipase/cholesteryl ester hydrolase Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25 acid cholesteryl ester hydrolase cholesteryl esterase lipase A, lysosomal acid, cholesterol esterase lysosomal acid lipase 1 lysosomal acid lipase A pancreatic cholesterol esterase sterol esterase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q53
Summary	hydrolase that is involved in intracellular degradation of cholesteryl esters and triglycerides; mutation in gene causes Wolman's disease [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012732.3	NP_036864.3	lysosomal acid lipase/cholesteryl ester hydrolase precursor
XM_008760321.2	XP_008758543.1	lysosomal acid lipase/cholesteryl ester hydrolase isoform X1
XM_006231275.3	XP_006231337.1	lysosomal acid lipase/cholesteryl ester hydrolase isoform X1
XM_017588801.1	XP_017444290.1	lysosomal acid lipase/cholesteryl ester hydrolase isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	LIPA	NP_001121077.1
Pan troglodytes (chimpanzee)	LIPA	XP_003312800.1
Caenorhabditis elegans (roundworm)	lipl-7	NP_501877.2
Saccharomyces cerevisiae (baker's yeast)	TGL1	NP_012782.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001652	XP_321444.5
Mus musculus (house mouse)	Lipa	NP_067435.3
Rattus norvegicus (Norway rat)	Lipa	NP_036864.3
Caenorhabditis elegans (roundworm)	lipl-4	NP_504662.1
Neurospora crassa	NCU02148	XP_964507.2
Macaca mulatta (Rhesus monkey)	LIPA	XP_001085160.2
Caenorhabditis elegans (roundworm)	lipl-5	NP_503184.1
Caenorhabditis elegans (roundworm)	lipl-3	NP_503233.1
Caenorhabditis elegans (roundworm)	lipl-2	NP_505527.1
Xenopus tropicalis (tropical clawed frog)	lipa	NP_001015847.2
Bos taurus (cattle)	LIPA	NP_001096793.1
Magnaporthe oryzae (rice blast fungus)	MGG_02622	XP_003721170.1
Schizosaccharomyces pombe (fission yeast)	SPCC1672.09	NP_587880.1
Gallus gallus (chicken)	LIPA	XP_421661.3
Caenorhabditis elegans (roundworm)	lipl-1	NP_506229.1
Caenorhabditis elegans (roundworm)	lipl-6	NP_504755.2
Canis lupus familiaris (dog)	LIPA	XP_005636708.1
Eremothecium gossypii	AGOS_AFR206C	NP_985753.1
Danio rerio (zebrafish)	lipf	NP_998569.1

Gene Ontology
Bibliography

Related articles in PubMed

Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung.
Lian X, Yan C, Yang L, Xu Y, Du H
American journal of physiology. Lung cellular and molecular physiology286(4)L801-7(2004 Apr)

Changes in the activity of lysosomal enzymes in rat kidneys in the course of acute pancreatitis.
Łakowska H, Maciejewski R, Szkodziak P, Staśkiewicz G
Medical science monitor : international medical journal of experimental and clinical research7(6)1193-7(2001 Nov-Dec)

Inhibition of the acid lipase activity by apolipoprotein A-I in the presence of lysosomal proteases.
Inoue Y, Ose T, Mukai S, Ehira S, Yonekura M, Hou DX, Fujii M
Bioscience, biotechnology, and biochemistry63(5)937-9(1999 May)

Cloning of rat lysosomal acid lipase cDNA and identification of the mutation in the rat model of Wolman's disease.
Nakagawa H, Matsubara S, Kuriyama M, Yoshidome H, Fujiyama J, Yoshida H, Osame M
Journal of lipid research36(10)2212-8(1995 Oct)

Mutations at the lysosomal acid cholesteryl ester hydrolase gene locus in Wolman disease.
Anderson RA, Byrum RS, Coates PM, Sando GN
Proceedings of the National Academy of Sciences of the United States of America91(7)2718-22(1994 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Lipa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lipa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa00781	NM_012732.3 Latest version!	Rattus norvegicus lipase A, lysosomal acid type (Lipa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa00781	XM_006231275.3 Latest version!	Rattus norvegicus lipase A, lysosomal acid type (Lipa), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa00781	XM_008760321.2 Latest version!	Rattus norvegicus lipase A, lysosomal acid type (Lipa), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa00781	XM_017588801.1 Latest version!	Rattus norvegicus lipase A, lysosomal acid type (Lipa), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lipa ( NM_012732.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036864.3 Rattus norvegicus lipase A, lysosomal acid type (Lipa), mRNA.

Price & Availability↑

CloneID	ORa00781
Clone ID Related Accession (Same CDS sequence)	NM_012732.3 , XM_008760321.2 , XM_006231275.3 , XM_017588801.1
Accession Version	NM_012732.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	lysosomal acid lipase/cholesteryl ester hydrolase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC072532.1. On Oct 20, 2005 this sequence version replaced NM_012732.2. ##Evidence-Data-START## Transcript exon combination :: BC072532.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906352, SAMN01906355 [ECO:0000348] ##Evidence-Data-END##

ATGCAACTGC TAGGCCGGGT GATCTGTTTC GTCGTTGGGA TCCTGCTTTC TGGGGGCCCA 
ACGGGGACCA TATCAGCTGT GGACCCTGAA GCAAACATGA ATGTGACTGA GATAATCATG 
CACTGGGGAT ATCCTGGCGA AGAGCACTCA GTACAGACAG GAGATGGCTA CATTCTGGGT 
GTTCACCGAA TCCCGCATGG GCGGAAGAAC CAGTTTGATA AAGGTCCCAA ACCAGTTGTG 
TATCTTCAGC ATGGCTTCCT GGCAGATTCT AGTAACTGGG TCACAAACAT TGACAACAAC 
AGCCTGGGCT TCATCCTGGC AGATGCTGGC TTTGATGTGT GGATGGGAAA CAGCAGAGGA 
AACACCTGGT CTCGGAAGCA CAAGACTCTG TCAGTTTCTC AGGATGAATA CTGGGCCTTC 
AGTTTTGATG AGATGGCAAA ATATGACCTC CCTGCTTCAA TTAACTACAT TTTGAATAAA 
ACTGGCCAAG AACAGCTGTA TTATGTGGGC CACTCTCAAG GCTGCACCAT AGGTTTTATA 
GCATTTTCAC AGATGCCTGA ACTGGCAAAG AAGGTTAAAA TGTTTTTTGC CCTGGCTCCT 
GTGTTGTCTC TCAATTTTGC TTCGGGCCCG ATGGTCAAAT TGGGACGGTT GCCGGATCTG 
CTTCTTGAGG ACTTGTTTGG GCAGAAGCAA TTTCTTCCTC AGAGTGCAAT GGTGAAATGG 
CTAAGCACTC ACATTTGCAC GCACGTCATC ATGAAGGAGC TTTGCGCCAA CATCTTCTTT 
CTGATATGTG GCTTCAATGA GAAGAATTTA AACATGTCTA GAGTGGATGT GTATACAACA 
CACTGTCCTG CGGGAACCTC TGTGCAAAAC ATGGTACACT GGACCCAGGT TGTTAAATAC 
CATAAGCTTC AAGCTTTTGA CTGGGGAAGC AGTGACAAGA ATTATTTTCA TTACAATCAG 
AGTTATCCAC CCTTGTACAG CATAAAAGAC ATGCAACTAC CCACTGCTTT ATGGAGCGGG 
GGCAAGGACT GGCTGGCAGA CACCAGTGAC ATCAATATCT TACTGACTGA AATCCCCACG 
TTAGTGTACC ACAAGAACAT TCCCGAGTGG GACCATCTGG ATTTTATCTG GGGTTTGGAT 
GCCCCCTGGA GGCTGTATAA TGAAGTAGTC AGTCTAATGA AGAAATACCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036864.3
CDS	287..1480
Translation	MQLLGRVICFVVGILLSGGPTGTISAVDPEANMNVTEIIMHWGYPGEEHSVQTGDGYILGVHRIPHGRKNQFDKGPKPVVYLQHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASINYILNKTGQEQLYYVGHSQGCTIGFIAFSQMPELAKKVKMFFALAPVLSLNFASGPMVKLGRLPDLLLEDLFGQKQFLPQSAMVKWLSTHICTHVIMKELCANIFFLICGFNEKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQSYPPLYSIKDMQLPTALWSGGKDWLADTSDINILLTEIPTLVYHKNIPEWDHLDFIWGLDAPWRLYNEVVSLMKKYQ

Target ORF information:

RefSeq Version	NM_012732.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lipase A, lysosomal acid type (Lipa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012732.3

ORF Insert Sequence:

ATGCAACTGC TAGGCCGGGT GATCTGTTTC GTCGTTGGGA TCCTGCTTTC TGGGGGCCCA 
ACGGGGACCA TATCAGCTGT GGACCCTGAA GCAAACATGA ATGTGACTGA GATAATCATG 
CACTGGGGAT ATCCTGGCGA AGAGCACTCA GTACAGACAG GAGATGGCTA CATTCTGGGT 
GTTCACCGAA TCCCGCATGG GCGGAAGAAC CAGTTTGATA AAGGTCCCAA ACCAGTTGTG 
TATCTTCAGC ATGGCTTCCT GGCAGATTCT AGTAACTGGG TCACAAACAT TGACAACAAC 
AGCCTGGGCT TCATCCTGGC AGATGCTGGC TTTGATGTGT GGATGGGAAA CAGCAGAGGA 
AACACCTGGT CTCGGAAGCA CAAGACTCTG TCAGTTTCTC AGGATGAATA CTGGGCCTTC 
AGTTTTGATG AGATGGCAAA ATATGACCTC CCTGCTTCAA TTAACTACAT TTTGAATAAA 
ACTGGCCAAG AACAGCTGTA TTATGTGGGC CACTCTCAAG GCTGCACCAT AGGTTTTATA 
GCATTTTCAC AGATGCCTGA ACTGGCAAAG AAGGTTAAAA TGTTTTTTGC CCTGGCTCCT 
GTGTTGTCTC TCAATTTTGC TTCGGGCCCG ATGGTCAAAT TGGGACGGTT GCCGGATCTG 
CTTCTTGAGG ACTTGTTTGG GCAGAAGCAA TTTCTTCCTC AGAGTGCAAT GGTGAAATGG 
CTAAGCACTC ACATTTGCAC GCACGTCATC ATGAAGGAGC TTTGCGCCAA CATCTTCTTT 
CTGATATGTG GCTTCAATGA GAAGAATTTA AACATGTCTA GAGTGGATGT GTATACAACA 
CACTGTCCTG CGGGAACCTC TGTGCAAAAC ATGGTACACT GGACCCAGGT TGTTAAATAC 
CATAAGCTTC AAGCTTTTGA CTGGGGAAGC AGTGACAAGA ATTATTTTCA TTACAATCAG 
AGTTATCCAC CCTTGTACAG CATAAAAGAC ATGCAACTAC CCACTGCTTT ATGGAGCGGG 
GGCAAGGACT GGCTGGCAGA CACCAGTGAC ATCAATATCT TACTGACTGA AATCCCCACG 
TTAGTGTACC ACAAGAACAT TCCCGAGTGG GACCATCTGG ATTTTATCTG GGGTTTGGAT 
GCCCCCTGGA GGCTGTATAA TGAAGTAGTC AGTCTAATGA AGAAATACCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lipa ( XM_008760321.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008758543.1 Rattus norvegicus lipase A, lysosomal acid type (Lipa), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa00781
Clone ID Related Accession (Same CDS sequence)	NM_012732.3 , XM_008760321.2 , XM_006231275.3 , XM_017588801.1
Accession Version	XM_008760321.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	lysosomal acid lipase/cholesteryl ester hydrolase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008760321.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAACTGC TAGGCCGGGT GATCTGTTTC GTCGTTGGGA TCCTGCTTTC TGGGGGCCCA 
ACGGGGACCA TATCAGCTGT GGACCCTGAA GCAAACATGA ATGTGACTGA GATAATCATG 
CACTGGGGAT ATCCTGGCGA AGAGCACTCA GTACAGACAG GAGATGGCTA CATTCTGGGT 
GTTCACCGAA TCCCGCATGG GCGGAAGAAC CAGTTTGATA AAGGTCCCAA ACCAGTTGTG 
TATCTTCAGC ATGGCTTCCT GGCAGATTCT AGTAACTGGG TCACAAACAT TGACAACAAC 
AGCCTGGGCT TCATCCTGGC AGATGCTGGC TTTGATGTGT GGATGGGAAA CAGCAGAGGA 
AACACCTGGT CTCGGAAGCA CAAGACTCTG TCAGTTTCTC AGGATGAATA CTGGGCCTTC 
AGTTTTGATG AGATGGCAAA ATATGACCTC CCTGCTTCAA TTAACTACAT TTTGAATAAA 
ACTGGCCAAG AACAGCTGTA TTATGTGGGC CACTCTCAAG GCTGCACCAT AGGTTTTATA 
GCATTTTCAC AGATGCCTGA ACTGGCAAAG AAGGTTAAAA TGTTTTTTGC CCTGGCTCCT 
GTGTTGTCTC TCAATTTTGC TTCGGGCCCG ATGGTCAAAT TGGGACGGTT GCCGGATCTG 
CTTCTTGAGG ACTTGTTTGG GCAGAAGCAA TTTCTTCCTC AGAGTGCAAT GGTGAAATGG 
CTAAGCACTC ACATTTGCAC GCACGTCATC ATGAAGGAGC TTTGCGCCAA CATCTTCTTT 
CTGATATGTG GCTTCAATGA GAAGAATTTA AACATGTCTA GAGTGGATGT GTATACAACA 
CACTGTCCTG CGGGAACCTC TGTGCAAAAC ATGGTACACT GGACCCAGGT TGTTAAATAC 
CATAAGCTTC AAGCTTTTGA CTGGGGAAGC AGTGACAAGA ATTATTTTCA TTACAATCAG 
AGTTATCCAC CCTTGTACAG CATAAAAGAC ATGCAACTAC CCACTGCTTT ATGGAGCGGG 
GGCAAGGACT GGCTGGCAGA CACCAGTGAC ATCAATATCT TACTGACTGA AATCCCCACG 
TTAGTGTACC ACAAGAACAT TCCCGAGTGG GACCATCTGG ATTTTATCTG GGGTTTGGAT 
GCCCCCTGGA GGCTGTATAA TGAAGTAGTC AGTCTAATGA AGAAATACCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008758543.1
CDS	363..1556
Translation	MQLLGRVICFVVGILLSGGPTGTISAVDPEANMNVTEIIMHWGYPGEEHSVQTGDGYILGVHRIPHGRKNQFDKGPKPVVYLQHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASINYILNKTGQEQLYYVGHSQGCTIGFIAFSQMPELAKKVKMFFALAPVLSLNFASGPMVKLGRLPDLLLEDLFGQKQFLPQSAMVKWLSTHICTHVIMKELCANIFFLICGFNEKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQSYPPLYSIKDMQLPTALWSGGKDWLADTSDINILLTEIPTLVYHKNIPEWDHLDFIWGLDAPWRLYNEVVSLMKKYQ

Target ORF information:

RefSeq Version	XM_008760321.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lipase A, lysosomal acid type (Lipa), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008760321.2

ORF Insert Sequence:

ATGCAACTGC TAGGCCGGGT GATCTGTTTC GTCGTTGGGA TCCTGCTTTC TGGGGGCCCA 
ACGGGGACCA TATCAGCTGT GGACCCTGAA GCAAACATGA ATGTGACTGA GATAATCATG 
CACTGGGGAT ATCCTGGCGA AGAGCACTCA GTACAGACAG GAGATGGCTA CATTCTGGGT 
GTTCACCGAA TCCCGCATGG GCGGAAGAAC CAGTTTGATA AAGGTCCCAA ACCAGTTGTG 
TATCTTCAGC ATGGCTTCCT GGCAGATTCT AGTAACTGGG TCACAAACAT TGACAACAAC 
AGCCTGGGCT TCATCCTGGC AGATGCTGGC TTTGATGTGT GGATGGGAAA CAGCAGAGGA 
AACACCTGGT CTCGGAAGCA CAAGACTCTG TCAGTTTCTC AGGATGAATA CTGGGCCTTC 
AGTTTTGATG AGATGGCAAA ATATGACCTC CCTGCTTCAA TTAACTACAT TTTGAATAAA 
ACTGGCCAAG AACAGCTGTA TTATGTGGGC CACTCTCAAG GCTGCACCAT AGGTTTTATA 
GCATTTTCAC AGATGCCTGA ACTGGCAAAG AAGGTTAAAA TGTTTTTTGC CCTGGCTCCT 
GTGTTGTCTC TCAATTTTGC TTCGGGCCCG ATGGTCAAAT TGGGACGGTT GCCGGATCTG 
CTTCTTGAGG ACTTGTTTGG GCAGAAGCAA TTTCTTCCTC AGAGTGCAAT GGTGAAATGG 
CTAAGCACTC ACATTTGCAC GCACGTCATC ATGAAGGAGC TTTGCGCCAA CATCTTCTTT 
CTGATATGTG GCTTCAATGA GAAGAATTTA AACATGTCTA GAGTGGATGT GTATACAACA 
CACTGTCCTG CGGGAACCTC TGTGCAAAAC ATGGTACACT GGACCCAGGT TGTTAAATAC 
CATAAGCTTC AAGCTTTTGA CTGGGGAAGC AGTGACAAGA ATTATTTTCA TTACAATCAG 
AGTTATCCAC CCTTGTACAG CATAAAAGAC ATGCAACTAC CCACTGCTTT ATGGAGCGGG 
GGCAAGGACT GGCTGGCAGA CACCAGTGAC ATCAATATCT TACTGACTGA AATCCCCACG 
TTAGTGTACC ACAAGAACAT TCCCGAGTGG GACCATCTGG ATTTTATCTG GGGTTTGGAT 
GCCCCCTGGA GGCTGTATAA TGAAGTAGTC AGTCTAATGA AGAAATACCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lipa ( XM_006231275.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006231337.1 Rattus norvegicus lipase A, lysosomal acid type (Lipa), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa00781
Clone ID Related Accession (Same CDS sequence)	NM_012732.3 , XM_008760321.2 , XM_006231275.3 , XM_017588801.1
Accession Version	XM_006231275.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	lysosomal acid lipase/cholesteryl ester hydrolase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006231275.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAACTGC TAGGCCGGGT GATCTGTTTC GTCGTTGGGA TCCTGCTTTC TGGGGGCCCA 
ACGGGGACCA TATCAGCTGT GGACCCTGAA GCAAACATGA ATGTGACTGA GATAATCATG 
CACTGGGGAT ATCCTGGCGA AGAGCACTCA GTACAGACAG GAGATGGCTA CATTCTGGGT 
GTTCACCGAA TCCCGCATGG GCGGAAGAAC CAGTTTGATA AAGGTCCCAA ACCAGTTGTG 
TATCTTCAGC ATGGCTTCCT GGCAGATTCT AGTAACTGGG TCACAAACAT TGACAACAAC 
AGCCTGGGCT TCATCCTGGC AGATGCTGGC TTTGATGTGT GGATGGGAAA CAGCAGAGGA 
AACACCTGGT CTCGGAAGCA CAAGACTCTG TCAGTTTCTC AGGATGAATA CTGGGCCTTC 
AGTTTTGATG AGATGGCAAA ATATGACCTC CCTGCTTCAA TTAACTACAT TTTGAATAAA 
ACTGGCCAAG AACAGCTGTA TTATGTGGGC CACTCTCAAG GCTGCACCAT AGGTTTTATA 
GCATTTTCAC AGATGCCTGA ACTGGCAAAG AAGGTTAAAA TGTTTTTTGC CCTGGCTCCT 
GTGTTGTCTC TCAATTTTGC TTCGGGCCCG ATGGTCAAAT TGGGACGGTT GCCGGATCTG 
CTTCTTGAGG ACTTGTTTGG GCAGAAGCAA TTTCTTCCTC AGAGTGCAAT GGTGAAATGG 
CTAAGCACTC ACATTTGCAC GCACGTCATC ATGAAGGAGC TTTGCGCCAA CATCTTCTTT 
CTGATATGTG GCTTCAATGA GAAGAATTTA AACATGTCTA GAGTGGATGT GTATACAACA 
CACTGTCCTG CGGGAACCTC TGTGCAAAAC ATGGTACACT GGACCCAGGT TGTTAAATAC 
CATAAGCTTC AAGCTTTTGA CTGGGGAAGC AGTGACAAGA ATTATTTTCA TTACAATCAG 
AGTTATCCAC CCTTGTACAG CATAAAAGAC ATGCAACTAC CCACTGCTTT ATGGAGCGGG 
GGCAAGGACT GGCTGGCAGA CACCAGTGAC ATCAATATCT TACTGACTGA AATCCCCACG 
TTAGTGTACC ACAAGAACAT TCCCGAGTGG GACCATCTGG ATTTTATCTG GGGTTTGGAT 
GCCCCCTGGA GGCTGTATAA TGAAGTAGTC AGTCTAATGA AGAAATACCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006231337.1
CDS	256..1449
Translation	MQLLGRVICFVVGILLSGGPTGTISAVDPEANMNVTEIIMHWGYPGEEHSVQTGDGYILGVHRIPHGRKNQFDKGPKPVVYLQHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASINYILNKTGQEQLYYVGHSQGCTIGFIAFSQMPELAKKVKMFFALAPVLSLNFASGPMVKLGRLPDLLLEDLFGQKQFLPQSAMVKWLSTHICTHVIMKELCANIFFLICGFNEKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQSYPPLYSIKDMQLPTALWSGGKDWLADTSDINILLTEIPTLVYHKNIPEWDHLDFIWGLDAPWRLYNEVVSLMKKYQ

Target ORF information:

RefSeq Version	XM_006231275.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lipase A, lysosomal acid type (Lipa), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006231275.3

ORF Insert Sequence:

ATGCAACTGC TAGGCCGGGT GATCTGTTTC GTCGTTGGGA TCCTGCTTTC TGGGGGCCCA 
ACGGGGACCA TATCAGCTGT GGACCCTGAA GCAAACATGA ATGTGACTGA GATAATCATG 
CACTGGGGAT ATCCTGGCGA AGAGCACTCA GTACAGACAG GAGATGGCTA CATTCTGGGT 
GTTCACCGAA TCCCGCATGG GCGGAAGAAC CAGTTTGATA AAGGTCCCAA ACCAGTTGTG 
TATCTTCAGC ATGGCTTCCT GGCAGATTCT AGTAACTGGG TCACAAACAT TGACAACAAC 
AGCCTGGGCT TCATCCTGGC AGATGCTGGC TTTGATGTGT GGATGGGAAA CAGCAGAGGA 
AACACCTGGT CTCGGAAGCA CAAGACTCTG TCAGTTTCTC AGGATGAATA CTGGGCCTTC 
AGTTTTGATG AGATGGCAAA ATATGACCTC CCTGCTTCAA TTAACTACAT TTTGAATAAA 
ACTGGCCAAG AACAGCTGTA TTATGTGGGC CACTCTCAAG GCTGCACCAT AGGTTTTATA 
GCATTTTCAC AGATGCCTGA ACTGGCAAAG AAGGTTAAAA TGTTTTTTGC CCTGGCTCCT 
GTGTTGTCTC TCAATTTTGC TTCGGGCCCG ATGGTCAAAT TGGGACGGTT GCCGGATCTG 
CTTCTTGAGG ACTTGTTTGG GCAGAAGCAA TTTCTTCCTC AGAGTGCAAT GGTGAAATGG 
CTAAGCACTC ACATTTGCAC GCACGTCATC ATGAAGGAGC TTTGCGCCAA CATCTTCTTT 
CTGATATGTG GCTTCAATGA GAAGAATTTA AACATGTCTA GAGTGGATGT GTATACAACA 
CACTGTCCTG CGGGAACCTC TGTGCAAAAC ATGGTACACT GGACCCAGGT TGTTAAATAC 
CATAAGCTTC AAGCTTTTGA CTGGGGAAGC AGTGACAAGA ATTATTTTCA TTACAATCAG 
AGTTATCCAC CCTTGTACAG CATAAAAGAC ATGCAACTAC CCACTGCTTT ATGGAGCGGG 
GGCAAGGACT GGCTGGCAGA CACCAGTGAC ATCAATATCT TACTGACTGA AATCCCCACG 
TTAGTGTACC ACAAGAACAT TCCCGAGTGG GACCATCTGG ATTTTATCTG GGGTTTGGAT 
GCCCCCTGGA GGCTGTATAA TGAAGTAGTC AGTCTAATGA AGAAATACCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lipa ( XM_017588801.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444290.1 Rattus norvegicus lipase A, lysosomal acid type (Lipa), transcript variant X2, mRNA.

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CloneID	ORa00781
Clone ID Related Accession (Same CDS sequence)	NM_012732.3 , XM_008760321.2 , XM_006231275.3 , XM_017588801.1
Accession Version	XM_017588801.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	lysosomal acid lipase/cholesteryl ester hydrolase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAACTGC TAGGCCGGGT GATCTGTTTC GTCGTTGGGA TCCTGCTTTC TGGGGGCCCA 
ACGGGGACCA TATCAGCTGT GGACCCTGAA GCAAACATGA ATGTGACTGA GATAATCATG 
CACTGGGGAT ATCCTGGCGA AGAGCACTCA GTACAGACAG GAGATGGCTA CATTCTGGGT 
GTTCACCGAA TCCCGCATGG GCGGAAGAAC CAGTTTGATA AAGGTCCCAA ACCAGTTGTG 
TATCTTCAGC ATGGCTTCCT GGCAGATTCT AGTAACTGGG TCACAAACAT TGACAACAAC 
AGCCTGGGCT TCATCCTGGC AGATGCTGGC TTTGATGTGT GGATGGGAAA CAGCAGAGGA 
AACACCTGGT CTCGGAAGCA CAAGACTCTG TCAGTTTCTC AGGATGAATA CTGGGCCTTC 
AGTTTTGATG AGATGGCAAA ATATGACCTC CCTGCTTCAA TTAACTACAT TTTGAATAAA 
ACTGGCCAAG AACAGCTGTA TTATGTGGGC CACTCTCAAG GCTGCACCAT AGGTTTTATA 
GCATTTTCAC AGATGCCTGA ACTGGCAAAG AAGGTTAAAA TGTTTTTTGC CCTGGCTCCT 
GTGTTGTCTC TCAATTTTGC TTCGGGCCCG ATGGTCAAAT TGGGACGGTT GCCGGATCTG 
CTTCTTGAGG ACTTGTTTGG GCAGAAGCAA TTTCTTCCTC AGAGTGCAAT GGTGAAATGG 
CTAAGCACTC ACATTTGCAC GCACGTCATC ATGAAGGAGC TTTGCGCCAA CATCTTCTTT 
CTGATATGTG GCTTCAATGA GAAGAATTTA AACATGTCTA GAGTGGATGT GTATACAACA 
CACTGTCCTG CGGGAACCTC TGTGCAAAAC ATGGTACACT GGACCCAGGT TGTTAAATAC 
CATAAGCTTC AAGCTTTTGA CTGGGGAAGC AGTGACAAGA ATTATTTTCA TTACAATCAG 
AGTTATCCAC CCTTGTACAG CATAAAAGAC ATGCAACTAC CCACTGCTTT ATGGAGCGGG 
GGCAAGGACT GGCTGGCAGA CACCAGTGAC ATCAATATCT TACTGACTGA AATCCCCACG 
TTAGTGTACC ACAAGAACAT TCCCGAGTGG GACCATCTGG ATTTTATCTG GGGTTTGGAT 
GCCCCCTGGA GGCTGTATAA TGAAGTAGTC AGTCTAATGA AGAAATACCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444290.1
CDS	484..1677
Translation	MQLLGRVICFVVGILLSGGPTGTISAVDPEANMNVTEIIMHWGYPGEEHSVQTGDGYILGVHRIPHGRKNQFDKGPKPVVYLQHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASINYILNKTGQEQLYYVGHSQGCTIGFIAFSQMPELAKKVKMFFALAPVLSLNFASGPMVKLGRLPDLLLEDLFGQKQFLPQSAMVKWLSTHICTHVIMKELCANIFFLICGFNEKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQSYPPLYSIKDMQLPTALWSGGKDWLADTSDINILLTEIPTLVYHKNIPEWDHLDFIWGLDAPWRLYNEVVSLMKKYQ

Target ORF information:

RefSeq Version	XM_017588801.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lipase A, lysosomal acid type (Lipa), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017588801.1

ORF Insert Sequence:

ATGCAACTGC TAGGCCGGGT GATCTGTTTC GTCGTTGGGA TCCTGCTTTC TGGGGGCCCA 
ACGGGGACCA TATCAGCTGT GGACCCTGAA GCAAACATGA ATGTGACTGA GATAATCATG 
CACTGGGGAT ATCCTGGCGA AGAGCACTCA GTACAGACAG GAGATGGCTA CATTCTGGGT 
GTTCACCGAA TCCCGCATGG GCGGAAGAAC CAGTTTGATA AAGGTCCCAA ACCAGTTGTG 
TATCTTCAGC ATGGCTTCCT GGCAGATTCT AGTAACTGGG TCACAAACAT TGACAACAAC 
AGCCTGGGCT TCATCCTGGC AGATGCTGGC TTTGATGTGT GGATGGGAAA CAGCAGAGGA 
AACACCTGGT CTCGGAAGCA CAAGACTCTG TCAGTTTCTC AGGATGAATA CTGGGCCTTC 
AGTTTTGATG AGATGGCAAA ATATGACCTC CCTGCTTCAA TTAACTACAT TTTGAATAAA 
ACTGGCCAAG AACAGCTGTA TTATGTGGGC CACTCTCAAG GCTGCACCAT AGGTTTTATA 
GCATTTTCAC AGATGCCTGA ACTGGCAAAG AAGGTTAAAA TGTTTTTTGC CCTGGCTCCT 
GTGTTGTCTC TCAATTTTGC TTCGGGCCCG ATGGTCAAAT TGGGACGGTT GCCGGATCTG 
CTTCTTGAGG ACTTGTTTGG GCAGAAGCAA TTTCTTCCTC AGAGTGCAAT GGTGAAATGG 
CTAAGCACTC ACATTTGCAC GCACGTCATC ATGAAGGAGC TTTGCGCCAA CATCTTCTTT 
CTGATATGTG GCTTCAATGA GAAGAATTTA AACATGTCTA GAGTGGATGT GTATACAACA 
CACTGTCCTG CGGGAACCTC TGTGCAAAAC ATGGTACACT GGACCCAGGT TGTTAAATAC 
CATAAGCTTC AAGCTTTTGA CTGGGGAAGC AGTGACAAGA ATTATTTTCA TTACAATCAG 
AGTTATCCAC CCTTGTACAG CATAAAAGAC ATGCAACTAC CCACTGCTTT ATGGAGCGGG 
GGCAAGGACT GGCTGGCAGA CACCAGTGAC ATCAATATCT TACTGACTGA AATCCCCACG 
TTAGTGTACC ACAAGAACAT TCCCGAGTGG GACCATCTGG ATTTTATCTG GGGTTTGGAT 
GCCCCCTGGA GGCTGTATAA TGAAGTAGTC AGTCTAATGA AGAAATACCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung.
American journal of physiology. Lung cellular and molecular physiology286(4)L801-7(2004 Apr)
Lian X,Yan C,Yang L,Xu Y,Du H

Changes in the activity of lysosomal enzymes in rat kidneys in the course of acute pancreatitis.
Medical science monitor : international medical journal of experimental and clinical research7(6)1193-7(2001 Nov-Dec)
Łakowska H,Maciejewski R,Szkodziak P,Staśkiewicz G

Inhibition of the acid lipase activity by apolipoprotein A-I in the presence of lysosomal proteases.
Bioscience, biotechnology, and biochemistry63(5)937-9(1999 May)
Inoue Y,Ose T,Mukai S,Ehira S,Yonekura M,Hou DX,Fujii M

Cloning of rat lysosomal acid lipase cDNA and identification of the mutation in the rat model of Wolman's disease.
Journal of lipid research36(10)2212-8(1995 Oct)
Nakagawa H,Matsubara S,Kuriyama M,Yoshidome H,Fujiyama J,Yoshida H,Osame M

Mutations at the lysosomal acid cholesteryl ester hydrolase gene locus in Wolman disease.
Proceedings of the National Academy of Sciences of the United States of America91(7)2718-22(1994 Mar)
Anderson RA,Byrum RS,Coates PM,Sando GN

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Lipa cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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