Itgam cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itgam
Entrez Gene ID	25021
Full Name	integrin subunit alpha M
Synonyms	Cd11b
General protein information	Preferred Names integrin subunit alpha M Names integrin alpha-M integrin, alpha M
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q37
Summary	mouse homolog is an integrin alpha subunit that interacts with integrin beta 2 subunit to form Mac-1; involved in immune response [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012711.1	NP_036843.1	integrin alpha-M precursor
XM_006230214.3	XP_006230276.1	integrin alpha-M isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ITGAM	NP_001139280.1
Pan troglodytes (chimpanzee)	ITGAM	NP_001181863.1
Rattus norvegicus (Norway rat)	Itgam	NP_036843.1
Danio rerio (zebrafish)	LOC563715	XP_692164.5
Canis lupus familiaris (dog)	ITGAM	XP_848527.1
Bos taurus (cattle)	ITGAM	NP_001035046.1
Xenopus tropicalis (tropical clawed frog)	itgad	XP_004918207.1
Xenopus tropicalis (tropical clawed frog)	itgam	XP_004918403.1
Xenopus tropicalis (tropical clawed frog)	LOC100495489	XP_002940816.2
Mus musculus (house mouse)	Itgam	NP_001076429.1
Danio rerio (zebrafish)	LOC101882585	XP_005156064.1

Gene Ontology
Bibliography

Related articles in PubMed

CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation.
Bai M, Grieshaber-Bouyer R, Wang J, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA
Blood130(19)2092-2100(2017 11)

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
Thaysen-Andersen M, Venkatakrishnan V, Loke I, Laurini C, Diestel S, Parker BL, Packer NH
The Journal of biological chemistry290(14)8789-802(2015 Apr)

Tumor progression is associated with increasing CD11b+ cells and CCL2 in Lewis rat sarcoma.
Mishra R, Kovalska J, Janda J, Vannucci L, Rajmon R, Horak V
Anticancer research35(2)703-11(2015 Feb)

Relationship between impaired adipogenesis of retroperitoneal adipose tissue and hypertrophic obesity: role of endogenous glucocorticoid excess.
Zubiría MG, Vidal-Bravo J, Spinedi E, Giovambattista A
Journal of cellular and molecular medicine18(8)1549-61(2014 Aug)

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K, Suda T, Nakamura T, Wolff L, Honda H, Inaba T
Cancer cell24(3)305-17(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Itgam gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itgam cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00703	NM_012711.1 Latest version!	Rattus norvegicus integrin subunit alpha M (Itgam), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
ORa23403	XM_006230214.3 Latest version!	Rattus norvegicus integrin subunit alpha M (Itgam), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itgam ( NM_012711.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036843.1 Rattus norvegicus integrin subunit alpha M (Itgam), mRNA.

Price & Availability↑

CloneID	ORa00703
Clone ID Related Accession (Same CDS sequence)	NM_012711.1
Accession Version	NM_012711.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1517673600000
Organism	Rattus norvegicus(Norway rat)
Product	integrin alpha-M precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF268593.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF268593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACTCTTA AAGTTCTTCT GGCGACAGTC CTAACCTTGT GTCATGGCTT CAATTTGGAC 
ACTGAAAATC CCATGACCTT CCAAGAGAAT GCAAGTGGCT TCGGGCAGAG TGTGATCCAG 
CTTGGTGAAA CCCGAGTGGT TGTTGCAGCC CCCCAGGAGG TAAAGGCGGT TAACCAGACA 
GGTGCCCTCT ACCAGTGTGA CTACAGCACA AACCGGTGCG ACCCCATTCC CCTGCAAGTA 
CCTCCAGAGG CTGTGAATAT GTCCTTGGGC CTGTCCCTGG CTGCTACTAC CGTCCCTCCA 
CAGCTGCTGG CTTGTGGCCC CACAGTACAC CAGAACTGCA AGGAGAACAC TTACGTCAAT 
GGATTGTGCT ACCTATTCGG CTCCAACCTG CTGAGGAAGC CCCAGCAGTT CCCAGAGGCT 
CTCAGAGGAT GTCCTCAGCA GGAGAGCAAC ATTGCCTTCT TGATTGACGG CTCCGGTAGC 
ATCAACACGA TCGACTTTCA GAAGATGAAG GAATTTGTCT CAACTGTGAT GGACCAGTTC 
CAAAAGTCTA AAACCTTGTT CTCTTTGATG CAGTACTCTG ATGAATTCCG GACTCACTTC 
ACCTTCAATG ATTTCAAGAG AAACCCTGAC CCAAAATCAC ATGTGAGACC CATAAGGCAG 
CTGAATGGAA GGACAAAAAC TGCCTCAGGG ATCCGTAAAG TAGTGAGAGA ACTGTTTCAG 
AAAATCAATG GGGCCCGGGA CAATGCCGCG AAGATCCTAG TTGTCATCAC AGACGGAGAA 
AAGTTTGGTG ACCCCCTAAA TTATGAGGAT GTCATTCCTG AGGCAGAGGA AGCAGGGATC 
ATTCGCTACG TTATTGGGGT GGGAAACGCC TTCCACAAAC CACAGTCCCG CAGAGAGCTT 
GACACCATCG CGTCTAAGCC AGCTGGTGAT CACGTGTTCC AAGTGGACAA CTTTGAAGCT 
CTGAATACCA TTCGGAACCA GCTCCAGGAA AAGATCTTTG CAATTGAGGG CACCCAGACA 
GGAAGTACCA GCTCCTTTGA GCATGAGATG TCTCAAGAAG GCTTTAGCGC TGCCATTACC 
TCCAACGGTC CCTTGCTGGG CTCCGTGGGG AGCTTTGACT GGGCAGGTGG AGCCTTCCTG 
TATCCATCAA AGGATAAAGC CAGTTTCATC AACACAACCA GAATAGATTC AGACATGAAC 
GATGCTTACT TGGGTTATGC TTCTGCAGTC ATCTCGAGGA ACCGCGTCCA AAGCTTGGTT 
TTAGGGGCAC CTCGATATCA GCATATCGGC CTGGTGGTGA TGTTCAAGCA GAATTTCGGT 
GCCTGGGAGC CCCACACTGA TATCAAGGGC AGCCAGATCG GCTCTTATTT TGGGGCCTCC 
CTCTGTTCTG TGGACATGGA CGCTGATGGC AATACCAACT TGATCCTCAT TGGGGCCCCT 
CATCACTATG AGAAGACCCG AGGGGGCCAG GTGTCAGTGT GCCCCTTGCC TAGGGGGAGA 
GCACGGTGGC AGTGTGAAGC TATTCTCCAT GGCGATCAGG GCCATCCATG GGGTCGCTTT 
GGGGCAGCAT TGACAGTGCT GGGAGATGTG AATGGAGACA AACTGACAGA TGTGGCCATT 
GGGGCCCCAG GAGAGCAGGA GAATCAGGGT GCTGTCTACA TTTTTCATGG AGCATCAGTA 
GCCAGCATCA GTACCCCTCA CAGCCAGCGG ATCGCAGGCG CCCGCTTCTC CCCCGGGCTC 
CAGTACTTTG GGCAGTCTCT GAGTGGGGGC AAGGATCTCA CAATGGACGG CCTGATGGAC 
TTGGCTGTGG GGGCGCAGGG GCGTCTTCTG CTGATCAGAG CCCAGCCTGT GCTGAGACTG 
GAGGCAACCA TGGAATTCAG CCCCAAGAAT CTAGCAAGGA GTGTGTTTGC GTGTCAAGAA 
GAAGTAGTCA AAAACAAGGA TGCTGGGGAG GTCAGAGTCT GCCTCCAAGT CCGCAAGAAC 
ACCAAGGACA GGCTGCGAGA AGGAGACATC CAGAGCACTG TCACTTATGA CCTGGCTTTA 
GACCCCGGCC GCTCAGTTGT CCGAGCCTTC TTTGATGAAA CAAAGAACGG CATACTCAGG 
CGCATCCGGG TCTTTGGATT GACACAGAAA TGTGAAACCC TGAAGCTAAT TTTACCGGAC 
TGTGTGGACA ACTCAGTGAG TCCCATCATC CTGCGCCTTA ATTACACACT GGTTGGGGAG 
CCCTTGCGGT CCTCTAGGGA CCTTCGGCCA GTTCTGGCTA TGGAGGCTCA GAGGATCTTC 
ACAGCTATGT TTCCCTTTGA GAAGAATTGT GGCAATGACA CCATTTGCCA GGATGATCTC 
AGCATCACCG TGAGTTCCAC ACGCGTGAAC ACTTTGGTGG TGGGAGACTC CCGGGACTTT 
GACGTGAGTG TGACTCTGAG AAATGATGGC GAGGATTCCT ATGGGACCAA GGTTACCTGC 
TATTACCCAT CTGGCTTGTC TTACCGGAAG GTGTCAGCAA GCCAGAACCA GTTCTCCAAG 
AAGCCTTGGC GTGTGATAGC TGAGCCCAGT TCTTCTGAAG GGCAAGGGGT TCTGAAGAGC 
ACCATCTGGG ACATAAACCA TCCCATCTTT CCCGCTAATT CTGAGGTCAC GTTTAATGTC 
ACATTTGATG TGGACTCTGA TGCCTCCCTT GGGAACAAAC TGCTCCTCAA GGTCGTTGTG 
ACCAGTGAGA ACAACGTGTC CAGGACCGAC AAAACTGAGT CTCAGTTGGA GTTGCCTGTG 
AAGTACGCCA TCTACATGGT CGTCACCAGT GGTGAGAGTT CTATCAAATA TCTCAACTTC 
ACAGCTTCAG AGATGACCAG TAAGGTCATA CAGCATCAGT ACCAGTTCAA CAACCTGGGC 
CAGAGGAGCT TCCCTGTCAG CGTGGTCTTC TGGATCCCTG TCCAGATCAA CAAGGTGACC 
ATATGGGATC CTCCCCAGGT CACCTTCTCC CAGAACCTCT CAAGTGTCTG TCGCACTGAG 
CAGAAATCCC CCTCTCACTC CAAGTTCCAG GATGAGCTTG AAAGGACCCC AGTGCTGAAC 
TGCTCTGTTG CAGTCTGCAA GAGAATCCAG TGTGACATCC CTTCCTTCAA CAGTAAAGAA 
ATATTCAACG TCACCCTCCA GGGCAATCTG CTATTTGACT GGTACATCGA GACTTCTCAT 
GACCACCTCC TGCTTGTGAG CACTGCCGAG ATCCTCTTTA ACGACTCCGC ATTTGCCCTA 
CTTCCGGGGC AGGAGACGTT TGTGAAGGCT CAGACAGAGA CCAAAGTGGA GCCATATACA 
GTTCACAATC CTGTACCACT CATTGTGGGC AGCTCCGTCG GAGGCCTGGT GCTCTTGGCT 
CTCATCACTG CTGGCCTATA CAAGCTTGGC TTTTTCAAAC GACAGTACAA GGACATGATG 
AATGAAGCCG GTGGCCAAGA TGGCCCACCT CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036843.1
CDS	1..3456
Translation	MTLKVLLATVLTLCHGFNLDTENPMTFQENASGFGQSVIQLGETRVVVAAPQEVKAVNQTGALYQCDYSTNRCDPIPLQVPPEAVNMSLGLSLAATTVPPQLLACGPTVHQNCKENTYVNGLCYLFGSNLLRKPQQFPEALRGCPQQESNIAFLIDGSGSINTIDFQKMKEFVSTVMDQFQKSKTLFSLMQYSDEFRTHFTFNDFKRNPDPKSHVRPIRQLNGRTKTASGIRKVVRELFQKINGARDNAAKILVVITDGEKFGDPLNYEDVIPEAEEAGIIRYVIGVGNAFHKPQSRRELDTIASKPAGDHVFQVDNFEALNTIRNQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSAAITSNGPLLGSVGSFDWAGGAFLYPSKDKASFINTTRIDSDMNDAYLGYASAVISRNRVQSLVLGAPRYQHIGLVVMFKQNFGAWEPHTDIKGSQIGSYFGASLCSVDMDADGNTNLILIGAPHHYEKTRGGQVSVCPLPRGRARWQCEAILHGDQGHPWGRFGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFHGASVASISTPHSQRIAGARFSPGLQYFGQSLSGGKDLTMDGLMDLAVGAQGRLLLIRAQPVLRLEATMEFSPKNLARSVFACQEEVVKNKDAGEVRVCLQVRKNTKDRLREGDIQSTVTYDLALDPGRSVVRAFFDETKNGILRRIRVFGLTQKCETLKLILPDCVDNSVSPIILRLNYTLVGEPLRSSRDLRPVLAMEAQRIFTAMFPFEKNCGNDTICQDDLSITVSSTRVNTLVVGDSRDFDVSVTLRNDGEDSYGTKVTCYYPSGLSYRKVSASQNQFSKKPWRVIAEPSSSEGQGVLKSTIWDINHPIFPANSEVTFNVTFDVDSDASLGNKLLLKVVVTSENNVSRTDKTESQLELPVKYAIYMVVTSGESSIKYLNFTASEMTSKVIQHQYQFNNLGQRSFPVSVVFWIPVQINKVTIWDPPQVTFSQNLSSVCRTEQKSPSHSKFQDELERTPVLNCSVAVCKRIQCDIPSFNSKEIFNVTLQGNLLFDWYIETSHDHLLLVSTAEILFNDSAFALLPGQETFVKAQTETKVEPYTVHNPVPLIVGSSVGGLVLLALITAGLYKLGFFKRQYKDMMNEAGGQDGPPQ

Target ORF information:

RefSeq Version	NM_012711.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus integrin subunit alpha M (Itgam), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012711.1

ORF Insert Sequence:

ATGACTCTTA AAGTTCTTCT GGCGACAGTC CTAACCTTGT GTCATGGCTT CAATTTGGAC 
ACTGAAAATC CCATGACCTT CCAAGAGAAT GCAAGTGGCT TCGGGCAGAG TGTGATCCAG 
CTTGGTGAAA CCCGAGTGGT TGTTGCAGCC CCCCAGGAGG TAAAGGCGGT TAACCAGACA 
GGTGCCCTCT ACCAGTGTGA CTACAGCACA AACCGGTGCG ACCCCATTCC CCTGCAAGTA 
CCTCCAGAGG CTGTGAATAT GTCCTTGGGC CTGTCCCTGG CTGCTACTAC CGTCCCTCCA 
CAGCTGCTGG CTTGTGGCCC CACAGTACAC CAGAACTGCA AGGAGAACAC TTACGTCAAT 
GGATTGTGCT ACCTATTCGG CTCCAACCTG CTGAGGAAGC CCCAGCAGTT CCCAGAGGCT 
CTCAGAGGAT GTCCTCAGCA GGAGAGCAAC ATTGCCTTCT TGATTGACGG CTCCGGTAGC 
ATCAACACGA TCGACTTTCA GAAGATGAAG GAATTTGTCT CAACTGTGAT GGACCAGTTC 
CAAAAGTCTA AAACCTTGTT CTCTTTGATG CAGTACTCTG ATGAATTCCG GACTCACTTC 
ACCTTCAATG ATTTCAAGAG AAACCCTGAC CCAAAATCAC ATGTGAGACC CATAAGGCAG 
CTGAATGGAA GGACAAAAAC TGCCTCAGGG ATCCGTAAAG TAGTGAGAGA ACTGTTTCAG 
AAAATCAATG GGGCCCGGGA CAATGCCGCG AAGATCCTAG TTGTCATCAC AGACGGAGAA 
AAGTTTGGTG ACCCCCTAAA TTATGAGGAT GTCATTCCTG AGGCAGAGGA AGCAGGGATC 
ATTCGCTACG TTATTGGGGT GGGAAACGCC TTCCACAAAC CACAGTCCCG CAGAGAGCTT 
GACACCATCG CGTCTAAGCC AGCTGGTGAT CACGTGTTCC AAGTGGACAA CTTTGAAGCT 
CTGAATACCA TTCGGAACCA GCTCCAGGAA AAGATCTTTG CAATTGAGGG CACCCAGACA 
GGAAGTACCA GCTCCTTTGA GCATGAGATG TCTCAAGAAG GCTTTAGCGC TGCCATTACC 
TCCAACGGTC CCTTGCTGGG CTCCGTGGGG AGCTTTGACT GGGCAGGTGG AGCCTTCCTG 
TATCCATCAA AGGATAAAGC CAGTTTCATC AACACAACCA GAATAGATTC AGACATGAAC 
GATGCTTACT TGGGTTATGC TTCTGCAGTC ATCTCGAGGA ACCGCGTCCA AAGCTTGGTT 
TTAGGGGCAC CTCGATATCA GCATATCGGC CTGGTGGTGA TGTTCAAGCA GAATTTCGGT 
GCCTGGGAGC CCCACACTGA TATCAAGGGC AGCCAGATCG GCTCTTATTT TGGGGCCTCC 
CTCTGTTCTG TGGACATGGA CGCTGATGGC AATACCAACT TGATCCTCAT TGGGGCCCCT 
CATCACTATG AGAAGACCCG AGGGGGCCAG GTGTCAGTGT GCCCCTTGCC TAGGGGGAGA 
GCACGGTGGC AGTGTGAAGC TATTCTCCAT GGCGATCAGG GCCATCCATG GGGTCGCTTT 
GGGGCAGCAT TGACAGTGCT GGGAGATGTG AATGGAGACA AACTGACAGA TGTGGCCATT 
GGGGCCCCAG GAGAGCAGGA GAATCAGGGT GCTGTCTACA TTTTTCATGG AGCATCAGTA 
GCCAGCATCA GTACCCCTCA CAGCCAGCGG ATCGCAGGCG CCCGCTTCTC CCCCGGGCTC 
CAGTACTTTG GGCAGTCTCT GAGTGGGGGC AAGGATCTCA CAATGGACGG CCTGATGGAC 
TTGGCTGTGG GGGCGCAGGG GCGTCTTCTG CTGATCAGAG CCCAGCCTGT GCTGAGACTG 
GAGGCAACCA TGGAATTCAG CCCCAAGAAT CTAGCAAGGA GTGTGTTTGC GTGTCAAGAA 
GAAGTAGTCA AAAACAAGGA TGCTGGGGAG GTCAGAGTCT GCCTCCAAGT CCGCAAGAAC 
ACCAAGGACA GGCTGCGAGA AGGAGACATC CAGAGCACTG TCACTTATGA CCTGGCTTTA 
GACCCCGGCC GCTCAGTTGT CCGAGCCTTC TTTGATGAAA CAAAGAACGG CATACTCAGG 
CGCATCCGGG TCTTTGGATT GACACAGAAA TGTGAAACCC TGAAGCTAAT TTTACCGGAC 
TGTGTGGACA ACTCAGTGAG TCCCATCATC CTGCGCCTTA ATTACACACT GGTTGGGGAG 
CCCTTGCGGT CCTCTAGGGA CCTTCGGCCA GTTCTGGCTA TGGAGGCTCA GAGGATCTTC 
ACAGCTATGT TTCCCTTTGA GAAGAATTGT GGCAATGACA CCATTTGCCA GGATGATCTC 
AGCATCACCG TGAGTTCCAC ACGCGTGAAC ACTTTGGTGG TGGGAGACTC CCGGGACTTT 
GACGTGAGTG TGACTCTGAG AAATGATGGC GAGGATTCCT ATGGGACCAA GGTTACCTGC 
TATTACCCAT CTGGCTTGTC TTACCGGAAG GTGTCAGCAA GCCAGAACCA GTTCTCCAAG 
AAGCCTTGGC GTGTGATAGC TGAGCCCAGT TCTTCTGAAG GGCAAGGGGT TCTGAAGAGC 
ACCATCTGGG ACATAAACCA TCCCATCTTT CCCGCTAATT CTGAGGTCAC GTTTAATGTC 
ACATTTGATG TGGACTCTGA TGCCTCCCTT GGGAACAAAC TGCTCCTCAA GGTCGTTGTG 
ACCAGTGAGA ACAACGTGTC CAGGACCGAC AAAACTGAGT CTCAGTTGGA GTTGCCTGTG 
AAGTACGCCA TCTACATGGT CGTCACCAGT GGTGAGAGTT CTATCAAATA TCTCAACTTC 
ACAGCTTCAG AGATGACCAG TAAGGTCATA CAGCATCAGT ACCAGTTCAA CAACCTGGGC 
CAGAGGAGCT TCCCTGTCAG CGTGGTCTTC TGGATCCCTG TCCAGATCAA CAAGGTGACC 
ATATGGGATC CTCCCCAGGT CACCTTCTCC CAGAACCTCT CAAGTGTCTG TCGCACTGAG 
CAGAAATCCC CCTCTCACTC CAAGTTCCAG GATGAGCTTG AAAGGACCCC AGTGCTGAAC 
TGCTCTGTTG CAGTCTGCAA GAGAATCCAG TGTGACATCC CTTCCTTCAA CAGTAAAGAA 
ATATTCAACG TCACCCTCCA GGGCAATCTG CTATTTGACT GGTACATCGA GACTTCTCAT 
GACCACCTCC TGCTTGTGAG CACTGCCGAG ATCCTCTTTA ACGACTCCGC ATTTGCCCTA 
CTTCCGGGGC AGGAGACGTT TGTGAAGGCT CAGACAGAGA CCAAAGTGGA GCCATATACA 
GTTCACAATC CTGTACCACT CATTGTGGGC AGCTCCGTCG GAGGCCTGGT GCTCTTGGCT 
CTCATCACTG CTGGCCTATA CAAGCTTGGC TTTTTCAAAC GACAGTACAA GGACATGATG 
AATGAAGCCG GTGGCCAAGA TGGCCCACCT CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itgam ( XM_006230214.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006230276.1 Rattus norvegicus integrin subunit alpha M (Itgam), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa23403
Clone ID Related Accession (Same CDS sequence)	XM_006230214.3
Accession Version	XM_006230214.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	integrin alpha-M isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006230214.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTCTTA AATTTCTTCT GGTGACAGTC CTAACCTTGT GTCATGGCTT CAATTTGGAC 
ACTGAAAATC CCATGACCTT CCAAGAGAAT GCAAGAGGCT TCGGGCAGAG TGTGATCCAG 
CTTGGTGAAA CCCGAGTGGT TGTTGCAGCC CCCCAGGAGG TAAAGGCGGT TAACCAGACA 
GGTGCCCTCT ACCAGTGTGA CTACAGCACA AACCGGTGCG ACCCCATTCC CCTGCAAGTA 
CCTCCAGAGG CTGTGAATAT GTCCTTGGGC CTGTCCCTGG CTGCTACTAC CGTCCCTCCA 
CAGCTGCTGG CTTGTGGCCC CACAGTACAC CAGAACTGCA AGGAGAACAC TTACGTCAAT 
GGATTGTGCT ACCTATTCGG CTCCAACCTG CTGAGGAAGC CCCAGCAGTT CCCAGAGGCT 
CTCAGAGGAT GTCCTCAGCA GGAGAGCGAC ATTGCCTTCT TGATTGACGG CTCCGGTAGC 
ATCAACAGCA TCGACTTTCA GAAGATGAAG GAATTTGTCT CAACTGTGAT GGACCAGTTC 
CAAAAGTCTA AAACCTTGTT CTCTTTGATG CAGTACTCTG ATGAATTCCG GACTCACTTC 
ACCTTCAATG ATTTCAAGAG AAACCCTGAC CCAAAATCAC ATGTGAGACC CATAAGGCAG 
CTGAATGGAA GGACAAAAAC TGCCTCAGGG ATCCGTAAAG TAGTGAGAGA ACTGTTTCAG 
AAAATCAATG GGGCCCGGGA CAATGCCGCG AAGATCCTAG TTGTCATCAC AGACGGAGAA 
AAGTTTGGTG ACCCCCTAAA TTATGAGGAT GTCATTCCTG AGGCAGAGGA AGCAGGGATC 
ATTCGCTACG TTATTGGGGT GGGAAACGCC TTCCACAAAC CACAGTCCCG CAGAGAGCTT 
GACACCATCG CGTCTAAGCC AGCTGGTGAT CACGTGTTCC AAGTGGACAA CTTTGAAGCT 
CTGAATACCA TTCGGAACCA GCTCCAGGAA AAGATCTTTG CAATTGAGGG CACCCAGACA 
GGAAGTACCA GCTCCTTTGA GCATGAGATG TCTCAAGAAG GCTTTAGCGC TGCCATTACC 
TCTAACGGTC CCTTGCTGGG CTCCGTGGGG AGCTTTGACT GGGCAGGTGG AGCCTTCCTG 
TATCCATCAA AGGATAAAGC CACTTTCATC AACACAACCA GAATAGATTC AGACATGAAC 
GATGCTTACT TGGGTTATGC TTCTGCAGTC ATCTCGAGGA ACCGCGTCCA AAGCTTGGTT 
TTAGGGGCAC CTCGATATCA GCATATCGGC CTGGTGGTGA TGTTCAAGCA GAATTTCGGT 
GCCTGGGAGC CCCACACTGA TATCAAGGGC AGCCAGATCG GCTCTTATTT TGGGGCCTCC 
CTCTGTTCTG TGGACATGGA CGCTGATGGC AATACCAACT TGATCCTCAT TGGGGCCCCT 
CATCACTATG AGAAGACCCG AGGGGGCCAG GTGTCAGTGT GCCCCTTGCC TAGGGGGCAG 
AGAGCACGGT GGCAGTGTGA AGCTATTCTC CATGGCGATC AGGGCCATCC ATGGGGTCGC 
TTTGGGGCAG CATTGACAGT GCTGGGAGAT GTGAATGGAG ACAAACTGAC AGATGTGGCC 
ATTGGGGCCC CAGGAGAGCA GGAGAATCAG GGTGCTGTCT ACATTTTTCA TGGAGCATCA 
GTAGCCAGCA TCAGTACCCC TCACAGCCAG CGGATCGCAG GCGCCCGCTT CTCCCCCGGG 
CTCCAGTACT TTGGGCAGTC TCTGAGTGGG GGCAAGGATC TCACAATGGA CGGCCTGATG 
GACTTGGCTG TGGGGGCGCA GGGGCGTCTT CTGCTGATCA GAGCCCAGCC TGTGCTGAGA 
CTGGAGGCAA CCATGGAATT CAGCCCCAAG AATCTAGCAA GGAGTGTGTT TGCGTGTCAA 
GAAGAAGTAG TCAAAAACAA GGATGCTGGG GAGGTCAGAG TCTGCCTCCA TGTCCGCAAG 
AACACCAAGG ACAGGCTGCG AGAAGGAGAC ATCCAGAGCA CTGTCACTTA TGACCTGGCT 
TTAGACCCCG GCCGCTCAGT TGTCCGAGCC TTCTTTGATG AAACAAAGAA CGGCATACTC 
AGGCGCATCC GGGTCTTTGG ATTGACACAG AAATGTGAAA CCCTGAAGCT AATTTTACCG 
GACTGTGTGG ACAACTCAGT GAGTCCCATC ATCCTGCGCC TTAATTACAC ACTGGTTGGG 
GAGCCCTTGC GGTCCTCTAG GGACCTTCGG CCAGTTCTGG CTATGGAGGC TCAGAGGATC 
TTCACAGCTA TGTTTCCCTT TGAGAAGAAT TGTGGCAATG ACACCATTTG CCAGGATGAT 
CTCAGCATCA CCGTGAGTTC CATACGCGTG AACACTTTGG TGGTGGGAGA CTCCCGGGAC 
TTTGACGTGA GTGTGACTCT GAGAAATGAT GGCGAGGATT CCTATGGGAC CAAGGTTACC 
TGTTATTACC CATCTGGCTT GTCTTACCGG AAGGTGTCAG CAAGCCAGAA CCAGTTCTCC 
AAGAAGCCTT GGCGTGTGAT AGCTGAGCCC AGTTCTTCTG AAGGGCAAGG GGTTCTGAAG 
AGCACCATCT GGGATATAAA CCATCCCATC TTTCCCGCTA ATTCTGAGGT CACGTTTAAT 
GTCACATTTG ATGTGGACTC TGATGCCTCC CTTGGGAACA AACTGCTCCT CAAGGTCGTT 
GTGACCAGCG AGAACAACGT GTCCAGGACC GACAAAACTG AGTCTCAGTT GGAGCTGCCT 
GTGAAGTACG CCATCTACAT GGTCGTCACC AGTGGTGAGA GTTCTATCAA ATATCTCAAC 
TTCACAGCTT CAGAGATGAC CAGTAAGGTC ATACAGCATC AGTACCAGTT CAACAACCTG 
GGCCAGAGGA GCTTCCCTGT CAGCGTGGTC TTCTGGATCC CTGTCCAGAT CAACAAGGTG 
ACCATATGGG ATCCTCCCCA GGTCACCTTC TCCCAGAACC TCTCAAGTGT CTGTCGCACT 
GAGCAGAAAT CCCCCTCTCA CTCCAAGTTC CAGGATGAGC TTGAAAGGAC CCCAGTGCTG 
AACTGCTCTG TTGCAGTCTG CAAGAGAATC CAGTGTGACA TCCCTTCCTT CAACAGTAAA 
GAAATATTCA ACGTCACCCT CCAGGGCAAT CTGCTATTTG ACTGGTACAT CGAGACTTCT 
CACGACCACC TCCTGCTTGT GAGCACTGCC GAGATCCTCT TTAACGACTC CGCATTTGCC 
CTACTTCCGG GGCAGGAGAC GTTTGTGAAG GCTCAGACAG AGACCAAAGT GGAGCCATAT 
AAAGTTCACA ACCCTGTACC ACTCATTGTG GGCAGCTCCG TCGGAGGCCT GGTGCTCTTG 
GCTCTCATCA CTGCTGGCCT GTACAAGCTT GGCTTTTTCA AACGACAGTA CAAGGACATG 
ATGAATGAAG CCGCTCCCCA AGATGGCCCC CCTCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006230276.1
CDS	116..3574
Translation	MTLKFLLVTVLTLCHGFNLDTENPMTFQENARGFGQSVIQLGETRVVVAAPQEVKAVNQTGALYQCDYSTNRCDPIPLQVPPEAVNMSLGLSLAATTVPPQLLACGPTVHQNCKENTYVNGLCYLFGSNLLRKPQQFPEALRGCPQQESDIAFLIDGSGSINSIDFQKMKEFVSTVMDQFQKSKTLFSLMQYSDEFRTHFTFNDFKRNPDPKSHVRPIRQLNGRTKTASGIRKVVRELFQKINGARDNAAKILVVITDGEKFGDPLNYEDVIPEAEEAGIIRYVIGVGNAFHKPQSRRELDTIASKPAGDHVFQVDNFEALNTIRNQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSAAITSNGPLLGSVGSFDWAGGAFLYPSKDKATFINTTRIDSDMNDAYLGYASAVISRNRVQSLVLGAPRYQHIGLVVMFKQNFGAWEPHTDIKGSQIGSYFGASLCSVDMDADGNTNLILIGAPHHYEKTRGGQVSVCPLPRGQRARWQCEAILHGDQGHPWGRFGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFHGASVASISTPHSQRIAGARFSPGLQYFGQSLSGGKDLTMDGLMDLAVGAQGRLLLIRAQPVLRLEATMEFSPKNLARSVFACQEEVVKNKDAGEVRVCLHVRKNTKDRLREGDIQSTVTYDLALDPGRSVVRAFFDETKNGILRRIRVFGLTQKCETLKLILPDCVDNSVSPIILRLNYTLVGEPLRSSRDLRPVLAMEAQRIFTAMFPFEKNCGNDTICQDDLSITVSSIRVNTLVVGDSRDFDVSVTLRNDGEDSYGTKVTCYYPSGLSYRKVSASQNQFSKKPWRVIAEPSSSEGQGVLKSTIWDINHPIFPANSEVTFNVTFDVDSDASLGNKLLLKVVVTSENNVSRTDKTESQLELPVKYAIYMVVTSGESSIKYLNFTASEMTSKVIQHQYQFNNLGQRSFPVSVVFWIPVQINKVTIWDPPQVTFSQNLSSVCRTEQKSPSHSKFQDELERTPVLNCSVAVCKRIQCDIPSFNSKEIFNVTLQGNLLFDWYIETSHDHLLLVSTAEILFNDSAFALLPGQETFVKAQTETKVEPYKVHNPVPLIVGSSVGGLVLLALITAGLYKLGFFKRQYKDMMNEAAPQDGPPQ

Target ORF information:

RefSeq Version	XM_006230214.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus integrin subunit alpha M (Itgam), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006230214.3

ORF Insert Sequence:

ATGACTCTTA AATTTCTTCT GGTGACAGTC CTAACCTTGT GTCATGGCTT CAATTTGGAC 
ACTGAAAATC CCATGACCTT CCAAGAGAAT GCAAGAGGCT TCGGGCAGAG TGTGATCCAG 
CTTGGTGAAA CCCGAGTGGT TGTTGCAGCC CCCCAGGAGG TAAAGGCGGT TAACCAGACA 
GGTGCCCTCT ACCAGTGTGA CTACAGCACA AACCGGTGCG ACCCCATTCC CCTGCAAGTA 
CCTCCAGAGG CTGTGAATAT GTCCTTGGGC CTGTCCCTGG CTGCTACTAC CGTCCCTCCA 
CAGCTGCTGG CTTGTGGCCC CACAGTACAC CAGAACTGCA AGGAGAACAC TTACGTCAAT 
GGATTGTGCT ACCTATTCGG CTCCAACCTG CTGAGGAAGC CCCAGCAGTT CCCAGAGGCT 
CTCAGAGGAT GTCCTCAGCA GGAGAGCGAC ATTGCCTTCT TGATTGACGG CTCCGGTAGC 
ATCAACAGCA TCGACTTTCA GAAGATGAAG GAATTTGTCT CAACTGTGAT GGACCAGTTC 
CAAAAGTCTA AAACCTTGTT CTCTTTGATG CAGTACTCTG ATGAATTCCG GACTCACTTC 
ACCTTCAATG ATTTCAAGAG AAACCCTGAC CCAAAATCAC ATGTGAGACC CATAAGGCAG 
CTGAATGGAA GGACAAAAAC TGCCTCAGGG ATCCGTAAAG TAGTGAGAGA ACTGTTTCAG 
AAAATCAATG GGGCCCGGGA CAATGCCGCG AAGATCCTAG TTGTCATCAC AGACGGAGAA 
AAGTTTGGTG ACCCCCTAAA TTATGAGGAT GTCATTCCTG AGGCAGAGGA AGCAGGGATC 
ATTCGCTACG TTATTGGGGT GGGAAACGCC TTCCACAAAC CACAGTCCCG CAGAGAGCTT 
GACACCATCG CGTCTAAGCC AGCTGGTGAT CACGTGTTCC AAGTGGACAA CTTTGAAGCT 
CTGAATACCA TTCGGAACCA GCTCCAGGAA AAGATCTTTG CAATTGAGGG CACCCAGACA 
GGAAGTACCA GCTCCTTTGA GCATGAGATG TCTCAAGAAG GCTTTAGCGC TGCCATTACC 
TCTAACGGTC CCTTGCTGGG CTCCGTGGGG AGCTTTGACT GGGCAGGTGG AGCCTTCCTG 
TATCCATCAA AGGATAAAGC CACTTTCATC AACACAACCA GAATAGATTC AGACATGAAC 
GATGCTTACT TGGGTTATGC TTCTGCAGTC ATCTCGAGGA ACCGCGTCCA AAGCTTGGTT 
TTAGGGGCAC CTCGATATCA GCATATCGGC CTGGTGGTGA TGTTCAAGCA GAATTTCGGT 
GCCTGGGAGC CCCACACTGA TATCAAGGGC AGCCAGATCG GCTCTTATTT TGGGGCCTCC 
CTCTGTTCTG TGGACATGGA CGCTGATGGC AATACCAACT TGATCCTCAT TGGGGCCCCT 
CATCACTATG AGAAGACCCG AGGGGGCCAG GTGTCAGTGT GCCCCTTGCC TAGGGGGCAG 
AGAGCACGGT GGCAGTGTGA AGCTATTCTC CATGGCGATC AGGGCCATCC ATGGGGTCGC 
TTTGGGGCAG CATTGACAGT GCTGGGAGAT GTGAATGGAG ACAAACTGAC AGATGTGGCC 
ATTGGGGCCC CAGGAGAGCA GGAGAATCAG GGTGCTGTCT ACATTTTTCA TGGAGCATCA 
GTAGCCAGCA TCAGTACCCC TCACAGCCAG CGGATCGCAG GCGCCCGCTT CTCCCCCGGG 
CTCCAGTACT TTGGGCAGTC TCTGAGTGGG GGCAAGGATC TCACAATGGA CGGCCTGATG 
GACTTGGCTG TGGGGGCGCA GGGGCGTCTT CTGCTGATCA GAGCCCAGCC TGTGCTGAGA 
CTGGAGGCAA CCATGGAATT CAGCCCCAAG AATCTAGCAA GGAGTGTGTT TGCGTGTCAA 
GAAGAAGTAG TCAAAAACAA GGATGCTGGG GAGGTCAGAG TCTGCCTCCA TGTCCGCAAG 
AACACCAAGG ACAGGCTGCG AGAAGGAGAC ATCCAGAGCA CTGTCACTTA TGACCTGGCT 
TTAGACCCCG GCCGCTCAGT TGTCCGAGCC TTCTTTGATG AAACAAAGAA CGGCATACTC 
AGGCGCATCC GGGTCTTTGG ATTGACACAG AAATGTGAAA CCCTGAAGCT AATTTTACCG 
GACTGTGTGG ACAACTCAGT GAGTCCCATC ATCCTGCGCC TTAATTACAC ACTGGTTGGG 
GAGCCCTTGC GGTCCTCTAG GGACCTTCGG CCAGTTCTGG CTATGGAGGC TCAGAGGATC 
TTCACAGCTA TGTTTCCCTT TGAGAAGAAT TGTGGCAATG ACACCATTTG CCAGGATGAT 
CTCAGCATCA CCGTGAGTTC CATACGCGTG AACACTTTGG TGGTGGGAGA CTCCCGGGAC 
TTTGACGTGA GTGTGACTCT GAGAAATGAT GGCGAGGATT CCTATGGGAC CAAGGTTACC 
TGTTATTACC CATCTGGCTT GTCTTACCGG AAGGTGTCAG CAAGCCAGAA CCAGTTCTCC 
AAGAAGCCTT GGCGTGTGAT AGCTGAGCCC AGTTCTTCTG AAGGGCAAGG GGTTCTGAAG 
AGCACCATCT GGGATATAAA CCATCCCATC TTTCCCGCTA ATTCTGAGGT CACGTTTAAT 
GTCACATTTG ATGTGGACTC TGATGCCTCC CTTGGGAACA AACTGCTCCT CAAGGTCGTT 
GTGACCAGCG AGAACAACGT GTCCAGGACC GACAAAACTG AGTCTCAGTT GGAGCTGCCT 
GTGAAGTACG CCATCTACAT GGTCGTCACC AGTGGTGAGA GTTCTATCAA ATATCTCAAC 
TTCACAGCTT CAGAGATGAC CAGTAAGGTC ATACAGCATC AGTACCAGTT CAACAACCTG 
GGCCAGAGGA GCTTCCCTGT CAGCGTGGTC TTCTGGATCC CTGTCCAGAT CAACAAGGTG 
ACCATATGGG ATCCTCCCCA GGTCACCTTC TCCCAGAACC TCTCAAGTGT CTGTCGCACT 
GAGCAGAAAT CCCCCTCTCA CTCCAAGTTC CAGGATGAGC TTGAAAGGAC CCCAGTGCTG 
AACTGCTCTG TTGCAGTCTG CAAGAGAATC CAGTGTGACA TCCCTTCCTT CAACAGTAAA 
GAAATATTCA ACGTCACCCT CCAGGGCAAT CTGCTATTTG ACTGGTACAT CGAGACTTCT 
CACGACCACC TCCTGCTTGT GAGCACTGCC GAGATCCTCT TTAACGACTC CGCATTTGCC 
CTACTTCCGG GGCAGGAGAC GTTTGTGAAG GCTCAGACAG AGACCAAAGT GGAGCCATAT 
AAAGTTCACA ACCCTGTACC ACTCATTGTG GGCAGCTCCG TCGGAGGCCT GGTGCTCTTG 
GCTCTCATCA CTGCTGGCCT GTACAAGCTT GGCTTTTTCA AACGACAGTA CAAGGACATG 
ATGAATGAAG CCGCTCCCCA AGATGGCCCC CCTCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation.
Blood130(19)2092-2100(2017 11)
Bai M,Grieshaber-Bouyer R,Wang J,Schmider AB,Wilson ZS,Zeng L,Halyabar O,Godin MD,Nguyen HN,Levescot A,Cunin P,Lefort CT,Soberman RJ,Nigrovic PA

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
The Journal of biological chemistry290(14)8789-802(2015 Apr)
Thaysen-Andersen M,Venkatakrishnan V,Loke I,Laurini C,Diestel S,Parker BL,Packer NH

Tumor progression is associated with increasing CD11b+ cells and CCL2 in Lewis rat sarcoma.
Anticancer research35(2)703-11(2015 Feb)
Mishra R,Kovalska J,Janda J,Vannucci L,Rajmon R,Horak V

Relationship between impaired adipogenesis of retroperitoneal adipose tissue and hypertrophic obesity: role of endogenous glucocorticoid excess.
Journal of cellular and molecular medicine18(8)1549-61(2014 Aug)
Zubiría MG,Vidal-Bravo J,Spinedi E,Giovambattista A

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Cancer cell24(3)305-17(2013 Sep)
Nagamachi A,Matsui H,Asou H,Ozaki Y,Aki D,Kanai A,Takubo K,Suda T,Nakamura T,Wolff L,Honda H,Inaba T

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Itgam cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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