Chm cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Chm
Entrez Gene ID	24942
Full Name	CHM, Rab escort protein 1
General protein information	Preferred Names CHM, Rab escort protein 1 Names rab proteins geranylgeranyltransferase component A 1 REP-1 choroideraemia protein homolog choroideremia (Rab escort protein 1) choroideremia protein homolog choroidermia rab escort protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq31
Summary	may function as Rab escort protein (REP); mutations in human homolog associated with choroideremia, a disease of retinal degeneration [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017067.1	NP_058763.1	rab proteins geranylgeranyltransferase component A 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Chm	NP_061288.2
Rattus norvegicus (Norway rat)	Chm	NP_058763.1
Homo sapiens (human)	CHM	NP_000381.1
Canis lupus familiaris (dog)	CHM	XP_538092.2
Xenopus tropicalis (tropical clawed frog)	chml	XP_002938593.1
Pan troglodytes (chimpanzee)	CHM	XP_001146272.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010419	XP_311529.4
Macaca mulatta (Rhesus monkey)	CHM	XP_001083432.1
Gallus gallus (chicken)	CHM	NP_001026290.1
Drosophila melanogaster (fruit fly)	Rep	NP_477420.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012773	XP_307378.4
Bos taurus (cattle)	CHM	NP_001192318.1

Gene Ontology
Bibliography

Related articles in PubMed

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
Guo Z, Wu YW, Das D, Delon C, Cramer J, Yu S, Thuns S, Lupilova N, Waldmann H, Brunsveld L, Goody RS, Alexandrov K, Blankenfeldt W
The EMBO journal27(18)2444-56(2008 Sep)

Choroideremia gene product affects trophoblast development and vascularization in mouse extra-embryonic tissues.
Shi W, van den Hurk JA, Alamo-Bethencourt V, Mayer W, Winkens HJ, Ropers HH, Cremers FP, Fundele R
Developmental biology272(1)53-65(2004 Aug)

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.
Rak A, Pylypenko O, Niculae A, Pyatkov K, Goody RS, Alexandrov K
Cell117(6)749-60(2004 Jun)

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Pylypenko O, Rak A, Reents R, Niculae A, Sidorovitch V, Cioaca MD, Bessolitsyna E, Thomä NH, Waldmann H, Schlichting I, Goody RS, Alexandrov K
Molecular cell11(2)483-94(2003 Feb)

Cloning, mapping and characterization of the human RAB27A gene.
Tolmachova T, Ramalho JS, Anant JS, Schultz RA, Huxley CM, Seabra MC
Gene239(1)109-16(1999 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Chm gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chm cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42502	NM_017067.1 Latest version!	Rattus norvegicus CHM Rab escort protein (Chm), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Chm ( NM_017067.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058763.1 Rattus norvegicus CHM Rab escort protein (Chm), mRNA.

Price & Availability↑

CloneID	ORa42502
Clone ID Related Accession (Same CDS sequence)	NM_017067.1
Accession Version	NM_017067.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1953bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568995200000
Organism	Rattus norvegicus(Norway rat)
Product	rab proteins geranylgeranyltransferase component A 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L13722.1. ##Evidence-Data-START## Transcript exon combination :: L13722.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCGGATA ATCTCCCTTC GGACTTTGAT GTGATCGTAA TAGGGACGGG TTTGCCTGAA 
TCCATCATTG CAGCTGCATG TTCAAGGAGT GGCCAGAGGG TTCTGCATGT TGATTCAAGA 
AGCTACTATG GAGGAAACTG GGCCAGTTTC AGCTTTTCAG GACTGTTGTC CTGGCTAAAG 
GAATACCAGG AAAATAATGA TGTTGTGACT GAAAATTCAA TGTGGCAAGA ACAGATACTT 
GAAAACGAAG AAGCTATTCC TCTTAGTAGC AAGGACAAAA CAATTCAACA TGTAGAAGTA 
TTTTGTTATG CCAGTCAGGA TTTGCACAAA GATGTTGAAG AAGCTGGTGC ACTGCAGAAA 
AATCATGCTT CTGTGACATC TGCACAGTCC GCAGAGGCTG CCGAGGCTGC AGAAACTTCT 
TGCCTTCCTA CTGCAGTGGA GCCATTAAGC ATGGGGAGCT GTGAAATACC TGCAGAACAA 
AGCCAGTGCC CTGGTCCAGA GAGTTCACCA GAAGTCAATG ATGCTGAAGC CACAGGAAAG 
AAAGAAAATA GTGATGCTAA AAGTTCAACA GAAGAACCAA GTGAAAATGT GCCTAAAGTC 
CAAGACAACA CAGAGACACC AAAGAAAAAC AGAATCACTT ACTCACAGAT TATTAAAGAA 
GGCAGAAGAT TTAACATTGA TTTAGTTTCA CAACTTCTGT ATTCTCGGGG ATTACTAATT 
GATCTTCTAA TCAAATCAAA TGTTAGTCGA TATGCAGAGT TTAAAAATAT TACGAGGATT 
CTTGCATTTC GAGAAGGAAC TGTGGAACAG GTTCCATGTT CCAGAGCAGA TGTCTTCAAT 
AGCAAACAAC TTACTATGGT AGAAAAGCGA ATGCTTATGA AATTTCTTAC GTTTTGTGTA 
GAATATGAAG AACATCCTGA CGAGTACAGA GCATATGAGG GAACTACATT TTCTGAATAT 
TTAAAAACTC AAAAATTAAC CCCTAACCTA CAATATTTTG TCCTGCACTC AATTGCAATG 
ACATCAGAGA CAACAAGCTG TACTGTAGAT GGTCTCAAAG CTACTAAAAA GTTTCTTCAG 
TGTCTTGGGC GATATGGCAA CACTCCATTT CTGTTTCCTT TATATGGCCA AGGAGAACTT 
CCACAGTGTT TTTGCAGAAT GTGTGCTGTA TTTGGTGGAA TCTATTGTCT TCGCCATTCT 
GTACAGTGCC TTGTAGTGGA CAAAGAATCC AGAAAATGTA AAGCAGTGAT AGATCAGTTT 
GGTCAAAGGA TAATCTCTAA ACATTTCATT ATTGAAGACA GTTACCTTTC TGAGAATACA 
TGTTCCCGTG TGCAATACAG GCAAATATCC AGGGCAGTAC TGATTACAGA TGGATCTGTA 
CTAAAAACGG ATGCAGACCA ACAGGTCTCC ATTTTGGCGG TGCCAGCAGA AGAGCCAGGA 
AGTTTTGGTG TACGAGTTAT TGAGTTATGC TCTTCAACAA TGACATGCAT GAAAGGCACA 
TATTTGGTGC ATTTGACTTG CATGTCTTCT AAAACAGCAA GAGAAGATTT AGAACGGGTA 
GTCCAGAAAT TGTTTACTCC GTATACAGAA ATAGAAGCAG AAAATGAACA GGTTGAAAAG 
CCAAGACTTC TATGGGCACT CTACTTCAAT ATGAGAGACT CTTCAGATAT CAGCAGAGAT 
TGTTATAATG ATTTACCATC CAATGTCTAT GTGTGCTCTG GCCCTGACTC CGGTCTAGGA 
AATGATAATG CAGTCAAACA GGCGGAAACA CTTTTCCAGC AAATCTGCCC AAATGAAGAC 
TTCTGTCCAG CCCCGCCAAA TCCTGAAGAT ATTGTTCTTG ATGGAGACAG CTCCCAACAA 
GAAGTTCCAG AATCCAGTGT CACACCCGAA ACCAACTCAG AGACTCCCAA GGAAAGTACA 
GTCCTGGGAA ACCCAGAAGA GCCTTCTGAA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058763.1
CDS	6..1958
Translation	MADNLPSDFDVIVIGTGLPESIIAAACSRSGQRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQENNDVVTENSMWQEQILENEEAIPLSSKDKTIQHVEVFCYASQDLHKDVEEAGALQKNHASVTSAQSAEAAEAAETSCLPTAVEPLSMGSCEIPAEQSQCPGPESSPEVNDAEATGKKENSDAKSSTEEPSENVPKVQDNTETPKKNRITYSQIIKEGRRFNIDLVSQLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGTVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCVEYEEHPDEYRAYEGTTFSEYLKTQKLTPNLQYFVLHSIAMTSETTSCTVDGLKATKKFLQCLGRYGNTPFLFPLYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKAVIDQFGQRIISKHFIIEDSYLSENTCSRVQYRQISRAVLITDGSVLKTDADQQVSILAVPAEEPGSFGVRVIELCSSTMTCMKGTYLVHLTCMSSKTAREDLERVVQKLFTPYTEIEAENEQVEKPRLLWALYFNMRDSSDISRDCYNDLPSNVYVCSGPDSGLGNDNAVKQAETLFQQICPNEDFCPAPPNPEDIVLDGDSSQQEVPESSVTPETNSETPKESTVLGNPEEPSE

Target ORF information:

RefSeq Version	NM_017067.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CHM Rab escort protein (Chm), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017067.1

ORF Insert Sequence:

ATGGCGGATA ATCTCCCTTC GGACTTTGAT GTGATCGTAA TAGGGACGGG TTTGCCTGAA 
TCCATCATTG CAGCTGCATG TTCAAGGAGT GGCCAGAGGG TTCTGCATGT TGATTCAAGA 
AGCTACTATG GAGGAAACTG GGCCAGTTTC AGCTTTTCAG GACTGTTGTC CTGGCTAAAG 
GAATACCAGG AAAATAATGA TGTTGTGACT GAAAATTCAA TGTGGCAAGA ACAGATACTT 
GAAAACGAAG AAGCTATTCC TCTTAGTAGC AAGGACAAAA CAATTCAACA TGTAGAAGTA 
TTTTGTTATG CCAGTCAGGA TTTGCACAAA GATGTTGAAG AAGCTGGTGC ACTGCAGAAA 
AATCATGCTT CTGTGACATC TGCACAGTCC GCAGAGGCTG CCGAGGCTGC AGAAACTTCT 
TGCCTTCCTA CTGCAGTGGA GCCATTAAGC ATGGGGAGCT GTGAAATACC TGCAGAACAA 
AGCCAGTGCC CTGGTCCAGA GAGTTCACCA GAAGTCAATG ATGCTGAAGC CACAGGAAAG 
AAAGAAAATA GTGATGCTAA AAGTTCAACA GAAGAACCAA GTGAAAATGT GCCTAAAGTC 
CAAGACAACA CAGAGACACC AAAGAAAAAC AGAATCACTT ACTCACAGAT TATTAAAGAA 
GGCAGAAGAT TTAACATTGA TTTAGTTTCA CAACTTCTGT ATTCTCGGGG ATTACTAATT 
GATCTTCTAA TCAAATCAAA TGTTAGTCGA TATGCAGAGT TTAAAAATAT TACGAGGATT 
CTTGCATTTC GAGAAGGAAC TGTGGAACAG GTTCCATGTT CCAGAGCAGA TGTCTTCAAT 
AGCAAACAAC TTACTATGGT AGAAAAGCGA ATGCTTATGA AATTTCTTAC GTTTTGTGTA 
GAATATGAAG AACATCCTGA CGAGTACAGA GCATATGAGG GAACTACATT TTCTGAATAT 
TTAAAAACTC AAAAATTAAC CCCTAACCTA CAATATTTTG TCCTGCACTC AATTGCAATG 
ACATCAGAGA CAACAAGCTG TACTGTAGAT GGTCTCAAAG CTACTAAAAA GTTTCTTCAG 
TGTCTTGGGC GATATGGCAA CACTCCATTT CTGTTTCCTT TATATGGCCA AGGAGAACTT 
CCACAGTGTT TTTGCAGAAT GTGTGCTGTA TTTGGTGGAA TCTATTGTCT TCGCCATTCT 
GTACAGTGCC TTGTAGTGGA CAAAGAATCC AGAAAATGTA AAGCAGTGAT AGATCAGTTT 
GGTCAAAGGA TAATCTCTAA ACATTTCATT ATTGAAGACA GTTACCTTTC TGAGAATACA 
TGTTCCCGTG TGCAATACAG GCAAATATCC AGGGCAGTAC TGATTACAGA TGGATCTGTA 
CTAAAAACGG ATGCAGACCA ACAGGTCTCC ATTTTGGCGG TGCCAGCAGA AGAGCCAGGA 
AGTTTTGGTG TACGAGTTAT TGAGTTATGC TCTTCAACAA TGACATGCAT GAAAGGCACA 
TATTTGGTGC ATTTGACTTG CATGTCTTCT AAAACAGCAA GAGAAGATTT AGAACGGGTA 
GTCCAGAAAT TGTTTACTCC GTATACAGAA ATAGAAGCAG AAAATGAACA GGTTGAAAAG 
CCAAGACTTC TATGGGCACT CTACTTCAAT ATGAGAGACT CTTCAGATAT CAGCAGAGAT 
TGTTATAATG ATTTACCATC CAATGTCTAT GTGTGCTCTG GCCCTGACTC CGGTCTAGGA 
AATGATAATG CAGTCAAACA GGCGGAAACA CTTTTCCAGC AAATCTGCCC AAATGAAGAC 
TTCTGTCCAG CCCCGCCAAA TCCTGAAGAT ATTGTTCTTG ATGGAGACAG CTCCCAACAA 
GAAGTTCCAG AATCCAGTGT CACACCCGAA ACCAACTCAG AGACTCCCAA GGAAAGTACA 
GTCCTGGGAA ACCCAGAAGA GCCTTCTGAA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
The EMBO journal27(18)2444-56(2008 Sep)
Guo Z,Wu YW,Das D,Delon C,Cramer J,Yu S,Thuns S,Lupilova N,Waldmann H,Brunsveld L,Goody RS,Alexandrov K,Blankenfeldt W

Choroideremia gene product affects trophoblast development and vascularization in mouse extra-embryonic tissues.
Developmental biology272(1)53-65(2004 Aug)
Shi W,van den Hurk JA,Alamo-Bethencourt V,Mayer W,Winkens HJ,Ropers HH,Cremers FP,Fundele R

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.
Cell117(6)749-60(2004 Jun)
Rak A,Pylypenko O,Niculae A,Pyatkov K,Goody RS,Alexandrov K

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Molecular cell11(2)483-94(2003 Feb)
Pylypenko O,Rak A,Reents R,Niculae A,Sidorovitch V,Cioaca MD,Bessolitsyna E,Thomä NH,Waldmann H,Schlichting I,Goody RS,Alexandrov K

Cloning, mapping and characterization of the human RAB27A gene.
Gene239(1)109-16(1999 Oct)
Tolmachova T,Ramalho JS,Anant JS,Schultz RA,Huxley CM,Seabra MC

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Chm cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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