Adrb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adrb1
Entrez Gene ID	24925
Full Name	adrenoceptor beta 1
Synonyms	B1AR,RATB1AR
General protein information	Preferred Names adrenoceptor beta 1 Names beta-1 adrenergic receptor adrenergic receptor, beta 1 adrenergic, beta-1-, receptor beta 1-adrenergic receptor beta 1-AR beta-1 adrenoceptor beta-1 adrenoreceptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q55
Summary	binds beta-adrenergic receptor agonists isoproterenol, norepinephrine, and epinephrine; mediates adenylylcyclase induction; involved in regulation of calcium current [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012701.1	NP_036833.1	beta-1 adrenergic receptor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Adrb1	NP_036833.1
Canis lupus familiaris (dog)	ADRB1	NP_001008713.1
Bos taurus (cattle)	ADRB1	NP_919242.1
Danio rerio (zebrafish)	LOC100538297	XP_005156317.1
Anopheles gambiae (African malaria mosquito)	GPRDOP2	XP_311193.4
Pan troglodytes (chimpanzee)	ADRB1	XP_521608.2
Danio rerio (zebrafish)	adrb1	NP_001122161.1
Gallus gallus (chicken)	ADRB1	XP_004942344.1
Mus musculus (house mouse)	Adrb1	NP_031445.2
Homo sapiens (human)	ADRB1	NP_000675.1
Drosophila melanogaster (fruit fly)	DopR2	NP_733299.1

Gene Ontology
Bibliography

Related articles in PubMed

Lower Sympathetic Nervous System Density and β-adrenoreceptor Expression Are Involved in Gastric Cancer Progression.
Bae GE, Kim HS, Won KY, Kim GY, Sung JY, Lim SJ
Anticancer research39(1)231-236(2019 Jan)

Ischemic Stroke Increases Heart Vulnerability to Ischemia-Reperfusion and Alters Myocardial Cardioprotective Pathways.
Meloux A, Rigal E, Rochette L, Cottin Y, Bejot Y, Vergely C
Stroke49(11)2752-2760(2018 11)

Altered expression of hepatic β-adrenergic receptors in aging rats: implications for age-related metabolic dysfunction in liver.
Shi Y, Shu ZJ, Wang H, Barnes JL, Yeh CK, Ghosh PM, Katz MS, Kamat A
American journal of physiology. Regulatory, integrative and comparative physiology314(4)R574-R583(2018 04)

NF2 signaling pathway plays a pro-apoptotic role in β-adrenergic receptor stimulated cardiac myocyte apoptosis.
Dalal S, Connelly B, Singh M, Singh K
PloS one13(4)e0196626(2018)

β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation.
Weeks KL, Ranieri A, Karaś A, Bernardo BC, Ashcroft AS, Molenaar C, McMullen JR, Avkiran M
Journal of the American Heart Association6(4)(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Adrb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adrb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13144	NM_012701.1 Latest version!	Rattus norvegicus adrenoceptor beta 1 (Adrb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adrb1 ( NM_012701.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036833.1 Rattus norvegicus adrenoceptor beta 1 (Adrb1), mRNA.

Price & Availability↑

CloneID	ORa13144
Clone ID Related Accession (Same CDS sequence)	NM_012701.1
Accession Version	NM_012701.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1401bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	beta-1 adrenergic receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J05561.1. On Jun 25, 2006 this sequence version replaced XM_001063787.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGGCGCGG GGGCGCTCGC CCTGGGCGCC TCCGAACCCT GCAACCTGTC GTCGGCCGCG 
CCGCTGCCCG ACGGCGCGGC CACCGCGGCA CGACTGCTGG TGCTCGCGTC GCCTCCCGCC 
TCGCTGCTGC CTCCAGCCAG CGAGGGCTCA GCGCCGCTGT CGCAGCAGTG GACCGCGGGT 
ATGGGCCTAC TCCTGGCGCT CATCGTGCTG CTCATCGTAG TGGGCAACGT GTTGGTGATC 
GTGGCCATCG CCAAGACCCC GCGGCTGCAG ACGCTCACCA ACCTCTTCAT CATGTCCCTG 
GCCAGCGCCG ATCTGGTCAT GGGACTGCTG GTGGTGCCTT TCGGGGCCAC CATTGTGGTG 
TGGGGCCGCT GGGAGTACGG CTCCTTCTTC TGTGAGCTCT GGACTTCGGT AGACGTGCTA 
TGTGTGACGG CCAGCATCGA GACCCTGTGT GTCATCGCCC TGGACCGCTA CCTCGCCATC 
ACGCTGCCCT TTCGCTACCA GAGCCTGCTG ACGCGCGCGC GAGCGCGGGC CCTCGTGTGC 
ACAGTGTGGG CCATCTCCGC GCTGGTGTCC TTCCTGCCCA TCCTCATGCA CTGGTGGCGG 
GCCGAGAGCG ACGAAGCGCG CCGCTGCTAC AACGACCCCA AGTGCTGCGA TTTCGTCACC 
AACCGGGCCT ACGCCATCGC CTCGTCCGTC GTCTCCTTCT ACGTGCCCCT GTGCATCATG 
GCCTTCGTGT ACCTCCGGGT GTTCCGCGAG GCCCAGAAAC AGGTGAAGAA GATCGACAGC 
TGCGAGCGCC GCTTCCTCAC GGGCCCGCCC CGGCCGCCCT CGCCCGCGCC CTCGCCATCA 
CCAGGGCCAC CGCGCCCCGC AGACTCGCTG GCCAACGGGC GCTCCAGCAA GCGGCGGCCG 
TCGCGCCTCG TGGCTCTGCG AGAGCAGAAG GCGCTCAAGA CACTGGGCAT CATCATGGGT 
GTGTTCACGC TCTGCTGGCT GCCCTTCTTC CTGGCCAACG TGGTGAAAGC TTTCCACCGC 
GACCTGGTGC CGGATCGCCT CTTCGTCTTC TTCAACTGGC TGGGCTACGC CAACTCGGCC 
TTCAACCCCA TCATCTACTG CCGCAGCCCC GACTTCCGCA AGGCTTTCCA GCGCCTGCTT 
TGCTGCGCGC GCCGGGCCGC CTGCAGACGC CGCGCAGCCC ACGGGGACCG GCCGCGCGCC 
TCGGGCTGCC TGGCGAGAGC TGGGCCGCCG CCGTCCCCCG GGGCTCCTTC GGACGACGAC 
GACGATGACG CCGGGGCCAC CCCACCCGCG CGCCTGTTGG AGCCCTGGGC CGGCTGCAAC 
GGCGGGACGA CCACTGTGGA CAGCGATTCG AGCCTGGACG AGCCGGGACG CCAGGGCTTC 
TCCTCCGAGT CCAAGGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036833.1
CDS	1..1401
Translation	MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV

Target ORF information:

RefSeq Version	NM_012701.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus adrenoceptor beta 1 (Adrb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012701.1

ORF Insert Sequence:

ATGGGCGCGG GGGCGCTCGC CCTGGGCGCC TCCGAACCCT GCAACCTGTC GTCGGCCGCG 
CCGCTGCCCG ACGGCGCGGC CACCGCGGCA CGACTGCTGG TGCTCGCGTC GCCTCCCGCC 
TCGCTGCTGC CTCCAGCCAG CGAGGGCTCA GCGCCGCTGT CGCAGCAGTG GACCGCGGGT 
ATGGGCCTAC TCCTGGCGCT CATCGTGCTG CTCATCGTAG TGGGCAACGT GTTGGTGATC 
GTGGCCATCG CCAAGACCCC GCGGCTGCAG ACGCTCACCA ACCTCTTCAT CATGTCCCTG 
GCCAGCGCCG ATCTGGTCAT GGGACTGCTG GTGGTGCCTT TCGGGGCCAC CATTGTGGTG 
TGGGGCCGCT GGGAGTACGG CTCCTTCTTC TGTGAGCTCT GGACTTCGGT AGACGTGCTA 
TGTGTGACGG CCAGCATCGA GACCCTGTGT GTCATCGCCC TGGACCGCTA CCTCGCCATC 
ACGCTGCCCT TTCGCTACCA GAGCCTGCTG ACGCGCGCGC GAGCGCGGGC CCTCGTGTGC 
ACAGTGTGGG CCATCTCCGC GCTGGTGTCC TTCCTGCCCA TCCTCATGCA CTGGTGGCGG 
GCCGAGAGCG ACGAAGCGCG CCGCTGCTAC AACGACCCCA AGTGCTGCGA TTTCGTCACC 
AACCGGGCCT ACGCCATCGC CTCGTCCGTC GTCTCCTTCT ACGTGCCCCT GTGCATCATG 
GCCTTCGTGT ACCTCCGGGT GTTCCGCGAG GCCCAGAAAC AGGTGAAGAA GATCGACAGC 
TGCGAGCGCC GCTTCCTCAC GGGCCCGCCC CGGCCGCCCT CGCCCGCGCC CTCGCCATCA 
CCAGGGCCAC CGCGCCCCGC AGACTCGCTG GCCAACGGGC GCTCCAGCAA GCGGCGGCCG 
TCGCGCCTCG TGGCTCTGCG AGAGCAGAAG GCGCTCAAGA CACTGGGCAT CATCATGGGT 
GTGTTCACGC TCTGCTGGCT GCCCTTCTTC CTGGCCAACG TGGTGAAAGC TTTCCACCGC 
GACCTGGTGC CGGATCGCCT CTTCGTCTTC TTCAACTGGC TGGGCTACGC CAACTCGGCC 
TTCAACCCCA TCATCTACTG CCGCAGCCCC GACTTCCGCA AGGCTTTCCA GCGCCTGCTT 
TGCTGCGCGC GCCGGGCCGC CTGCAGACGC CGCGCAGCCC ACGGGGACCG GCCGCGCGCC 
TCGGGCTGCC TGGCGAGAGC TGGGCCGCCG CCGTCCCCCG GGGCTCCTTC GGACGACGAC 
GACGATGACG CCGGGGCCAC CCCACCCGCG CGCCTGTTGG AGCCCTGGGC CGGCTGCAAC 
GGCGGGACGA CCACTGTGGA CAGCGATTCG AGCCTGGACG AGCCGGGACG CCAGGGCTTC 
TCCTCCGAGT CCAAGGTGTA G