| Gene Symbol | Ppp2ca |
| Entrez Gene ID | 24672 |
| Full Name | protein phosphatase 2, catalytic subunit, alpha isozyme |
| Synonyms | Pp2a1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | catalyzes the removal of serine- and threonine- bound phosphate groups [RGD, Feb 2006]. |
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Ppp2ca cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Ppp2ca gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp2ca cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa13075 Clone ID Related Accession (Same CDS sequence) NM_017039.2 Accession Version NM_017039.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 930bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577289600000 Organism Rattus norvegicus(Norway rat) Product serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC072531.1. On Jun 13, 2004 this sequence version replaced NM_017039.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC072531.1, M33114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906349, SAMN01906350 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGGACGAGA AGTTGTTCAC CAAGGAGCTG GACCAGTGGA TCGAGCAGCT GAACGAGTGC
AAGCAGCTCT CCGAGTCCCA GGTCAAGAGC CTCTGCGAGA AGGCTAAAGA AATCCTGACA
AAAGAATCTA ATGTTCAGGA GGTTCGATGT CCAGTCACTG TGTGTGGAGA TGTGCATGGG
CAATTTCATG ACCTCATGGA ACTCTTTAGA ATTGGTGGTA AATCACCAGA TACAAATTAC
TTGTTTATGG GAGACTATGT GGACAGAGGA TATTACTCAG TTGAAACAGT TACACTGCTT
GTAGCTCTTA AGGTTCGTTA CCGAGAGCGT ATCACCATAC TCCGAGGGAA TCACGAGAGC
AGACAGATCA CACAAGTTTA TGGTTTCTAC GATGAGTGTT TAAGGAAATA CGGAAATGCA
AATGTTTGGA AATACTTCAC AGACCTTTTT GACTACCTTC CTCTCACTGC CTTGGTGGAT
GGGCAGATCT TCTGTCTACA TGGTGGTCTT TCACCATCCA TAGACACACT GGATCACATC
CGAGCACTTG ATCGCCTACA AGAAGTTCCT CATGAGGGTC CAATGTGTGA CTTGCTGTGG
TCAGATCCAG ATGACCGTGG TGGCTGGGGG ATATCTCCTC GGGGAGCTGG TTATACCTTT
GGCCAAGATA TTTCTGAGAC ATTTAATCAT GCCAATGGCC TCACGTTGGT GTCCAGAGCT
CACCAGCTGG TGATGGAGGG ATATAACTGG TGCCATGACC GGAATGTAGT AACAATTTTC
AGTGCTCCAA ACTATTGCTA TCGTTGTGGT AACCAAGCTG CAATCATGGA ACTTGATGAC
ACTCTTAAGT ATTCTTTCTT GCAGTTCGAT CCAGCACCTC GTAGAGGCGA GCCACATGTC
ACTCGTCGTA CCCCAGACTA CTTCCTGTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_058735.1 CDS 198..1127 Translation 
Target ORF information:
RefSeq Version NM_017039.2 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus protein phosphatase 2 catalytic subunit alpha (Ppp2ca), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_017039.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGGACGAGA AGTTGTTCAC CAAGGAGCTG GACCAGTGGA TCGAGCAGCT GAACGAGTGC
AAGCAGCTCT CCGAGTCCCA GGTCAAGAGC CTCTGCGAGA AGGCTAAAGA AATCCTGACA
AAAGAATCTA ATGTTCAGGA GGTTCGATGT CCAGTCACTG TGTGTGGAGA TGTGCATGGG
CAATTTCATG ACCTCATGGA ACTCTTTAGA ATTGGTGGTA AATCACCAGA TACAAATTAC
TTGTTTATGG GAGACTATGT GGACAGAGGA TATTACTCAG TTGAAACAGT TACACTGCTT
GTAGCTCTTA AGGTTCGTTA CCGAGAGCGT ATCACCATAC TCCGAGGGAA TCACGAGAGC
AGACAGATCA CACAAGTTTA TGGTTTCTAC GATGAGTGTT TAAGGAAATA CGGAAATGCA
AATGTTTGGA AATACTTCAC AGACCTTTTT GACTACCTTC CTCTCACTGC CTTGGTGGAT
GGGCAGATCT TCTGTCTACA TGGTGGTCTT TCACCATCCA TAGACACACT GGATCACATC
CGAGCACTTG ATCGCCTACA AGAAGTTCCT CATGAGGGTC CAATGTGTGA CTTGCTGTGG
TCAGATCCAG ATGACCGTGG TGGCTGGGGG ATATCTCCTC GGGGAGCTGG TTATACCTTT
GGCCAAGATA TTTCTGAGAC ATTTAATCAT GCCAATGGCC TCACGTTGGT GTCCAGAGCT
CACCAGCTGG TGATGGAGGG ATATAACTGG TGCCATGACC GGAATGTAGT AACAATTTTC
AGTGCTCCAA ACTATTGCTA TCGTTGTGGT AACCAAGCTG CAATCATGGA ACTTGATGAC
ACTCTTAAGT ATTCTTTCTT GCAGTTCGAT CCAGCACCTC GTAGAGGCGA GCCACATGTC
ACTCGTCGTA CCCCAGACTA CTTCCTGTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID ORa56281 Clone ID Related Accession (Same CDS sequence) XM_017597004.1 Accession Version XM_017597004.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 879bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1469376000000 Organism Rattus norvegicus(Norway rat) Product serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841ATGACCCGTT TGGCACACCA GTGTCTAGCA CGGGGTGGAA TCACTCAGAT GGCTAAAGAA
ATCCTGACAA AAGAATCTAA TGTTCAGGAG GTTCGATGTC CAGTCACTGT GTGTGGAGAT
GTGCATGGGC AATTTCATGA CCTCATGGAA CTCTTTAGAA TTGGTGGTAA ATCACCAGAT
ACAAATTACT TGTTTATGGG AGACTATGTG GACAGAGGAT ATTACTCAGT TGAAACAGTT
ACACTGCTTG TAGCTCTTAA GGTTCGTTAC CGAGAGCGTA TCACCATACT CCGAGGGAAT
CACGAGAGCA GACAGATCAC ACAAGTTTAT GGTTTCTACG ATGAGTGTTT AAGGAAATAC
GGAAATGCAA ATGTTTGGAA ATACTTCACA GACCTTTTTG ACTACCTTCC TCTCACTGCC
TTGGTGGATG GGCAGATCTT CTGTCTACAT GGTGGTCTTT CACCATCCAT AGACACACTG
GATCACATCC GAGCACTTGA TCGCCTACAA GAAGTTCCTC ATGAGGGTCC AATGTGTGAC
TTGCTGTGGT CAGATCCAGA TGACCGTGGT GGCTGGGGGA TATCTCCTCG GGGAGCTGGT
TATACCTTTG GCCAAGATAT TTCTGAGACA TTTAATCATG CCAATGGCCT CACGTTGGTG
TCCAGAGCTC ACCAGCTGGT GATGGAGGGA TATAACTGGT GCCATGACCG GAATGTAGTA
ACAATTTTCA GTGCTCCAAA CTATTGCTAT CGTTGTGGTA ACCAAGCTGC AATCATGGAA
CTTGATGACA CTCTTAAGTA TTCTTTCTTG CAGTTCGATC CAGCACCTCG TAGAGGCGAG
CCACATGTCA CTCGTCGTAC CCCAGACTAC TTCCTGTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_017452493.1 CDS 108..986 Translation
Target ORF information:
RefSeq Version XM_017597004.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus protein phosphatase 2, catalytic subunit, alpha isozyme (Ppp2ca), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_017597004.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841ATGACCCGTT TGGCACACCA GTGTCTAGCA CGGGGTGGAA TCACTCAGAT GGCTAAAGAA
ATCCTGACAA AAGAATCTAA TGTTCAGGAG GTTCGATGTC CAGTCACTGT GTGTGGAGAT
GTGCATGGGC AATTTCATGA CCTCATGGAA CTCTTTAGAA TTGGTGGTAA ATCACCAGAT
ACAAATTACT TGTTTATGGG AGACTATGTG GACAGAGGAT ATTACTCAGT TGAAACAGTT
ACACTGCTTG TAGCTCTTAA GGTTCGTTAC CGAGAGCGTA TCACCATACT CCGAGGGAAT
CACGAGAGCA GACAGATCAC ACAAGTTTAT GGTTTCTACG ATGAGTGTTT AAGGAAATAC
GGAAATGCAA ATGTTTGGAA ATACTTCACA GACCTTTTTG ACTACCTTCC TCTCACTGCC
TTGGTGGATG GGCAGATCTT CTGTCTACAT GGTGGTCTTT CACCATCCAT AGACACACTG
GATCACATCC GAGCACTTGA TCGCCTACAA GAAGTTCCTC ATGAGGGTCC AATGTGTGAC
TTGCTGTGGT CAGATCCAGA TGACCGTGGT GGCTGGGGGA TATCTCCTCG GGGAGCTGGT
TATACCTTTG GCCAAGATAT TTCTGAGACA TTTAATCATG CCAATGGCCT CACGTTGGTG
TCCAGAGCTC ACCAGCTGGT GATGGAGGGA TATAACTGGT GCCATGACCG GAATGTAGTA
ACAATTTTCA GTGCTCCAAA CTATTGCTAT CGTTGTGGTA ACCAAGCTGC AATCATGGAA
CTTGATGACA CTCTTAAGTA TTCTTTCTTG CAGTTCGATC CAGCACCTCG TAGAGGCGAG
CCACATGTCA CTCGTCGTAC CCCAGACTAC TTCCTGTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.
iScience11134-145(2019 Jan)
Sonntag T,Ostojić J,Vaughan JM,Moresco JJ,Yoon YS,Yates JR 3rd,Montminy M
De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.
American journal of human genetics104(1)139-156(2019 01)
Reynhout S,Jansen S,Haesen D,van Belle S,de Munnik SA,Bongers EMHF,Schieving JH,Marcelis C,Amiel J,Rio M,Mclaughlin H,Ladda R,Sell S,Kriek M,Peeters-Scholte CMPCD,Terhal PA,van Gassen KL,Verbeek N,Henry S,Scott Schwoerer J,Malik S,Revencu N,Ferreira CR,Macnamara E,Braakman HMH,Brimble E,Ruzhnikov MRZ,Wagner M,Harrer P,Wieczorek D,Kuechler A,Tziperman B,Barel O,de Vries BBA,Gordon CT,Janssens V,Vissers LELM
Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A.
The Journal of biological chemistry292(23)9451-9464(2017 06)
Lin L,Lo LH,Lyu Q,Lai KO
Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson's disease model.
Oncotarget7(38)60823-60843(2016 Sep)
Liu J,Chen M,Wang X,Wang Y,Duan C,Gao G,Lu L,Wu X,Wang X,Yang H
Knockdown of microRNA-195 contributes to protein phosphatase-2A inactivation in rats with chronic brain hypoperfusion.
Neurobiology of aging4576-87(2016 09)
Liu CD,Wang Q,Zong DK,Pei SC,Yan Y,Yan ML,Sun LL,Hao YY,Mao M,Xing WJ,Ren H,Ai J
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