Ivd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ivd
Entrez Gene ID	24513
Full Name	isovaleryl-CoA dehydrogenase
General protein information	Preferred Names isovaleryl-CoA dehydrogenase Names isovaleryl-CoA dehydrogenase, mitochondrial isovaleryl coenzyme A dehydrogenase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q35
Summary	is an acyl-CoA dehydrogenase involved in leucine metabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012592.2	NP_036724.1	isovaleryl-CoA dehydrogenase, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IVD	XP_001143110.2
Macaca mulatta (Rhesus monkey)	IVD	XP_001096354.1
Mus musculus (house mouse)	Ivd	NP_062800.1
Rattus norvegicus (Norway rat)	Ivd	NP_036724.1
Xenopus tropicalis (tropical clawed frog)	ivd	NP_001011380.1
Bos taurus (cattle)	IVD	NP_001029554.1
Arabidopsis thaliana (thale cress)	IVD	NP_190116.1
Neurospora crassa	NCU02126	XP_964284.1
Magnaporthe oryzae (rice blast fungus)	MGG_02540	XP_003721261.1
Canis lupus familiaris (dog)	IVD	XP_003640086.1
Homo sapiens (human)	IVD	NP_002216.2
Gallus gallus (chicken)	IVD	NP_001186490.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006780	XP_308965.3
Caenorhabditis elegans (roundworm)	ivd-1	NP_500720.1
Oryza sativa (rice)	Os05g0125500	NP_001054521.1
Danio rerio (zebrafish)	ivd	NP_958899.1
Drosophila melanogaster (fruit fly)	CG6638	NP_648239.1

Gene Ontology
Bibliography

Related articles in PubMed

Comparative studies of Acyl-CoA dehydrogenases for monomethyl branched chain substrates in amino acid metabolism.
Liu X, Wu L, Deng G, Chen G, Li N, Chu X, Li D
Bioorganic chemistry471-8(2013 Apr)

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)

Exon skipping in IVD RNA processing in isovaleric acidemia caused by point mutations in the coding region of the IVD gene.
Vockley J, Rogan PK, Anderson BD, Willard J, Seelan RS, Smith DI, Liu W
American journal of human genetics66(2)356-67(2000 Feb)

Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,.
Tiffany KA, Roberts DL, Wang M, Paschke R, Mohsen AW, Vockley J, Kim JJ
Biochemistry36(28)8455-64(1997 Jul)

Purification and characterization of isovaleryl coenzyme A dehydrogenase from rat liver mitochondria.
Ikeda Y, Tanaka K
The Journal of biological chemistry258(2)1077-85(1983 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ivd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ivd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12028	NM_012592.2 Latest version!	Rattus norvegicus isovaleryl-CoA dehydrogenase (Ivd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ivd ( NM_012592.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036724.1 Rattus norvegicus isovaleryl-CoA dehydrogenase (Ivd), mRNA.

Price & Availability↑

CloneID	ORa12028
Clone ID Related Accession (Same CDS sequence)	NM_012592.2
Accession Version	NM_012592.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	isovaleryl-CoA dehydrogenase, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088401.1. On Jun 10, 2007 this sequence version replaced NM_012592.1. ##Evidence-Data-START## Transcript exon combination :: BC088401.1, J05031.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCGACTG CAGTCCGGCT GCTGGGGCGG CGAGTTTCCA GTTGGAGACT GCGGCCTTTA 
CCGTCGCCCC TTGCTGTCCC GCAGCGGGCC CACTCGATGT TGCCTGTGGA TGATGATATC 
AACGGGCTAA ACGAGGAGCA GAAGCAGCTT CGTCATACGA TATCTAAGTT CGTTCAAGAG 
AACCTGGCCC CCAAGGCCCA AGAGATTGAT CAAAGCAATG ACTTCAAGAA CCTGAGAGAG 
TTCTGGAAGC AGCTGGGAAG CCTGGGAGTC CTGGGCATCA CAGCCCCCGT TCAGTATGGT 
GGCTCTGGCC TGGGCTACCT AGAACATGTG TTGGTGATGG AAGAGATATC CCGGGCTTCA 
GCAGCTGTGG GGCTCAGCTA TGGCGCTCAC TCCAACCTCT GCATCAACCA GATTGTCCGC 
AATGGGAATG AGGCACAGAA AGAGAAATAT CTTCCCAAGC TCATCAGTGG TGAGTTCATC 
GGAGCCCTGG CCATGAGTGA GCCCAACGCT GGCTCTGACG TTGTCTCCAT GAGGCTGAAA 
GCAGAGAAGA AAGGAGATCA CTACGTTCTG AATGGCAACA AGTTCTGGAT CACCAATGGC 
CCTGACGCTG ATGTCCTAGT TGTCTATGCC AAGACAGACT TGACTGCTGT GCCTGCGTCT 
CGGGGCATCA CAGCCTTCAT TGTGGAAAAG GATATGCCTG GTTTCAGCAC CTCGAAGAAG 
CTGGACAAGC TAGGCATGAG GGGCTCCAAC ACCTGTGAGC TAGTCTTTGA AGACTGCAAG 
GTTCCTGCTG CTAACATCCT GAGCCAAGAG AGTAAGGGTG TCTACGTACT GATGAGCGGG 
CTGGACCTAG AACGCCTGGT GCTGGCAGGT GGACCCCTTG GGATCATGCA GGCTGTCCTG 
GACCACACCA TTCCCTATTT GCATGTGAGG GAAGCCTTTG GCCAGAAGAT CGGCCAATTC 
CAGCTGATGC AGGGAAAGAT GGCTGACATG TACACCCGCC TCATGGCATG TCGACAGTAT 
GTCTACAATG TCGCCAGGGC CTGTGACGAG GGCCACATCA CTGCCAAGGA CTGTGCTGGT 
GTGATTCTGT ATACAGCCGA GTGTGCCACA CAAGTAGCCC TGGATGGCAT TCAATGTTTA 
GGTGGAAATG GCTACATCAA TGACTTCCCC ATGGGCCGCT TTCTTCGAGA TGCCAAACTG 
TACGAGATCG GAGGTGGGAC CAGTGAGGTG AGGCGGCTAG TCATTGGCAG AGCTTTCAAC 
GCAGACTTCC GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036724.1
CDS	6..1280
Translation	MATAVRLLGRRVSSWRLRPLPSPLAVPQRAHSMLPVDDDINGLNEEQKQLRHTISKFVQENLAPKAQEIDQSNDFKNLREFWKQLGSLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASAAVGLSYGAHSNLCINQIVRNGNEAQKEKYLPKLISGEFIGALAMSEPNAGSDVVSMRLKAEKKGDHYVLNGNKFWITNGPDADVLVVYAKTDLTAVPASRGITAFIVEKDMPGFSTSKKLDKLGMRGSNTCELVFEDCKVPAANILSQESKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQGKMADMYTRLMACRQYVYNVARACDEGHITAKDCAGVILYTAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGGGTSEVRRLVIGRAFNADFR

Target ORF information:

RefSeq Version	NM_012592.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus isovaleryl-CoA dehydrogenase (Ivd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012592.2

ORF Insert Sequence:

ATGGCGACTG CAGTCCGGCT GCTGGGGCGG CGAGTTTCCA GTTGGAGACT GCGGCCTTTA 
CCGTCGCCCC TTGCTGTCCC GCAGCGGGCC CACTCGATGT TGCCTGTGGA TGATGATATC 
AACGGGCTAA ACGAGGAGCA GAAGCAGCTT CGTCATACGA TATCTAAGTT CGTTCAAGAG 
AACCTGGCCC CCAAGGCCCA AGAGATTGAT CAAAGCAATG ACTTCAAGAA CCTGAGAGAG 
TTCTGGAAGC AGCTGGGAAG CCTGGGAGTC CTGGGCATCA CAGCCCCCGT TCAGTATGGT 
GGCTCTGGCC TGGGCTACCT AGAACATGTG TTGGTGATGG AAGAGATATC CCGGGCTTCA 
GCAGCTGTGG GGCTCAGCTA TGGCGCTCAC TCCAACCTCT GCATCAACCA GATTGTCCGC 
AATGGGAATG AGGCACAGAA AGAGAAATAT CTTCCCAAGC TCATCAGTGG TGAGTTCATC 
GGAGCCCTGG CCATGAGTGA GCCCAACGCT GGCTCTGACG TTGTCTCCAT GAGGCTGAAA 
GCAGAGAAGA AAGGAGATCA CTACGTTCTG AATGGCAACA AGTTCTGGAT CACCAATGGC 
CCTGACGCTG ATGTCCTAGT TGTCTATGCC AAGACAGACT TGACTGCTGT GCCTGCGTCT 
CGGGGCATCA CAGCCTTCAT TGTGGAAAAG GATATGCCTG GTTTCAGCAC CTCGAAGAAG 
CTGGACAAGC TAGGCATGAG GGGCTCCAAC ACCTGTGAGC TAGTCTTTGA AGACTGCAAG 
GTTCCTGCTG CTAACATCCT GAGCCAAGAG AGTAAGGGTG TCTACGTACT GATGAGCGGG 
CTGGACCTAG AACGCCTGGT GCTGGCAGGT GGACCCCTTG GGATCATGCA GGCTGTCCTG 
GACCACACCA TTCCCTATTT GCATGTGAGG GAAGCCTTTG GCCAGAAGAT CGGCCAATTC 
CAGCTGATGC AGGGAAAGAT GGCTGACATG TACACCCGCC TCATGGCATG TCGACAGTAT 
GTCTACAATG TCGCCAGGGC CTGTGACGAG GGCCACATCA CTGCCAAGGA CTGTGCTGGT 
GTGATTCTGT ATACAGCCGA GTGTGCCACA CAAGTAGCCC TGGATGGCAT TCAATGTTTA 
GGTGGAAATG GCTACATCAA TGACTTCCCC ATGGGCCGCT TTCTTCGAGA TGCCAAACTG 
TACGAGATCG GAGGTGGGAC CAGTGAGGTG AGGCGGCTAG TCATTGGCAG AGCTTTCAAC 
GCAGACTTCC GCTAA