Il11 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il11
Entrez Gene ID	171040
Full Name	interleukin 11
Synonyms	Il-11
General protein information	Preferred Names interleukin 11 Names interleukin-11
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q12
Summary	enhances cellular recovery after ischemia-reperfusion injury [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133519.4	NP_598203.4	interleukin-11 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL11	NP_000632.1
Pan troglodytes (chimpanzee)	IL11	XP_001136017.2
Mus musculus (house mouse)	Il11	NP_032376.1
Rattus norvegicus (Norway rat)	Il11	NP_598203.4
Canis lupus familiaris (dog)	IL11	XP_005616902.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-21 is a key determinant in IL-11/Stat3 anti-apoptotic signalling pathway in preconditioning of skeletal myoblasts.
Haider KH, Idris NM, Kim HW, Ahmed RP, Shujia J, Ashraf M
Cardiovascular research88(1)168-78(2010 Oct)

The role of IL-6 and IL-11 in hyperoxic injury in developing lung.
Chetty A, Cao GJ, Manzo N, Nielsen HC, Waxman A
Pediatric pulmonology43(3)297-304(2008 Mar)

IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway.
Grehan JF, Levay-Young BK, Fogelson JL, François-Bongarçon V, Benson BA, Dalmasso AP
Journal of immunology (Baltimore, Md. : 1950)175(3)1903-10(2005 Aug)

Interleukin-11 enhances intestinal absorptive function after ischemia-reperfusion injury.
Kuenzler KA, Pearson PY, Schwartz MZ
Journal of pediatric surgery37(3)457-9(2002 Mar)

Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy.
Zourbas S, Dubanchet S, Martal J, Chaouat G
Clinical and experimental immunology126(3)519-28(2001 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Il11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00815	NM_133519.4 Latest version!	Rattus norvegicus interleukin 11 (Il11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il11 ( NM_133519.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598203.4 Rattus norvegicus interleukin 11 (Il11), mRNA.

Price & Availability↑

CloneID	ORa00815
Clone ID Related Accession (Same CDS sequence)	NM_133519.4
Accession Version	NM_133519.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-11 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07071876.1. On Jul 22, 2011 this sequence version replaced NM_133519.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## CDS exon combination :: AF347935.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAACTGTG TTTGTCACCT GGTCCTGGTG GTGCTGAGCC TCTGGCCAGA TAGAGTCGTT 
GCCCCTGGGC CACCAGCTGG CTCCCCTCGA GTGTCTTCAG ACCCTCGTGC AGATCTGGAT 
AGCGCTGTCC TCTTGACCAG GTCCCTCCTG GCAGACACAC GGCAACTAGC TGCACAGATG 
AGAGACAAAT TCCCAGCTGA TGGAGACCAC AATCTGGACT CCCTACCTAC CTTGGCCATG 
AGCGCTGGGA CACTGGGATC TTTGCAGCTT CCTGGAGTGC TGACAAGGCT TCGAGTAGAC 
TTAATGTCCT ACTTCCGACA TGTACAGTGG TTGCGCCGGG CAGCTGGTCC TTCCCTAAAG 
ACTCTGGAGC CAGAGCTGGG TGCCCTGCAA GCCCGACTGG AACGGCTACT TCGTCGCTTA 
CAGCTCTTGA TGTCTCGCCT AGCCTTGCCC CAGGCAGCCC CGGACCAACC TGCGGTCCCT 
CTGGGCCCTC CTGCCTCGGC CTGGGGAAGC ATCCGGGCAG CTCATGCCAT CCTAGGAGGG 
CTGCACCTGA CCTTGGACTG GGCCGTGCGG GGCCTGCTGT TGTTAAAGAC TCGGCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598203.4
CDS	115..714
Translation	MNCVCHLVLVVLSLWPDRVVAPGPPAGSPRVSSDPRADLDSAVLLTRSLLADTRQLAAQMRDKFPADGDHNLDSLPTLAMSAGTLGSLQLPGVLTRLRVDLMSYFRHVQWLRRAAGPSLKTLEPELGALQARLERLLRRLQLLMSRLALPQAAPDQPAVPLGPPASAWGSIRAAHAILGGLHLTLDWAVRGLLLLKTRL

Target ORF information:

RefSeq Version	NM_133519.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 11 (Il11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133519.4

ORF Insert Sequence:

ATGAACTGTG TTTGTCACCT GGTCCTGGTG GTGCTGAGCC TCTGGCCAGA TAGAGTCGTT 
GCCCCTGGGC CACCAGCTGG CTCCCCTCGA GTGTCTTCAG ACCCTCGTGC AGATCTGGAT 
AGCGCTGTCC TCTTGACCAG GTCCCTCCTG GCAGACACAC GGCAACTAGC TGCACAGATG 
AGAGACAAAT TCCCAGCTGA TGGAGACCAC AATCTGGACT CCCTACCTAC CTTGGCCATG 
AGCGCTGGGA CACTGGGATC TTTGCAGCTT CCTGGAGTGC TGACAAGGCT TCGAGTAGAC 
TTAATGTCCT ACTTCCGACA TGTACAGTGG TTGCGCCGGG CAGCTGGTCC TTCCCTAAAG 
ACTCTGGAGC CAGAGCTGGG TGCCCTGCAA GCCCGACTGG AACGGCTACT TCGTCGCTTA 
CAGCTCTTGA TGTCTCGCCT AGCCTTGCCC CAGGCAGCCC CGGACCAACC TGCGGTCCCT 
CTGGGCCCTC CTGCCTCGGC CTGGGGAAGC ATCCGGGCAG CTCATGCCAT CCTAGGAGGG 
CTGCACCTGA CCTTGGACTG GGCCGTGCGG GGCCTGCTGT TGTTAAAGAC TCGGCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-21 is a key determinant in IL-11/Stat3 anti-apoptotic signalling pathway in preconditioning of skeletal myoblasts.
Cardiovascular research88(1)168-78(2010 Oct)
Haider KH,Idris NM,Kim HW,Ahmed RP,Shujia J,Ashraf M

The role of IL-6 and IL-11 in hyperoxic injury in developing lung.
Pediatric pulmonology43(3)297-304(2008 Mar)
Chetty A,Cao GJ,Manzo N,Nielsen HC,Waxman A

IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway.
Journal of immunology (Baltimore, Md. : 1950)175(3)1903-10(2005 Aug)
Grehan JF,Levay-Young BK,Fogelson JL,François-Bongarçon V,Benson BA,Dalmasso AP

Interleukin-11 enhances intestinal absorptive function after ischemia-reperfusion injury.
Journal of pediatric surgery37(3)457-9(2002 Mar)
Kuenzler KA,Pearson PY,Schwartz MZ

Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy.
Clinical and experimental immunology126(3)519-28(2001 Dec)
Zourbas S,Dubanchet S,Martal J,Chaouat G