| Gene Symbol | Tmlhe |
| Entrez Gene ID | 170898 |
| Full Name | trimethyllysine hydroxylase, epsilon |
| Synonyms | Tmlh |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | first enzyme in the carnitine biosynthesis pathway; plays an important role in the transport of fatty acids across the inner mitochondrial membrane [RGD, Feb 2006]. |
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Tmlhe cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Tmlhe gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tmlhe cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa12474 Clone ID Related Accession (Same CDS sequence) NM_133387.2 Accession Version NM_133387.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1302bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1536940800000 Organism Rattus norvegicus(Norway rat) Product trimethyllysine dioxygenase, mitochondrial Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085923.1. On Oct 27, 2005 this sequence version replaced NM_133387.1. ##Evidence-Data-START## Transcript exon combination :: BC085923.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGTGGTACC ATAAGTTGTT GCACCAACAA AGCAGGCTCC AGAACTTGAT GAAGAGAGGA
GACATAGCTC ACGGTCTTCG TCTGTCCGGC TTTAAAAGTT TATTTCCATT TTCGCTCCAT
TGGTGCCATA CGGCTTCCAA GTCTGTGAAT TGTACTTGGC ACCAACATGA AGATCATTTG
GAGCTGGGGA CCAAACCCAG GGCCTTGCGC TTGCTAGAAC TGCAATATGC CAGCACTGTG
ATGCGCTTCG ATTATGTCTG GCTTCGAGAC CACTGCCGCT CAGCCTCGTG CTATAATTCT
AAGACTCACC AGCGGAGCCT GGACACTGCC AGTGTGGATT TATGCATTAA GCCAAAGACG
ATTCGTCTGG ATGAAAGTAC ACTCTTTTTC ACTTGGCCAG ATGGTCATGT GACTAGATAC
GACCTGGATT GGCTGGTGAA AAACAGCTAC GAAGGGCAGA AGCAGGAGGT CATCCAACCC
AGGGTGCTGT GGAACGCCAA GCTCTACCAG GACGCCCAGC TTCCGTCTGT TGATTTCCAG
GGTTTCTTGG AAACAAAGGA AGGACTGAAG AAGTTTCTGC AGAACTTTCT GCTCTACGGA
ATTGCGTTTG TAGAAAATGT CCCTCCCACT CAGGAGCACA CGGAAAAGCT GGCACGAAGG
GTCAGCCTAA TCAGAGAAAC CATTTATGGA AGGATGTGGT ATTTCACGTC AGACTTTTCC
AGAGGTGACA CTGCGTACAC CAAGCTAGCC CTAGATCGCC ATACCGATAC CACCTACTTT
CAAGAGCCCT GTGGCATTCA AGTATTTCAT TGTCTTAAGC ACGAAGGAAC AGGTGGCAGG
ACACTGTTGG TGGATGGATT CTATGCAGCG CAACAAGTAC TCCAAAGAGC ACCTGAGGAA
TTTGACCTCC TCAGCCAAGT ACCATTGAAG CATGAATATA TTGAAAATGT TGGACAATGT
CACAATCACA TGATAGGGGT TGGACCCATC TTAAATATCT ACCCATGGAA TAAGGAGCTG
TATTTGATCA GGTACAACAA CTACGACAGG GCTGTCATCA ACACTGTGCC TTACGACGTT
GTCCGTCGTT GGTATGCAGC ACACCGAACC CTAACGACTG AACTGAGAAG GCCTGAGAAT
GAACTTTGGG TCAAACTGAA GCCTGGAAAG GTACTATTTA TAGACAACTG GCGAGTCCTT
CACGGCAGGG AGTCATTCAC TGGCTACCGT CAACTGTGTG GCTGCTATTT GACTAGAGAT
GATGTACTGA ATACTGCTCG AATTCTAGGT CTTCATGCCT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_596878.2 CDS 80..1381 Translation 
Target ORF information:
RefSeq Version NM_133387.2 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus trimethyllysine hydroxylase, epsilon (Tmlhe), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_133387.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGTGGTACC ATAAGTTGTT GCACCAACAA AGCAGGCTCC AGAACTTGAT GAAGAGAGGA
GACATAGCTC ACGGTCTTCG TCTGTCCGGC TTTAAAAGTT TATTTCCATT TTCGCTCCAT
TGGTGCCATA CGGCTTCCAA GTCTGTGAAT TGTACTTGGC ACCAACATGA AGATCATTTG
GAGCTGGGGA CCAAACCCAG GGCCTTGCGC TTGCTAGAAC TGCAATATGC CAGCACTGTG
ATGCGCTTCG ATTATGTCTG GCTTCGAGAC CACTGCCGCT CAGCCTCGTG CTATAATTCT
AAGACTCACC AGCGGAGCCT GGACACTGCC AGTGTGGATT TATGCATTAA GCCAAAGACG
ATTCGTCTGG ATGAAAGTAC ACTCTTTTTC ACTTGGCCAG ATGGTCATGT GACTAGATAC
GACCTGGATT GGCTGGTGAA AAACAGCTAC GAAGGGCAGA AGCAGGAGGT CATCCAACCC
AGGGTGCTGT GGAACGCCAA GCTCTACCAG GACGCCCAGC TTCCGTCTGT TGATTTCCAG
GGTTTCTTGG AAACAAAGGA AGGACTGAAG AAGTTTCTGC AGAACTTTCT GCTCTACGGA
ATTGCGTTTG TAGAAAATGT CCCTCCCACT CAGGAGCACA CGGAAAAGCT GGCACGAAGG
GTCAGCCTAA TCAGAGAAAC CATTTATGGA AGGATGTGGT ATTTCACGTC AGACTTTTCC
AGAGGTGACA CTGCGTACAC CAAGCTAGCC CTAGATCGCC ATACCGATAC CACCTACTTT
CAAGAGCCCT GTGGCATTCA AGTATTTCAT TGTCTTAAGC ACGAAGGAAC AGGTGGCAGG
ACACTGTTGG TGGATGGATT CTATGCAGCG CAACAAGTAC TCCAAAGAGC ACCTGAGGAA
TTTGACCTCC TCAGCCAAGT ACCATTGAAG CATGAATATA TTGAAAATGT TGGACAATGT
CACAATCACA TGATAGGGGT TGGACCCATC TTAAATATCT ACCCATGGAA TAAGGAGCTG
TATTTGATCA GGTACAACAA CTACGACAGG GCTGTCATCA ACACTGTGCC TTACGACGTT
GTCCGTCGTT GGTATGCAGC ACACCGAACC CTAACGACTG AACTGAGAAG GCCTGAGAAT
GAACTTTGGG TCAAACTGAA GCCTGGAAAG GTACTATTTA TAGACAACTG GCGAGTCCTT
CACGGCAGGG AGTCATTCAC TGGCTACCGT CAACTGTGTG GCTGCTATTT GACTAGAGAT
GATGTACTGA ATACTGCTCG AATTCTAGGT CTTCATGCCT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID ORa39078 Clone ID Related Accession (Same CDS sequence) XM_006255855.1 Accession Version XM_006255855.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1266bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1469376000000 Organism Rattus norvegicus(Norway rat) Product trimethyllysine dioxygenase, mitochondrial isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005119.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGTGGTACC ATAAGTTGTT GCACCAACAA AGCAGGCTCC AGAACTTGAT GAAGAGAGGA
GACATAGCTC ACGGTCTTCG TCTGTCCGGC TTTAAAAGTT TATTTCCATT TTCGCTCCAT
TGGTGCCATA CGGCTTCCAA GTCTGTGAAT TGTACTTGGC ACCAACATGA AGATCATTTG
GAACTGCAAT ATGCCAGCAC TGTGATGCGC TTCGATTATG TCTGGCTTCG AGACCACTGC
CGCTCAGCCT CGTGCTATAA TTCTAAGACT CACCAGCGGA GCCTGGACAC TGCCAGTGTG
GATTTATGCA TTAAGCCAAA GACGATTCGT CTGGATGAAA GTACACTCTT TTTCACTTGG
CCAGATGGTC ATGTGACTAG ATACGACCTG GATTGGCTGG TGAAAAACAG CTACGAAGGG
CAGAAGCAGG AGGTCATCCA ACCCAGGGTG CTGTGGAACG CCAAGCTCTA CCAGGACGCC
CAGCTTCCGT CTGTTGATTT CCAGGGTTTC TTGGAAACAA AGGAAGGACT GAAGAAGTTT
CTGCAGAACT TTCTGCTCTA CGGAATTGCG TTTGTAGAAA ATGTCCCTCC CACTCAGGAG
CACACGGAAA AGCTGGCACG AAGGGTCAGC CTAATCAGAG AAACCATTTA TGGAAGGATG
TGGTATTTCA CGTCAGACTT TTCCAGAGGT GACACTGCGT ACACCAAGCT AGCCCTAGAT
CGCCATACCG ATACCACCTA CTTTCAAGAG CCCTGTGGCA TTCAAGTATT TCATTGTCTT
AAGCACGAAG GAACAGGTGG CAGGACACTG TTGGTGGATG GATTCTATGC AGCGCAACAA
GTACTCCAAA GAGCACCTGA GGAATTTGAC CTCCTCAGCC AAGTACCATT GAAGCATGAA
TATATTGAAA ATGTTGGACA ATGTCACAAT CACATGATAG GGGTTGGACC CATCTTAAAT
ATCTACCCAT GGAATAAGGA GCTGTATTTG ATCAGGTACA ACAACTACGA CAGGGCTGTC
ATCAACACTG TGCCTTACGA CGTTGTCCGT CGTTGGTATG CAGCACACCG AACCCTAACG
ACTGAACTGA GAAGGCCTGA GAATGAACTT TGGGTCAAAC TGAAGCCTGG AAAGGTACTA
TTTATAGACA ACTGGCGAGT CCTTCACGGC AGGGAGTCAT TCACTGGCTA CCGTCAACTG
TGTGGCTGCT ATTTGACTAG AGATGATGTA CTGAATACTG CTCGAATTCT AGGTCTTCAT
GCCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_006255917.1 CDS 125..1390 Translation
Target ORF information:
RefSeq Version XM_006255855.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus trimethyllysine hydroxylase, epsilon (Tmlhe), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_006255855.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGTGGTACC ATAAGTTGTT GCACCAACAA AGCAGGCTCC AGAACTTGAT GAAGAGAGGA
GACATAGCTC ACGGTCTTCG TCTGTCCGGC TTTAAAAGTT TATTTCCATT TTCGCTCCAT
TGGTGCCATA CGGCTTCCAA GTCTGTGAAT TGTACTTGGC ACCAACATGA AGATCATTTG
GAACTGCAAT ATGCCAGCAC TGTGATGCGC TTCGATTATG TCTGGCTTCG AGACCACTGC
CGCTCAGCCT CGTGCTATAA TTCTAAGACT CACCAGCGGA GCCTGGACAC TGCCAGTGTG
GATTTATGCA TTAAGCCAAA GACGATTCGT CTGGATGAAA GTACACTCTT TTTCACTTGG
CCAGATGGTC ATGTGACTAG ATACGACCTG GATTGGCTGG TGAAAAACAG CTACGAAGGG
CAGAAGCAGG AGGTCATCCA ACCCAGGGTG CTGTGGAACG CCAAGCTCTA CCAGGACGCC
CAGCTTCCGT CTGTTGATTT CCAGGGTTTC TTGGAAACAA AGGAAGGACT GAAGAAGTTT
CTGCAGAACT TTCTGCTCTA CGGAATTGCG TTTGTAGAAA ATGTCCCTCC CACTCAGGAG
CACACGGAAA AGCTGGCACG AAGGGTCAGC CTAATCAGAG AAACCATTTA TGGAAGGATG
TGGTATTTCA CGTCAGACTT TTCCAGAGGT GACACTGCGT ACACCAAGCT AGCCCTAGAT
CGCCATACCG ATACCACCTA CTTTCAAGAG CCCTGTGGCA TTCAAGTATT TCATTGTCTT
AAGCACGAAG GAACAGGTGG CAGGACACTG TTGGTGGATG GATTCTATGC AGCGCAACAA
GTACTCCAAA GAGCACCTGA GGAATTTGAC CTCCTCAGCC AAGTACCATT GAAGCATGAA
TATATTGAAA ATGTTGGACA ATGTCACAAT CACATGATAG GGGTTGGACC CATCTTAAAT
ATCTACCCAT GGAATAAGGA GCTGTATTTG ATCAGGTACA ACAACTACGA CAGGGCTGTC
ATCAACACTG TGCCTTACGA CGTTGTCCGT CGTTGGTATG CAGCACACCG AACCCTAACG
ACTGAACTGA GAAGGCCTGA GAATGAACTT TGGGTCAAAC TGAAGCCTGG AAAGGTACTA
TTTATAGACA ACTGGCGAGT CCTTCACGGC AGGGAGTCAT TCACTGGCTA CCGTCAACTG
TGTGGCTGCT ATTTGACTAG AGATGATGTA CTGAATACTG CTCGAATTCT AGGTCTTCAT
GCCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.
Translational psychiatry2e179(2012 Oct)
Nava C,Lamari F,Héron D,Mignot C,Rastetter A,Keren B,Cohen D,Faudet A,Bouteiller D,Gilleron M,Jacquette A,Whalen S,Afenjar A,Périsse D,Laurent C,Dupuits C,Gautier C,Gérard M,Huguet G,Caillet S,Leheup B,Leboyer M,Gillberg C,Delorme R,Bourgeron T,Brice A,Depienne C
Functional analysis of TMLH variants and definition of domains required for catalytic activity and mitochondrial targeting.
Journal of cellular physiology204(3)839-47(2005 Sep)
Monfregola J,Cevenini A,Terracciano A,van Vlies N,Arbucci S,Wanders RJ,D'Urso M,Vaz FM,Ursini MV
Structural basis of allotypes of ecto-nucleotide pyrophosphatase/phosphodiesterase (plasma cell membrane glycoprotein PC-1) in the mouse and rat, and analysis of allele-specific xenogeneic antibodies.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics29(4)307-13(2002 Aug)
Banakh I,Sali A,Dubljevic V,Grobben B,Slegers H,Goding JW
Molecular and Biochemical Characterization of Rat epsilon -N-Trimethyllysine Hydroxylase, the First Enzyme of Carnitine Biosynthesis.
The Journal of biological chemistry276(36)33512-7(2001 Sep)
Vaz FM,Ofman R,Westinga K,Back JW,Wanders RJ
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