Txnip cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Txnip
Entrez Gene ID	117514
Full Name	thioredoxin interacting protein
Synonyms	Vdup1
General protein information	Preferred Names thioredoxin interacting protein Names thioredoxin-interacting protein upregulated by 1,25-dihydroxyvitamin D-3 vitamin D3 up-regulated protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	regulates thioredoxin to play an important role in the preservation of cellular viability [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001008767.1	NP_001008767.1	thioredoxin-interacting protein

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	TXNIP	XP_001092636.1
Xenopus tropicalis (tropical clawed frog)	txnip	XP_002938510.2
Canis lupus familiaris (dog)	TXNIP	XP_533037.2
Bos taurus (cattle)	TXNIP	NP_001095345.2
Rattus norvegicus (Norway rat)	Txnip	NP_001008767.1
Homo sapiens (human)	TXNIP	NP_006463.3
Pan troglodytes (chimpanzee)	TXNIP	XP_001156564.1
Danio rerio (zebrafish)	txnipa	NP_956381.1
Danio rerio (zebrafish)	txnipb	NP_001239433.1
Mus musculus (house mouse)	Txnip	NP_076208.2

Gene Ontology
Bibliography

Related articles in PubMed

Role of TXNIP/NLRP3 in sepsis-induced myocardial dysfunction.
Yang C, Xia W, Liu X, Lin J, Wu A
International journal of molecular medicine44(2)417-426(2019 Aug)

Role of the thioredoxin interacting protein in diabetic nephropathy and the mechanism of regulating NOD‑like receptor protein 3 inflammatory corpuscle.
Gu C, Liu S, Wang H, Dou H
International journal of molecular medicine43(6)2440-2450(2019 Jun)

Thioredoxin-interacting protein mediates mitochondrion-dependent apoptosis in early brain injury after subarachnoid hemorrhage.
Liang Y, Che X, Zhao Q, Darwazeh R, Zhang H, Jiang D, Zhao J, Xiang X, Qin W, Liu L, He Z
Molecular and cellular biochemistry450(1-2)149-158(2019 Jan)

Immobilization rapidly induces thioredoxin-interacting protein gene expression together with insulin resistance in rat skeletal muscle.
Kawamoto E, Tamakoshi K, Ra SG, Masuda H, Kawanaka K
Journal of applied physiology (Bethesda, Md. : 1985)125(2)596-604(2018 08)

Acupuncture inhibits TXNIP-associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats.
Du SQ, Wang XR, Zhu W, Ye Y, Yang JW, Ma SM, Ji CS, Liu CZ
CNS neuroscience & therapeutics24(1)39-46(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Txnip gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Txnip cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00328	NM_001008767.1 Latest version!	Rattus norvegicus thioredoxin interacting protein (Txnip), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Txnip ( NM_001008767.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001008767.1 Rattus norvegicus thioredoxin interacting protein (Txnip), mRNA.

Price & Availability↑

CloneID	ORa00328
Clone ID Related Accession (Same CDS sequence)	NM_001008767.1
Accession Version	NM_001008767.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Rattus norvegicus(Norway rat)
Product	thioredoxin-interacting protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088411.1. On Jan 1, 2005 this sequence version replaced XM_342299.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC088411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTGATGT TCAAGAAGAT CAAGTCTTTT GAGGTGGTCT TCAACGACCC TGAGAAGGTG 
TATGGCAGCG GGGAGAAGGT GGCCGGCCGG GTGACAGTGG AAGTGTGTGA AGTTACCCGA 
GTCAAAGCCG TCAGGATCCT GGCTTGCGGT GTGGCCAAGG TCCTGTGGAT GCAAGGGTCT 
CAGCAGTGCA AACAGACCTT GGACTACTTG CGCTATGAAG ACACCCTTCT CCTAGAAGAC 
CAGCCTACAG GTGAGAACGA GATGGTGATC ATGAGACCAG GAAACAAATA TGAGTACAAG 
TTCGGCTTTG AGCTTCCTCA AGGGCCCCTG GGAACATCCT TCAAAGGGAA ATATGGCTGT 
GTAGACTACT GGGTGAAGGC TTTTCTCGAT CGTCCCAGCC AGCCAACTCA AGAGGCAAAG 
AAAAACTTTG AAGTGATGGA TCTAGTGGAC GTCAATACTC CTGACTTAAT GGCACCAGTG 
TCTGCCAAAA AGGAGAAGAA AGTTTCCTGC ATGTTCATTC CTGATGGACG CGTGTCAGTC 
TCCGCTCGAA TCGACAGAAA AGGATTCTGT GAAGGTGATG ACATTTCCAT CCACGCTGAC 
TTTGAGAACA CATGTTCCCG AATCGTGGTC CCCAAAGCAG CTATTGTGGC CCGGCACACT 
TACCTTGCCA ATGGCCAGAC CAAAGTGCTC ACTCAGAAGC TGTCCTCAGT CAGAGGCAAT 
CACATTATCT CAGGGACTTG CGCATCATGG CGTGGCAAGA GTCTCCGAGT GCAGAAGATC 
AGACCGTCCA TTCTGGGCTG CAACATCCTC AGAGTTGAAT ACTCCTTGCT GATCTATGTT 
AGTGTCCCTG GCTCCAAGAA AGTCATCCTC GATCTGCCCC TAGTGATTGG CAGCAGGTCG 
GGCCTAAGCA GCCGGACATC CAGCATGGCT AGCCGGACAA GCTCTGAAAT GAGCTGGATA 
GACCTAAACA TCCCAGACAC CCCAGAAGCT CCACCTTGCT ATATGGACGT GATTCCTGAA 
GATCACAGAC TGGAGAGCCC CACCACCCCC CTGCTAGATG ATGTGGATGA TTCTCAAGAC 
AGCCCTATCT TTATGTACGC CCCCGAGTTC CAGTTCATGC CTCCGCCCAC TTACACTGAG 
GTGGATCCCT GCGTCCTTAA CAACAACAAC AACAACGTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008767.1
CDS	191..1375
Translation	MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVTVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDDISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNNNVQ

Target ORF information:

RefSeq Version	NM_001008767.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus thioredoxin interacting protein (Txnip), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008767.1

ORF Insert Sequence:

ATGGTGATGT TCAAGAAGAT CAAGTCTTTT GAGGTGGTCT TCAACGACCC TGAGAAGGTG 
TATGGCAGCG GGGAGAAGGT GGCCGGCCGG GTGACAGTGG AAGTGTGTGA AGTTACCCGA 
GTCAAAGCCG TCAGGATCCT GGCTTGCGGT GTGGCCAAGG TCCTGTGGAT GCAAGGGTCT 
CAGCAGTGCA AACAGACCTT GGACTACTTG CGCTATGAAG ACACCCTTCT CCTAGAAGAC 
CAGCCTACAG GTGAGAACGA GATGGTGATC ATGAGACCAG GAAACAAATA TGAGTACAAG 
TTCGGCTTTG AGCTTCCTCA AGGGCCCCTG GGAACATCCT TCAAAGGGAA ATATGGCTGT 
GTAGACTACT GGGTGAAGGC TTTTCTCGAT CGTCCCAGCC AGCCAACTCA AGAGGCAAAG 
AAAAACTTTG AAGTGATGGA TCTAGTGGAC GTCAATACTC CTGACTTAAT GGCACCAGTG 
TCTGCCAAAA AGGAGAAGAA AGTTTCCTGC ATGTTCATTC CTGATGGACG CGTGTCAGTC 
TCCGCTCGAA TCGACAGAAA AGGATTCTGT GAAGGTGATG ACATTTCCAT CCACGCTGAC 
TTTGAGAACA CATGTTCCCG AATCGTGGTC CCCAAAGCAG CTATTGTGGC CCGGCACACT 
TACCTTGCCA ATGGCCAGAC CAAAGTGCTC ACTCAGAAGC TGTCCTCAGT CAGAGGCAAT 
CACATTATCT CAGGGACTTG CGCATCATGG CGTGGCAAGA GTCTCCGAGT GCAGAAGATC 
AGACCGTCCA TTCTGGGCTG CAACATCCTC AGAGTTGAAT ACTCCTTGCT GATCTATGTT 
AGTGTCCCTG GCTCCAAGAA AGTCATCCTC GATCTGCCCC TAGTGATTGG CAGCAGGTCG 
GGCCTAAGCA GCCGGACATC CAGCATGGCT AGCCGGACAA GCTCTGAAAT GAGCTGGATA 
GACCTAAACA TCCCAGACAC CCCAGAAGCT CCACCTTGCT ATATGGACGT GATTCCTGAA 
GATCACAGAC TGGAGAGCCC CACCACCCCC CTGCTAGATG ATGTGGATGA TTCTCAAGAC 
AGCCCTATCT TTATGTACGC CCCCGAGTTC CAGTTCATGC CTCCGCCCAC TTACACTGAG 
GTGGATCCCT GCGTCCTTAA CAACAACAAC AACAACGTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of TXNIP/NLRP3 in sepsis-induced myocardial dysfunction.
International journal of molecular medicine44(2)417-426(2019 Aug)
Yang C,Xia W,Liu X,Lin J,Wu A

Role of the thioredoxin interacting protein in diabetic nephropathy and the mechanism of regulating NOD‑like receptor protein 3 inflammatory corpuscle.
International journal of molecular medicine43(6)2440-2450(2019 Jun)
Gu C,Liu S,Wang H,Dou H

Thioredoxin-interacting protein mediates mitochondrion-dependent apoptosis in early brain injury after subarachnoid hemorrhage.
Molecular and cellular biochemistry450(1-2)149-158(2019 Jan)
Liang Y,Che X,Zhao Q,Darwazeh R,Zhang H,Jiang D,Zhao J,Xiang X,Qin W,Liu L,He Z

Immobilization rapidly induces thioredoxin-interacting protein gene expression together with insulin resistance in rat skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985)125(2)596-604(2018 08)
Kawamoto E,Tamakoshi K,Ra SG,Masuda H,Kawanaka K

Acupuncture inhibits TXNIP-associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats.
CNS neuroscience & therapeutics24(1)39-46(2018 Jan)
Du SQ,Wang XR,Zhu W,Ye Y,Yang JW,Ma SM,Ji CS,Liu CZ