Nlgn2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nlgn2
Entrez Gene ID	117096
Full Name	neuroligin 2
General protein information	Preferred Names neuroligin 2 Names neuroligin-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	cell surface protein that binds to a subset of neurexins [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053992.1	NP_446444.1	neuroligin-2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NLGN2	XP_849499.2
Mus musculus (house mouse)	Nlgn2	NP_942562.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003568	XP_562412.4
Homo sapiens (human)	NLGN2	NP_065846.1
Pan troglodytes (chimpanzee)	NLGN2	XP_523830.3
Macaca mulatta (Rhesus monkey)	NLGN2	XP_001108431.2
Bos taurus (cattle)	NLGN2	NP_001178171.1
Rattus norvegicus (Norway rat)	Nlgn2	NP_446444.1
Danio rerio (zebrafish)	nlgn2b	NP_001159801.1
Drosophila melanogaster (fruit fly)	CG34127	NP_001036685.2
Danio rerio (zebrafish)	nlgn2a	NP_001159808.1
Xenopus tropicalis (tropical clawed frog)	nlgn2	XP_002944465.2

Gene Ontology
Bibliography

Related articles in PubMed

Neuroligins Differentially Mediate Subtype-Specific Synapse Formation in Pyramidal Neurons and Interneurons.
Xia QQ, Xu J, Liao TL, Yu J, Shi L, Xia J, Luo JH, Xu J
Neuroscience bulletin35(3)497-506(2019 Jun)

Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to control inhibitory synapse number.
Binda CS, Nakamura Y, Henley JM, Wilkinson KA
The Biochemical journal476(2)293-306(2019 01)

Increased Neuroligin 2 Levels in the Postsynaptic Membrane in Spinal Dorsal Horn may Contribute to Postoperative Pain.
Guo R, Li H, Li X, Sun Y, Miao H, Ma D, Hong F, Zhang Y, Guan Y, Li J, Tian M, Wang Y
Neuroscience38214-22(2018 07)

GARLH Family Proteins Stabilize GABA
Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S
Neuron93(5)1138-1152.e6(2017 Mar)

Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses.
Nguyen QA, Horn ME, Nicoll RA
eLife5(2016 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Nlgn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nlgn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11273	NM_053992.1 Latest version!	Rattus norvegicus neuroligin 2 (Nlgn2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nlgn2 ( NM_053992.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446444.1 Rattus norvegicus neuroligin 2 (Nlgn2), mRNA.

Price & Availability↑

CloneID	ORa11273
Clone ID Related Accession (Same CDS sequence)	NM_053992.1
Accession Version	NM_053992.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2511bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573660800000
Organism	Rattus norvegicus(Norway rat)
Product	neuroligin-2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U41662.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U41662.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTGGCTCC TGGCGTTGTG TCTGGTGGGG CTGGCTGGGG CTCAACGGGG AGGAGGGGGT 
CCCGGCGGCG GCGCCCCGGG CGGCCCAGGC CTGGGCCTCG GCAGCCTCGG GGAGGAGCGC 
TTCCCGGTGG TGAACACAGC CTACGGGCGA GTGCGCGGTG TGCGGCGCGA GCTCAACAAC 
GAGATCCTGG GCCCGGTCGT GCAGTTCTTG GGCGTGCCCT ACGCCACGCC GCCCTTGGGC 
GCCCGCCGCT TCCAGCCGCC TGAGGCACCT GCCTCGTGGC CCGGCGTGCG CAACGCCACC 
ACCCTGCCGC CCGCCTGCCC GCAGAACCTG CACGGGGCCC TGCCGGCCAT CATGCTGCCT 
GTGTGGTTCA CCGACAACTT GGAGGCGGCC GCCACCTACG TGCAGAACCA GAGCGAGGAC 
TGCCTGTACC TCAACCTCTA CGTGCCCACT GAGGACGGTC CGCTCACAAA AAAACGTGAC 
GAGGCGACGC TCAATCCGCC AGACACAGAT ATCCGGGACT CTGGGAAGAA ACCAGTCATG 
CTGTTTCTAC ACGGCGGCTC CTACATGGAG GGCACCGGGA ACATGTTCGA CGGCTCAGTC 
CTGGCTGCCT ATGGCAATGT CATCGTAGCC ACACTCAACT ACCGTCTTGG GGTGCTCGGC 
TTTCTCAGCA CTGGTGACCA GGCTGCAAAA GGCAACTACG GGCTCCTGGA CCAGATCCAG 
GCCCTGCGCT GGCTCAGTGA AAACATTGCC CACTTTGGCG GTGACCCTGA ACGCATCACC 
ATCTTTGGGT CTGGTGCGGG GGCCTCCTGT GTCAACTTGC TGATCCTCTC CCACCATTCA 
GAAGGGCTGT TCCAGAAGGC CATTGCTCAG AGTGGCACTG CCATTTCCAG CTGGTCTGTC 
AACTACCAGC CGCTCAAGTA CACGCGGCTG CTGGCAGCCA AAGTGGGCTG TGACCGAGAG 
GACAGCACGG AAGCTGTGGA ATGTCTACGC CGGAAGTCTT CCCGGGAGCT AGTAGACCAG 
GATGTGCAGC CTGCCCGCTA CCACATTGCC TTTGGGCCTG TGGTGGACGG CGATGTAGTC 
CCTGATGACC CTGAGATCCT CATGCAACAG GGAGAATTCC TCAACTACGA CATGCTCATT 
GGCGTCAACC AGGGAGAGGG TCTCAAGTTC GTGGAGGACT CTGCAGAGAG TGAGGACGGG 
GTGTCTGCCA GCGCCTTTGA CTTCACTGTC TCCAACTTTG TGGACAACTT GTATGGGTAT 
CCAGAGGGCA AGGATGTGCT TCGAGAGACC ATCAAGTTCA TGTACACGGA CTGGGCTGAC 
CGGGACAATG GCGAGATGCG GCGTAAGACC CTGTTGGCAC TCTTTACTGA CCACCAGTGG 
GTAGCCCCAG CTGTGGCCAC TGCCAAGCTA CATGCTGACT ACCAGTCCCC TGTCTACTTT 
TACACTTTTT ACCACCACTG CCAGGCTGAG GGCCGGCCAG AGTGGGCAGA TGCAGCGCAT 
GGGGATGAGC TGCCCTACGT CTTTGGTGTG CCCATGGTGG GCGCCACCGA CCTCTTCCCC 
TGCAACTTCT CCAAGAATGA TGTCATGCTC AGCGCAGTAG TCATGACCTA CTGGACCAAC 
TTCGCCAAGA CTGGTGACCC CAACCAGCCT GTGCCACAGG ACACCAAGTT CATCCACACC 
AAGCCCAACC GCTTTGAAGA GGTGGTATGG AGCAAGTTCA ACAGCAAGGA AAAGCAGTAC 
CTGCACATAG GCTTGAAACC ACGCGTGCGT GACAACTACC GTGCCAACAA GGTGGCCTTC 
TGGCTGGAGC TCGTGCCCCA CCTGCACAAC CTGCACACAG AGCTCTTCAC CACCACCACT 
CGCCTGCCTC CCTACGCCAC ACGCTGGCCA CCTCGCACAC CGGGTCCTGG CACTTCCGGC 
ACACGCCGTC CTCCCCCACC CGCCACTCTG CCACCTGAGT CTGATATTGA CCTGGGCCCA 
AGGGCCTATG ACCGCTTCCC CGGTGACTCG AGGGACTACT CCACGGAGCT AAGCGTGACT 
GTAGCAGTGG GTGCCTCCCT CCTCTTCCTC AACATCCTTG CCTTTGCCGC CCTCTACTAC 
AAGCGGGACC GGCGCCAGGA GCTGCGGTGC AGGCGGCTTA GCCCACCAGG AGGCTCAGGC 
TCAGGTGTGC CTGGTGGGGG CCCCTTGCTT CCCACTGCTG GCCGTGAGCT ACCCCCTGAG 
GAGGAGCTGG TATCGCTGCA GCTGAAGCGG GGTGGTGGCG TTGGGGCGGA CCCTGCTGAG 
GCCCTGCGCC CTGCCTGTCC ACCCGACTAT ACCCTGGCCT TGCGCCGGGC ACCGGACGAT 
GTGCCTCTCT TGGCCCCGGG GGCCCTGACC CTGCTGCCCA GTGGCCTGGG GCCCCCGCCC 
CCACCCCCAC CTCCTTCTCT CCATCCCTTT GGGCCCTTCC CACCACCACC CCCTACTGCT 
ACCAGCCACA ACAACACGCT ACCCCATCCC CACTCCACCA CTCGGGTATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446444.1
CDS	551..3061
Translation	MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAVECLRRKSSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRTPGPGTSGTRRPPPPATLPPESDIDLGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPTAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV

Target ORF information:

RefSeq Version	NM_053992.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuroligin 2 (Nlgn2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053992.1

ORF Insert Sequence:

ATGTGGCTCC TGGCGTTGTG TCTGGTGGGG CTGGCTGGGG CTCAACGGGG AGGAGGGGGT 
CCCGGCGGCG GCGCCCCGGG CGGCCCAGGC CTGGGCCTCG GCAGCCTCGG GGAGGAGCGC 
TTCCCGGTGG TGAACACAGC CTACGGGCGA GTGCGCGGTG TGCGGCGCGA GCTCAACAAC 
GAGATCCTGG GCCCGGTCGT GCAGTTCTTG GGCGTGCCCT ACGCCACGCC GCCCTTGGGC 
GCCCGCCGCT TCCAGCCGCC TGAGGCACCT GCCTCGTGGC CCGGCGTGCG CAACGCCACC 
ACCCTGCCGC CCGCCTGCCC GCAGAACCTG CACGGGGCCC TGCCGGCCAT CATGCTGCCT 
GTGTGGTTCA CCGACAACTT GGAGGCGGCC GCCACCTACG TGCAGAACCA GAGCGAGGAC 
TGCCTGTACC TCAACCTCTA CGTGCCCACT GAGGACGGTC CGCTCACAAA AAAACGTGAC 
GAGGCGACGC TCAATCCGCC AGACACAGAT ATCCGGGACT CTGGGAAGAA ACCAGTCATG 
CTGTTTCTAC ACGGCGGCTC CTACATGGAG GGCACCGGGA ACATGTTCGA CGGCTCAGTC 
CTGGCTGCCT ATGGCAATGT CATCGTAGCC ACACTCAACT ACCGTCTTGG GGTGCTCGGC 
TTTCTCAGCA CTGGTGACCA GGCTGCAAAA GGCAACTACG GGCTCCTGGA CCAGATCCAG 
GCCCTGCGCT GGCTCAGTGA AAACATTGCC CACTTTGGCG GTGACCCTGA ACGCATCACC 
ATCTTTGGGT CTGGTGCGGG GGCCTCCTGT GTCAACTTGC TGATCCTCTC CCACCATTCA 
GAAGGGCTGT TCCAGAAGGC CATTGCTCAG AGTGGCACTG CCATTTCCAG CTGGTCTGTC 
AACTACCAGC CGCTCAAGTA CACGCGGCTG CTGGCAGCCA AAGTGGGCTG TGACCGAGAG 
GACAGCACGG AAGCTGTGGA ATGTCTACGC CGGAAGTCTT CCCGGGAGCT AGTAGACCAG 
GATGTGCAGC CTGCCCGCTA CCACATTGCC TTTGGGCCTG TGGTGGACGG CGATGTAGTC 
CCTGATGACC CTGAGATCCT CATGCAACAG GGAGAATTCC TCAACTACGA CATGCTCATT 
GGCGTCAACC AGGGAGAGGG TCTCAAGTTC GTGGAGGACT CTGCAGAGAG TGAGGACGGG 
GTGTCTGCCA GCGCCTTTGA CTTCACTGTC TCCAACTTTG TGGACAACTT GTATGGGTAT 
CCAGAGGGCA AGGATGTGCT TCGAGAGACC ATCAAGTTCA TGTACACGGA CTGGGCTGAC 
CGGGACAATG GCGAGATGCG GCGTAAGACC CTGTTGGCAC TCTTTACTGA CCACCAGTGG 
GTAGCCCCAG CTGTGGCCAC TGCCAAGCTA CATGCTGACT ACCAGTCCCC TGTCTACTTT 
TACACTTTTT ACCACCACTG CCAGGCTGAG GGCCGGCCAG AGTGGGCAGA TGCAGCGCAT 
GGGGATGAGC TGCCCTACGT CTTTGGTGTG CCCATGGTGG GCGCCACCGA CCTCTTCCCC 
TGCAACTTCT CCAAGAATGA TGTCATGCTC AGCGCAGTAG TCATGACCTA CTGGACCAAC 
TTCGCCAAGA CTGGTGACCC CAACCAGCCT GTGCCACAGG ACACCAAGTT CATCCACACC 
AAGCCCAACC GCTTTGAAGA GGTGGTATGG AGCAAGTTCA ACAGCAAGGA AAAGCAGTAC 
CTGCACATAG GCTTGAAACC ACGCGTGCGT GACAACTACC GTGCCAACAA GGTGGCCTTC 
TGGCTGGAGC TCGTGCCCCA CCTGCACAAC CTGCACACAG AGCTCTTCAC CACCACCACT 
CGCCTGCCTC CCTACGCCAC ACGCTGGCCA CCTCGCACAC CGGGTCCTGG CACTTCCGGC 
ACACGCCGTC CTCCCCCACC CGCCACTCTG CCACCTGAGT CTGATATTGA CCTGGGCCCA 
AGGGCCTATG ACCGCTTCCC CGGTGACTCG AGGGACTACT CCACGGAGCT AAGCGTGACT 
GTAGCAGTGG GTGCCTCCCT CCTCTTCCTC AACATCCTTG CCTTTGCCGC CCTCTACTAC 
AAGCGGGACC GGCGCCAGGA GCTGCGGTGC AGGCGGCTTA GCCCACCAGG AGGCTCAGGC 
TCAGGTGTGC CTGGTGGGGG CCCCTTGCTT CCCACTGCTG GCCGTGAGCT ACCCCCTGAG 
GAGGAGCTGG TATCGCTGCA GCTGAAGCGG GGTGGTGGCG TTGGGGCGGA CCCTGCTGAG 
GCCCTGCGCC CTGCCTGTCC ACCCGACTAT ACCCTGGCCT TGCGCCGGGC ACCGGACGAT 
GTGCCTCTCT TGGCCCCGGG GGCCCTGACC CTGCTGCCCA GTGGCCTGGG GCCCCCGCCC 
CCACCCCCAC CTCCTTCTCT CCATCCCTTT GGGCCCTTCC CACCACCACC CCCTACTGCT 
ACCAGCCACA ACAACACGCT ACCCCATCCC CACTCCACCA CTCGGGTATA G