Pcsk5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pcsk5
Entrez Gene ID	116548
Full Name	proprotein convertase subtilisin/kexin type 5
Synonyms	PC6,Pc5
General protein information	Preferred Names proprotein convertase subtilisin/kexin type 5 Names proprotein convertase subtilisin/kexin type 5 proprotein convertase 6 subtilisin/kexin-like protease PC5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q51
Summary	may play a role in peptide processing and maturation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053823.1	NP_446275.1	proprotein convertase subtilisin/kexin type 5 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	PCSK5	NP_001177411.1
Canis lupus familiaris (dog)	PCSK5	XP_005616874.1
Rattus norvegicus (Norway rat)	Pcsk5	NP_446275.1
Drosophila melanogaster (fruit fly)	Fur2	NP_727965.1
Xenopus tropicalis (tropical clawed frog)	pcsk5	NP_001072506.1
Bos taurus (cattle)	PCSK5	XP_005210111.1
Mus musculus (house mouse)	Pcsk5	NP_001177412.1
Danio rerio (zebrafish)	pcsk5a	XP_003198725.2
Pan troglodytes (chimpanzee)	PCSK5	XP_520079.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002915	XP_311989.5
Gallus gallus (chicken)	PCSK5	XP_424841.4

Gene Ontology
Bibliography

Related articles in PubMed

Spatiotemporal expression of proprotein convertase subtilisin/kexin type 5 in the development of anorectal malformations in fetal rats.
Tang XB, Chen L, Wang WL, Yuan ZW, Bai YZ
Journal of molecular histology48(5-6)379-387(2017 Dec)

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW
Nature521(7553)520-4(2015 May)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
Kato S, Zhang R, Roberts JD Jr
American journal of physiology. Lung cellular and molecular physiology305(2)L130-40(2013 Jul)

Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
Sun X, Essalmani R, Susan-Resiga D, Prat A, Seidah NG
The Journal of biological chemistry286(33)29063-73(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pcsk5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pcsk5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10778	NM_053823.1 Latest version!	Rattus norvegicus proprotein convertase subtilisin/kexin type 5 (Pcsk5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pcsk5 ( NM_053823.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446275.1 Rattus norvegicus proprotein convertase subtilisin/kexin type 5 (Pcsk5), mRNA.

Price & Availability↑

CloneID	ORa10778
Clone ID Related Accession (Same CDS sequence)	NM_053823.1
Accession Version	NM_053823.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2748bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564934400000
Organism	Rattus norvegicus(Norway rat)
Product	proprotein convertase subtilisin/kexin type 5 preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07006468.1, AABR07006469.1 and AABR07006470.1. On or before Mar 3, 2013 this sequence version replaced XM_001078022.2, XM_342032.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L14933.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTGGG GCTGGGGGAG CCGCTGCTGT CGCCCGGGAC GGCGGGATCT GCTGTGCGTG 
CTGGCACTGC TCGCCGGCTG TCTGCTCCCA GTGTGCCGGA CGCGTGTCTA CACCAACCAC 
TGGGCAGTGA AGATCGCCGG CGGATTCGCG GAGGCAGACC GCATAGCCAG CAAGTACGGA 
TTCATCAACG TAGGACAGAT CGGTGCGCTG AAGGACTACT ATCATTTCTA CCACAGTAGG 
ACCATTAAAA GATCTGTTCT CTCAAGCAGA GGAACCCACA GTTTCATTTC AATGGAACCA 
AAGGTGGAGT GGATCCAACA GCAAGTGGTG AAAAAACGAA CCAAGAGAGA TTATGACCTC 
AGTCGTGCCC AGTCGACTTA CTTCAATGAT CCTAAGTGGC CAAGTATGTG GTACATGCAC 
TGCAGTGACA ACACACATCC TTGCCAGTCG GACATGAATA TTGAAGGAGC CTGGAAGAGA 
GGCTACACGG GGAAGAACAT CGTGGTGACT ATCCTGGATG ATGGCATCGA GAGAACCCAC 
CCCGATCTGA TGCAAAACTA CGATGCTCTG GCAAGTTGCG ATGTGAATGG GAATGACTTG 
GATCCGATGC CTCGTTATGA TGCAAGCAAT GAAAACAAGC ATGGGACCCG CTGTGCCGGA 
GAAGTGGCAG CCACTGCGAA CAACTCTCAC TGCACCGTTG GAATCGCTTT CAACGCCAAA 
ATCGGAGGTG TGAGAATGCT GGATGGTGAT GTCACCGACA TGGTGGAGGC AAAGTCTGTC 
AGCTATAACC CACAGCATGT ACACATCTAC AGTGCCAGCT GGGGCCCAGA TGATGATGGC 
AAGACCGTGG ATGGGCCAGC TCCCCTCACC CGGCAAGCCT TTGAGAATGG TGTGAGAATG 
GGTCGGAGAG GCCTTGGTTC TGTGTTTGTG TGGGCATCTG GCAATGGTGG ACGGAGTAAG 
GACCACTGCT CTTGTGATGG CTATACCAAC AGCATCTATA CCATCTCCAT CAGCAGTACG 
GCCGAAAGTG GAAAGAAACC TTGGTACTTG GAAGAGTGTT CGTCTACACT GGCCACAACC 
TACAGCAGTG GAGAATCCTA TGATAAGAAA ATAATCACTA CTGATCTAAG GCAGCGGTGC 
ACAGACAATC ACACTGGAAC ATCAGCCTCA GCCCCCATGG CTGCTGGCAT CATTGCCCTG 
GCCCTGGAAG CCAATCCGTT TCTGACCTGG AGAGACGTAC AGCATGTTAT TGTCAGGACT 
TCCCGTGCGG GACATTTGAA CGCTAATGAC TGGAAAACCA ATGCTGCTGG TTTTAAGGTG 
AGCCATCTCT ATGGATTTGG ACTGATGGAT GCTGAAGCCA TGGTGATGGA GGCAGAGAAG 
TGGACAACTG TTCCTCAGCA GCACGTGTGT GTGGAGAGCA CGGACCGACA AATCAAGACC 
ATTCGCCCAA ACAGTGCAGT GCGCTCCATC TACAAAGCCT CAGGCTGCTC GGATAATCCC 
AACCATCATG TCAATTACCT GGAGCATGTA GTCGTGCGTA TTACCATCAC ACATCCACGG 
AGGGGAGACC TGGCCATCTA TCTGACCTCA CCCTCAGGAA CAAGATCCCA GCTTTTGGCC 
AACAGGCTAT TTGATCATTC CATGGAAGGA TTTAAGAACT GGGAGTTCAT GACCATTCAT 
TGCTGGGGAG AACGGGCTGC TGGGGACTGG GTCCTTGAAG TTTATGATAC TCCATCTCAA 
CTGAGGAACT TCAAGACTCC AGGTAAATTG AAAGAATGGT CCTTAGTCCT CTATGGCACA 
TCCGTACAGC CATACTCCCC AACCAACGAG TTTCCCAAAG TGGAACGCTT CCGCTACAGC 
CGGGTGGAGG ACCCCACAGA TGACTATGGT GCTGAAGATT ATGCAGGTCC TTGTGACCCT 
GAGTGCAGTG AAGTTGGATG TGATGGGCCG GGACCGGATC ACTGCACTGA CTGTTTACAC 
TATCACTACA AGCTGAAGAA TAACACCAGA ATCTGTGTCT CCAGCTGCCC TCCTGGCCAC 
TTCCATGCTG ACAAGAAGAG GTGCCGGAAG TGCGCCCCCA ACTGCGAGTC CTGCTTTGGT 
AGCCATGCTG ATCAGTGCCT GTCCTGTAAA TATGGCTACT TCCTGAATGA AGAAACTAGC 
AGCTGTGTTG CTCAGTGCCC TGAGGGGTCA TACCAGGATA TCAAGAAAAA TATCTGTGGG 
AAATGCAGCG AGAACTGTAA GACGTGCACT GGATTTCACA ACTGCACAGA GTGCAAGGGC 
GGGTTAAGCC TCCAGGGATC CCGCTGTTCT GTCACCTGCG AGGATGGACA GTTCTTCAGT 
GGTCACGATT GCCAGCCCTG CCACCGCTTC TGTGCCACCT GTGCTGGGGC CGGAGCCGAT 
GGATGTATTA ACTGCACCGA GGGTTATGTC ATGGAGGAGG GAAGATGTGT ACAGAGCTGT 
AGTGTGAGCT ACTACTTGGA CCACTCTTTA GAGGGTGGAT ACAAGTCCTG CAAGAGATGT 
GATAACAGCT GCTTGACATG CAATGGCCCA GGATTCAAGA ACTGCTCCAG CTGCCCCAGT 
GGCTATCTAT TAGACTTGGG AATGTGTCAG ATGGGAGCCA TCTGCAAGGA TGCAACGGAA 
GAGTCCTGGG CAGAAGGAGG CTTCTGTATG CTTGTGAAAA AGAACAATCT ATGTCAGCGG 
AAAGTTCTAC AACAACTGTG CTGCAAAACA TGTACATTCC AAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446275.1
CDS	8..2755
Translation	MDWGWGSRCCRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDLSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCTDCLHYHYKLKNNTRICVSSCPPGHFHADKKRCRKCAPNCESCFGSHADQCLSCKYGYFLNEETSSCVAQCPEGSYQDIKKNICGKCSENCKTCTGFHNCTECKGGLSLQGSRCSVTCEDGQFFSGHDCQPCHRFCATCAGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSLEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCTFQG

Target ORF information:

RefSeq Version	NM_053823.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proprotein convertase subtilisin/kexin type 5 (Pcsk5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053823.1

ORF Insert Sequence:

ATGGACTGGG GCTGGGGGAG CCGCTGCTGT CGCCCGGGAC GGCGGGATCT GCTGTGCGTG 
CTGGCACTGC TCGCCGGCTG TCTGCTCCCA GTGTGCCGGA CGCGTGTCTA CACCAACCAC 
TGGGCAGTGA AGATCGCCGG CGGATTCGCG GAGGCAGACC GCATAGCCAG CAAGTACGGA 
TTCATCAACG TAGGACAGAT CGGTGCGCTG AAGGACTACT ATCATTTCTA CCACAGTAGG 
ACCATTAAAA GATCTGTTCT CTCAAGCAGA GGAACCCACA GTTTCATTTC AATGGAACCA 
AAGGTGGAGT GGATCCAACA GCAAGTGGTG AAAAAACGAA CCAAGAGAGA TTATGACCTC 
AGTCGTGCCC AGTCGACTTA CTTCAATGAT CCTAAGTGGC CAAGTATGTG GTACATGCAC 
TGCAGTGACA ACACACATCC TTGCCAGTCG GACATGAATA TTGAAGGAGC CTGGAAGAGA 
GGCTACACGG GGAAGAACAT CGTGGTGACT ATCCTGGATG ATGGCATCGA GAGAACCCAC 
CCCGATCTGA TGCAAAACTA CGATGCTCTG GCAAGTTGCG ATGTGAATGG GAATGACTTG 
GATCCGATGC CTCGTTATGA TGCAAGCAAT GAAAACAAGC ATGGGACCCG CTGTGCCGGA 
GAAGTGGCAG CCACTGCGAA CAACTCTCAC TGCACCGTTG GAATCGCTTT CAACGCCAAA 
ATCGGAGGTG TGAGAATGCT GGATGGTGAT GTCACCGACA TGGTGGAGGC AAAGTCTGTC 
AGCTATAACC CACAGCATGT ACACATCTAC AGTGCCAGCT GGGGCCCAGA TGATGATGGC 
AAGACCGTGG ATGGGCCAGC TCCCCTCACC CGGCAAGCCT TTGAGAATGG TGTGAGAATG 
GGTCGGAGAG GCCTTGGTTC TGTGTTTGTG TGGGCATCTG GCAATGGTGG ACGGAGTAAG 
GACCACTGCT CTTGTGATGG CTATACCAAC AGCATCTATA CCATCTCCAT CAGCAGTACG 
GCCGAAAGTG GAAAGAAACC TTGGTACTTG GAAGAGTGTT CGTCTACACT GGCCACAACC 
TACAGCAGTG GAGAATCCTA TGATAAGAAA ATAATCACTA CTGATCTAAG GCAGCGGTGC 
ACAGACAATC ACACTGGAAC ATCAGCCTCA GCCCCCATGG CTGCTGGCAT CATTGCCCTG 
GCCCTGGAAG CCAATCCGTT TCTGACCTGG AGAGACGTAC AGCATGTTAT TGTCAGGACT 
TCCCGTGCGG GACATTTGAA CGCTAATGAC TGGAAAACCA ATGCTGCTGG TTTTAAGGTG 
AGCCATCTCT ATGGATTTGG ACTGATGGAT GCTGAAGCCA TGGTGATGGA GGCAGAGAAG 
TGGACAACTG TTCCTCAGCA GCACGTGTGT GTGGAGAGCA CGGACCGACA AATCAAGACC 
ATTCGCCCAA ACAGTGCAGT GCGCTCCATC TACAAAGCCT CAGGCTGCTC GGATAATCCC 
AACCATCATG TCAATTACCT GGAGCATGTA GTCGTGCGTA TTACCATCAC ACATCCACGG 
AGGGGAGACC TGGCCATCTA TCTGACCTCA CCCTCAGGAA CAAGATCCCA GCTTTTGGCC 
AACAGGCTAT TTGATCATTC CATGGAAGGA TTTAAGAACT GGGAGTTCAT GACCATTCAT 
TGCTGGGGAG AACGGGCTGC TGGGGACTGG GTCCTTGAAG TTTATGATAC TCCATCTCAA 
CTGAGGAACT TCAAGACTCC AGGTAAATTG AAAGAATGGT CCTTAGTCCT CTATGGCACA 
TCCGTACAGC CATACTCCCC AACCAACGAG TTTCCCAAAG TGGAACGCTT CCGCTACAGC 
CGGGTGGAGG ACCCCACAGA TGACTATGGT GCTGAAGATT ATGCAGGTCC TTGTGACCCT 
GAGTGCAGTG AAGTTGGATG TGATGGGCCG GGACCGGATC ACTGCACTGA CTGTTTACAC 
TATCACTACA AGCTGAAGAA TAACACCAGA ATCTGTGTCT CCAGCTGCCC TCCTGGCCAC 
TTCCATGCTG ACAAGAAGAG GTGCCGGAAG TGCGCCCCCA ACTGCGAGTC CTGCTTTGGT 
AGCCATGCTG ATCAGTGCCT GTCCTGTAAA TATGGCTACT TCCTGAATGA AGAAACTAGC 
AGCTGTGTTG CTCAGTGCCC TGAGGGGTCA TACCAGGATA TCAAGAAAAA TATCTGTGGG 
AAATGCAGCG AGAACTGTAA GACGTGCACT GGATTTCACA ACTGCACAGA GTGCAAGGGC 
GGGTTAAGCC TCCAGGGATC CCGCTGTTCT GTCACCTGCG AGGATGGACA GTTCTTCAGT 
GGTCACGATT GCCAGCCCTG CCACCGCTTC TGTGCCACCT GTGCTGGGGC CGGAGCCGAT 
GGATGTATTA ACTGCACCGA GGGTTATGTC ATGGAGGAGG GAAGATGTGT ACAGAGCTGT 
AGTGTGAGCT ACTACTTGGA CCACTCTTTA GAGGGTGGAT ACAAGTCCTG CAAGAGATGT 
GATAACAGCT GCTTGACATG CAATGGCCCA GGATTCAAGA ACTGCTCCAG CTGCCCCAGT 
GGCTATCTAT TAGACTTGGG AATGTGTCAG ATGGGAGCCA TCTGCAAGGA TGCAACGGAA 
GAGTCCTGGG CAGAAGGAGG CTTCTGTATG CTTGTGAAAA AGAACAATCT ATGTCAGCGG 
AAAGTTCTAC AACAACTGTG CTGCAAAACA TGTACATTCC AAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Spatiotemporal expression of proprotein convertase subtilisin/kexin type 5 in the development of anorectal malformations in fetal rats.
Journal of molecular histology48(5-6)379-387(2017 Dec)
Tang XB,Chen L,Wang WL,Yuan ZW,Bai YZ

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Nature521(7553)520-4(2015 May)
Li Y,Klena NT,Gabriel GC,Liu X,Kim AJ,Lemke K,Chen Y,Chatterjee B,Devine W,Damerla RR,Chang C,Yagi H,San Agustin JT,Thahir M,Anderton S,Lawhead C,Vescovi A,Pratt H,Morgan J,Haynes L,Smith CL,Eppig JT,Reinholdt L,Francis R,Leatherbury L,Ganapathiraju MK,Tobita K,Pazour GJ,Lo CW

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
American journal of physiology. Lung cellular and molecular physiology305(2)L130-40(2013 Jul)
Kato S,Zhang R,Roberts JD Jr

Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
The Journal of biological chemistry286(33)29063-73(2011 Aug)
Sun X,Essalmani R,Susan-Resiga D,Prat A,Seidah NG

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Pcsk5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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