Clca4a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clca4a
Entrez Gene ID	99663
Full Name	chloride channel accessory 4A
Synonyms	9130020L07Rik,AI504701,Clca4,Clca6
General protein information	Preferred Names chloride channel accessory 4A Names calcium-activated chloride channel regulator 4A calcium activated chloride channel calcium-activated chloride channel regulator 4 calcium-activated chloride channel regulator 6 chloride channel calcium activated 4A chloride channel calcium activated 6 mClca6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 H2

mRNA and Protein(s)

mRNA	Protein	Name
NM_207208.3	NP_997091.3	calcium-activated chloride channel regulator 4A precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CLCA4	NP_036260.2
Mus musculus (house mouse)	AI747448	NP_001028371.1
Mus musculus (house mouse)	Clca6	NP_997091.3
Rattus norvegicus (Norway rat)	Clca4	NP_958822.1
Pan troglodytes (chimpanzee)	CLCA4	XP_524757.3
Canis lupus familiaris (dog)	CLCA4	XP_005622030.1
Macaca mulatta (Rhesus monkey)	CLCA4	XP_001109489.2
Bos taurus (cattle)	CLCA4	NP_001029472.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells.
Rajagopal M, Kathpalia PP, Widdicombe JH, Pao AC
American journal of physiology. Renal physiology303(4)F483-91(2012 Aug)

Impaired autoproteolytic cleavage of mCLCA6, a murine integral membrane protein expressed in enterocytes, leads to cleavage at the plasma membrane instead of the endoplasmic reticulum.
Bothe MK, Mundhenk L, Beck CL, Kaup M, Gruber AD
Molecules and cells33(3)251-7(2012 Mar)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous system.
Piirsoo M, Meijer D, Timmusk T
BMC developmental biology910(2009 Feb)

Murine mCLCA6 is an integral apical membrane protein of non-goblet cell enterocytes and co-localizes with the cystic fibrosis transmembrane conductance regulator.
Bothe MK, Braun J, Mundhenk L, Gruber AD
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society56(5)495-509(2008 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Clca4a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clca4a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09824	NM_207208.3 Latest version!	Mus musculus chloride channel accessory 4A (Clca4a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clca4a ( NM_207208.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_997091.3 Mus musculus chloride channel accessory 4A (Clca4a), mRNA.

Price & Availability↑

CloneID	OMu09824
Clone ID Related Accession (Same CDS sequence)	NM_207208.3
Accession Version	NM_207208.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2778bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550246400000
Organism	Mus musculus(house mouse)
Product	calcium-activated chloride channel regulator 4A precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK033591.1. On Jul 19, 2006 this sequence version replaced NM_207208.2. ##Evidence-Data-START## Transcript exon combination :: AK033591.1, AY560902.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGGCTT TCTCCAGAGG GCCTGTTTTC CTCCTCCTCC TCCTGTACCT GCTTTGGGGG 
TCAGACACTT CCTTGATAAG GCTGAATGAG AATGGTTATG AAGACATCAT TATTGCCATT 
GATCCTGCTG TGCCAGAAGA TACAACAATA ATTGAACACA TAAAGGGAAT GGTGACTAAA 
GCATCTACAT ACCTTTTTGA AGCTACAGAA AAAAGATTTT TCTTCAAAAA TGTATCTATA 
TTAATTCCTG AGAGTTGGAA AGACAGTCCC CAGTACAGGA GGCCAAAACA GGAGAGTTAC 
AAGCATGCTG ACATTAAAGT GGCACCTCCC ACCGTTGAGG GCAGAGATGA GCCCTACACC 
AGGCAATTCA CACAGTGTGA AGAGAAAGCA GAATACATCC ACTTCACCCC TGACTTTGTA 
CTGGGGAGAA AACAAGATGA ATATGGAGAT TCAGGAAAAG TGTTGGTCCA TGAATGGGCC 
CACCTTCGCT GGGGAGTATT TGATGAATAC AATGAAGACC AGCCATTCTA CAGCGCTTCA 
TCAAAGAAAA TCGAAGCAAC AAGGTGCTCC ACAGGTATCA CGGGGACGAA TAGAGTCTAT 
GCATGCCAAG GGGGCAGCTG TGCGATGAGA AGGTGCAGAA CTAATTCCAC CACAAAGTTA 
TATGAAAAGG ATTGTCAATT CTTCCCTGAT AAAGTTCAAT CAGAAAAGGC TTCCATAATG 
TTCATGCAAA GTATCGATTC TGTGACTGAA TTCTGTAAAA AGGAAAACCA TAATCGAGAG 
GCTCCAACTC TACATAATAA AAAGTGCAAT TACAGAAGCA CTTGGGAAGT AATCAGCACT 
TCTGAGGATT TTAACAGCAG CACGCCCATG GAGACGTCAC CCTCTCCACC CTTCTTCTCC 
CTGCTGAGGA TCAGTGAGAG AATTATGTGC CTAGTTCTTG ATGTGTCTGG GAGTATGACT 
TCTTATGATC GCCTGAATCG AATGAACCAA GCAGCAAAAT ACTTTCTAAG CCAGATAATT 
GAAAATAGGT CCTGGGTAGG GATGGTGCAC TTTAGTAGCC AGGCCACTAT TGTGCATGAG 
CTGATCCAAA TAAACAGTGA CATCGAGAGA AACCAGCTCT TGCAAACCTT ACCTACAAGT 
GCCAATGGAG GGACGTCCAT CTGCTCTGGA ATCAAGGCTG CATTTCAGGT ATTTAAAAAT 
GGAGAATACC AAACAGATGG GACTGAGATC TTGCTGTTGA GTGATGGTGA GGACAGCACA 
GCCAAAGACT GTATTGATGA GGTGAAAGAC AGCGGGTCCA TAGTTCATTT CATTGCCTTG 
GGACCATCGG CTGACTTAGC TGTAACAAAC ATGAGCATTT TAACAGGTGG AAACCATAAG 
CTTGCTACAG ATGAAGCCCA GAACAATGGA CTCATTGATG CTTTCGGGGC CCTGGCTTCA 
GAAAATGCTG ATATCACCCA GAAGTCACTT CAGCTTGAAA GTAAGGGTGC CATACTGAAC 
AATAGCCTCT GGCTGAATGA CACTGTTGTA ATTGACAGCA CCTTGGGAAG GGACACATTC 
TTTCTTGTCA CCTGGAGCAA ACAAGCCCCT GCCATTTATC TCAGGGATCC CAAAGGAACA 
CAAACCACCA ATTTCACAAT GGACTCTGCT TCCAAAATGG CCTATCTCAG TATTCCAGGA 
ACAGCTCAGG TGGGTGTTTG GACTTACAAC CTGGAAGCCA AAGAAAACTC AGAGATACTA 
ACGATTACAG TAACCTCTCG GGCAGCAAAT TCTTCTGTGC CACCAATCAC TGTAAATGCT 
AAGGTAAACA CGGACACTAA CACTTTCCCC AGCCCAATGA TTGTGTATGC TGAAGTTCTA 
CAAGGTTACA CTCCCATCAT TGGAGCCCGA GTGACAGCCA CCATAGAATC TAACAGTGGG 
AAGACAGAAG AGCTAGTCCT TCTGGACAAC GGTGCAGGGG CTGATGCTTT CAAGGATGAT 
GGGGTCTACT CCAGGTTCTT CACAGCTTAT TCAGTGAATG GCAGGTATAG CTTAAAAGTC 
CGTGCAGATG GAGGAAGAAA TTCTGCGAGG AGGAGTTTAC GCCACCCATC AAGCAGAGCT 
GCATACATAC CAGGCTGGGT AGTAGATGGA GAAATTCAAG GGAACCCACC CAGACCCGAA 
ACGACTGAGG CTACTCAGCC AGTCTTGGAG GATTTCAGCA GGACAGCATC TGGAGGTGCC 
TTTGTGATGT CCAATGTTCC AATTGGTCCA TTGCCTGATG TATACCCACC AAATCGAATC 
ACAGACCTCC AGGCCACACT CGATGGGGAA GAGATCAGTC TAACATGGAC GGCCCCAGGA 
GATGATTATG ATGTTGGAAG AGTTCAACAG TATATCATAA GAACAAGCAA AAACATCATT 
GAACTGAGAG ACAATTTTAA TAACTCTCCT CGGGTTGATA CAACTAACCT TACACCAAAA 
GAAGCCAACT CCGAGGAAAC CTTTGCCTTT AAACCAGAAA ATATCACAGA AGAAAATGCA 
ACGTACATAT TCATTGCCAT TGAAAGTGTC GACAAAAGCA GTTTGAGTTC GGGACCATCC 
AACATCGCAC AAGTGGCACT GTTCACCCCT CAGGCAGAGC CTGACCCTGA TGAAAGTCCA 
AGTTTATCAG GAGTTAGTGT TGCTACTATT GTGCTGTCTG TTTTGGGCGC TCTTGTTCTA 
GTTTGTATTA TTGTAGGTAC CACAATTTGT ATCTTAAAGA ACAAAAGGTC CTCATCAGCA 
GCTATAACAA AATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997091.3
CDS	32..2809
Translation	MMAFSRGPVFLLLLLYLLWGSDTSLIRLNENGYEDIIIAIDPAVPEDTTIIEHIKGMVTKASTYLFEATEKRFFFKNVSILIPESWKDSPQYRRPKQESYKHADIKVAPPTVEGRDEPYTRQFTQCEEKAEYIHFTPDFVLGRKQDEYGDSGKVLVHEWAHLRWGVFDEYNEDQPFYSASSKKIEATRCSTGITGTNRVYACQGGSCAMRRCRTNSTTKLYEKDCQFFPDKVQSEKASIMFMQSIDSVTEFCKKENHNREAPTLHNKKCNYRSTWEVISTSEDFNSSTPMETSPSPPFFSLLRISERIMCLVLDVSGSMTSYDRLNRMNQAAKYFLSQIIENRSWVGMVHFSSQATIVHELIQINSDIERNQLLQTLPTSANGGTSICSGIKAAFQVFKNGEYQTDGTEILLLSDGEDSTAKDCIDEVKDSGSIVHFIALGPSADLAVTNMSILTGGNHKLATDEAQNNGLIDAFGALASENADITQKSLQLESKGAILNNSLWLNDTVVIDSTLGRDTFFLVTWSKQAPAIYLRDPKGTQTTNFTMDSASKMAYLSIPGTAQVGVWTYNLEAKENSEILTITVTSRAANSSVPPITVNAKVNTDTNTFPSPMIVYAEVLQGYTPIIGARVTATIESNSGKTEELVLLDNGAGADAFKDDGVYSRFFTAYSVNGRYSLKVRADGGRNSARRSLRHPSSRAAYIPGWVVDGEIQGNPPRPETTEATQPVLEDFSRTASGGAFVMSNVPIGPLPDVYPPNRITDLQATLDGEEISLTWTAPGDDYDVGRVQQYIIRTSKNIIELRDNFNNSPRVDTTNLTPKEANSEETFAFKPENITEENATYIFIAIESVDKSSLSSGPSNIAQVALFTPQAEPDPDESPSLSGVSVATIVLSVLGALVLVCIIVGTTICILKNKRSSSAAITKF

Target ORF information:

RefSeq Version	NM_207208.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus chloride channel accessory 4A (Clca4a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207208.3

ORF Insert Sequence:

ATGATGGCTT TCTCCAGAGG GCCTGTTTTC CTCCTCCTCC TCCTGTACCT GCTTTGGGGG 
TCAGACACTT CCTTGATAAG GCTGAATGAG AATGGTTATG AAGACATCAT TATTGCCATT 
GATCCTGCTG TGCCAGAAGA TACAACAATA ATTGAACACA TAAAGGGAAT GGTGACTAAA 
GCATCTACAT ACCTTTTTGA AGCTACAGAA AAAAGATTTT TCTTCAAAAA TGTATCTATA 
TTAATTCCTG AGAGTTGGAA AGACAGTCCC CAGTACAGGA GGCCAAAACA GGAGAGTTAC 
AAGCATGCTG ACATTAAAGT GGCACCTCCC ACCGTTGAGG GCAGAGATGA GCCCTACACC 
AGGCAATTCA CACAGTGTGA AGAGAAAGCA GAATACATCC ACTTCACCCC TGACTTTGTA 
CTGGGGAGAA AACAAGATGA ATATGGAGAT TCAGGAAAAG TGTTGGTCCA TGAATGGGCC 
CACCTTCGCT GGGGAGTATT TGATGAATAC AATGAAGACC AGCCATTCTA CAGCGCTTCA 
TCAAAGAAAA TCGAAGCAAC AAGGTGCTCC ACAGGTATCA CGGGGACGAA TAGAGTCTAT 
GCATGCCAAG GGGGCAGCTG TGCGATGAGA AGGTGCAGAA CTAATTCCAC CACAAAGTTA 
TATGAAAAGG ATTGTCAATT CTTCCCTGAT AAAGTTCAAT CAGAAAAGGC TTCCATAATG 
TTCATGCAAA GTATCGATTC TGTGACTGAA TTCTGTAAAA AGGAAAACCA TAATCGAGAG 
GCTCCAACTC TACATAATAA AAAGTGCAAT TACAGAAGCA CTTGGGAAGT AATCAGCACT 
TCTGAGGATT TTAACAGCAG CACGCCCATG GAGACGTCAC CCTCTCCACC CTTCTTCTCC 
CTGCTGAGGA TCAGTGAGAG AATTATGTGC CTAGTTCTTG ATGTGTCTGG GAGTATGACT 
TCTTATGATC GCCTGAATCG AATGAACCAA GCAGCAAAAT ACTTTCTAAG CCAGATAATT 
GAAAATAGGT CCTGGGTAGG GATGGTGCAC TTTAGTAGCC AGGCCACTAT TGTGCATGAG 
CTGATCCAAA TAAACAGTGA CATCGAGAGA AACCAGCTCT TGCAAACCTT ACCTACAAGT 
GCCAATGGAG GGACGTCCAT CTGCTCTGGA ATCAAGGCTG CATTTCAGGT ATTTAAAAAT 
GGAGAATACC AAACAGATGG GACTGAGATC TTGCTGTTGA GTGATGGTGA GGACAGCACA 
GCCAAAGACT GTATTGATGA GGTGAAAGAC AGCGGGTCCA TAGTTCATTT CATTGCCTTG 
GGACCATCGG CTGACTTAGC TGTAACAAAC ATGAGCATTT TAACAGGTGG AAACCATAAG 
CTTGCTACAG ATGAAGCCCA GAACAATGGA CTCATTGATG CTTTCGGGGC CCTGGCTTCA 
GAAAATGCTG ATATCACCCA GAAGTCACTT CAGCTTGAAA GTAAGGGTGC CATACTGAAC 
AATAGCCTCT GGCTGAATGA CACTGTTGTA ATTGACAGCA CCTTGGGAAG GGACACATTC 
TTTCTTGTCA CCTGGAGCAA ACAAGCCCCT GCCATTTATC TCAGGGATCC CAAAGGAACA 
CAAACCACCA ATTTCACAAT GGACTCTGCT TCCAAAATGG CCTATCTCAG TATTCCAGGA 
ACAGCTCAGG TGGGTGTTTG GACTTACAAC CTGGAAGCCA AAGAAAACTC AGAGATACTA 
ACGATTACAG TAACCTCTCG GGCAGCAAAT TCTTCTGTGC CACCAATCAC TGTAAATGCT 
AAGGTAAACA CGGACACTAA CACTTTCCCC AGCCCAATGA TTGTGTATGC TGAAGTTCTA 
CAAGGTTACA CTCCCATCAT TGGAGCCCGA GTGACAGCCA CCATAGAATC TAACAGTGGG 
AAGACAGAAG AGCTAGTCCT TCTGGACAAC GGTGCAGGGG CTGATGCTTT CAAGGATGAT 
GGGGTCTACT CCAGGTTCTT CACAGCTTAT TCAGTGAATG GCAGGTATAG CTTAAAAGTC 
CGTGCAGATG GAGGAAGAAA TTCTGCGAGG AGGAGTTTAC GCCACCCATC AAGCAGAGCT 
GCATACATAC CAGGCTGGGT AGTAGATGGA GAAATTCAAG GGAACCCACC CAGACCCGAA 
ACGACTGAGG CTACTCAGCC AGTCTTGGAG GATTTCAGCA GGACAGCATC TGGAGGTGCC 
TTTGTGATGT CCAATGTTCC AATTGGTCCA TTGCCTGATG TATACCCACC AAATCGAATC 
ACAGACCTCC AGGCCACACT CGATGGGGAA GAGATCAGTC TAACATGGAC GGCCCCAGGA 
GATGATTATG ATGTTGGAAG AGTTCAACAG TATATCATAA GAACAAGCAA AAACATCATT 
GAACTGAGAG ACAATTTTAA TAACTCTCCT CGGGTTGATA CAACTAACCT TACACCAAAA 
GAAGCCAACT CCGAGGAAAC CTTTGCCTTT AAACCAGAAA ATATCACAGA AGAAAATGCA 
ACGTACATAT TCATTGCCAT TGAAAGTGTC GACAAAAGCA GTTTGAGTTC GGGACCATCC 
AACATCGCAC AAGTGGCACT GTTCACCCCT CAGGCAGAGC CTGACCCTGA TGAAAGTCCA 
AGTTTATCAG GAGTTAGTGT TGCTACTATT GTGCTGTCTG TTTTGGGCGC TCTTGTTCTA 
GTTTGTATTA TTGTAGGTAC CACAATTTGT ATCTTAAAGA ACAAAAGGTC CTCATCAGCA 
GCTATAACAA AATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells.
American journal of physiology. Renal physiology303(4)F483-91(2012 Aug)
Rajagopal M,Kathpalia PP,Widdicombe JH,Pao AC

Impaired autoproteolytic cleavage of mCLCA6, a murine integral membrane protein expressed in enterocytes, leads to cleavage at the plasma membrane instead of the endoplasmic reticulum.
Molecules and cells33(3)251-7(2012 Mar)
Bothe MK,Mundhenk L,Beck CL,Kaup M,Gruber AD

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous system.
BMC developmental biology910(2009 Feb)
Piirsoo M,Meijer D,Timmusk T

Murine mCLCA6 is an integral apical membrane protein of non-goblet cell enterocytes and co-localizes with the cystic fibrosis transmembrane conductance regulator.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society56(5)495-509(2008 May)
Bothe MK,Braun J,Mundhenk L,Gruber AD

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Clca4a cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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