Hcar2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hcar2
Entrez Gene ID	80885
Full Name	hydroxycarboxylic acid receptor 2
Synonyms	Gpr109a,Gpr109b,HM74,Niacr1,PUMA-G,Pumag,mHM74b
General protein information	Preferred Names hydroxycarboxylic acid receptor 2 Names hydroxycarboxylic acid receptor 2 G protein-coupled receptor 109A G protein-coupled receptor 109B G-protein coupled receptor 109 G-protein coupled receptor HM74 interferon-gamma inducible gene, Puma-g niacin receptor 1 nicotinic acid receptor putative seven transmembrane spanning receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 F

mRNA and Protein(s)

mRNA	Protein	Name
NM_030701.3	NP_109626.1	hydroxycarboxylic acid receptor 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	HCAR2	NP_808219.1
Mus musculus (house mouse)	Niacr1	NP_109626.1
Pan troglodytes (chimpanzee)	GPR109A	XP_003314054.1
Rattus norvegicus (Norway rat)	Niacr1	NP_852141.1

Gene Ontology
Bibliography

Related articles in PubMed

Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.
Subramani K, Chu X, Warren M, Lee M, Lu S, Singh N, Raju R
Biochimica et biophysica acta. Molecular basis of disease1865(3)688-695(2019 03)

The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.
Trotta MC, Maisto R, Guida F, Boccella S, Luongo L, Balta C, D'Amico G, Herman H, Hermenean A, Bucolo C, D'Amico M
PloS one14(1)e0211005(2019)

Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.
Boccella S, Guida F, De Logu F, De Gregorio D, Mazzitelli M, Belardo C, Iannotta M, Serra N, Nassini R, de Novellis V, Geppetti P, Maione S, Luongo L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology33(1)1062-1073(2019 01)

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.
Wannick M, Assmann JC, Vielhauer JF, Offermanns S, Zillikens D, Sadik CD, Schwaninger M
Frontiers in immunology91890(2018)

G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.
Chen G, Huang B, Fu S, Li B, Ran X, He D, Jiang L, Li Y, Liu B, Xie L, Liu J, Wang W
Frontiers in immunology92079(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Hcar2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hcar2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21625	NM_030701.3 Latest version!	Mus musculus hydroxycarboxylic acid receptor 2 (Hcar2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hcar2 ( NM_030701.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_109626.1 Mus musculus hydroxycarboxylic acid receptor 2 (Hcar2), mRNA.

Price & Availability↑

CloneID	OMu21625
Clone ID Related Accession (Same CDS sequence)	NM_030701.3
Accession Version	NM_030701.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Mus musculus(house mouse)
Product	hydroxycarboxylic acid receptor 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC129582.10, AK150795.1 and BY516126.1. On Mar 4, 2011 this sequence version replaced NM_030701.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGAGCAAGT CAGACCATTT TCTAGTGATA AACGGCAAGA ACTGCTGTGT GTTCCGAGAT 
GAAAACATCG CCAAGGTCTT GCCACCGGTG TTGGGGCTGG AATTTGTGTT CGGACTCCTG 
GGCAATGGCC TTGCCTTGTG GATTTTCTGT TTCCACCTCA AGTCCTGGAA ATCCAGCCGG 
ATTTTCTTGT TCAACTTGGC CGTGGCTGAC TTTCTCCTGA TCATCTGCCT GCCGTTCCTG 
ACGGACAACT ATGTCCATAA CTGGGACTGG AGGTTCGGAG GCATCCCCTG CCGTGTGATG 
CTCTTCATGT TGGCTATGAA CCGACAGGGC AGCATCATCT TCCTCACCGT GGTGGCTGTG 
GACCGCTACT TCCGGGTGGT CCATCCACAC CACTTCTTGA ACAAGATCTC CAACCGGACG 
GCGGCCATCA TTTCTTGCTT CTTGTGGGGT CTCACCATCG GCCTGACTGT CCACCTCCTC 
TATACAAACA TGATGACCAA AAATGGCGAG GCATATCTGT GTAGCAGCTT CAGCATCTGT 
TACAACTTCA GGTGGCACGA TGCTATGTTC CTCTTGGAAT TCTTCTTGCC CCTGGCCATC 
ATCTTGTTCT GCTCAGGCAG GATCATCTGG AGCCTGAGGC AGAGACAGAT GGACAGACAT 
GCCAAGATCA AGAGGGCCAT CAACTTCATC ATGGTGGTGG CTATTGTATT CATCATTTGC 
TTCCTACCCA GTGTGGCTGT GCGCATCCGC ATCTTCTGGC TTCTCTACAA ATATAACGTA 
CGCAACTGTG ACATCTACTC CTCGGTGGAC CTGGCTTTCT TTACCACCCT TAGCTTTACC 
TACATGAACA GCATGCTGGA CCCTGTGGTC TACTATTTCT CCAGCCCATC TTTCCCCAAC 
TTCTTCTCCA CGTGTATCAA CCGCTGCCTT CGAAAGAAAA CATTGGGTGA ACCCGATAAT 
AACCGAAGCA CTAGTGTGGA GCTCACGGGG GACCCCAGCA CAACCAGAAG TATTCCAGGG 
GCGCTAATGG CTGACCCCAG TGAGCCAGGC AGCCCCCCTT ATCTGGCTTC CACATCTCGT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_109626.1
CDS	79..1161
Translation	MSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR

Target ORF information:

RefSeq Version	NM_030701.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus hydroxycarboxylic acid receptor 2 (Hcar2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030701.3

ORF Insert Sequence:

ATGAGCAAGT CAGACCATTT TCTAGTGATA AACGGCAAGA ACTGCTGTGT GTTCCGAGAT 
GAAAACATCG CCAAGGTCTT GCCACCGGTG TTGGGGCTGG AATTTGTGTT CGGACTCCTG 
GGCAATGGCC TTGCCTTGTG GATTTTCTGT TTCCACCTCA AGTCCTGGAA ATCCAGCCGG 
ATTTTCTTGT TCAACTTGGC CGTGGCTGAC TTTCTCCTGA TCATCTGCCT GCCGTTCCTG 
ACGGACAACT ATGTCCATAA CTGGGACTGG AGGTTCGGAG GCATCCCCTG CCGTGTGATG 
CTCTTCATGT TGGCTATGAA CCGACAGGGC AGCATCATCT TCCTCACCGT GGTGGCTGTG 
GACCGCTACT TCCGGGTGGT CCATCCACAC CACTTCTTGA ACAAGATCTC CAACCGGACG 
GCGGCCATCA TTTCTTGCTT CTTGTGGGGT CTCACCATCG GCCTGACTGT CCACCTCCTC 
TATACAAACA TGATGACCAA AAATGGCGAG GCATATCTGT GTAGCAGCTT CAGCATCTGT 
TACAACTTCA GGTGGCACGA TGCTATGTTC CTCTTGGAAT TCTTCTTGCC CCTGGCCATC 
ATCTTGTTCT GCTCAGGCAG GATCATCTGG AGCCTGAGGC AGAGACAGAT GGACAGACAT 
GCCAAGATCA AGAGGGCCAT CAACTTCATC ATGGTGGTGG CTATTGTATT CATCATTTGC 
TTCCTACCCA GTGTGGCTGT GCGCATCCGC ATCTTCTGGC TTCTCTACAA ATATAACGTA 
CGCAACTGTG ACATCTACTC CTCGGTGGAC CTGGCTTTCT TTACCACCCT TAGCTTTACC 
TACATGAACA GCATGCTGGA CCCTGTGGTC TACTATTTCT CCAGCCCATC TTTCCCCAAC 
TTCTTCTCCA CGTGTATCAA CCGCTGCCTT CGAAAGAAAA CATTGGGTGA ACCCGATAAT 
AACCGAAGCA CTAGTGTGGA GCTCACGGGG GACCCCAGCA CAACCAGAAG TATTCCAGGG 
GCGCTAATGG CTGACCCCAG TGAGCCAGGC AGCCCCCCTT ATCTGGCTTC CACATCTCGT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.
Biochimica et biophysica acta. Molecular basis of disease1865(3)688-695(2019 03)
Subramani K,Chu X,Warren M,Lee M,Lu S,Singh N,Raju R

The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.
PloS one14(1)e0211005(2019)
Trotta MC,Maisto R,Guida F,Boccella S,Luongo L,Balta C,D'Amico G,Herman H,Hermenean A,Bucolo C,D'Amico M

Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology33(1)1062-1073(2019 01)
Boccella S,Guida F,De Logu F,De Gregorio D,Mazzitelli M,Belardo C,Iannotta M,Serra N,Nassini R,de Novellis V,Geppetti P,Maione S,Luongo L

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.
Frontiers in immunology91890(2018)
Wannick M,Assmann JC,Vielhauer JF,Offermanns S,Zillikens D,Sadik CD,Schwaninger M

G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.
Frontiers in immunology92079(2018)
Chen G,Huang B,Fu S,Li B,Ran X,He D,Jiang L,Li Y,Liu B,Xie L,Liu J,Wang W

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Hcar2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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