Prss8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prss8
Entrez Gene ID	76560
Full Name	protease, serine 8 (prostasin)
Synonyms	2410039E18Rik,AI313909,C79772,CAP1,fr,mCAP1
General protein information	Preferred Names protease, serine 8 (prostasin) Names prostasin channel activating protease 1 serine protease 8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 F3\|7 69.84 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006508306.3	XP_006508369.1	prostasin isoform X1
NM_133351.3	NP_579929.1	prostasin precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Prss8	NP_579929.1
Homo sapiens (human)	PRSS8	NP_002764.1
Bos taurus (cattle)	PRSS8	NP_001070399.1
Pan troglodytes (chimpanzee)	PRSS8	XP_001157509.1
Macaca mulatta (Rhesus monkey)	PRSS8	XP_001112412.1
Rattus norvegicus (Norway rat)	Prss8	NP_620191.1
Canis lupus familiaris (dog)	PRSS8	XP_005621300.1
Xenopus tropicalis (tropical clawed frog)	prss8	NP_001016980.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of new genes in vertebrate tooth development and p63 signaling.
Rostampour N, Appelt CM, Abid A, Boughner JC
Developmental dynamics : an official publication of the American Association of Anatomists248(8)744-755(2019 08)

PRSS8 suppresses colorectal carcinogenesis and metastasis.
Bao Y, Guo Y, Yang Y, Wei X, Zhang S, Zhang Y, Li K, Yuan M, Guo D, Macias V, Zhu X, Zhang W, Yang W
Oncogene38(4)497-517(2019 01)

Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy.
Szabo R, Bugge TH
PloS one13(4)e0194660(2018)

Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
Buzza MS, Johnson TA, Conway GD, Martin EW, Mukhopadhyay S, Shea-Donohue T, Antalis TM
The Journal of biological chemistry292(26)10801-10812(2017 06)

Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases.
Shuto T, Kamei S, Nohara H, Fujikawa H, Tasaki Y, Sugahara T, Ono T, Matsumoto C, Sakaguchi Y, Maruta K, Nakashima R, Kawakami T, Suico MA, Kondo Y, Ishigami A, Takeo T, Tanaka KI, Watanabe H, Nakagata N, Uchimura K, Kitamura K, Li JD, Kai H
Scientific reports639305(2016 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Prss8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prss8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10004	NM_133351.3 Latest version!	Mus musculus protease, serine 8 (prostasin) (Prss8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu10004	XM_006508306.3 Latest version!	Mus musculus protease, serine 8 (prostasin) (Prss8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prss8 ( NM_133351.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_579929.1 Mus musculus protease, serine 8 (prostasin) (Prss8), mRNA.

Price & Availability↑

CloneID	OMu10004
Clone ID Related Accession (Same CDS sequence)	XM_006508306.3 , NM_133351.3
Accession Version	NM_133351.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	prostasin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB600036.1 and AB038244.1. On Oct 20, 2009 this sequence version replaced NM_133351.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038244.1, AF378085.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCTAA GGGTGGGCCT GGGACTTGGG CAGCTGGAAG CTGTGACCAT TCTGCTCCTT 
CTCGGATTGC TCCAGTCGGG AATCCGAGCT GACGGGACTG AAGCCTCCTG TGGTGCCGTC 
ATCCAGCCAC GCATCACCGG TGGTGGCAGT GCAAAGCCCG GTCAGTGGCC CTGGCAGGTC 
AGCATCACCT ACGATGGCAA CCATGTTTGT GGCGGGTCGC TCGTGTCAAA TAAATGGGTG 
GTGTCTGCTG CTCACTGCTT CCCCAGAGAA CACAGCAGGG AAGCGTATGA GGTGAAGCTG 
GGGGCCCACC AGCTAGACTC CTACAGCAAT GACACTGTGG TCCACACAGT GGCTCAGATC 
ATCACCCACT CAAGCTACCG AGAAGAGGGC TCCCAGGGGG ACATCGCGCT CATCCGCCTC 
AGCAGTCCTG TCACCTTCTC CCGCTACATC AGACCCATCT GCCTCCCTGC AGCCAATGCC 
TCCTTTCCCA ACGGCCTTCA CTGTACTGTC ACGGGATGGG GTCATGTGGC TCCTTCAGTG 
AGCCTCCAGA CCCCTAGGCC TCTGCAGCAG CTCGAGGTAC CACTCATCAG CCGGGAAACC 
TGTAGCTGCC TGTACAACAT TAATGCGGTG CCTGAAGAAC CGCACACTAT CCAGCAGGAC 
ATGCTGTGTG CTGGCTATGT GAAGGGAGGC AAGGATGCCT GCCAGGGTGA CTCTGGGGGC 
CCACTCTCTT GTCCCATGGA GGGCATCTGG TACTTGGCAG GCATTGTGAG TTGGGGTGAT 
GCCTGTGGTG CCCCCAACAG GCCTGGAGTA TACACTCTGA CTTCTACCTA TGCTTCCTGG 
ATCCACCACC ATGTGGCAGA GCTCCAGCCT CGAGTTGTCC CCCAGACTCA GGAGTCCCAG 
CCGGATGGCC ACCTCTGCAA CCATCATCCT GTCTTCAGCT CAGCGGCAGC CCCGAAATTG 
TTAAGGCCCG TACTTTTCCT GCCACTTGGT CTGACCCTGG GCCTCTTGTC TTTGGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_579929.1
CDS	232..1251
Translation	MALRVGLGLGQLEAVTILLLLGLLQSGIRADGTEASCGAVIQPRITGGGSAKPGQWPWQVSITYDGNHVCGGSLVSNKWVVSAAHCFPREHSREAYEVKLGAHQLDSYSNDTVVHTVAQIITHSSYREEGSQGDIALIRLSSPVTFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLQTPRPLQQLEVPLISRETCSCLYNINAVPEEPHTIQQDMLCAGYVKGGKDACQGDSGGPLSCPMEGIWYLAGIVSWGDACGAPNRPGVYTLTSTYASWIHHHVAELQPRVVPQTQESQPDGHLCNHHPVFSSAAAPKLLRPVLFLPLGLTLGLLSLA

Target ORF information:

RefSeq Version	NM_133351.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus protease, serine 8 (prostasin) (Prss8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133351.3

ORF Insert Sequence:

ATGGCCCTAA GGGTGGGCCT GGGACTTGGG CAGCTGGAAG CTGTGACCAT TCTGCTCCTT 
CTCGGATTGC TCCAGTCGGG AATCCGAGCT GACGGGACTG AAGCCTCCTG TGGTGCCGTC 
ATCCAGCCAC GCATCACCGG TGGTGGCAGT GCAAAGCCCG GTCAGTGGCC CTGGCAGGTC 
AGCATCACCT ACGATGGCAA CCATGTTTGT GGCGGGTCGC TCGTGTCAAA TAAATGGGTG 
GTGTCTGCTG CTCACTGCTT CCCCAGAGAA CACAGCAGGG AAGCGTATGA GGTGAAGCTG 
GGGGCCCACC AGCTAGACTC CTACAGCAAT GACACTGTGG TCCACACAGT GGCTCAGATC 
ATCACCCACT CAAGCTACCG AGAAGAGGGC TCCCAGGGGG ACATCGCGCT CATCCGCCTC 
AGCAGTCCTG TCACCTTCTC CCGCTACATC AGACCCATCT GCCTCCCTGC AGCCAATGCC 
TCCTTTCCCA ACGGCCTTCA CTGTACTGTC ACGGGATGGG GTCATGTGGC TCCTTCAGTG 
AGCCTCCAGA CCCCTAGGCC TCTGCAGCAG CTCGAGGTAC CACTCATCAG CCGGGAAACC 
TGTAGCTGCC TGTACAACAT TAATGCGGTG CCTGAAGAAC CGCACACTAT CCAGCAGGAC 
ATGCTGTGTG CTGGCTATGT GAAGGGAGGC AAGGATGCCT GCCAGGGTGA CTCTGGGGGC 
CCACTCTCTT GTCCCATGGA GGGCATCTGG TACTTGGCAG GCATTGTGAG TTGGGGTGAT 
GCCTGTGGTG CCCCCAACAG GCCTGGAGTA TACACTCTGA CTTCTACCTA TGCTTCCTGG 
ATCCACCACC ATGTGGCAGA GCTCCAGCCT CGAGTTGTCC CCCAGACTCA GGAGTCCCAG 
CCGGATGGCC ACCTCTGCAA CCATCATCCT GTCTTCAGCT CAGCGGCAGC CCCGAAATTG 
TTAAGGCCCG TACTTTTCCT GCCACTTGGT CTGACCCTGG GCCTCTTGTC TTTGGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Prss8 ( XM_006508306.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006508369.1 Mus musculus protease, serine 8 (prostasin) (Prss8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu10004
Clone ID Related Accession (Same CDS sequence)	XM_006508306.3 , NM_133351.3
Accession Version	XM_006508306.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	prostasin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006508306.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCTAA GGGTGGGCCT GGGACTTGGG CAGCTGGAAG CTGTGACCAT TCTGCTCCTT 
CTCGGATTGC TCCAGTCGGG AATCCGAGCT GACGGGACTG AAGCCTCCTG TGGTGCCGTC 
ATCCAGCCAC GCATCACCGG TGGTGGCAGT GCAAAGCCCG GTCAGTGGCC CTGGCAGGTC 
AGCATCACCT ACGATGGCAA CCATGTTTGT GGCGGGTCGC TCGTGTCAAA TAAATGGGTG 
GTGTCTGCTG CTCACTGCTT CCCCAGAGAA CACAGCAGGG AAGCGTATGA GGTGAAGCTG 
GGGGCCCACC AGCTAGACTC CTACAGCAAT GACACTGTGG TCCACACAGT GGCTCAGATC 
ATCACCCACT CAAGCTACCG AGAAGAGGGC TCCCAGGGGG ACATCGCGCT CATCCGCCTC 
AGCAGTCCTG TCACCTTCTC CCGCTACATC AGACCCATCT GCCTCCCTGC AGCCAATGCC 
TCCTTTCCCA ACGGCCTTCA CTGTACTGTC ACGGGATGGG GTCATGTGGC TCCTTCAGTG 
AGCCTCCAGA CCCCTAGGCC TCTGCAGCAG CTCGAGGTAC CACTCATCAG CCGGGAAACC 
TGTAGCTGCC TGTACAACAT TAATGCGGTG CCTGAAGAAC CGCACACTAT CCAGCAGGAC 
ATGCTGTGTG CTGGCTATGT GAAGGGAGGC AAGGATGCCT GCCAGGGTGA CTCTGGGGGC 
CCACTCTCTT GTCCCATGGA GGGCATCTGG TACTTGGCAG GCATTGTGAG TTGGGGTGAT 
GCCTGTGGTG CCCCCAACAG GCCTGGAGTA TACACTCTGA CTTCTACCTA TGCTTCCTGG 
ATCCACCACC ATGTGGCAGA GCTCCAGCCT CGAGTTGTCC CCCAGACTCA GGAGTCCCAG 
CCGGATGGCC ACCTCTGCAA CCATCATCCT GTCTTCAGCT CAGCGGCAGC CCCGAAATTG 
TTAAGGCCCG TACTTTTCCT GCCACTTGGT CTGACCCTGG GCCTCTTGTC TTTGGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006508369.1
CDS	125..1144
Translation	MALRVGLGLGQLEAVTILLLLGLLQSGIRADGTEASCGAVIQPRITGGGSAKPGQWPWQVSITYDGNHVCGGSLVSNKWVVSAAHCFPREHSREAYEVKLGAHQLDSYSNDTVVHTVAQIITHSSYREEGSQGDIALIRLSSPVTFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLQTPRPLQQLEVPLISRETCSCLYNINAVPEEPHTIQQDMLCAGYVKGGKDACQGDSGGPLSCPMEGIWYLAGIVSWGDACGAPNRPGVYTLTSTYASWIHHHVAELQPRVVPQTQESQPDGHLCNHHPVFSSAAAPKLLRPVLFLPLGLTLGLLSLA

Target ORF information:

RefSeq Version	XM_006508306.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus protease, serine 8 (prostasin) (Prss8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006508306.3

ORF Insert Sequence:

ATGGCCCTAA GGGTGGGCCT GGGACTTGGG CAGCTGGAAG CTGTGACCAT TCTGCTCCTT 
CTCGGATTGC TCCAGTCGGG AATCCGAGCT GACGGGACTG AAGCCTCCTG TGGTGCCGTC 
ATCCAGCCAC GCATCACCGG TGGTGGCAGT GCAAAGCCCG GTCAGTGGCC CTGGCAGGTC 
AGCATCACCT ACGATGGCAA CCATGTTTGT GGCGGGTCGC TCGTGTCAAA TAAATGGGTG 
GTGTCTGCTG CTCACTGCTT CCCCAGAGAA CACAGCAGGG AAGCGTATGA GGTGAAGCTG 
GGGGCCCACC AGCTAGACTC CTACAGCAAT GACACTGTGG TCCACACAGT GGCTCAGATC 
ATCACCCACT CAAGCTACCG AGAAGAGGGC TCCCAGGGGG ACATCGCGCT CATCCGCCTC 
AGCAGTCCTG TCACCTTCTC CCGCTACATC AGACCCATCT GCCTCCCTGC AGCCAATGCC 
TCCTTTCCCA ACGGCCTTCA CTGTACTGTC ACGGGATGGG GTCATGTGGC TCCTTCAGTG 
AGCCTCCAGA CCCCTAGGCC TCTGCAGCAG CTCGAGGTAC CACTCATCAG CCGGGAAACC 
TGTAGCTGCC TGTACAACAT TAATGCGGTG CCTGAAGAAC CGCACACTAT CCAGCAGGAC 
ATGCTGTGTG CTGGCTATGT GAAGGGAGGC AAGGATGCCT GCCAGGGTGA CTCTGGGGGC 
CCACTCTCTT GTCCCATGGA GGGCATCTGG TACTTGGCAG GCATTGTGAG TTGGGGTGAT 
GCCTGTGGTG CCCCCAACAG GCCTGGAGTA TACACTCTGA CTTCTACCTA TGCTTCCTGG 
ATCCACCACC ATGTGGCAGA GCTCCAGCCT CGAGTTGTCC CCCAGACTCA GGAGTCCCAG 
CCGGATGGCC ACCTCTGCAA CCATCATCCT GTCTTCAGCT CAGCGGCAGC CCCGAAATTG 
TTAAGGCCCG TACTTTTCCT GCCACTTGGT CTGACCCTGG GCCTCTTGTC TTTGGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of new genes in vertebrate tooth development and p63 signaling.
Developmental dynamics : an official publication of the American Association of Anatomists248(8)744-755(2019 08)
Rostampour N,Appelt CM,Abid A,Boughner JC

PRSS8 suppresses colorectal carcinogenesis and metastasis.
Oncogene38(4)497-517(2019 01)
Bao Y,Guo Y,Yang Y,Wei X,Zhang S,Zhang Y,Li K,Yuan M,Guo D,Macias V,Zhu X,Zhang W,Yang W

Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy.
PloS one13(4)e0194660(2018)
Szabo R,Bugge TH

Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
The Journal of biological chemistry292(26)10801-10812(2017 06)
Buzza MS,Johnson TA,Conway GD,Martin EW,Mukhopadhyay S,Shea-Donohue T,Antalis TM

Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases.
Scientific reports639305(2016 12)
Shuto T,Kamei S,Nohara H,Fujikawa H,Tasaki Y,Sugahara T,Ono T,Matsumoto C,Sakaguchi Y,Maruta K,Nakashima R,Kawakami T,Suico MA,Kondo Y,Ishigami A,Takeo T,Tanaka KI,Watanabe H,Nakagata N,Uchimura K,Kitamura K,Li JD,Kai H

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Prss8 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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