| Gene Symbol | Klk4 |
| Entrez Gene ID | 56640 |
| Full Name | kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) |
| Synonyms | ESMP1,KLK-L1,PSTS,Prss17 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Klk4 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Klk4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klk4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu11794 Clone ID Related Accession (Same CDS sequence) NM_019928.2 , NM_019928.1 Accession Version NM_019928.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 768bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577635200000 Organism Mus musculus(house mouse) Product kallikrein-4 precursor Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK087426.1 and BC100717.1. On Jun 5, 2018 this sequence version replaced NM_019928.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK087426.1, BC100716.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721ATGATGGTCA CTGCACGAAC CCCCTGGGGC TGGTTCCTGG GGTGCCTCAT CCTTGAGGTC
ACAGGAGCCT CCGCCTCAAG TGTCAGCAGC CGGATCATAC AAGGCCAGGA CTGCTCCCCA
CACTCGCAAC CCTGGCAGGC GGCACTGTTC TCAGAAGACG GTTTTTTCTG CTCGGGAGTC
TTGGTGCATC CGCAGTGGGT GCTGTCAGCA GCACATTGCT TACAGGAGTC CTACATCGTG
GGACTGGGCC TGCATAACCT GAAAGGCTCC CAAGAGCCTG GCAGCCGGAT GTTAGAGGCC
CACCTCTCCA TCCAGCACCC CAACTTCAAC GATCCTTCTT TTGCAAACGA TCTCATGCTC
ATCAAACTGA ACGAGTCAGT GATAGAGTCT AACACTATCA GGAGCATCCC TGTGGCTACC
CAATGCCCCA CTCCTGGAGA TACCTGCCTA GTCTCTGGTT GGGGTCAACT AAAGAATGGG
AAACTGCCCA GCCTCCTGCA GTGTGTGAAT CTCTCAGTGG CGTCAGAGGA GACTTGCCGG
CTGCTGTATG ACCCTGTGTA CCACCTCAGT ATGTTCTGCG CTGGAGGAGG ACAGGACCAA
AAGGACTCCT GCAATGGGGA CTCTGGGGGT CCCATAGTGT GCAACAGATC CCTACAAGGG
CTCGTGTCTA TGGGACAAGG AAAGTGTGGG CAGCCTGGCA TACCAAGTGT CTACACCAAT
CTCTGCAAGT TCACTAACTG GATCCAGACC ATCATTCAGA CAAACTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_064312.1 CDS 64..831 Translation 
Target ORF information:
RefSeq Version NM_019928.2 Organism Mus musculus(house mouse) Definition Mus musculus kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) (Klk4), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_019928.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721ATGATGGTCA CTGCACGAAC CCCCTGGGGC TGGTTCCTGG GGTGCCTCAT CCTTGAGGTC
ACAGGAGCCT CCGCCTCAAG TGTCAGCAGC CGGATCATAC AAGGCCAGGA CTGCTCCCCA
CACTCGCAAC CCTGGCAGGC GGCACTGTTC TCAGAAGACG GTTTTTTCTG CTCGGGAGTC
TTGGTGCATC CGCAGTGGGT GCTGTCAGCA GCACATTGCT TACAGGAGTC CTACATCGTG
GGACTGGGCC TGCATAACCT GAAAGGCTCC CAAGAGCCTG GCAGCCGGAT GTTAGAGGCC
CACCTCTCCA TCCAGCACCC CAACTTCAAC GATCCTTCTT TTGCAAACGA TCTCATGCTC
ATCAAACTGA ACGAGTCAGT GATAGAGTCT AACACTATCA GGAGCATCCC TGTGGCTACC
CAATGCCCCA CTCCTGGAGA TACCTGCCTA GTCTCTGGTT GGGGTCAACT AAAGAATGGG
AAACTGCCCA GCCTCCTGCA GTGTGTGAAT CTCTCAGTGG CGTCAGAGGA GACTTGCCGG
CTGCTGTATG ACCCTGTGTA CCACCTCAGT ATGTTCTGCG CTGGAGGAGG ACAGGACCAA
AAGGACTCCT GCAATGGGGA CTCTGGGGGT CCCATAGTGT GCAACAGATC CCTACAAGGG
CTCGTGTCTA TGGGACAAGG AAAGTGTGGG CAGCCTGGCA TACCAAGTGT CTACACCAAT
CTCTGCAAGT TCACTAACTG GATCCAGACC ATCATTCAGA CAAACTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu11794 Clone ID Related Accession (Same CDS sequence) NM_019928.2 , NM_019928.1 Accession Version NM_019928.1 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 768bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1514217600000 Organism Mus musculus(house mouse) Product kallikrein-4 precursor Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF019979.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF019979.1, AK087426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721ATGATGGTCA CTGCACGAAC CCCCTGGGGC TGGTTCCTGG GGTGCCTCAT CCTTGAGGTC
ACAGGAGCCT CCGCCTCAAG TGTCAGCAGC CGGATCATAC AAGGCCAGGA CTGCTCCCCA
CACTCGCAAC CCTGGCAGGC GGCACTGTTC TCAGAAGACG GTTTTTTCTG CTCGGGAGTC
TTGGTGCATC CGCAGTGGGT GCTGTCAGCA GCACATTGCT TACAGGAGTC CTACATCGTG
GGACTGGGCC TGCATAACCT GAAAGGCTCC CAAGAGCCTG GCAGCCGGAT GTTAGAGGCC
CACCTCTCCA TCCAGCACCC CAACTTCAAC GATCCTTCTT TTGCAAACGA TCTCATGCTC
ATCAAACTGA ACGAGTCAGT GATAGAGTCT AACACTATCA GGAGCATCCC TGTGGCTACC
CAATGCCCCA CTCCTGGAGA TACCTGCCTA GTCTCTGGTT GGGGTCAACT AAAGAATGGG
AAACTGCCCA GCCTCCTGCA GTGTGTGAAT CTCTCAGTGG CGTCAGAGGA GACTTGCCGG
CTGCTGTATG ACCCTGTGTA CCACCTCAGT ATGTTCTGCG CTGGAGGAGG ACAGGACCAA
AAGGACTCCT GCAATGGGGA CTCTGGGGGT CCCATAGTGT GCAACAGATC CCTACAAGGG
CTCGTGTCTA TGGGACAAGG AAAGTGTGGG CAGCCTGGCA TACCAAGTGT CTACACCAAT
CTCTGCAAGT TCACTAACTG GATCCAGACC ATCATTCAGA CAAACTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_064312.1 CDS 52..819 Translation
Target ORF information:
RefSeq Version NM_019928.1 Organism Mus musculus(house mouse) Definition Mus musculus kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) (Klk4), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_019928.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721ATGATGGTCA CTGCACGAAC CCCCTGGGGC TGGTTCCTGG GGTGCCTCAT CCTTGAGGTC
ACAGGAGCCT CCGCCTCAAG TGTCAGCAGC CGGATCATAC AAGGCCAGGA CTGCTCCCCA
CACTCGCAAC CCTGGCAGGC GGCACTGTTC TCAGAAGACG GTTTTTTCTG CTCGGGAGTC
TTGGTGCATC CGCAGTGGGT GCTGTCAGCA GCACATTGCT TACAGGAGTC CTACATCGTG
GGACTGGGCC TGCATAACCT GAAAGGCTCC CAAGAGCCTG GCAGCCGGAT GTTAGAGGCC
CACCTCTCCA TCCAGCACCC CAACTTCAAC GATCCTTCTT TTGCAAACGA TCTCATGCTC
ATCAAACTGA ACGAGTCAGT GATAGAGTCT AACACTATCA GGAGCATCCC TGTGGCTACC
CAATGCCCCA CTCCTGGAGA TACCTGCCTA GTCTCTGGTT GGGGTCAACT AAAGAATGGG
AAACTGCCCA GCCTCCTGCA GTGTGTGAAT CTCTCAGTGG CGTCAGAGGA GACTTGCCGG
CTGCTGTATG ACCCTGTGTA CCACCTCAGT ATGTTCTGCG CTGGAGGAGG ACAGGACCAA
AAGGACTCCT GCAATGGGGA CTCTGGGGGT CCCATAGTGT GCAACAGATC CCTACAAGGG
CTCGTGTCTA TGGGACAAGG AAAGTGTGGG CAGCCTGGCA TACCAAGTGT CTACACCAAT
CTCTGCAAGT TCACTAACTG GATCCAGACC ATCATTCAGA CAAACTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Deletion of epithelial cell-specific Cdc42 leads to enamel hypermaturation in a conditional knockout mouse model.
Biochimica et biophysica acta. Molecular basis of disease1864(8)2623-2632(2018 Aug)
Tian Z,Lv X,Zhang M,Wang X,Chen Y,Tang P,Xu P,Zhang L,Wu B,Zhang L
A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
Science signaling10(465)(2017 02)
Cantù C,Pagella P,Shajiei TD,Zimmerli D,Valenta T,Hausmann G,Basler K,Mitsiadis TA
High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bućan M,Murray SA
Maturation stage enamel malformations in Amtn and Klk4 null mice.
Matrix biology : journal of the International Society for Matrix Biology52-54219-233(2016 May-Jul)
Núñez SM,Chun YP,Ganss B,Hu Y,Richardson AS,Schmitz JE,Fajardo R,Yang J,Hu JC,Simmer JP
MMP20, KLK4, and MMP20/KLK4 double null mice define roles for matrix proteases during dental enamel formation.
Molecular genetics & genomic medicine4(2)178-96(2016 Mar)
Hu Y,Smith CE,Richardson AS,Bartlett JD,Hu JC,Simmer JP
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