Apom cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Apom
Entrez Gene ID	55938
Full Name	apolipoprotein M
Synonyms	1190010O19Rik,G3a,NG20
General protein information	Preferred Names apolipoprotein M Names apolipoprotein M apo-M
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_018816.2	NP_061286.1	apolipoprotein M precursor
NM_018816.1	NP_061286.1	apolipoprotein M precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	APOM	XP_518354.2
Canis lupus familiaris (dog)	APOM	XP_532074.1
Mus musculus (house mouse)	Apom	NP_061286.1
Xenopus tropicalis (tropical clawed frog)	apom	NP_001090778.1
Homo sapiens (human)	APOM	NP_061974.2
Bos taurus (cattle)	APOM	NP_001029429.2
Macaca mulatta (Rhesus monkey)	APOM	XP_001112572.1
Rattus norvegicus (Norway rat)	Apom	NP_062246.1

Gene Ontology
Bibliography

Related articles in PubMed

Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis.
Mathiesen Janiurek M, Soylu-Kucharz R, Christoffersen C, Kucharz K, Lauritzen M
eLife8(2019 11)

Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways.
Wang M, Luo GH, Liu H, Zhang YP, Wang B, Di DM, Zhan XH, Yu Y, Yao S, Zhang XY, Xu N
Molecular medicine reports19(2)1272-1283(2019 Feb)

Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom".
Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC, Vasiliou V, Nebert DW
Human genomics13(1)11(2019 02)

Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes.
Feng YH, Zheng L, Wei J, Yu MM, Zhang J, Luo GH, Xu N
Lipids in health and disease17(1)200(2018 Aug)

Regulation of the metabolism of apolipoprotein M and sphingosine 1-phosphate by hepatic PPARγ activity.
Kurano M, Ikeda H, Iso-O N, Hara M, Tsukamoto K, Yatomi Y
The Biochemical journal475(12)2009-2024(2018 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Apom gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apom cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu11036	NM_018816.2 Latest version!	Mus musculus apolipoprotein M (Apom), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu11036	NM_018816.1	Mus musculus apolipoprotein M (Apom), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Apom ( NM_018816.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061286.1 Mus musculus apolipoprotein M (Apom), mRNA.

Price & Availability↑

CloneID	OMu11036
Clone ID Related Accession (Same CDS sequence)	NM_018816.2 , NM_018816.1
Accession Version	NM_018816.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Mus musculus(house mouse)
Product	apolipoprotein M precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR974444.18. On Jan 22, 2019 this sequence version replaced NM_018816.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF207820.1, BC021597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGTTCCACC AAGTTTGGGC AGCTCTGCTC TCTCTCTATG GCCTTCTCTT TAACTCCATG 
AATCAGTGCC CTGAGCACAG TCAACTAACT GCGCTGGGAA TGGACGACAC AGAGACCCCA 
GAGCCCCACC TGGGCCTGTG GTACTTTATT GCGGGAGCAG CCTCCACCAC GGAAGAGTTG 
GCAACTTTTG ATCCGGTGGA CAATATTGTC TTCAACATGG CTGCCGGCTC TGCCCCAAGG 
CAGCTCCAGC TTCGTGCTAC CATCCGCACG AAAAGTGGGG TCTGTGTGCC CCGGAAGTGG 
ACATACCGAT TGACTGAAGG GAAAGGAAAC ATGGAACTCA GAACTGAAGG GCGCCCAGAC 
ATGAAAACAG ACCTGTTCTC CAGCTCGTGC CCAGGAGGAA TCATGCTGAA AGAGACGGGC 
CAGGGCTACC AGCGCTTTCT CCTCTACAAT CGGTCACCAC ACCCTCCAGA GAAGTGTGTG 
GAGGAATTCC AGTCTCTGAC CTCTTGCTTG GACTTCAAAG CCTTCTTAGT GACTCCCAGG 
AATCAAGAGG CCTGCCCGCT GTCCAGCAAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061286.1
CDS	79..651
Translation	MFHQVWAALLSLYGLLFNSMNQCPEHSQLTALGMDDTETPEPHLGLWYFIAGAASTTEELATFDPVDNIVFNMAAGSAPRQLQLRATIRTKSGVCVPRKWTYRLTEGKGNMELRTEGRPDMKTDLFSSSCPGGIMLKETGQGYQRFLLYNRSPHPPEKCVEEFQSLTSCLDFKAFLVTPRNQEACPLSSK

Target ORF information:

RefSeq Version	NM_018816.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus apolipoprotein M (Apom), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018816.2

ORF Insert Sequence:

ATGTTCCACC AAGTTTGGGC AGCTCTGCTC TCTCTCTATG GCCTTCTCTT TAACTCCATG 
AATCAGTGCC CTGAGCACAG TCAACTAACT GCGCTGGGAA TGGACGACAC AGAGACCCCA 
GAGCCCCACC TGGGCCTGTG GTACTTTATT GCGGGAGCAG CCTCCACCAC GGAAGAGTTG 
GCAACTTTTG ATCCGGTGGA CAATATTGTC TTCAACATGG CTGCCGGCTC TGCCCCAAGG 
CAGCTCCAGC TTCGTGCTAC CATCCGCACG AAAAGTGGGG TCTGTGTGCC CCGGAAGTGG 
ACATACCGAT TGACTGAAGG GAAAGGAAAC ATGGAACTCA GAACTGAAGG GCGCCCAGAC 
ATGAAAACAG ACCTGTTCTC CAGCTCGTGC CCAGGAGGAA TCATGCTGAA AGAGACGGGC 
CAGGGCTACC AGCGCTTTCT CCTCTACAAT CGGTCACCAC ACCCTCCAGA GAAGTGTGTG 
GAGGAATTCC AGTCTCTGAC CTCTTGCTTG GACTTCAAAG CCTTCTTAGT GACTCCCAGG 
AATCAAGAGG CCTGCCCGCT GTCCAGCAAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Apom ( NM_018816.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061286.1 Mus musculus apolipoprotein M (Apom), mRNA.

Price & Availability↑

CloneID	OMu11036
Clone ID Related Accession (Same CDS sequence)	NM_018816.2 , NM_018816.1
Accession Version	NM_018816.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1542384000000
Organism	Mus musculus(house mouse)
Product	apolipoprotein M precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF207820.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF207820.1, BI219461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGTTCCACC AAGTTTGGGC AGCTCTGCTC TCTCTCTATG GCCTTCTCTT TAACTCCATG 
AATCAGTGCC CTGAGCACAG TCAACTAACT GCGCTGGGAA TGGACGACAC AGAGACCCCA 
GAGCCCCACC TGGGCCTGTG GTACTTTATT GCGGGAGCAG CCTCCACCAC GGAAGAGTTG 
GCAACTTTTG ATCCGGTGGA CAATATTGTC TTCAACATGG CTGCCGGCTC TGCCCCAAGG 
CAGCTCCAGC TTCGTGCTAC CATCCGCACG AAAAGTGGGG TCTGTGTGCC CCGGAAGTGG 
ACATACCGAT TGACTGAAGG GAAAGGAAAC ATGGAACTCA GAACTGAAGG GCGCCCAGAC 
ATGAAAACAG ACCTGTTCTC CAGCTCGTGC CCAGGAGGAA TCATGCTGAA AGAGACGGGC 
CAGGGCTACC AGCGCTTTCT CCTCTACAAT CGGTCACCAC ACCCTCCAGA GAAGTGTGTG 
GAGGAATTCC AGTCTCTGAC CTCTTGCTTG GACTTCAAAG CCTTCTTAGT GACTCCCAGG 
AATCAAGAGG CCTGCCCGCT GTCCAGCAAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061286.1
CDS	30..602
Translation	MFHQVWAALLSLYGLLFNSMNQCPEHSQLTALGMDDTETPEPHLGLWYFIAGAASTTEELATFDPVDNIVFNMAAGSAPRQLQLRATIRTKSGVCVPRKWTYRLTEGKGNMELRTEGRPDMKTDLFSSSCPGGIMLKETGQGYQRFLLYNRSPHPPEKCVEEFQSLTSCLDFKAFLVTPRNQEACPLSSK

Target ORF information:

RefSeq Version	NM_018816.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus apolipoprotein M (Apom), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018816.1

ORF Insert Sequence:

ATGTTCCACC AAGTTTGGGC AGCTCTGCTC TCTCTCTATG GCCTTCTCTT TAACTCCATG 
AATCAGTGCC CTGAGCACAG TCAACTAACT GCGCTGGGAA TGGACGACAC AGAGACCCCA 
GAGCCCCACC TGGGCCTGTG GTACTTTATT GCGGGAGCAG CCTCCACCAC GGAAGAGTTG 
GCAACTTTTG ATCCGGTGGA CAATATTGTC TTCAACATGG CTGCCGGCTC TGCCCCAAGG 
CAGCTCCAGC TTCGTGCTAC CATCCGCACG AAAAGTGGGG TCTGTGTGCC CCGGAAGTGG 
ACATACCGAT TGACTGAAGG GAAAGGAAAC ATGGAACTCA GAACTGAAGG GCGCCCAGAC 
ATGAAAACAG ACCTGTTCTC CAGCTCGTGC CCAGGAGGAA TCATGCTGAA AGAGACGGGC 
CAGGGCTACC AGCGCTTTCT CCTCTACAAT CGGTCACCAC ACCCTCCAGA GAAGTGTGTG 
GAGGAATTCC AGTCTCTGAC CTCTTGCTTG GACTTCAAAG CCTTCTTAGT GACTCCCAGG 
AATCAAGAGG CCTGCCCGCT GTCCAGCAAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis.
eLife8(2019 11)
Mathiesen Janiurek M,Soylu-Kucharz R,Christoffersen C,Kucharz K,Lauritzen M

Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways.
Molecular medicine reports19(2)1272-1283(2019 Feb)
Wang M,Luo GH,Liu H,Zhang YP,Wang B,Di DM,Zhan XH,Yu Y,Yao S,Zhang XY,Xu N

Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom".
Human genomics13(1)11(2019 02)
Charkoftaki G,Wang Y,McAndrews M,Bruford EA,Thompson DC,Vasiliou V,Nebert DW

Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes.
Lipids in health and disease17(1)200(2018 Aug)
Feng YH,Zheng L,Wei J,Yu MM,Zhang J,Luo GH,Xu N

Regulation of the metabolism of apolipoprotein M and sphingosine 1-phosphate by hepatic PPARγ activity.
The Biochemical journal475(12)2009-2024(2018 06)
Kurano M,Ikeda H,Iso-O N,Hara M,Tsukamoto K,Yatomi Y