Map3k14 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Map3k14
Entrez Gene ID	53859
Full Name	mitogen-activated protein kinase kinase kinase 14
Synonyms	Nik,aly
General protein information	Preferred Names mitogen-activated protein kinase kinase kinase 14 Names mitogen-activated protein kinase kinase kinase 14 NF kappa B-inducing kinase NF-kappa-beta-inducing kinase Nfkb inducing kinase alymphoplasia protein kinase serine/threonine-protein kinase NIK
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 E1\|11 66.8 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_016896.3	NP_058592.1	mitogen-activated protein kinase kinase kinase 14

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MAP3K14	XP_003315444.1
Macaca mulatta (Rhesus monkey)	MAP3K14	XP_001115548.1
Canis lupus familiaris (dog)	MAP3K14	XP_548049.2
Rattus norvegicus (Norway rat)	Map3k14	NP_001101771.1
Danio rerio (zebrafish)	si:dkey-260c8.4	XP_005164214.1
Xenopus tropicalis (tropical clawed frog)	map3k14	XP_002935595.2
Mus musculus (house mouse)	Map3k14	NP_058592.1
Gallus gallus (chicken)	MAP3K14	NP_001026098.1
Homo sapiens (human)	MAP3K14	NP_003945.2
Bos taurus (cattle)	MAP3K14	NP_001179107.1

Gene Ontology
Bibliography

Related articles in PubMed

Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice.
Shen H, Ji Y, Xiong Y, Kim H, Zhong X, Jin MG, Shah YM, Omary MB, Liu Y, Qi L, Rui L
Proceedings of the National Academy of Sciences of the United States of America116(38)19090-19097(2019 Sep)

Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization.
Li Y, Yang JY, Xie X, Jie Z, Zhang L, Shi J, Lin D, Gu M, Zhou X, Li HS, Watowich SS, Jain A, Yun Jung S, Qin J, Cheng X, Sun SC
Cell research29(6)474-485(2019 Jun)

NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis.
Jie Z, Yang JY, Gu M, Wang H, Xie X, Li Y, Liu T, Zhu L, Shi J, Zhang L, Zhou X, Joo D, Brightbill HD, Cong Y, Lin D, Cheng X, Sun SC
Nature immunology19(11)1224-1235(2018 11)

Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases.
Xiong Y, Torsoni AS, Wu F, Shen H, Liu Y, Zhong X, Canet MJ, Shah YM, Omary MB, Liu Y, Rui L
eLife7(2018 08)

Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice.
Li X, Jia L, Chen X, Dong Y, Ren X, Dong Y, Chen Y, Xie L, Liu M, Shiota C, Gittes GK, Rui L, Chen Z
Theranostics8(21)5960-5971(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Map3k14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map3k14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22264	NM_016896.3 Latest version!	Mus musculus mitogen-activated protein kinase kinase kinase 14 (Map3k14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Map3k14 ( NM_016896.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058592.1 Mus musculus mitogen-activated protein kinase kinase kinase 14 (Map3k14), mRNA.

Price & Availability↑

CloneID	OMu22264
Clone ID Related Accession (Same CDS sequence)	NM_016896.3
Accession Version	NM_016896.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2829bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Mus musculus(house mouse)
Product	mitogen-activated protein kinase kinase kinase 14
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK036200.1. On Apr 6, 2007 this sequence version replaced NM_016896.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036200.1, AK172518.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGTGA TGGAAGTGGC CTGCCCGGGC ACTCCTGGGT CAGCAGTCGG GCAGCAGAAG 
GAGCTTGCCA AAGCCAAGGA GAAGACACAG TCACTGGGGA AGAAGCAGAG CTGCATCTTC 
AAGCTTGAGG CCGTGGAGAA GAGCCCCGTG TTCTGTGGGA AGTGGGAGAT CCTAAACGAC 
GTGATCACCA AAGGCACAGC CAAGGACGGC TCTGAGGGAG GACCACCGGC CATCTCCATC 
ATCGCCCAGG CTGAATGTGA GAATAGCCAA GAGTTCAGCC CCACCTTCTC AGAGCGCATT 
TTCATCGCGG GGTCACAGCA GTACAGCCAG TCTGAGAGTC TCGATCAAAT CCCCAACAAT 
GTGGCCCATG CAACTGAAGG CAAAATGGCC CGTGTGTGCC GGAGGGGAAA ACGTCACGGC 
AAAGCCCGAA AAAAACGTAG GAAGAAGAGG TCGAAGTCAC TGGCCCAGGC AGGAGTGGCC 
TTAGCCAAGC CCCTGCCCAG AACCCCTGAG CAAGAGAGCT GTACCATCCC AGTACAGGAA 
GATGAGTCTC CACTAGGCAA CCTCTATGCC AGAAATGTCT CCCAGTTCAC CAAGCCTCTG 
GGGGGACCAG GCCTTGGCCA CCTGTGCTTT AAGAAACAAG ATGAAGGCCT GCGACCGGTA 
CTGCCTCGAC CAGAACTCCA CAAACTGATC AGCCCCTTGC AATGTCTAAA CCACGTGTGG 
AAACTCCACC ACCCCCAGGC CACAGGCCCC CGGCCCCACC CGACTCACCC CTTCCCCTAC 
AGCGGAATGC CCCATCCTTT CCCATTCTAC CCCCTGGAGC CCTGGAAACC CTATATGCTG 
GACTCTGCCG TCCTGGACAA ACTAGCCGGT GTCAGCGGCC AGCGGCCTCT GCCTGGCCCA 
CCGCATCTAA GCCAACTGGC CCATGGAGAC AGTCAGAAGC CGCTGCCTGG CCCACACCTG 
GAGTCCAGCT GCCCGTCTCG GGGTGCCCTA GAAAAGGTTC CCGTGGAGGA ATACCTGGTG 
CATGCGCTCC AAGGAAGTGT GAGCTCAGGC CAGGCCCACA GCCTGGCCAG CCTGGCTAAG 
ACATGGTCCT CGGGAAGCGC CAAGCTGCAG AGGCTCGGCC CCGAAACTGA GGACAACGAG 
GGGGTCCTGC TTACTGAGAA ACTCAAGCCA GTGGATTATG AGTATCGAGA AGAGGTCCAC 
TGGATGACAC ACCAGCCTCG GGTGGGCAGA GGCTCCTTCG GCGAGGTCCA CAGAATGAAG 
GACAAGCAGA CAGGCTTCCA GTGTGCTGTC AAAAAGGTAC GACTCGAGGT GTTTCGGGTA 
GAGGAACTAG TGGCCTGTGC TGGTCTGAGC TCGCCCAGAA TCGTCCCTCT CTATGGAGCT 
GTGAGAGAAG GCCCGTGGGT GAACATCTTC ATGGAACTGC TAGAAGGTGG CTCGCTGGGT 
CAGCTCATAA AGCAAATGGG CTGTCTGCCA GAAGACCGAG CCCTTTACTA CCTGGGCCAG 
GCCCTGGAGG GGCTGGAGTA CCTCCACACA CGCAGGATTC TGCATGGCGA TGTCAAAGCT 
GACAACGTGC TCCTGTCCAG TGATGGAAGC CGAGCGGCCC TCTGCGACTT TGGCCACGCC 
TTGTGCCTGC AACCTGACGG CCTAGGGAAA TCCTTGCTCA CAGGGGACTA CATTCCTGGC 
ACGGAGACCC ACATGGCACC AGAAGTGGTG ATGGGAAAGC CCTGCGATGC CAAGGTGGAC 
ATCTGGAGCA GCTGCTGCAT GATGCTCCAC ATGCTCAACG GCTGCCACCC CTGGACTCAG 
TACTTCCGAG GCCCGCTTTG TCTCAAGATT GCCAGCGAGC CTCCACCGAT CAGGGAGATC 
CCACCTTCCT GCGCACCCCT CACAGCCCAG GCCATCCAAG AGGGGCTGAG GAAAGAGCCC 
GTCCACCGAG CATCTGCCAT GGAGCTTCGG AGGAAAGTGG GCAAGGCACT ACAGGAAGTG 
GGAGGTCTGA AAAGCCCTTG GAAAGGAGAA TATAAAGAAC CAAGACCTCC ACCCCAAGAC 
CAAGCCACCT GCCACCAGAC CCTACCTACT CCGCCGAGAG AGAACCCACC AGCCAAGGCC 
AACACAGACG GGGCTCCTGA GCCTCAGCCT CCTCTACCGC CAGAACCACC AGAACCGAGC 
AAAGCGCCAG CCCTGAACCT GAGCAAGGAG GAGTCTGGCA CATGGGAACC CCTGCCTCTG 
TCCTCCCTGG ACCCAGCCAC TGCCAAAGGC CCCAGCTTCC CAGACCGGAG GGCAACCTTG 
CCAGAGCTGG AGCTACAGCA ACTGGAGATA GAACTGTTTC TCAACAGCCT GTCCCAGCCG 
TTCTCTCTGG AGGAACAGGA ACAAATCCTC TCCTGCCTCA GCATCGACAG CCTCTCGCTG 
TCAGATGACA GTGAAAAGAA TCCATCGAAG GCCTCTCAGA GCTCACGGGA CACCCTGAGT 
TCTGGCGTGC ACTCTTGGAA CAGCCAAGCT GAGGCAAGAA CCTGCAGCTG CAGCACGGCG 
CTGGCCCGGG GGCGGCCTAC TGACATCCCG AGCTACTTCA ACGGGGTCAA GGTCCAGATC 
CAGTCTCTCA ATGGCGAACA CCTGCATATC CGGGAATTCC ACCGCGTCAA GGTGGGAGAC 
ATTGCCACCG GCATCAGCAG CCAGATCCCA GCCACAGCTT TCAGCCTGGT GACCAAAGAT 
GGACAGCCTG TTTGCTATGA CATGGAGGTG CCAGACTCGG GCATCGACCT GCAGTGCACC 
CTGGCCCCTG ATGGCAGCTT TGCTTGGACC TGGAGGGTCA AGCATGGTCA GCTGGAGAAC 
CGACCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058592.1
CDS	84..2912
Translation	MAVMEVACPGTPGSAVGQQKELAKAKEKTQSLGKKQSCIFKLEAVEKSPVFCGKWEILNDVITKGTAKDGSEGGPPAISIIAQAECENSQEFSPTFSERIFIAGSQQYSQSESLDQIPNNVAHATEGKMARVCRRGKRHGKARKKRRKKRSKSLAQAGVALAKPLPRTPEQESCTIPVQEDESPLGNLYARNVSQFTKPLGGPGLGHLCFKKQDEGLRPVLPRPELHKLISPLQCLNHVWKLHHPQATGPRPHPTHPFPYSGMPHPFPFYPLEPWKPYMLDSAVLDKLAGVSGQRPLPGPPHLSQLAHGDSQKPLPGPHLESSCPSRGALEKVPVEEYLVHALQGSVSSGQAHSLASLAKTWSSGSAKLQRLGPETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGLKSPWKGEYKEPRPPPQDQATCHQTLPTPPRENPPAKANTDGAPEPQPPLPPEPPEPSKAPALNLSKEESGTWEPLPLSSLDPATAKGPSFPDRRATLPELELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWNSQAEARTCSCSTALARGRPTDIPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPATAFSLVTKDGQPVCYDMEVPDSGIDLQCTLAPDGSFAWTWRVKHGQLENRP

Target ORF information:

RefSeq Version	NM_016896.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitogen-activated protein kinase kinase kinase 14 (Map3k14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016896.3

ORF Insert Sequence:

ATGGCCGTGA TGGAAGTGGC CTGCCCGGGC ACTCCTGGGT CAGCAGTCGG GCAGCAGAAG 
GAGCTTGCCA AAGCCAAGGA GAAGACACAG TCACTGGGGA AGAAGCAGAG CTGCATCTTC 
AAGCTTGAGG CCGTGGAGAA GAGCCCCGTG TTCTGTGGGA AGTGGGAGAT CCTAAACGAC 
GTGATCACCA AAGGCACAGC CAAGGACGGC TCTGAGGGAG GACCACCGGC CATCTCCATC 
ATCGCCCAGG CTGAATGTGA GAATAGCCAA GAGTTCAGCC CCACCTTCTC AGAGCGCATT 
TTCATCGCGG GGTCACAGCA GTACAGCCAG TCTGAGAGTC TCGATCAAAT CCCCAACAAT 
GTGGCCCATG CAACTGAAGG CAAAATGGCC CGTGTGTGCC GGAGGGGAAA ACGTCACGGC 
AAAGCCCGAA AAAAACGTAG GAAGAAGAGG TCGAAGTCAC TGGCCCAGGC AGGAGTGGCC 
TTAGCCAAGC CCCTGCCCAG AACCCCTGAG CAAGAGAGCT GTACCATCCC AGTACAGGAA 
GATGAGTCTC CACTAGGCAA CCTCTATGCC AGAAATGTCT CCCAGTTCAC CAAGCCTCTG 
GGGGGACCAG GCCTTGGCCA CCTGTGCTTT AAGAAACAAG ATGAAGGCCT GCGACCGGTA 
CTGCCTCGAC CAGAACTCCA CAAACTGATC AGCCCCTTGC AATGTCTAAA CCACGTGTGG 
AAACTCCACC ACCCCCAGGC CACAGGCCCC CGGCCCCACC CGACTCACCC CTTCCCCTAC 
AGCGGAATGC CCCATCCTTT CCCATTCTAC CCCCTGGAGC CCTGGAAACC CTATATGCTG 
GACTCTGCCG TCCTGGACAA ACTAGCCGGT GTCAGCGGCC AGCGGCCTCT GCCTGGCCCA 
CCGCATCTAA GCCAACTGGC CCATGGAGAC AGTCAGAAGC CGCTGCCTGG CCCACACCTG 
GAGTCCAGCT GCCCGTCTCG GGGTGCCCTA GAAAAGGTTC CCGTGGAGGA ATACCTGGTG 
CATGCGCTCC AAGGAAGTGT GAGCTCAGGC CAGGCCCACA GCCTGGCCAG CCTGGCTAAG 
ACATGGTCCT CGGGAAGCGC CAAGCTGCAG AGGCTCGGCC CCGAAACTGA GGACAACGAG 
GGGGTCCTGC TTACTGAGAA ACTCAAGCCA GTGGATTATG AGTATCGAGA AGAGGTCCAC 
TGGATGACAC ACCAGCCTCG GGTGGGCAGA GGCTCCTTCG GCGAGGTCCA CAGAATGAAG 
GACAAGCAGA CAGGCTTCCA GTGTGCTGTC AAAAAGGTAC GACTCGAGGT GTTTCGGGTA 
GAGGAACTAG TGGCCTGTGC TGGTCTGAGC TCGCCCAGAA TCGTCCCTCT CTATGGAGCT 
GTGAGAGAAG GCCCGTGGGT GAACATCTTC ATGGAACTGC TAGAAGGTGG CTCGCTGGGT 
CAGCTCATAA AGCAAATGGG CTGTCTGCCA GAAGACCGAG CCCTTTACTA CCTGGGCCAG 
GCCCTGGAGG GGCTGGAGTA CCTCCACACA CGCAGGATTC TGCATGGCGA TGTCAAAGCT 
GACAACGTGC TCCTGTCCAG TGATGGAAGC CGAGCGGCCC TCTGCGACTT TGGCCACGCC 
TTGTGCCTGC AACCTGACGG CCTAGGGAAA TCCTTGCTCA CAGGGGACTA CATTCCTGGC 
ACGGAGACCC ACATGGCACC AGAAGTGGTG ATGGGAAAGC CCTGCGATGC CAAGGTGGAC 
ATCTGGAGCA GCTGCTGCAT GATGCTCCAC ATGCTCAACG GCTGCCACCC CTGGACTCAG 
TACTTCCGAG GCCCGCTTTG TCTCAAGATT GCCAGCGAGC CTCCACCGAT CAGGGAGATC 
CCACCTTCCT GCGCACCCCT CACAGCCCAG GCCATCCAAG AGGGGCTGAG GAAAGAGCCC 
GTCCACCGAG CATCTGCCAT GGAGCTTCGG AGGAAAGTGG GCAAGGCACT ACAGGAAGTG 
GGAGGTCTGA AAAGCCCTTG GAAAGGAGAA TATAAAGAAC CAAGACCTCC ACCCCAAGAC 
CAAGCCACCT GCCACCAGAC CCTACCTACT CCGCCGAGAG AGAACCCACC AGCCAAGGCC 
AACACAGACG GGGCTCCTGA GCCTCAGCCT CCTCTACCGC CAGAACCACC AGAACCGAGC 
AAAGCGCCAG CCCTGAACCT GAGCAAGGAG GAGTCTGGCA CATGGGAACC CCTGCCTCTG 
TCCTCCCTGG ACCCAGCCAC TGCCAAAGGC CCCAGCTTCC CAGACCGGAG GGCAACCTTG 
CCAGAGCTGG AGCTACAGCA ACTGGAGATA GAACTGTTTC TCAACAGCCT GTCCCAGCCG 
TTCTCTCTGG AGGAACAGGA ACAAATCCTC TCCTGCCTCA GCATCGACAG CCTCTCGCTG 
TCAGATGACA GTGAAAAGAA TCCATCGAAG GCCTCTCAGA GCTCACGGGA CACCCTGAGT 
TCTGGCGTGC ACTCTTGGAA CAGCCAAGCT GAGGCAAGAA CCTGCAGCTG CAGCACGGCG 
CTGGCCCGGG GGCGGCCTAC TGACATCCCG AGCTACTTCA ACGGGGTCAA GGTCCAGATC 
CAGTCTCTCA ATGGCGAACA CCTGCATATC CGGGAATTCC ACCGCGTCAA GGTGGGAGAC 
ATTGCCACCG GCATCAGCAG CCAGATCCCA GCCACAGCTT TCAGCCTGGT GACCAAAGAT 
GGACAGCCTG TTTGCTATGA CATGGAGGTG CCAGACTCGG GCATCGACCT GCAGTGCACC 
CTGGCCCCTG ATGGCAGCTT TGCTTGGACC TGGAGGGTCA AGCATGGTCA GCTGGAGAAC 
CGACCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice.
Proceedings of the National Academy of Sciences of the United States of America116(38)19090-19097(2019 Sep)
Shen H,Ji Y,Xiong Y,Kim H,Zhong X,Jin MG,Shah YM,Omary MB,Liu Y,Qi L,Rui L

Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization.
Cell research29(6)474-485(2019 Jun)
Li Y,Yang JY,Xie X,Jie Z,Zhang L,Shi J,Lin D,Gu M,Zhou X,Li HS,Watowich SS,Jain A,Yun Jung S,Qin J,Cheng X,Sun SC

NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis.
Nature immunology19(11)1224-1235(2018 11)
Jie Z,Yang JY,Gu M,Wang H,Xie X,Li Y,Liu T,Zhu L,Shi J,Zhang L,Zhou X,Joo D,Brightbill HD,Cong Y,Lin D,Cheng X,Sun SC

Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases.
eLife7(2018 08)
Xiong Y,Torsoni AS,Wu F,Shen H,Liu Y,Zhong X,Canet MJ,Shah YM,Omary MB,Liu Y,Rui L

Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice.
Theranostics8(21)5960-5971(2018)
Li X,Jia L,Chen X,Dong Y,Ren X,Dong Y,Chen Y,Xie L,Liu M,Shiota C,Gittes GK,Rui L,Chen Z

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Map3k14 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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