Dna2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dna2
Entrez Gene ID	327762
Full Name	DNA replication helicase/nuclease 2
Synonyms	Dna2l,E130315B21Rik
General protein information	Preferred Names DNA replication helicase/nuclease 2 Names DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication ATP-dependent helicase-like homolog DNA replication helicase 2 homolog DNA2-like helicase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 B4

mRNA and Protein(s)

mRNA	Protein	Name
NM_177372.3	NP_796346.2	DNA replication ATP-dependent helicase/nuclease DNA2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	DNA2	NP_001006497.1
Bos taurus (cattle)	DNA2	NP_001179731.2
Rattus norvegicus (Norway rat)	Dna2	XP_241671.6
Arabidopsis thaliana (thale cress)	emb2411	NP_001184943.1
Oryza sativa (rice)	Os04g0588200	NP_001053694.2
Canis lupus familiaris (dog)	DNA2	XP_005619489.1
Danio rerio (zebrafish)	dna2	XP_687974.5
Pan troglodytes (chimpanzee)	DNA2	XP_001163213.2
Mus musculus (house mouse)	Dna2	NP_796346.2
Drosophila melanogaster (fruit fly)	CG2990	NP_727386.1
Homo sapiens (human)	DNA2	NP_001073918.2
Macaca mulatta (Rhesus monkey)	DNA2	XP_002808547.1
Caenorhabditis elegans (roundworm)	dna-2	NP_496515.1
Magnaporthe oryzae (rice blast fungus)	MGG_02491	XP_003709288.1
Schizosaccharomyces pombe (fission yeast)	dna2	NP_596499.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004685	XP_307265.4
Xenopus tropicalis (tropical clawed frog)	dna2	XP_002936016.2

Gene Ontology
Bibliography

Related articles in PubMed

Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis.
Kiyama T, Chen CK, Wang SW, Pan P, Ju Z, Wang J, Takada S, Klein WH, Mao CA
Molecular neurodegeneration13(1)56(2018 10)

Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.
Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, Yang L, Wu X, Xu H, Hua Y, Xu J, Zheng L, Shen B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(1)132-147(2017 01)

Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.
Zhou C, Pourmal S, Pavletich NP
eLife4(2015 Nov)

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
Lin W, Sampathi S, Dai H, Liu C, Zhou M, Hu J, Huang Q, Campbell J, Shin-Ya K, Zheng L, Chai W, Shen B
The EMBO journal32(10)1425-39(2013 May)

Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.
Fortini BK, Pokharel S, Polaczek P, Balakrishnan L, Bambara RA, Campbell JL
The Journal of biological chemistry286(27)23763-70(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dna2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dna2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22714	NM_177372.3 Latest version!	Mus musculus DNA replication helicase/nuclease 2 (Dna2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dna2 ( NM_177372.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_796346.2 Mus musculus DNA replication helicase/nuclease 2 (Dna2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu22714
Clone ID Related Accession (Same CDS sequence)	NM_177372.3
Accession Version	NM_177372.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565539200000
Organism	Mus musculus(house mouse)
Product	DNA replication ATP-dependent helicase/nuclease DNA2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY768981.1, AK028381.1, CO433698.1, AK053856.1 and BM202919.2. On Jan 14, 2010 this sequence version replaced NM_177372.2. ##Evidence-Data-START## Transcript exon combination :: AK129051.1, AK028381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCGC TGGACGAGCT GGACCTGCTG CTGCTGGAAG AGGACGGCGG AGCGGAGGCC 
GTGCCGCGGG TGGAGCTACT TCGGAAGAAG GCGGACGCTT TGTTTCCAGA GACAGTTCTG 
AGCCGAGGAG TGGATAACCG GTACCTGGTG CTAGCTGTTG AGACCTCGCA GAATGAAAGA 
GGAGCCGAGG AGAAGCGCTT GCACGTCACG GCGTCCCAGG ACCGAGAGCA CGAAGTTCTG 
TGCATCCTGA GGAATGGCTG GAGCTCAGTA CCAGTTGAGC CAGGGGACAT CGTTCACTTA 
GAGGGAGACT GCACATCTGA GCCGTGGATA ATAGACGATG ACTTTGGATA TTTTATTCTG 
TACCCGGACA TGATGATCTC CGGCACAAGC GTCGCTAGCA GCATTCGGTG TCTGAGAAGA 
GCTGTCCTGA GCGAGACCTT CAGGGGCTCT GATCCAGCCA CTCGCCAGAT GCTGATCGGT 
ACAATTCTCC ACGAAGTCTT TCAGAAAGCG ATAAGTGAGA GCTTTGCTCC AGAAAGGCTA 
CAAGAGCTTG CTCTTCAGAC CCTCCGAGAA GTGAGGCATT TGAAGGAAAT GTATCGCTTG 
AATCTGAGCC AAGATGAAAT ACTCTGTGAA GTTGAGGAGT ATCTCCCTTC TTTCTCTAAG 
TGGGCGGAGG ACTTCATGCG TAAGGGCCCT TCGTCTGAAT TCCCTCAAAT GCAGCTCTCT 
CTGCCAAGCG ATGGCAGTAA CAGAAGTTCA CCTTGTAACA TTGAAGTAGT CAAGTCACTG 
GATATCGAAG AAAGCATCTG GTCCCCTAGG TTTGGACTGA AGGGCAAAAT AGACGTCACA 
GTCGGGGTCA AAATACATCG AGATTGTAAA ATGAAATACA AGGTAATGCC ACTGGAGCTG 
AAGACCGGCA AAGAGTCCAA CTCCATCGAG CACCGGAGTC AGGTGGTCCT GTACACGCTG 
CTAAGCCAGG AGAGGCGAGA GGACCCCGAG GCTGGCTGGC TTCTCTACCT CAAGACCGGG 
CAGATGTACC CTGTGCCCGC CAACCATCTG GACAAAAGAG AACTGCTGAA GCTCAGGAAC 
TGGCTGGCCG CCTCGCTGCT GCACCGTGTG AGCCGAGCAG CTCCGGGGGA GGAAGCTCGG 
CTCTCTGCCT TGCCACAGAT AATCGAGGAA GAGAAAACTT GTAAATACTG TTCGCAGATA 
GGCAACTGTG CTCTTTATAG CAGAGCAGTT GAAGAGCAGG GAGATGACGC ATCCATCCCA 
GAAGCCATGC TGTCCAAAAT CCAGGAAGAA ACACGGCACC TGCAGCTGGC GCACTTGAAG 
TATTTCAGCC TGTGGTGTCT CATGTTAACG CTGGAGTCGC AATCTAAAGA CAACCGGAAG 
ACTCACCAGA GTATCTGGTT AACGCCTGCC TCTGAACTGG AGGAGAGTGG CAACTGTGTT 
GGAAACCTGG TCAGGACGGA GCCTGTATCA AGAGTTTGTG ATGGACAGTA TTTACATAAT 
TTTCAGCGGA AAAATGGTCC CATGCCAGCC ACCAATCTGA TGGCAGGTGA CAGGATTATT 
TTAAGTGGAG AAGAGAGAAA ACTATTTGCT TTGTCCAAAG GCTACGTGAA GAAGATGAAC 
AAGGCAGCCG TTACCTGCTT GCTAGACAGG AACTTGTCGA CACTCCCAGC AACAACGGTG 
TTTCGATTAG ACCGGGAAGA AAGACATGGC GACATAAGTA CTCCACTAGG AAATCTGTCT 
AAATTGATGG AAAGCACAGA TCCCAGCAAA AGACTTCGAG AATTAATCAT CGATTTCAGG 
GAACCTCAGT TCATCGCCTA CCTCAGCTCC GTCCTTCCAC ACGATGCGAA GGATACGGTG 
GCCAACATTC TAAAGGGTTT GAATAAACCC CAGAGACAAG CAATGAAGAG AGTCCTTCTT 
TCGAAAGACT ACACGCTCAT TGTTGGGATG CCAGGGACAG GAAAGACAAC CACCATCTGT 
GCCCTGGTGA GGATCCTCTC TGCCTGTGGG TTCAGCGTTC TGCTGACCAG CTACACGCAC 
TCCGCCGTTG ACAATATTCT CCTGAAGTTA GCCAAGTTTA AAGTCGGATT TTTGCGCTTG 
GGTCAGTCTC ATAAGGTCCA TCCAGACATC CAGAAGTTTA CAGAGGAGGA GATTTGCAGA 
TCGAGGTCCA TTGCGTCTTT AGCCCATCTA GAAGAACTCT ATAACAGTCA CCCTATTGTT 
GCAACAACCT GCATGGGAAT AAATCACCCA ATATTTTCCC GAAAAACCTT TGATTTCTGT 
ATTGTGGATG AAGCATCTCA AATCAGCCAG CCCGTCTGCC TGGGCCCACT GTTCTTTTCG 
CGGAGGTTTG TGCTGGTGGG GGACCATCAG CAGCTGCCTC CCCTGGTTGT AAACCGAGAG 
GCAAGAGCTC TGGGCATGAG CGAGAGCTTG TTCAAGAGGC TGGAGCGGAA CGAGAGCGCT 
GTGGTGCAGC TGACCGTGCA ATACCGAATG AACAGGAAGA TTATGTCCCT GAGCAACAAG 
CTCACATACG CAGGGAAACT GGAGTGTGGG TCAGACCGAG TGGCCAACGC AGTGCTAGCC 
CTGCCCAACC TCAAGGACGC AAGGCTGAGC CTCCAGCTTT ATGCCGACTA CTCTGACAGC 
CCCTGGCTGG CTGGAGTGTT AGAGCCAGAC AATCCCGTGT GTTTCCTTAA CACAGACAAG 
GTCCCAGCTC CAGAGCAAGT TGAAAATGGT GGTGTTAGCA ATGTCACAGA AGCCAGACTC 
ATTGTCTTCC TAACCTCAAC TTTTATAAAG GCAGGCTGCA GCCCCTCAGA CATTGGCGTC 
ATCGCCCCGT ACCGACAGCA GCTGCGGATC ATCAGCGACT TACTGGCCCG GTCTTCTGTT 
GGGATGGTTG AGGTTAACAC AGTAGACAAA TACCAAGGAA GGGACAAGAG TCTCATCCTG 
GTGTCCTTTG TTAGGAGTAA TGAGGATGGA ACTCTCGGCG AGCTCCTGAA AGATTGGCGG 
AGACTCAACG TGGCACTCAC CAGAGCCAAG CATAAACTGA TCCTGCTGGG CAGCGTGTCC 
TCGCTGAAGC GCTTCCCGCC TCTGGGGACG CTCTTTGACC ATCTGAATGC AGAGCAGTTA 
ATCCTGGACC TTCCTTCCAG AGAGCATGAG AGCCTCAGCC ACATCCTGGG CGATTGTCAG 
CGAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_796346.2
CDS	65..3253
Translation	MEPLDELDLLLLEEDGGAEAVPRVELLRKKADALFPETVLSRGVDNRYLVLAVETSQNERGAEEKRLHVTASQDREHEVLCILRNGWSSVPVEPGDIVHLEGDCTSEPWIIDDDFGYFILYPDMMISGTSVASSIRCLRRAVLSETFRGSDPATRQMLIGTILHEVFQKAISESFAPERLQELALQTLREVRHLKEMYRLNLSQDEILCEVEEYLPSFSKWAEDFMRKGPSSEFPQMQLSLPSDGSNRSSPCNIEVVKSLDIEESIWSPRFGLKGKIDVTVGVKIHRDCKMKYKVMPLELKTGKESNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQMYPVPANHLDKRELLKLRNWLAASLLHRVSRAAPGEEARLSALPQIIEEEKTCKYCSQIGNCALYSRAVEEQGDDASIPEAMLSKIQEETRHLQLAHLKYFSLWCLMLTLESQSKDNRKTHQSIWLTPASELEESGNCVGNLVRTEPVSRVCDGQYLHNFQRKNGPMPATNLMAGDRIILSGEERKLFALSKGYVKKMNKAAVTCLLDRNLSTLPATTVFRLDREERHGDISTPLGNLSKLMESTDPSKRLRELIIDFREPQFIAYLSSVLPHDAKDTVANILKGLNKPQRQAMKRVLLSKDYTLIVGMPGTGKTTTICALVRILSACGFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHKVHPDIQKFTEEEICRSRSIASLAHLEELYNSHPIVATTCMGINHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNREARALGMSESLFKRLERNESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVANAVLALPNLKDARLSLQLYADYSDSPWLAGVLEPDNPVCFLNTDKVPAPEQVENGGVSNVTEARLIVFLTSTFIKAGCSPSDIGVIAPYRQQLRIISDLLARSSVGMVEVNTVDKYQGRDKSLILVSFVRSNEDGTLGELLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAEQLILDLPSREHESLSHILGDCQRD

Target ORF information:

RefSeq Version	NM_177372.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus DNA replication helicase/nuclease 2 (Dna2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177372.3

ORF Insert Sequence:

ATGGAGCCGC TGGACGAGCT GGACCTGCTG CTGCTGGAAG AGGACGGCGG AGCGGAGGCC 
GTGCCGCGGG TGGAGCTACT TCGGAAGAAG GCGGACGCTT TGTTTCCAGA GACAGTTCTG 
AGCCGAGGAG TGGATAACCG GTACCTGGTG CTAGCTGTTG AGACCTCGCA GAATGAAAGA 
GGAGCCGAGG AGAAGCGCTT GCACGTCACG GCGTCCCAGG ACCGAGAGCA CGAAGTTCTG 
TGCATCCTGA GGAATGGCTG GAGCTCAGTA CCAGTTGAGC CAGGGGACAT CGTTCACTTA 
GAGGGAGACT GCACATCTGA GCCGTGGATA ATAGACGATG ACTTTGGATA TTTTATTCTG 
TACCCGGACA TGATGATCTC CGGCACAAGC GTCGCTAGCA GCATTCGGTG TCTGAGAAGA 
GCTGTCCTGA GCGAGACCTT CAGGGGCTCT GATCCAGCCA CTCGCCAGAT GCTGATCGGT 
ACAATTCTCC ACGAAGTCTT TCAGAAAGCG ATAAGTGAGA GCTTTGCTCC AGAAAGGCTA 
CAAGAGCTTG CTCTTCAGAC CCTCCGAGAA GTGAGGCATT TGAAGGAAAT GTATCGCTTG 
AATCTGAGCC AAGATGAAAT ACTCTGTGAA GTTGAGGAGT ATCTCCCTTC TTTCTCTAAG 
TGGGCGGAGG ACTTCATGCG TAAGGGCCCT TCGTCTGAAT TCCCTCAAAT GCAGCTCTCT 
CTGCCAAGCG ATGGCAGTAA CAGAAGTTCA CCTTGTAACA TTGAAGTAGT CAAGTCACTG 
GATATCGAAG AAAGCATCTG GTCCCCTAGG TTTGGACTGA AGGGCAAAAT AGACGTCACA 
GTCGGGGTCA AAATACATCG AGATTGTAAA ATGAAATACA AGGTAATGCC ACTGGAGCTG 
AAGACCGGCA AAGAGTCCAA CTCCATCGAG CACCGGAGTC AGGTGGTCCT GTACACGCTG 
CTAAGCCAGG AGAGGCGAGA GGACCCCGAG GCTGGCTGGC TTCTCTACCT CAAGACCGGG 
CAGATGTACC CTGTGCCCGC CAACCATCTG GACAAAAGAG AACTGCTGAA GCTCAGGAAC 
TGGCTGGCCG CCTCGCTGCT GCACCGTGTG AGCCGAGCAG CTCCGGGGGA GGAAGCTCGG 
CTCTCTGCCT TGCCACAGAT AATCGAGGAA GAGAAAACTT GTAAATACTG TTCGCAGATA 
GGCAACTGTG CTCTTTATAG CAGAGCAGTT GAAGAGCAGG GAGATGACGC ATCCATCCCA 
GAAGCCATGC TGTCCAAAAT CCAGGAAGAA ACACGGCACC TGCAGCTGGC GCACTTGAAG 
TATTTCAGCC TGTGGTGTCT CATGTTAACG CTGGAGTCGC AATCTAAAGA CAACCGGAAG 
ACTCACCAGA GTATCTGGTT AACGCCTGCC TCTGAACTGG AGGAGAGTGG CAACTGTGTT 
GGAAACCTGG TCAGGACGGA GCCTGTATCA AGAGTTTGTG ATGGACAGTA TTTACATAAT 
TTTCAGCGGA AAAATGGTCC CATGCCAGCC ACCAATCTGA TGGCAGGTGA CAGGATTATT 
TTAAGTGGAG AAGAGAGAAA ACTATTTGCT TTGTCCAAAG GCTACGTGAA GAAGATGAAC 
AAGGCAGCCG TTACCTGCTT GCTAGACAGG AACTTGTCGA CACTCCCAGC AACAACGGTG 
TTTCGATTAG ACCGGGAAGA AAGACATGGC GACATAAGTA CTCCACTAGG AAATCTGTCT 
AAATTGATGG AAAGCACAGA TCCCAGCAAA AGACTTCGAG AATTAATCAT CGATTTCAGG 
GAACCTCAGT TCATCGCCTA CCTCAGCTCC GTCCTTCCAC ACGATGCGAA GGATACGGTG 
GCCAACATTC TAAAGGGTTT GAATAAACCC CAGAGACAAG CAATGAAGAG AGTCCTTCTT 
TCGAAAGACT ACACGCTCAT TGTTGGGATG CCAGGGACAG GAAAGACAAC CACCATCTGT 
GCCCTGGTGA GGATCCTCTC TGCCTGTGGG TTCAGCGTTC TGCTGACCAG CTACACGCAC 
TCCGCCGTTG ACAATATTCT CCTGAAGTTA GCCAAGTTTA AAGTCGGATT TTTGCGCTTG 
GGTCAGTCTC ATAAGGTCCA TCCAGACATC CAGAAGTTTA CAGAGGAGGA GATTTGCAGA 
TCGAGGTCCA TTGCGTCTTT AGCCCATCTA GAAGAACTCT ATAACAGTCA CCCTATTGTT 
GCAACAACCT GCATGGGAAT AAATCACCCA ATATTTTCCC GAAAAACCTT TGATTTCTGT 
ATTGTGGATG AAGCATCTCA AATCAGCCAG CCCGTCTGCC TGGGCCCACT GTTCTTTTCG 
CGGAGGTTTG TGCTGGTGGG GGACCATCAG CAGCTGCCTC CCCTGGTTGT AAACCGAGAG 
GCAAGAGCTC TGGGCATGAG CGAGAGCTTG TTCAAGAGGC TGGAGCGGAA CGAGAGCGCT 
GTGGTGCAGC TGACCGTGCA ATACCGAATG AACAGGAAGA TTATGTCCCT GAGCAACAAG 
CTCACATACG CAGGGAAACT GGAGTGTGGG TCAGACCGAG TGGCCAACGC AGTGCTAGCC 
CTGCCCAACC TCAAGGACGC AAGGCTGAGC CTCCAGCTTT ATGCCGACTA CTCTGACAGC 
CCCTGGCTGG CTGGAGTGTT AGAGCCAGAC AATCCCGTGT GTTTCCTTAA CACAGACAAG 
GTCCCAGCTC CAGAGCAAGT TGAAAATGGT GGTGTTAGCA ATGTCACAGA AGCCAGACTC 
ATTGTCTTCC TAACCTCAAC TTTTATAAAG GCAGGCTGCA GCCCCTCAGA CATTGGCGTC 
ATCGCCCCGT ACCGACAGCA GCTGCGGATC ATCAGCGACT TACTGGCCCG GTCTTCTGTT 
GGGATGGTTG AGGTTAACAC AGTAGACAAA TACCAAGGAA GGGACAAGAG TCTCATCCTG 
GTGTCCTTTG TTAGGAGTAA TGAGGATGGA ACTCTCGGCG AGCTCCTGAA AGATTGGCGG 
AGACTCAACG TGGCACTCAC CAGAGCCAAG CATAAACTGA TCCTGCTGGG CAGCGTGTCC 
TCGCTGAAGC GCTTCCCGCC TCTGGGGACG CTCTTTGACC ATCTGAATGC AGAGCAGTTA 
ATCCTGGACC TTCCTTCCAG AGAGCATGAG AGCCTCAGCC ACATCCTGGG CGATTGTCAG 
CGAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis.
Molecular neurodegeneration13(1)56(2018 10)
Kiyama T,Chen CK,Wang SW,Pan P,Ju Z,Wang J,Takada S,Klein WH,Mao CA

Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(1)132-147(2017 01)
Zhou L,Dai H,Wu J,Zhou M,Yuan H,Du J,Yang L,Wu X,Xu H,Hua Y,Xu J,Zheng L,Shen B

Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.
eLife4(2015 Nov)
Zhou C,Pourmal S,Pavletich NP

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
The EMBO journal32(10)1425-39(2013 May)
Lin W,Sampathi S,Dai H,Liu C,Zhou M,Hu J,Huang Q,Campbell J,Shin-Ya K,Zheng L,Chai W,Shen B

Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.
The Journal of biological chemistry286(27)23763-70(2011 Jul)
Fortini BK,Pokharel S,Polaczek P,Balakrishnan L,Bambara RA,Campbell JL

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Dna2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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