Mat2a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mat2a
Entrez Gene ID	232087
Full Name	methionine adenosyltransferase II, alpha
Synonyms	D630045P18Rik
General protein information	Preferred Names methionine adenosyltransferase II, alpha Names S-adenosylmethionine synthase isoform type-2 MAT 2 S-adenosylmethionine synthetase isoform type-2 adoMet synthase 2 adoMet synthetase 2 methionine adenosyltransferase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_145569.4	NP_663544.1	S-adenosylmethionine synthase isoform type-2
NM_001363799.1	NP_001350728.1	S-adenosylmethionine synthase isoform type-2 isoform 3
NM_145569.5	NP_663544.1	S-adenosylmethionine synthase isoform type-2 isoform 1
NM_001363798.1	NP_001350727.1	S-adenosylmethionine synthase isoform type-2 isoform 2

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	sam1	NP_596731.1
Bos taurus (cattle)	MAT2A	NP_001094601.1
Rattus norvegicus (Norway rat)	Mat2a	NP_599178.1
Caenorhabditis elegans (roundworm)	sams-3	NP_500872.1
Caenorhabditis elegans (roundworm)	sams-5	NP_741415.1
Caenorhabditis elegans (roundworm)	sams-4	NP_500871.1
Caenorhabditis elegans (roundworm)	sams-1	NP_510002.1
Saccharomyces cerevisiae (baker's yeast)	SAM2	NP_010790.3
Neurospora crassa	NCU02657	XP_965430.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009447	XP_307863.1
Homo sapiens (human)	MAT2A	NP_005902.1
Drosophila melanogaster (fruit fly)	Sam-S	NP_524923.1
Saccharomyces cerevisiae (baker's yeast)	SAM1	NP_013281.1
Pan troglodytes (chimpanzee)	MAT2A	XP_001167501.1
Canis lupus familiaris (dog)	MAT2A	XP_532980.2
Danio rerio (zebrafish)	mat2ab	NP_001014318.1
Kluyveromyces lactis	KLLA0C01782g	XP_452275.1
Magnaporthe oryzae (rice blast fungus)	MGG_00383	XP_003718693.1
Eremothecium gossypii	AGOS_AFR692C	NP_986240.1
Mus musculus (house mouse)	Mat2a	NP_663544.1
Arabidopsis thaliana (thale cress)	MAT3	NP_001118458.1
Xenopus tropicalis (tropical clawed frog)	mat2a	NP_989395.1

Gene Ontology
Bibliography

Related articles in PubMed

Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
Pascale RM, Peitta G, Simile MM, Feo F
Medicina (Kaunas, Lithuania)55(6)(2019 Jun)

Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition†.
Sun H, Kang J, Su J, Zhang J, Zhang L, Liu X, Zhang J, Wang F, Lu Z, Xing X, Chen H, Zhang Y
Biology of reproduction100(3)601-617(2019 03)

A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
Wang R, Jin Y, Yao XH, Fan W, Zhang J, Cao Y, Li J
Molecular carcinogenesis57(9)1201-1212(2018 09)

Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.
Tang S, Fang Y, Huang G, Xu X, Padilla-Banks E, Fan W, Xu Q, Sanderson SM, Foley JF, Dowdy S, McBurney MW, Fargo DC, Williams CJ, Locasale JW, Guan Z, Li X
The EMBO journal36(21)3175-3193(2017 11)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA
Nature537(7621)508-514(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mat2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mat2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu73589	NM_001363799.1 Latest version!	Mus musculus methionine adenosyltransferase II, alpha (Mat2a), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu84334	NM_001363798.1 Latest version!	Mus musculus methionine adenosyltransferase II, alpha (Mat2a), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu21855	NM_145569.5 Latest version!	Mus musculus methionine adenosyltransferase II, alpha (Mat2a), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00
View Old Accession Versions >>
OMu21855	NM_145569.4	Mus musculus methionine adenosyltransferase II, alpha (Mat2a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mat2a ( NM_145569.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_663544.1 Mus musculus methionine adenosyltransferase II, alpha (Mat2a), mRNA.

Price & Availability↑

CloneID	OMu21855
Clone ID Related Accession (Same CDS sequence)	NM_145569.4 , NM_145569.5
Accession Version	NM_145569.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514304000000
Organism	Mus musculus(house mouse)
Product	S-adenosylmethionine synthase isoform type-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC116115.11. On May 1, 2007 this sequence version replaced NM_145569.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK034757.1, AK052764.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC 
ACTTCCGAGT CTGTAGGGGA AGGTCACCCA GATAAGATTT GTGACCAAAT CAGTGATGCT 
GTCCTTGATG CACACCTTCA ACAAGACCCT GATGCTAAAG TGGCTTGTGA AACTGTTGCT 
AAAACTGGAA TGATTCTTCT TGCTGGGGAA ATTACATCCA GAGCTGCCAT TGATTACCAG 
AAAGTGGTTC GTGAAGCCAT AAAGCACATT GGATATGATG ACTCTTCCAA AGGGTTTGAC 
TACAAGACTT GTAATGTGTT GGTTGCCTTG GAACAACAGT CACCAGATAT TGCCCAAGGT 
GTTCATCTTG ACCGGAATGA GGAAGATATT GGTGCAGGAG ACCAGGGTTT GATGTTTGGT 
TATGCCACTG ATGAAACTGA AGAGTGTATG CCTTTAACCA TTGTCTTAGC ACACAAGCTA 
AATGCCAAAT TGGCTGAACT ACGCCGCAAT GGTACATTGC CTTGGTTACG CCCAGATTCT 
AAAACTCAAG TGACTGTGCA ATATATGCAA GATCGGGGTG CTGTGCTTCC CATCAGAGTC 
CACACGATTG TTATATCTGT TCAGCACGAT GAAGAAGTTT GTCTTGATGA GATGAGGGAT 
GCTCTGAAGG AGAAAGTGAT CAAGGCTGTT GTACCTGCAA AATACCTTGA TGAGGATACA 
ATTTACCACC TACAGCCAAG TGGCAGATTT GTTATTGGTG GGCCTCAGGG TGATGCTGGC 
CTGACTGGCC GAAAAATCAT TGTGGATACT TATGGCGGTT GGGGAGCTCA TGGAGGAGGG 
GCCTTTTCAG GAAAGGATTA TACCAAAGTG GACCGTTCAG CTGCTTATGC TGCTCGTTGG 
GTGGCAAAAT CCCTTGTTAA AGGAGGTCTG TGCAGGAGGG TTCTTGTTCA GGTCTCTTAT 
GCTATTGGAG TTTCTCATCC ATTGTCGATC TCCATTTTCC ATTATGGCAC TTCTCAGAAG 
AGTGAGAGAG AGCTATTAGA AATTGTAAAG AAGAATTTTG ATCTTCGCCC TGGGGTCATT 
GTCAGGGATC TGGATCTGAA GAAGCCAATT TATCAGAGGA CTGCAGCCTA TGGCCACTTT 
GGTAGGGACA GCTTCCCATG GGAAGTGCCC AAAAAGCTTA AATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663544.1
CDS	123..1310
Translation	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY

Target ORF information:

RefSeq Version	NM_145569.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus methionine adenosyltransferase II, alpha (Mat2a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145569.4

ORF Insert Sequence:

ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC 
ACTTCCGAGT CTGTAGGGGA AGGTCACCCA GATAAGATTT GTGACCAAAT CAGTGATGCT 
GTCCTTGATG CACACCTTCA ACAAGACCCT GATGCTAAAG TGGCTTGTGA AACTGTTGCT 
AAAACTGGAA TGATTCTTCT TGCTGGGGAA ATTACATCCA GAGCTGCCAT TGATTACCAG 
AAAGTGGTTC GTGAAGCCAT AAAGCACATT GGATATGATG ACTCTTCCAA AGGGTTTGAC 
TACAAGACTT GTAATGTGTT GGTTGCCTTG GAACAACAGT CACCAGATAT TGCCCAAGGT 
GTTCATCTTG ACCGGAATGA GGAAGATATT GGTGCAGGAG ACCAGGGTTT GATGTTTGGT 
TATGCCACTG ATGAAACTGA AGAGTGTATG CCTTTAACCA TTGTCTTAGC ACACAAGCTA 
AATGCCAAAT TGGCTGAACT ACGCCGCAAT GGTACATTGC CTTGGTTACG CCCAGATTCT 
AAAACTCAAG TGACTGTGCA ATATATGCAA GATCGGGGTG CTGTGCTTCC CATCAGAGTC 
CACACGATTG TTATATCTGT TCAGCACGAT GAAGAAGTTT GTCTTGATGA GATGAGGGAT 
GCTCTGAAGG AGAAAGTGAT CAAGGCTGTT GTACCTGCAA AATACCTTGA TGAGGATACA 
ATTTACCACC TACAGCCAAG TGGCAGATTT GTTATTGGTG GGCCTCAGGG TGATGCTGGC 
CTGACTGGCC GAAAAATCAT TGTGGATACT TATGGCGGTT GGGGAGCTCA TGGAGGAGGG 
GCCTTTTCAG GAAAGGATTA TACCAAAGTG GACCGTTCAG CTGCTTATGC TGCTCGTTGG 
GTGGCAAAAT CCCTTGTTAA AGGAGGTCTG TGCAGGAGGG TTCTTGTTCA GGTCTCTTAT 
GCTATTGGAG TTTCTCATCC ATTGTCGATC TCCATTTTCC ATTATGGCAC TTCTCAGAAG 
AGTGAGAGAG AGCTATTAGA AATTGTAAAG AAGAATTTTG ATCTTCGCCC TGGGGTCATT 
GTCAGGGATC TGGATCTGAA GAAGCCAATT TATCAGAGGA CTGCAGCCTA TGGCCACTTT 
GGTAGGGACA GCTTCCCATG GGAAGTGCCC AAAAAGCTTA AATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mat2a ( NM_001363799.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001350728.1 Mus musculus methionine adenosyltransferase II, alpha (Mat2a), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu73589
Clone ID Related Accession (Same CDS sequence)	NM_001363799.1
Accession Version	NM_001363799.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Mus musculus(house mouse)
Product	S-adenosylmethionine synthase isoform type-2 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK133960.1 and BC058360.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133960.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164133 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC 
ACTTCCGAGT CTGTAGGGGA AGGTCACCCA GATAAGATTT GTGACCAAAT CAGTGATGCT 
GTCCTTGATG CACACCTTCA ACAAGACCCT GATGCTAAAG TGGCTTGTGA AACTGTTGCT 
AAAACTGGAA TGATTCTTCT TGCTGGGGAA ATTACATCCA GAGCTGCCAT TGATTACCAG 
AAAGTGGTTC GTGAAGCCAT AAAGCACATT GGATATGATG ACTCTTCCAA AGGGTTTGAC 
TACAAGACTT GTAATGTGTT GGTTGCCTTG GAACAACAGT CACCAGATAT TGCCCAAGGT 
GTTCATCTTG ACCGGAATGA GGAAGATATT GGTGCAGGAG ACCAGGGTTT GATGTTTGGT 
TATGCCACTG ATGAAACTGA AGAGTGTATG CCTTTAACCA TTGTCTTAGC ACACAAGCTA 
AATGCCAAAT TGGCTGAACT ACGCCGCAAT GGTACATTGC CTTGGTTACG CCCAGATTCT 
AAAACTCAAG TGACTGTGCA ATATATGCAA GATCGGGGTG CTGTGCTTCC CATCAGAGTC 
CACACGATTG TTATATCTGT TCAGCACGAT GAAGAAGTTT GTCTTGATGA GATGAGGGAT 
GCTCTGAAGG AGAAAGTGAT CAAGGCTGTT GTACCTGCAA AATACCTTGA TGAGGATACA 
ATTTACCACC TACAGCCAAG TGGCAGATTT GTTATTGGTG GGCCTCAGGG TGATGCTGGC 
CTGACTGGCC GAAAAATCAT TGTGGATACT TATGGCGGTT GGGGAGCTCA TGGAGGAGGG 
GCCTTTTCAG GAAAGGATTA TACCAAAGTG GACCGTTCAG CTGCTTATGC TGCTCGTTGG 
GTGGCAAAAT CCCTTGTTAA AGGAGGTCTG TGCAGGAGGG TTCTTGTTCA GGTCTCTTAT 
GCTATTGGAG TTTCTCATCC ATTGTCGATC TCCATTTTCC ATTATGGCAC TTCTCAGAAG 
AGTGAGAGAG AGCTATTAGA AATTGTAAAG AAGAATTTTG ATCTTCGCCC TGGGGTCATT 
GTCAGGGTGC TACATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350728.1
CDS	121..1218
Translation	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRVLH

Target ORF information:

RefSeq Version	NM_001363799.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus methionine adenosyltransferase II, alpha (Mat2a), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363799.1

ORF Insert Sequence:

ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC 
ACTTCCGAGT CTGTAGGGGA AGGTCACCCA GATAAGATTT GTGACCAAAT CAGTGATGCT 
GTCCTTGATG CACACCTTCA ACAAGACCCT GATGCTAAAG TGGCTTGTGA AACTGTTGCT 
AAAACTGGAA TGATTCTTCT TGCTGGGGAA ATTACATCCA GAGCTGCCAT TGATTACCAG 
AAAGTGGTTC GTGAAGCCAT AAAGCACATT GGATATGATG ACTCTTCCAA AGGGTTTGAC 
TACAAGACTT GTAATGTGTT GGTTGCCTTG GAACAACAGT CACCAGATAT TGCCCAAGGT 
GTTCATCTTG ACCGGAATGA GGAAGATATT GGTGCAGGAG ACCAGGGTTT GATGTTTGGT 
TATGCCACTG ATGAAACTGA AGAGTGTATG CCTTTAACCA TTGTCTTAGC ACACAAGCTA 
AATGCCAAAT TGGCTGAACT ACGCCGCAAT GGTACATTGC CTTGGTTACG CCCAGATTCT 
AAAACTCAAG TGACTGTGCA ATATATGCAA GATCGGGGTG CTGTGCTTCC CATCAGAGTC 
CACACGATTG TTATATCTGT TCAGCACGAT GAAGAAGTTT GTCTTGATGA GATGAGGGAT 
GCTCTGAAGG AGAAAGTGAT CAAGGCTGTT GTACCTGCAA AATACCTTGA TGAGGATACA 
ATTTACCACC TACAGCCAAG TGGCAGATTT GTTATTGGTG GGCCTCAGGG TGATGCTGGC 
CTGACTGGCC GAAAAATCAT TGTGGATACT TATGGCGGTT GGGGAGCTCA TGGAGGAGGG 
GCCTTTTCAG GAAAGGATTA TACCAAAGTG GACCGTTCAG CTGCTTATGC TGCTCGTTGG 
GTGGCAAAAT CCCTTGTTAA AGGAGGTCTG TGCAGGAGGG TTCTTGTTCA GGTCTCTTAT 
GCTATTGGAG TTTCTCATCC ATTGTCGATC TCCATTTTCC ATTATGGCAC TTCTCAGAAG 
AGTGAGAGAG AGCTATTAGA AATTGTAAAG AAGAATTTTG ATCTTCGCCC TGGGGTCATT 
GTCAGGGTGC TACATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mat2a ( NM_001363798.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001350727.1 Mus musculus methionine adenosyltransferase II, alpha (Mat2a), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu84334
Clone ID Related Accession (Same CDS sequence)	NM_001363798.1
Accession Version	NM_001363798.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Mus musculus(house mouse)
Product	S-adenosylmethionine synthase isoform type-2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK160869.1 and BC058360.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058360.1, AK160869.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC 
ACTTCCGAGT CTGTAGGGGA AGGTCACCCA GATAAGATTT GTGACCAAAT CAGTGATGCT 
GTCCTTGATG CACACCTTCA ACAAGACCCT GATGCTAAAG TGGCTTGTGA AACTGTTGCT 
AAAACTGGAA TGATTCTTCT TGCTGGGGAA ATTACATCCA GAGCTGCCAT TGATTACCAG 
AAAGTGGTTC GTGAAGCCAT AAAGCACATT GGATATGATG ACTCTTCCAA AGGGTTTGAC 
TACAAGACTT GTAATGTGTT GGTTGCCTTG GAACAACAGT CACCAGATAT TGCCCAAGGT 
GTTCATCTTG ACCGGAATGA GGAAGATATT GGTGCAGGAG ACCAGGGTTT GATGTTTGGT 
TATGCCACTG ATGAAACTGA AGAGTGTATG CCTTTAACCA TTGTCTTAGC ACACAAGCTA 
AATGCCAAAT TGGCTGAACT ACGCCGCAAT GGTACATTGC CTTGGTTACG CCCAGATTCT 
AAAACTCAAG TGACTGTGCA ATATATGCAA GATCGGGGTG CTGTGCTTCC CATCAGAGTC 
CACACGATTG TTATATCTGT TCAGCACGAT GAAGAAGTTT GTCTTGATGA GATGAGGGAT 
GCTCTGAAGG AGAAAGTGAT CAAGGCTGTT GTACCTGCAA AATACCTTGA TGAGGATACA 
ATTTACCACC TACAGCCAAG TGGCAGATTT GTTATTGGTG GGCCTCAGGG TGATGCTGGC 
CTGACTGGCC GAAAAATCAT TGTGGATACT TATGGCGGTT GGGGAGCTCA TGGAGGAGGG 
GCCTTTTCAG GAAAGGATTA TACCAAAGTG GACCGTTCAG CTGCTTATGC TGCTCGTTGG 
GTGGCAAAAT CCCTTGTTAA AGGAGGTCTG TGCAGGAGGG TTCTTGTTCA GGTCTCTTAT 
GCTATTGGAG TTTCTCATCC ATTGTCGATC TCCATTTTCC ATTATGGCAC TTCTCAGAAG 
AGTGAGAGAG AGCTATTAGA AATTGTAAAG AAGAATTTTG ATCTTCGCCC TGGGGTCATT 
GTCAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350727.1
CDS	121..1209
Translation	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVR

Target ORF information:

RefSeq Version	NM_001363798.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus methionine adenosyltransferase II, alpha (Mat2a), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363798.1

ORF Insert Sequence:

ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC 
ACTTCCGAGT CTGTAGGGGA AGGTCACCCA GATAAGATTT GTGACCAAAT CAGTGATGCT 
GTCCTTGATG CACACCTTCA ACAAGACCCT GATGCTAAAG TGGCTTGTGA AACTGTTGCT 
AAAACTGGAA TGATTCTTCT TGCTGGGGAA ATTACATCCA GAGCTGCCAT TGATTACCAG 
AAAGTGGTTC GTGAAGCCAT AAAGCACATT GGATATGATG ACTCTTCCAA AGGGTTTGAC 
TACAAGACTT GTAATGTGTT GGTTGCCTTG GAACAACAGT CACCAGATAT TGCCCAAGGT 
GTTCATCTTG ACCGGAATGA GGAAGATATT GGTGCAGGAG ACCAGGGTTT GATGTTTGGT 
TATGCCACTG ATGAAACTGA AGAGTGTATG CCTTTAACCA TTGTCTTAGC ACACAAGCTA 
AATGCCAAAT TGGCTGAACT ACGCCGCAAT GGTACATTGC CTTGGTTACG CCCAGATTCT 
AAAACTCAAG TGACTGTGCA ATATATGCAA GATCGGGGTG CTGTGCTTCC CATCAGAGTC 
CACACGATTG TTATATCTGT TCAGCACGAT GAAGAAGTTT GTCTTGATGA GATGAGGGAT 
GCTCTGAAGG AGAAAGTGAT CAAGGCTGTT GTACCTGCAA AATACCTTGA TGAGGATACA 
ATTTACCACC TACAGCCAAG TGGCAGATTT GTTATTGGTG GGCCTCAGGG TGATGCTGGC 
CTGACTGGCC GAAAAATCAT TGTGGATACT TATGGCGGTT GGGGAGCTCA TGGAGGAGGG 
GCCTTTTCAG GAAAGGATTA TACCAAAGTG GACCGTTCAG CTGCTTATGC TGCTCGTTGG 
GTGGCAAAAT CCCTTGTTAA AGGAGGTCTG TGCAGGAGGG TTCTTGTTCA GGTCTCTTAT 
GCTATTGGAG TTTCTCATCC ATTGTCGATC TCCATTTTCC ATTATGGCAC TTCTCAGAAG 
AGTGAGAGAG AGCTATTAGA AATTGTAAAG AAGAATTTTG ATCTTCGCCC TGGGGTCATT 
GTCAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mat2a ( NM_145569.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_663544.1 Mus musculus methionine adenosyltransferase II, alpha (Mat2a), transcript variant 1, mRNA.

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CloneID	OMu21855
Clone ID Related Accession (Same CDS sequence)	NM_145569.4 , NM_145569.5
Accession Version	NM_145569.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Mus musculus(house mouse)
Product	S-adenosylmethionine synthase isoform type-2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC116115.11. On Jun 3, 2018 this sequence version replaced NM_145569.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK034757.1, AK144189.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC 
ACTTCCGAGT CTGTAGGGGA AGGTCACCCA GATAAGATTT GTGACCAAAT CAGTGATGCT 
GTCCTTGATG CACACCTTCA ACAAGACCCT GATGCTAAAG TGGCTTGTGA AACTGTTGCT 
AAAACTGGAA TGATTCTTCT TGCTGGGGAA ATTACATCCA GAGCTGCCAT TGATTACCAG 
AAAGTGGTTC GTGAAGCCAT AAAGCACATT GGATATGATG ACTCTTCCAA AGGGTTTGAC 
TACAAGACTT GTAATGTGTT GGTTGCCTTG GAACAACAGT CACCAGATAT TGCCCAAGGT 
GTTCATCTTG ACCGGAATGA GGAAGATATT GGTGCAGGAG ACCAGGGTTT GATGTTTGGT 
TATGCCACTG ATGAAACTGA AGAGTGTATG CCTTTAACCA TTGTCTTAGC ACACAAGCTA 
AATGCCAAAT TGGCTGAACT ACGCCGCAAT GGTACATTGC CTTGGTTACG CCCAGATTCT 
AAAACTCAAG TGACTGTGCA ATATATGCAA GATCGGGGTG CTGTGCTTCC CATCAGAGTC 
CACACGATTG TTATATCTGT TCAGCACGAT GAAGAAGTTT GTCTTGATGA GATGAGGGAT 
GCTCTGAAGG AGAAAGTGAT CAAGGCTGTT GTACCTGCAA AATACCTTGA TGAGGATACA 
ATTTACCACC TACAGCCAAG TGGCAGATTT GTTATTGGTG GGCCTCAGGG TGATGCTGGC 
CTGACTGGCC GAAAAATCAT TGTGGATACT TATGGCGGTT GGGGAGCTCA TGGAGGAGGG 
GCCTTTTCAG GAAAGGATTA TACCAAAGTG GACCGTTCAG CTGCTTATGC TGCTCGTTGG 
GTGGCAAAAT CCCTTGTTAA AGGAGGTCTG TGCAGGAGGG TTCTTGTTCA GGTCTCTTAT 
GCTATTGGAG TTTCTCATCC ATTGTCGATC TCCATTTTCC ATTATGGCAC TTCTCAGAAG 
AGTGAGAGAG AGCTATTAGA AATTGTAAAG AAGAATTTTG ATCTTCGCCC TGGGGTCATT 
GTCAGGGATC TGGATCTGAA GAAGCCAATT TATCAGAGGA CTGCAGCCTA TGGCCACTTT 
GGTAGGGACA GCTTCCCATG GGAAGTGCCC AAAAAGCTTA AATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663544.1
CDS	121..1308
Translation	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY

Target ORF information:

RefSeq Version	NM_145569.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus methionine adenosyltransferase II, alpha (Mat2a), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145569.5

ORF Insert Sequence:

ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC 
ACTTCCGAGT CTGTAGGGGA AGGTCACCCA GATAAGATTT GTGACCAAAT CAGTGATGCT 
GTCCTTGATG CACACCTTCA ACAAGACCCT GATGCTAAAG TGGCTTGTGA AACTGTTGCT 
AAAACTGGAA TGATTCTTCT TGCTGGGGAA ATTACATCCA GAGCTGCCAT TGATTACCAG 
AAAGTGGTTC GTGAAGCCAT AAAGCACATT GGATATGATG ACTCTTCCAA AGGGTTTGAC 
TACAAGACTT GTAATGTGTT GGTTGCCTTG GAACAACAGT CACCAGATAT TGCCCAAGGT 
GTTCATCTTG ACCGGAATGA GGAAGATATT GGTGCAGGAG ACCAGGGTTT GATGTTTGGT 
TATGCCACTG ATGAAACTGA AGAGTGTATG CCTTTAACCA TTGTCTTAGC ACACAAGCTA 
AATGCCAAAT TGGCTGAACT ACGCCGCAAT GGTACATTGC CTTGGTTACG CCCAGATTCT 
AAAACTCAAG TGACTGTGCA ATATATGCAA GATCGGGGTG CTGTGCTTCC CATCAGAGTC 
CACACGATTG TTATATCTGT TCAGCACGAT GAAGAAGTTT GTCTTGATGA GATGAGGGAT 
GCTCTGAAGG AGAAAGTGAT CAAGGCTGTT GTACCTGCAA AATACCTTGA TGAGGATACA 
ATTTACCACC TACAGCCAAG TGGCAGATTT GTTATTGGTG GGCCTCAGGG TGATGCTGGC 
CTGACTGGCC GAAAAATCAT TGTGGATACT TATGGCGGTT GGGGAGCTCA TGGAGGAGGG 
GCCTTTTCAG GAAAGGATTA TACCAAAGTG GACCGTTCAG CTGCTTATGC TGCTCGTTGG 
GTGGCAAAAT CCCTTGTTAA AGGAGGTCTG TGCAGGAGGG TTCTTGTTCA GGTCTCTTAT 
GCTATTGGAG TTTCTCATCC ATTGTCGATC TCCATTTTCC ATTATGGCAC TTCTCAGAAG 
AGTGAGAGAG AGCTATTAGA AATTGTAAAG AAGAATTTTG ATCTTCGCCC TGGGGTCATT 
GTCAGGGATC TGGATCTGAA GAAGCCAATT TATCAGAGGA CTGCAGCCTA TGGCCACTTT 
GGTAGGGACA GCTTCCCATG GGAAGTGCCC AAAAAGCTTA AATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
Medicina (Kaunas, Lithuania)55(6)(2019 Jun)
Pascale RM,Peitta G,Simile MM,Feo F

Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition†.
Biology of reproduction100(3)601-617(2019 03)
Sun H,Kang J,Su J,Zhang J,Zhang L,Liu X,Zhang J,Wang F,Lu Z,Xing X,Chen H,Zhang Y

A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
Molecular carcinogenesis57(9)1201-1212(2018 09)
Wang R,Jin Y,Yao XH,Fan W,Zhang J,Cao Y,Li J

Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.
The EMBO journal36(21)3175-3193(2017 11)
Tang S,Fang Y,Huang G,Xu X,Padilla-Banks E,Fan W,Xu Q,Sanderson SM,Foley JF,Dowdy S,McBurney MW,Fargo DC,Williams CJ,Locasale JW,Guan Z,Li X

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bućan M,Murray SA

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Mat2a cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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