| Gene Symbol | Nmrk1 |
| Entrez Gene ID | 225994 |
| Full Name | nicotinamide riboside kinase 1 |
| Synonyms | AA408380,D630020N23Rik,Nrk1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Nmrk1 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Nmrk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nmrk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu73266 Clone ID Related Accession (Same CDS sequence) XM_011247225.2 Accession Version XM_011247225.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 402bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1565107200000 Organism Mus musculus(house mouse) Product nicotinamide riboside kinase 1 isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000085.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011247225.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361ATGGAAAAAA TGATGTCAGC AGTTTCCTGT TGGATGGAAA ACCCAGGAAG CTCTGCGGGA
CCAGCAGCCT TGGAAAGTGC TCAAGGGGTT CCCATTTTAA TTATTGAAGG TTTCCTTCTC
TTTAATTATA AGCCTCTGGA CACCATATGG AACAGAAGTT ACTTCCTGAC CGTTCCATAT
GAAGAATGTA AGAGGAGAAG GAGTACCAGA GTATATGAGC CTCCAGACCC TCCAGGGTAC
TTCGATGGCC ACGTGTGGCC CATGTACCTA AAGCACAGAC AGGAAATGAG CTCCATCACC
TGGGACATTG TTTACCTGGA TGGAACAAGG TCTGAAGAGG ACCTCTTCTC TCAGGTGTAT
GAAGATGTCA AGCAGGAACT AGAGAAGCAA AATGGTTTGT GAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_011245527.1 CDS 640..1041 Translation 
Target ORF information:
RefSeq Version XM_011247225.2 Organism Mus musculus(house mouse) Definition Mus musculus nicotinamide riboside kinase 1 (Nmrk1), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
XM_011247225.2
ORF Insert Sequence:
1
61
121
181
241
301
361ATGGAAAAAA TGATGTCAGC AGTTTCCTGT TGGATGGAAA ACCCAGGAAG CTCTGCGGGA
CCAGCAGCCT TGGAAAGTGC TCAAGGGGTT CCCATTTTAA TTATTGAAGG TTTCCTTCTC
TTTAATTATA AGCCTCTGGA CACCATATGG AACAGAAGTT ACTTCCTGAC CGTTCCATAT
GAAGAATGTA AGAGGAGAAG GAGTACCAGA GTATATGAGC CTCCAGACCC TCCAGGGTAC
TTCGATGGCC ACGTGTGGCC CATGTACCTA AAGCACAGAC AGGAAATGAG CTCCATCACC
TGGGACATTG TTTACCTGGA TGGAACAAGG TCTGAAGAGG ACCTCTTCTC TCAGGTGTAT
GAAGATGTCA AGCAGGAACT AGAGAAGCAA AATGGTTTGT GAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu11687 Clone ID Related Accession (Same CDS sequence) NM_145497.2 Accession Version NM_145497.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 588bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577116800000 Organism Mus musculus(house mouse) Product nicotinamide riboside kinase 1 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC134906.3. On Mar 21, 2007 this sequence version replaced NM_145497.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC016495.1, AK050579.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541ATGAAGAGAT TTGTCATTGG AATTGGTGGT GTGACAAACG GAGGGAAGAC GACACTGGCT
AAGAGCTTGC AGAAGCACCT TCCCAACTGC AGCGTCATAT CTCAGGATGA CTTCTTCAAG
CCAGAGTCTG AGATAGACAT AGATGAAAAT GGTTTTTTGC AGTATGATGT GCTTGAAGCG
CTAAATATGG AAAAAATGAT GTCAGCAGTT TCCTGTTGGA TGGAAAACCC AGGAAGCTCT
GCGGGACCAG CAGCCTTGGA AAGTGCTCAA GGGGTTCCCA TTTTAATTAT TGAAGGTTTC
CTTCTCTTTA ATTATAAGCC TCTGGACACC ATATGGAACA GAAGTTACTT CCTGACCGTT
CCATATGAAG AATGTAAGAG GAGAAGGAGT ACCAGAGTAT ATGAGCCTCC AGACCCTCCA
GGGTACTTCG ATGGCCACGT GTGGCCCATG TACCTAAAGC ACAGACAGGA AATGAGCTCC
ATCACCTGGG ACATTGTTTA CCTGGATGGA ACAAGGTCTG AAGAGGACCT CTTCTCTCAG
GTGTATGAAG ATGTCAAGCA GGAACTAGAG AAGCAAAATG GTTTGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_663472.1 CDS 102..689 Translation
Target ORF information:
RefSeq Version NM_145497.2 Organism Mus musculus(house mouse) Definition Mus musculus nicotinamide riboside kinase 1 (Nmrk1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_145497.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541ATGAAGAGAT TTGTCATTGG AATTGGTGGT GTGACAAACG GAGGGAAGAC GACACTGGCT
AAGAGCTTGC AGAAGCACCT TCCCAACTGC AGCGTCATAT CTCAGGATGA CTTCTTCAAG
CCAGAGTCTG AGATAGACAT AGATGAAAAT GGTTTTTTGC AGTATGATGT GCTTGAAGCG
CTAAATATGG AAAAAATGAT GTCAGCAGTT TCCTGTTGGA TGGAAAACCC AGGAAGCTCT
GCGGGACCAG CAGCCTTGGA AAGTGCTCAA GGGGTTCCCA TTTTAATTAT TGAAGGTTTC
CTTCTCTTTA ATTATAAGCC TCTGGACACC ATATGGAACA GAAGTTACTT CCTGACCGTT
CCATATGAAG AATGTAAGAG GAGAAGGAGT ACCAGAGTAT ATGAGCCTCC AGACCCTCCA
GGGTACTTCG ATGGCCACGT GTGGCCCATG TACCTAAAGC ACAGACAGGA AATGAGCTCC
ATCACCTGGG ACATTGTTTA CCTGGATGGA ACAAGGTCTG AAGAGGACCT CTTCTCTCAG
GTGTATGAAG ATGTCAAGCA GGAACTAGAG AAGCAAAATG GTTTGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Overexpression of NRK1 ameliorates diet- and age-induced hepatic steatosis and insulin resistance.
Biochemical and biophysical research communications500(2)476-483(2018 06)
Fan R,Cui J,Ren F,Wang Q,Huang Y,Zhao B,Wei L,Qian X,Xiong X
Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.
Molecular metabolism6(8)819-832(2017 08)
Fletcher RS,Ratajczak J,Doig CL,Oakey LA,Callingham R,Da Silva Xavier G,Garten A,Elhassan YS,Redpath P,Migaud ME,Philp A,Brenner C,Canto C,Lavery GG
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.
Nature communications713103(2016 10)
Ratajczak J,Joffraud M,Trammell SA,Ras R,Canela N,Boutant M,Kulkarni SS,Rodrigues M,Redpath P,Migaud ME,Auwerx J,Yanes O,Brenner C,Cantó C
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
Cell129(3)473-84(2007 May)
Belenky P,Racette FG,Bogan KL,McClure JM,Smith JS,Brenner C
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