| Gene Symbol | Tubb5 |
| Entrez Gene ID | 22154 |
| Full Name | tubulin, beta 5 class I |
| Synonyms | AA408537,AI596182,B130022C14Rik,M(beta)5 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Tubb5 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Tubb5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tubb5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu23277 Clone ID Related Accession (Same CDS sequence) NM_011655.5 Accession Version NM_011655.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1335bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1567353600000 Organism Mus musculus(house mouse) Product tubulin beta-5 chain Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY111488.1, AK146567.1 and CR974451.9. On Apr 18, 2009 this sequence version replaced NM_011655.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146567.1, AK169210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321ATGAGGGAAA TCGTGCACAT CCAGGCCGGA CAGTGTGGCA ACCAGATCGG TGCTAAGTTC
TGGGAGGTGA TAAGCGATGA ACATGGCATC GACCCCACCG GTACCTACCA CGGTGACAGC
GACCTGCAGC TGGACCGAAT CTCTGTGTAC TATAATGAAG CCACAGGTGG CAAGTATGTC
CCTCGAGCTA TCTTGGTGGA TCTAGAACCT GGGACTATGG ACTCCGTTCG CTCAGGTCCT
TTTGGCCAGA TCTTCAGACC AGACAACTTC GTTTTCGGTC AGTCTGGGGC AGGCAACAAC
TGGGCTAAAG GCCACTACAC AGAGGGAGCT GAGTTGGTTG ACTCTGTCTT GGATGTGGTG
CGGAAGGAGG CGGAGAGCTG TGATTGCCTG CAAGGCTTTC AGCTGACCCA CTCACTGGGT
GGAGGCACTG GCTCTGGCAT GGGCACCCTG CTCATCAGCA AGATCCGGGA AGAATATCCT
GACCGTATCA TGAATACCTT CAGTGTGGTG CCCTCGCCCA AAGTGTCTGA TACCGTGGTC
GAGCCCTACA ATGCCACCCT GTCTGTCCAT CAGTTGGTTG AGAACACGGA TGAGACCTAC
TGCATCGACA ACGAGGCCCT CTACGACATC TGCTTCCGTA CCCTCAAGCT CACCACGCCA
ACCTACGGAG ACCTGAACCA TCTCGTCTCG GCCACCATGA GCGGCGTCAC CACCTGCCTC
CGTTTCCCGG GCCAGCTTAA TGCTGACCTT CGAAAGCTGG CTGTCAACAT GGTGCCATTC
CCACGTCTCC ACTTCTTCAT GCCTGGCTTT GCCCCTCTCA CCAGCCGTGG AAGCCAGCAG
TACCGGGCCC TCACTGTGCC TGAACTTACC CAGCAGGTCT TCGATGCCAA GAACATGATG
GCCGCCTGCG ACCCGCGCCA CGGCCGGTAC CTCACAGTTG CCGCCGTCTT CCGTGGACGG
ATGTCCATGA AGGAGGTGGA TGAGCAGATG CTCAACGTGC AGAACAAGAA TAGCAGCTAC
TTCGTGGAAT GGATCCCCAA CAATGTCAAG ACAGCTGTCT GTGACATCCC ACCGCGTGGC
CTCAAGATGG CAGTCACCTT CATTGGAAAC AGCACAGCCA TCCAGGAGCT CTTCAAGCGC
ATCTCTGAGC AGTTTACGGC TATGTTCCGC CGGAAGGCTT TCCTCCACTG GTATACGGGT
GAGGGCATGG ACGAGATGGA GTTCACCGAA GCTGAGAGCA ACATGAACGA CCTCGTCTCT
GAGTACCAGC AGTACCAGGA TGCCACCGCG GAAGAGGAAG AGGATTTCGG AGAGGAGGCA
GAAGAGGAGG CCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_035785.1 CDS 249..1583 Translation 
Target ORF information:
RefSeq Version NM_011655.5 Organism Mus musculus(house mouse) Definition Mus musculus tubulin, beta 5 class I (Tubb5), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_011655.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321ATGAGGGAAA TCGTGCACAT CCAGGCCGGA CAGTGTGGCA ACCAGATCGG TGCTAAGTTC
TGGGAGGTGA TAAGCGATGA ACATGGCATC GACCCCACCG GTACCTACCA CGGTGACAGC
GACCTGCAGC TGGACCGAAT CTCTGTGTAC TATAATGAAG CCACAGGTGG CAAGTATGTC
CCTCGAGCTA TCTTGGTGGA TCTAGAACCT GGGACTATGG ACTCCGTTCG CTCAGGTCCT
TTTGGCCAGA TCTTCAGACC AGACAACTTC GTTTTCGGTC AGTCTGGGGC AGGCAACAAC
TGGGCTAAAG GCCACTACAC AGAGGGAGCT GAGTTGGTTG ACTCTGTCTT GGATGTGGTG
CGGAAGGAGG CGGAGAGCTG TGATTGCCTG CAAGGCTTTC AGCTGACCCA CTCACTGGGT
GGAGGCACTG GCTCTGGCAT GGGCACCCTG CTCATCAGCA AGATCCGGGA AGAATATCCT
GACCGTATCA TGAATACCTT CAGTGTGGTG CCCTCGCCCA AAGTGTCTGA TACCGTGGTC
GAGCCCTACA ATGCCACCCT GTCTGTCCAT CAGTTGGTTG AGAACACGGA TGAGACCTAC
TGCATCGACA ACGAGGCCCT CTACGACATC TGCTTCCGTA CCCTCAAGCT CACCACGCCA
ACCTACGGAG ACCTGAACCA TCTCGTCTCG GCCACCATGA GCGGCGTCAC CACCTGCCTC
CGTTTCCCGG GCCAGCTTAA TGCTGACCTT CGAAAGCTGG CTGTCAACAT GGTGCCATTC
CCACGTCTCC ACTTCTTCAT GCCTGGCTTT GCCCCTCTCA CCAGCCGTGG AAGCCAGCAG
TACCGGGCCC TCACTGTGCC TGAACTTACC CAGCAGGTCT TCGATGCCAA GAACATGATG
GCCGCCTGCG ACCCGCGCCA CGGCCGGTAC CTCACAGTTG CCGCCGTCTT CCGTGGACGG
ATGTCCATGA AGGAGGTGGA TGAGCAGATG CTCAACGTGC AGAACAAGAA TAGCAGCTAC
TTCGTGGAAT GGATCCCCAA CAATGTCAAG ACAGCTGTCT GTGACATCCC ACCGCGTGGC
CTCAAGATGG CAGTCACCTT CATTGGAAAC AGCACAGCCA TCCAGGAGCT CTTCAAGCGC
ATCTCTGAGC AGTTTACGGC TATGTTCCGC CGGAAGGCTT TCCTCCACTG GTATACGGGT
GAGGGCATGG ACGAGATGGA GTTCACCGAA GCTGAGAGCA ACATGAACGA CCTCGTCTCT
GAGTACCAGC AGTACCAGGA TGCCACCGCG GAAGAGGAAG AGGATTTCGG AGAGGAGGCA
GAAGAGGAGG CCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.
Neuron100(6)1354-1368.e5(2018 12)
Tripathy R,Leca I,van Dijk T,Weiss J,van Bon BW,Sergaki MC,Gstrein T,Breuss M,Tian G,Bahi-Buisson N,Paciorkowski AR,Pagnamenta AT,Wenninger-Weinzierl A,Martinez-Reza MF,Landler L,Lise S,Taylor JC,Terrone G,Vitiello G,Del Giudice E,Brunetti-Pierri N,D'Amico A,Reymond A,Voisin N,Bernstein JA,Farrelly E,Kini U,Leonard TA,Valence S,Burglen L,Armstrong L,Hiatt SM,Cooper GM,Aldinger KA,Dobyns WB,Mirzaa G,Pierson TM,Baas F,Chelly J,Cowan NJ,Keays DA
Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration.
Cell reports24(7)1865-1879.e9(2018 08)
Latremoliere A,Cheng L,DeLisle M,Wu C,Chew S,Hutchinson EB,Sheridan A,Alexandre C,Latremoliere F,Sheu SH,Golidy S,Omura T,Huebner EA,Fan Y,Whitman MC,Nguyen E,Hermawan C,Pierpaoli C,Tischfield MA,Woolf CJ,Engle EC
Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.
Behavioural brain research32347-55(2017 04)
Breuss MW,Hansen AH,Landler L,Keays DA
Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.
Development (Cambridge, England)143(7)1126-33(2016 Apr)
Breuss M,Fritz T,Gstrein T,Chan K,Ushakova L,Yu N,Vonberg FW,Werner B,Elling U,Keays DA
TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons.
Human molecular genetics23(19)5147-58(2014 Oct)
Ngo L,Haas M,Qu Z,Li SS,Zenker J,Teng KS,Gunnersen JM,Breuss M,Habgood M,Keays DA,Heng JI
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