Ccl2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccl2
Entrez Gene ID	20296
Full Name	chemokine (C-C motif) ligand 2
Synonyms	AI323594,HC11,JE,MCAF,MCP-1,MCP1,SMC-CF,Scya2,Sigje
General protein information	Preferred Names chemokine (C-C motif) ligand 2 Names C-C motif chemokine 2 monocyte chemoattractant protein 1 monocyte chemotactic protein 1 platelet-derived growth factor-inducible protein JE small-inducible cytokine A2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 C\|11 49.82 cM
Summary	This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_011333.3	NP_035463.1	C-C motif chemokine 2 precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	CCL13	XP_001113462.1
Homo sapiens (human)	CCL13	NP_005399.1
Pan troglodytes (chimpanzee)	CCL13	XP_001174525.3
Mus musculus (house mouse)	Ccl2	NP_035463.1
Rattus norvegicus (Norway rat)	Ccl2	NP_113718.1

Gene Ontology
Bibliography

Related articles in PubMed

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.
Zhang X, Zhang H, Xu C, Li X, Li M, Wu X, Pu W, Zhou B, Wang H, Li D, Ding Q, Ying H, Wang H, Zhang H
Nature communications10(1)4158(2019 09)

Involvement of multiple transcription factors in regulation of IL-β-induced MCP-1 expression in alveolar type II epithelial cells.
Yan C, Li B, Liu X, Deng C, Cai R, Shen Y, Tang H
Molecular immunology11195-105(2019 07)

Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.
Lee KM, Wilson GJ, Pingen M, Fukuoka A, Hansell CAH, Bartolini R, Medina-Ruiz L, Graham GJ
PLoS biology17(5)e3000287(2019 05)

Adipose-specific Monocyte Chemotactic Protein-1 Deficiency Reduces Pulmonary Metastasis of Lewis Lung Carcinoma in Mice.
Sundaram S, Yan L
Anticancer research39(4)1729-1738(2019 Apr)

Mechanical stretch induces hair regeneration through the alternative activation of macrophages.
Chu SY, Chou CH, Huang HD, Yen MH, Hong HC, Chao PH, Wang YH, Chen PY, Nian SX, Chen YR, Liou LY, Liu YC, Chen HM, Lin FM, Chang YT, Chen CC, Lee OK
Nature communications10(1)1524(2019 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ccl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19558	NM_011333.3 Latest version!	Mus musculus chemokine (C-C motif) ligand 2 (Ccl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccl2 ( NM_011333.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035463.1 Mus musculus chemokine (C-C motif) ligand 2 (Ccl2), mRNA.

Price & Availability↑

CloneID	OMu19558
Clone ID Related Accession (Same CDS sequence)	NM_011333.3
Accession Version	NM_011333.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Mus musculus(house mouse)
Product	C-C motif chemokine 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK150937.1. On Apr 5, 2007 this sequence version replaced NM_011333.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK150937.1, AK153520.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGTCC CTGTCATGCT TCTGGGCCTG CTGTTCACAG TTGCCGGCTG GAGCATCCAC 
GTGTTGGCTC AGCCAGATGC AGTTAACGCC CCACTCACCT GCTGCTACTC ATTCACCAGC 
AAGATGATCC CAATGAGTAG GCTGGAGAGC TACAAGAGGA TCACCAGCAG CAGGTGTCCC 
AAAGAAGCTG TAGTTTTTGT CACCAAGCTC AAGAGAGAGG TCTGTGCTGA CCCCAAGAAG 
GAATGGGTCC AGACATACAT TAAAAACCTG GATCGGAACC AAATGAGATC AGAACCTACA 
ACTTTATTTA AAACTGCATC TGCCCTAAGG TCTTCAGCAC CTTTGAATGT GAAGTTGACC 
CGTAAATCTG AAGCTAATGC ATCCACTACC TTTTCCACAA CCACCTCAAG CACTTCTGTA 
GGAGTGACCA GTGTGACAGT GAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035463.1
CDS	86..532
Translation	MQVPVMLLGLLFTVAGWSIHVLAQPDAVNAPLTCCYSFTSKMIPMSRLESYKRITSSRCPKEAVVFVTKLKREVCADPKKEWVQTYIKNLDRNQMRSEPTTLFKTASALRSSAPLNVKLTRKSEANASTTFSTTTSSTSVGVTSVTVN

Target ORF information:

RefSeq Version	NM_011333.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-C motif) ligand 2 (Ccl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011333.3

ORF Insert Sequence:

ATGCAGGTCC CTGTCATGCT TCTGGGCCTG CTGTTCACAG TTGCCGGCTG GAGCATCCAC 
GTGTTGGCTC AGCCAGATGC AGTTAACGCC CCACTCACCT GCTGCTACTC ATTCACCAGC 
AAGATGATCC CAATGAGTAG GCTGGAGAGC TACAAGAGGA TCACCAGCAG CAGGTGTCCC 
AAAGAAGCTG TAGTTTTTGT CACCAAGCTC AAGAGAGAGG TCTGTGCTGA CCCCAAGAAG 
GAATGGGTCC AGACATACAT TAAAAACCTG GATCGGAACC AAATGAGATC AGAACCTACA 
ACTTTATTTA AAACTGCATC TGCCCTAAGG TCTTCAGCAC CTTTGAATGT GAAGTTGACC 
CGTAAATCTG AAGCTAATGC ATCCACTACC TTTTCCACAA CCACCTCAAG CACTTCTGTA 
GGAGTGACCA GTGTGACAGT GAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.
Nature communications10(1)4158(2019 09)
Zhang X,Zhang H,Xu C,Li X,Li M,Wu X,Pu W,Zhou B,Wang H,Li D,Ding Q,Ying H,Wang H,Zhang H

Involvement of multiple transcription factors in regulation of IL-β-induced MCP-1 expression in alveolar type II epithelial cells.
Molecular immunology11195-105(2019 07)
Yan C,Li B,Liu X,Deng C,Cai R,Shen Y,Tang H

Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.
PLoS biology17(5)e3000287(2019 05)
Lee KM,Wilson GJ,Pingen M,Fukuoka A,Hansell CAH,Bartolini R,Medina-Ruiz L,Graham GJ

Adipose-specific Monocyte Chemotactic Protein-1 Deficiency Reduces Pulmonary Metastasis of Lewis Lung Carcinoma in Mice.
Anticancer research39(4)1729-1738(2019 Apr)
Sundaram S,Yan L

Mechanical stretch induces hair regeneration through the alternative activation of macrophages.
Nature communications10(1)1524(2019 04)
Chu SY,Chou CH,Huang HD,Yen MH,Hong HC,Chao PH,Wang YH,Chen PY,Nian SX,Chen YR,Liou LY,Liu YC,Chen HM,Lin FM,Chang YT,Chen CC,Lee OK

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Ccl2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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