Prodh cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prodh
Entrez Gene ID	19125
Full Name	proline dehydrogenase
Synonyms	Pro-1,Pro1,Ym24d07
General protein information	Preferred Names proline dehydrogenase Names proline dehydrogenase 1, mitochondrial proline dehydrogenase, mitochondrial proline oxidase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 A3\|16 11.19 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006521863.2	XP_006521926.1	proline dehydrogenase 1, mitochondrial isoform X1
NM_011172.2	NP_035302.2	proline dehydrogenase 1, mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	PRODH	NP_057419.4
Homo sapiens (human)	LOC102724788	XP_006724998.1
Xenopus tropicalis (tropical clawed frog)	LOC100494891	XP_002932121.2
Danio rerio (zebrafish)	LOC100537991	XP_003198647.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003860	XP_310420.5
Macaca mulatta (Rhesus monkey)	LOC695506	XP_001082216.1
Canis lupus familiaris (dog)	PRODH	XP_005636623.1
Bos taurus (cattle)	PRODH	NP_001068653.1
Mus musculus (house mouse)	Prodh	NP_035302.2
Rattus norvegicus (Norway rat)	Prodh	NP_001129250.1
Drosophila melanogaster (fruit fly)	slgA	NP_996527.1
Caenorhabditis elegans (roundworm)	CELE_B0513.5	NP_502669.2
Pan troglodytes (chimpanzee)	PRODH	XP_525525.2
Gallus gallus (chicken)	PRODH	XP_001234062.3

Gene Ontology
Bibliography

Related articles in PubMed

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.
Olivares O, Mayers JR, Gouirand V, Torrence ME, Gicquel T, Borge L, Lac S, Roques J, Lavaut MN, Berthezène P, Rubis M, Secq V, Garcia S, Moutardier V, Lombardo D, Iovanna JL, Tomasini R, Guillaumond F, Vander Heiden MG, Vasseur S
Nature communications816031(2017 07)

Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.
Crabtree GW, Park AJ, Gordon JA, Gogos JA
Cell reports17(2)570-582(2016 10)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA
Nature537(7621)508-514(2016 09)

Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate.
Hancock CN, Liu W, Alvord WG, Phang JM
Amino acids48(3)859-872(2016 Mar)

Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.
Paronett EM, Meechan DW, Karpinski BA, LaMantia AS, Maynard TM
Cerebral cortex (New York, N.Y. : 1991)25(10)3977-93(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Prodh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prodh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15049	NM_011172.2 Latest version!	Mus musculus proline dehydrogenase (Prodh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu51932	XM_006521863.2 Latest version!	Mus musculus proline dehydrogenase (Prodh), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prodh ( NM_011172.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035302.2 Mus musculus proline dehydrogenase (Prodh), mRNA.

Price & Availability↑

CloneID	OMu15049
Clone ID Related Accession (Same CDS sequence)	NM_011172.2
Accession Version	NM_011172.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1800bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Mus musculus(house mouse)
Product	proline dehydrogenase 1, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY785647.1, AK144068.1, BB611875.1, AF120279.1 and AV225532.2. On Dec 2, 2006 this sequence version replaced NM_011172.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF120279.1, U80020.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCTCTCA AGCGCGTCTT CTTGCTGCGG TCGGTGGCAC CACGCGTCGC TGCCCTCTCA 
ACCAAACCGC AAGCCCAGGA ACAGCCTCCC GCGAGCCCTG AGGCTCTTCG GGGATGTGGG 
GCGGCCAAGG CTGTGCGGCC GCCTGTGCCA GCCGTGGACT TCACCAACAC GCAGGAGGCG 
TATCGCAGCC GGCGGAGTTG GGAGTTGGTG CGCAACCTGC TAGTGCTGCG GCTGTGTGCG 
TCGCCGGTGC TGCTAGCGCA CCACGAGCAG TTGTTCCAAG TTGCCAGGAA GCTTCTGGGG 
CAAAGGATGT TCGAGAGATT GATGAAGATG ACCTTCTATG GCCATTTTGT GGCTGGCGAG 
GACCAGGAGT CTATCAGGCC TCTGATCCGG CACAACAAAG CCTTTGGTGT TGGCTTTATC 
CTGGACTATG GAGTGGAGGA AGATCTGAGC CCTGAGGAGG CGGAGCGCAA AGAGATGGAG 
TCATGCACTT CTGAAGCAGA GAGAGATGGC AGTGGAGCAA ATAAGAGGGA GAAGCAGTAT 
CAGGTGCACC CCGCCTTTGG AGACCGCAGA GATGGTGTCA TCAGTGCCCG CACCTACTTC 
TATGCCAATG AAGCCAAGTG TGACAACTAC ATGGAGAACT TACTGCAGTG CATCAAGGCC 
TCAGGTGGAG CCAGTGATGG TGGTTTCTCA GCCATTAAGC TCACTGCACT GGGGAGACCA 
CAGTTTCTGC TGCAGTTCTC AGACGTGCTG ACCAGGTGGA GACGGTTCTT CCATCAAATG 
GCTGCAGAGC AGGGACAGGC TGGGCGTGCT GCTGTAGACA CAAAGCTGGA GGTGGCGGTG 
CTCCAGGACA GCATCGCAAA GATGGGCATC GCATCCAGGG CTGAGATTGA AGGGTGGTTC 
ACGCCAGAGA CGCTGGGAGT GTCTGGCACC GTGGACTTGC TGGACTGGAA CAGCCTCATT 
GACAGCAGGA CCCGGCTCTC CAGGCACTTG GTGGTCCCCA ATGTGCAGAC TGGCCAGCTG 
GAGCCCCTGC TGTCACGGTT CACTGAGGAG GAAGAGCAGC AGATGAAAAG GATGCTGCAG 
AGGATGGATG TACTGGCCAA GAAAGCAAAA GAGGCAGGTG TGCGCCTGAT GATTGATGCT 
GAGCAGAGCT ACTTCCAACC AGCCATCAGC CGCCTGACCC TGGAGATGCA GCGCAGGTTC 
AATGTGGATA AGCCGTTCAT CTTCAACACA TTCCAGTGCT ACCTCAAGGA TGCCTATGAC 
AATGTGACCT TGGATATGGA ACTGGCTCGC CGTGAGGGCT GGTGTTTTGG GGCCAAGCTG 
GTACGTGGTG CATACATGGC CCAAGAGCGT GTCAGGGCAG CAGAGATCGG TTATGAGGAC 
CCCATCAACC CTACATATGA AGCCACCAAT GCTATGTACC ACAGGTGCCT TAACTATGTT 
CTGGAGGAGC TGAAGCACAG CACCAAGGCA GAGGTGATGG TGGCTTCCCA CAACGAGGAC 
ACCGTGCACT TCACGTTGTG CAGGATGAAG GAGATAGGCC TGCATCCTGC TGATGGTCAG 
GTGTGCTTCG GACAGCTGCT GGGGATGTGT GACCAAATCA GCTTCCCACT AGGCCAGGCA 
GGCTTTCCTG TGTACAAGTA TGTGCCCTAT GGCCCTGTGA TGGAGGTACT CCCTTACCTG 
TCCCGCCGTG CCCTGGAGAA CAGCAGCATC ATGAAGGGTG CTCAGCGAGA GAGGCAGCTG 
CTATGGCAGG AGCTCCGCAG GCGGCTGCGC ACTGGCAGCC TCTTCCACCA TCCGGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035302.2
CDS	34..1833
Translation	MALKRVFLLRSVAPRVAALSTKPQAQEQPPASPEALRGCGAAKAVRPPVPAVDFTNTQEAYRSRRSWELVRNLLVLRLCASPVLLAHHEQLFQVARKLLGQRMFERLMKMTFYGHFVAGEDQESIRPLIRHNKAFGVGFILDYGVEEDLSPEEAERKEMESCTSEAERDGSGANKREKQYQVHPAFGDRRDGVISARTYFYANEAKCDNYMENLLQCIKASGGASDGGFSAIKLTALGRPQFLLQFSDVLTRWRRFFHQMAAEQGQAGRAAVDTKLEVAVLQDSIAKMGIASRAEIEGWFTPETLGVSGTVDLLDWNSLIDSRTRLSRHLVVPNVQTGQLEPLLSRFTEEEEQQMKRMLQRMDVLAKKAKEAGVRLMIDAEQSYFQPAISRLTLEMQRRFNVDKPFIFNTFQCYLKDAYDNVTLDMELARREGWCFGAKLVRGAYMAQERVRAAEIGYEDPINPTYEATNAMYHRCLNYVLEELKHSTKAEVMVASHNEDTVHFTLCRMKEIGLHPADGQVCFGQLLGMCDQISFPLGQAGFPVYKYVPYGPVMEVLPYLSRRALENSSIMKGAQRERQLLWQELRRRLRTGSLFHHPA

Target ORF information:

RefSeq Version	NM_011172.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus proline dehydrogenase (Prodh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011172.2

ORF Insert Sequence:

ATGGCTCTCA AGCGCGTCTT CTTGCTGCGG TCGGTGGCAC CACGCGTCGC TGCCCTCTCA 
ACCAAACCGC AAGCCCAGGA ACAGCCTCCC GCGAGCCCTG AGGCTCTTCG GGGATGTGGG 
GCGGCCAAGG CTGTGCGGCC GCCTGTGCCA GCCGTGGACT TCACCAACAC GCAGGAGGCG 
TATCGCAGCC GGCGGAGTTG GGAGTTGGTG CGCAACCTGC TAGTGCTGCG GCTGTGTGCG 
TCGCCGGTGC TGCTAGCGCA CCACGAGCAG TTGTTCCAAG TTGCCAGGAA GCTTCTGGGG 
CAAAGGATGT TCGAGAGATT GATGAAGATG ACCTTCTATG GCCATTTTGT GGCTGGCGAG 
GACCAGGAGT CTATCAGGCC TCTGATCCGG CACAACAAAG CCTTTGGTGT TGGCTTTATC 
CTGGACTATG GAGTGGAGGA AGATCTGAGC CCTGAGGAGG CGGAGCGCAA AGAGATGGAG 
TCATGCACTT CTGAAGCAGA GAGAGATGGC AGTGGAGCAA ATAAGAGGGA GAAGCAGTAT 
CAGGTGCACC CCGCCTTTGG AGACCGCAGA GATGGTGTCA TCAGTGCCCG CACCTACTTC 
TATGCCAATG AAGCCAAGTG TGACAACTAC ATGGAGAACT TACTGCAGTG CATCAAGGCC 
TCAGGTGGAG CCAGTGATGG TGGTTTCTCA GCCATTAAGC TCACTGCACT GGGGAGACCA 
CAGTTTCTGC TGCAGTTCTC AGACGTGCTG ACCAGGTGGA GACGGTTCTT CCATCAAATG 
GCTGCAGAGC AGGGACAGGC TGGGCGTGCT GCTGTAGACA CAAAGCTGGA GGTGGCGGTG 
CTCCAGGACA GCATCGCAAA GATGGGCATC GCATCCAGGG CTGAGATTGA AGGGTGGTTC 
ACGCCAGAGA CGCTGGGAGT GTCTGGCACC GTGGACTTGC TGGACTGGAA CAGCCTCATT 
GACAGCAGGA CCCGGCTCTC CAGGCACTTG GTGGTCCCCA ATGTGCAGAC TGGCCAGCTG 
GAGCCCCTGC TGTCACGGTT CACTGAGGAG GAAGAGCAGC AGATGAAAAG GATGCTGCAG 
AGGATGGATG TACTGGCCAA GAAAGCAAAA GAGGCAGGTG TGCGCCTGAT GATTGATGCT 
GAGCAGAGCT ACTTCCAACC AGCCATCAGC CGCCTGACCC TGGAGATGCA GCGCAGGTTC 
AATGTGGATA AGCCGTTCAT CTTCAACACA TTCCAGTGCT ACCTCAAGGA TGCCTATGAC 
AATGTGACCT TGGATATGGA ACTGGCTCGC CGTGAGGGCT GGTGTTTTGG GGCCAAGCTG 
GTACGTGGTG CATACATGGC CCAAGAGCGT GTCAGGGCAG CAGAGATCGG TTATGAGGAC 
CCCATCAACC CTACATATGA AGCCACCAAT GCTATGTACC ACAGGTGCCT TAACTATGTT 
CTGGAGGAGC TGAAGCACAG CACCAAGGCA GAGGTGATGG TGGCTTCCCA CAACGAGGAC 
ACCGTGCACT TCACGTTGTG CAGGATGAAG GAGATAGGCC TGCATCCTGC TGATGGTCAG 
GTGTGCTTCG GACAGCTGCT GGGGATGTGT GACCAAATCA GCTTCCCACT AGGCCAGGCA 
GGCTTTCCTG TGTACAAGTA TGTGCCCTAT GGCCCTGTGA TGGAGGTACT CCCTTACCTG 
TCCCGCCGTG CCCTGGAGAA CAGCAGCATC ATGAAGGGTG CTCAGCGAGA GAGGCAGCTG 
CTATGGCAGG AGCTCCGCAG GCGGCTGCGC ACTGGCAGCC TCTTCCACCA TCCGGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Prodh ( XM_006521863.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006521926.1 Mus musculus proline dehydrogenase (Prodh), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu51932
Clone ID Related Accession (Same CDS sequence)	XM_006521863.2
Accession Version	XM_006521863.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1596bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	proline dehydrogenase 1, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006521863.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAGCGG AGCCACTGGG TGGTAGGTGG GGCTTCCGGG AATGGGGCGT GATCGGGGCG 
TGGCCCCAGG GCGTGGCTAA CCCAGTGTAC TTAAGCCTCC TGAGCGCGTG TATCGGCTCC 
GCCATGGCTC TCAAGCGCGT CTTCTTGCTG CGGTCGGTGG CACCACGCGT CGCTGCCCTC 
TCAACCAAAC CGCAAGCCCA GGAACAGCCT CCCGCGAGCC CTGAGGCTCT TCGGGGATGT 
GGGGCGGCCA AGGCTGTGCG GCCGCCTGTG CCAGCCGTGG ACTTCACCAA CACGCAGGAG 
GCGTATCGCA GCCGGCGGAG TTGGGAGTTG GTGCGCAACC TGCTAGTGCT GCGGCTGTGT 
GCGTCGCCGG TGCTGCTAGC GCACCACGAG CAGTTGTTCC AAGTTGCCAG GAAGCTTCTG 
GGGCAAAGGA TGTTCGAGAG ATTGATGAAG ATGACCTTCT ATGGCCATTT TGTGGCTGGC 
GAGGACCAGG AGTCTATCAG GCCTCTGATC CGGCACAACA AAGCCTTTGG TGTTGGCTTT 
ATCCTGGACT ATGGAGTGGA GGAAGATCTG AGCCCTGAGG AGGCGGAGCG CAAAGAGATG 
GAGTCATGCA CTTCTGAAGC AGAGAGAGAT GGCAGTGGAG CAAATAAGAG GGAGAAGCAG 
TATCAGGTGC ACCCCGCCTT TGGAGACCGC AGAGATGGTG TCATCAGTGC CCGCACCTAC 
TTCTATGCCA ATGAAGCCAA GTGTGACAAC TACATGGAGA ACTTACTGCA GTGCATCAAG 
GCCTCAGGTG GAGCCAGTGA TGGTGGTTTC TCAGCCATTA AGCTCACTGC ACTGGGGAGA 
CCACAGTTTC TGCTGCAGTT CTCAGACGTG CTGACCAGGT GGAGACGGTT CTTCCATCAA 
ATGGCTGCAG AGCAGGGACA GGCTGGGCGT GCTGCTGTAG ACACAAAGCT GGAGGTGGCG 
GTGCTCCAGG ACAGCATCGC AAAGATGGGC ATCGCATCCA GGGCTGAGAT TGAAGGGTGG 
TTCACGCCAG AGACGCTGGG AGTGTCTGGC ACCGTGGACT TGCTGGACTG GAACAGCCTC 
ATTGACAGCA GGACCCGGCT CTCCAGGCAC TTGGTGGTCC CCAATGTGCA GACTGGCCAG 
CTGGAGCCCC TGCTGTCACG GTTCACTGAG GAGGAAGAGC AGCAGATGAA AAGGATGCTG 
CAGAGGATGG ATGTACTGGC CAAGAAAGCA AAAGAGGCAG GTGTGCGCCT GATGATTGAT 
GCTGAGCAGA GCTACTTCCA ACCAGCCATC AGCCGCCTGA CCCTGGAGAT GCAGCGCAGG 
TTCAATGTGG ATAAGCCGTT CATCTTCAAC ACATTCCAGT GCTACCTCAA GGATGCCTAT 
GACAATGTGA CCTTGGATAT GGAACTGGCT CGCCGTGAGG GCTGGTGTTT TGGGGCCAAG 
CTGGTACGTG GTGCATACAT GGCCCAAGAG CGTGTCAGGG CAGCAGAGAT CGGTTATGAG 
GACCCCATCA ACCCTACATA TGAAGCCACC AATGCTATGT ACCACAGAGC CAACAGGGGT 
TCACGTAGTG GTTGGCCTGG AGCCAAGCTT AGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006521926.1
CDS	4..1599
Translation	MGAEPLGGRWGFREWGVIGAWPQGVANPVYLSLLSACIGSAMALKRVFLLRSVAPRVAALSTKPQAQEQPPASPEALRGCGAAKAVRPPVPAVDFTNTQEAYRSRRSWELVRNLLVLRLCASPVLLAHHEQLFQVARKLLGQRMFERLMKMTFYGHFVAGEDQESIRPLIRHNKAFGVGFILDYGVEEDLSPEEAERKEMESCTSEAERDGSGANKREKQYQVHPAFGDRRDGVISARTYFYANEAKCDNYMENLLQCIKASGGASDGGFSAIKLTALGRPQFLLQFSDVLTRWRRFFHQMAAEQGQAGRAAVDTKLEVAVLQDSIAKMGIASRAEIEGWFTPETLGVSGTVDLLDWNSLIDSRTRLSRHLVVPNVQTGQLEPLLSRFTEEEEQQMKRMLQRMDVLAKKAKEAGVRLMIDAEQSYFQPAISRLTLEMQRRFNVDKPFIFNTFQCYLKDAYDNVTLDMELARREGWCFGAKLVRGAYMAQERVRAAEIGYEDPINPTYEATNAMYHRANRGSRSGWPGAKLR

Target ORF information:

RefSeq Version	XM_006521863.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus proline dehydrogenase (Prodh), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006521863.2

ORF Insert Sequence:

ATGGGAGCGG AGCCACTGGG TGGTAGGTGG GGCTTCCGGG AATGGGGCGT GATCGGGGCG 
TGGCCCCAGG GCGTGGCTAA CCCAGTGTAC TTAAGCCTCC TGAGCGCGTG TATCGGCTCC 
GCCATGGCTC TCAAGCGCGT CTTCTTGCTG CGGTCGGTGG CACCACGCGT CGCTGCCCTC 
TCAACCAAAC CGCAAGCCCA GGAACAGCCT CCCGCGAGCC CTGAGGCTCT TCGGGGATGT 
GGGGCGGCCA AGGCTGTGCG GCCGCCTGTG CCAGCCGTGG ACTTCACCAA CACGCAGGAG 
GCGTATCGCA GCCGGCGGAG TTGGGAGTTG GTGCGCAACC TGCTAGTGCT GCGGCTGTGT 
GCGTCGCCGG TGCTGCTAGC GCACCACGAG CAGTTGTTCC AAGTTGCCAG GAAGCTTCTG 
GGGCAAAGGA TGTTCGAGAG ATTGATGAAG ATGACCTTCT ATGGCCATTT TGTGGCTGGC 
GAGGACCAGG AGTCTATCAG GCCTCTGATC CGGCACAACA AAGCCTTTGG TGTTGGCTTT 
ATCCTGGACT ATGGAGTGGA GGAAGATCTG AGCCCTGAGG AGGCGGAGCG CAAAGAGATG 
GAGTCATGCA CTTCTGAAGC AGAGAGAGAT GGCAGTGGAG CAAATAAGAG GGAGAAGCAG 
TATCAGGTGC ACCCCGCCTT TGGAGACCGC AGAGATGGTG TCATCAGTGC CCGCACCTAC 
TTCTATGCCA ATGAAGCCAA GTGTGACAAC TACATGGAGA ACTTACTGCA GTGCATCAAG 
GCCTCAGGTG GAGCCAGTGA TGGTGGTTTC TCAGCCATTA AGCTCACTGC ACTGGGGAGA 
CCACAGTTTC TGCTGCAGTT CTCAGACGTG CTGACCAGGT GGAGACGGTT CTTCCATCAA 
ATGGCTGCAG AGCAGGGACA GGCTGGGCGT GCTGCTGTAG ACACAAAGCT GGAGGTGGCG 
GTGCTCCAGG ACAGCATCGC AAAGATGGGC ATCGCATCCA GGGCTGAGAT TGAAGGGTGG 
TTCACGCCAG AGACGCTGGG AGTGTCTGGC ACCGTGGACT TGCTGGACTG GAACAGCCTC 
ATTGACAGCA GGACCCGGCT CTCCAGGCAC TTGGTGGTCC CCAATGTGCA GACTGGCCAG 
CTGGAGCCCC TGCTGTCACG GTTCACTGAG GAGGAAGAGC AGCAGATGAA AAGGATGCTG 
CAGAGGATGG ATGTACTGGC CAAGAAAGCA AAAGAGGCAG GTGTGCGCCT GATGATTGAT 
GCTGAGCAGA GCTACTTCCA ACCAGCCATC AGCCGCCTGA CCCTGGAGAT GCAGCGCAGG 
TTCAATGTGG ATAAGCCGTT CATCTTCAAC ACATTCCAGT GCTACCTCAA GGATGCCTAT 
GACAATGTGA CCTTGGATAT GGAACTGGCT CGCCGTGAGG GCTGGTGTTT TGGGGCCAAG 
CTGGTACGTG GTGCATACAT GGCCCAAGAG CGTGTCAGGG CAGCAGAGAT CGGTTATGAG 
GACCCCATCA ACCCTACATA TGAAGCCACC AATGCTATGT ACCACAGAGC CAACAGGGGT 
TCACGTAGTG GTTGGCCTGG AGCCAAGCTT AGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.
Nature communications816031(2017 07)
Olivares O,Mayers JR,Gouirand V,Torrence ME,Gicquel T,Borge L,Lac S,Roques J,Lavaut MN,Berthezène P,Rubis M,Secq V,Garcia S,Moutardier V,Lombardo D,Iovanna JL,Tomasini R,Guillaumond F,Vander Heiden MG,Vasseur S

Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.
Cell reports17(2)570-582(2016 10)
Crabtree GW,Park AJ,Gordon JA,Gogos JA

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bućan M,Murray SA

Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate.
Amino acids48(3)859-872(2016 Mar)
Hancock CN,Liu W,Alvord WG,Phang JM

Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.
Cerebral cortex (New York, N.Y. : 1991)25(10)3977-93(2015 Oct)
Paronett EM,Meechan DW,Karpinski BA,LaMantia AS,Maynard TM

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Prodh cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

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