Pkp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pkp1
Entrez Gene ID	18772
Full Name	plakophilin 1
General protein information	Preferred Names plakophilin 1 Names plakophilin-1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 E4

mRNA and Protein(s)

mRNA	Protein	Name
NM_001313701.1	NP_001300630.1	plakophilin-1
NM_019645.3	NP_062619.1	plakophilin-1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Pkp1	NP_062619.1
Canis lupus familiaris (dog)	PKP1	XP_856621.1
Homo sapiens (human)	PKP1	NP_001005337.1
Macaca mulatta (Rhesus monkey)	PKP1	XP_002802045.1
Rattus norvegicus (Norway rat)	Pkp1	NP_001100651.1
Gallus gallus (chicken)	PKP1	XP_419240.3
Canis lupus familiaris (dog)	LOC100855871	XP_003639190.1
Pan troglodytes (chimpanzee)	PKP1	XP_003308733.1
Bos taurus (cattle)	PKP1	NP_776570.1
Danio rerio (zebrafish)	pkp1b	XP_001338299.2
Xenopus tropicalis (tropical clawed frog)	pkp1	XP_002932184.2

Gene Ontology
Bibliography

Related articles in PubMed

Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering.
Fuchs M, Foresti M, Radeva MY, Kugelmann D, Keil R, Hatzfeld M, Spindler V, Waschke J, Vielmuth F
Cellular and molecular life sciences : CMLS76(17)3465-3476(2019 Sep)

Coexpression network analysis identified that plakophilin 1 is associated with the metastasis in human melanoma.
Wang HZ, Wang F, Chen PF, Zhang M, Yu MX, Wang HL, Zhao Q, Liu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1111234-1242(2019 Mar)

RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.
Choi YJ, Laclef C, Yang N, Andreu-Cervera A, Lewis J, Mao X, Li L, Snedecor ER, Takemaru KI, Qin C, Schneider-Maunoury S, Shroyer KR, Hannun YA, Koch PJ, Clark RA, Payne AS, Kowalczyk AP, Chen J
PLoS genetics15(1)e1007914(2019 01)

Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation.
Urwyler-Rösselet C, Tanghe G, Leurs K, Gilbert B, De Rycke R, De Bruyne M, Lippens S, Bartunkova S, De Groote P, Niessen C, Haftek M, Vandenabeele P, Declercq W
The Journal of investigative dermatology138(6)1268-1278(2018 06)

p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.
Richardson R, Mitchell K, Hammond NL, Mollo MR, Kouwenhoven EN, Wyatt ND, Donaldson IJ, Zeef L, Burgis T, Blance R, van Heeringen SJ, Stunnenberg HG, Zhou H, Missero C, Romano RA, Sinha S, Dixon MJ, Dixon J
PLoS genetics13(6)e1006828(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pkp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pkp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11243	NM_001313701.1 Latest version!	Mus musculus plakophilin 1 (Pkp1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$391.30 $559.00
OMu11243	NM_019645.3 Latest version!	Mus musculus plakophilin 1 (Pkp1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pkp1 ( NM_001313701.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001300630.1 Mus musculus plakophilin 1 (Pkp1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu11243
Clone ID Related Accession (Same CDS sequence)	NM_001313701.1 , NM_019645.3
Accession Version	NM_001313701.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2187bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570377600000
Organism	Mus musculus(house mouse)
Product	plakophilin-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK036856.1, BC139042.1, Y07941.1 and AC162441.11. On Aug 27, 2015 this sequence version replaced XM_006529251.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC139042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCACT CTCCGCTCAA GACCGCGCTG GCGTACGAAT GCTTCCAGGA CCAGGACAAC 
TCCACGCTGG CTTTGCCCTC TGACCAAAAG ATGAAGACCG GCACGTCGGG CAGGCAGCGC 
GTGCAGGAGC AAGTGATGAT GACCGTCAAA CGGCAGAAGT CCAAGTCTTC CCAGTCGTCC 
ACCTTGAGTC ACTCCAACCG AGGTTCCATG TATGATGGGC TGGCTGACAA TTACAACAAC 
TACGGCACCA CGAGCAGAAG CAGCTACTTC TCCAAGTTCC AGGCAGGGAA TGGCTCGTGG 
GGATATCCGA TCTACAATGG GACCCTCAAG CGGGAGCCCG ACAACAGACG CTTCAGCTCC 
TATAGCCAGA TGGAGAACTG GAGCCGGCAC TATCCCCGAG GCAGCTGTGC CACCCCGGGC 
GCTGGCAGTG ACATCTGCTT CATGCAGAAA ATCAAGGCAA GCCGCAGTGA GCCTGACCTC 
TACTGTGACC CAAGGGGCAC ACTGCGCAAG GGCACCCTGG GCAGCAAGGG CCACAAGACC 
ACCCAGAACC GATGCAGCTT CTACAGCACT TGCAGTGGTC AGAAGGCTGT CAAGAAGTGT 
CCCGTGCGGC CGCCCTCCTG CACCTCCAAG CAAGACCCGG TGTATGTGCC GCCTATCTCC 
TGCAACAAGG ACCTGTCCTT CGGCCACTCG AGGGCCAGTT CCAAGATCTG CAGTGAGGAC 
ATTGAGTGTA GTGGGCTGAC CATCCCCAAG GCTGTGCAGT ACCTGTGCTC CCAGGATGAG 
AAGTACCAGG CCATCGGAGC CTATTACATC CAGCACACCT GCTTCCAGGA TGAATCTGCC 
AAGCAACAGG TCTATCAGCT GGGGGGCATC TGCAAGCTGG TGGACCTCCT CCGCAGCCCC 
AATCAGAATG TCCAGCAGGC TGCTGCCGGG GCCCTGCGCA ACCTGGTGTT CAGGAGCACC 
CCCAACAAGC TGGAGACCAG GAGGCAGAAC GGAATCCGTG AAGCTGTCAG CCTCCTGAGG 
AGAAGCGGGA GCACGGAGAT CCAAAAACAG CTGACTGGGC TCCTCTGGAA CCTGTCTTCC 
ACTGATGAGC TGAAGGAGGA GCTGGTGGCC GACGCCCTGC CTGTTCTGAC TGACCGGGTC 
ATCATTCCTT TCTCTGGCTG GTGTGATGGT AACAGCAACA TGTCCCGGGA AGTAGTGGAC 
CCTGAGGTCT TCTTCAATGC TACAGGCTGC TTGAGGAACC TGAGTTCAGC TGATGCTGGC 
CGCCAGACTA TGCGGAACTA CTCTGGGCTC ATTGACTCCC TCATGGCCTA TGTCCAGAAC 
TGCGTGGCTG CCAGCCGCTG CGATGACAAG TCTGTGGAGA ACTGCATGTG TATCCTGCAT 
AACCTCTCCT ACCGCCTGGA CGCCGAGGTG CCCACCCGCT ACCGCCAGCT GGAGTACAAT 
ACCCGCAATG CCTACACCGA GAAGTCCTCC ACTGGCTGCT TCAGCAACAG GGGTGACAAG 
ATGATGAACA ATAACTATGA CTGCCCACTT CCGGAGGAAG AGACCAACCC CAAGGGCAGC 
AGCTGGCTGT ACCACTCAGA TGCCATCCGG ACCTACCTGA ACCTCATGGG AAAGAGCAAG 
AAAGATGCTA CCTTGGAGGC CTGTGCTGGG GCCCTGCAAA ACCTGACAGC CAGCAAGGGG 
CTGATGTCCA ATGGTATGAG TCAGTTAATT GGAATAAAGG AAAAGGGCCT GCCACAAATC 
GCCCGTCTCC TGCAATCTGG CAATTCGGAT GTGGTGCGGT CCGGAGCCTC TCTGCTGAGC 
AACATGTCTC GCCACCCTGT GCTGCACAGA GTGATGGGAA ACCAGGTGTT CCCAGAGGTA 
ACCAGACTCC TCACTAGCCA CACCGGCAAT ACCAGCAACT CTGAAGATAT CTTGTCCTCA 
GCCTGCTACA CTGTGAGGAA CCTGATGACC TCACAGCCTC AGATGGCCAA GCAGTACTTC 
TCCAACAGCA TGCTCAACAA TGTCTTCAAC TTGTGCCGCA ACACTGCCTC CTCACCTAAG 
GCTGCAGAGG CTGCCCGGCT ACTCCTGTCT GACATGTGGG CCAGCAAGGA GCTGCAGAGT 
GTCCTCAGGC AGCAAGGTTT CGATAGGAAT ATGATGGGAA ACATAGCTGG GGCCAACAAC 
CTCAGAAACT TCACCTCCCG GTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001300630.1
CDS	196..2382
Translation	MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHSNRGSMYDGLADNYNNYGTTSRSSYFSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRHYPRGSCATPGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGHKTTQNRCSFYSTCSGQKAVKKCPVRPPSCTSKQDPVYVPPISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLCSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTPNKLETRRQNGIREAVSLLRRSGSTEIQKQLTGLLWNLSSTDELKEELVADALPVLTDRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCILHNLSYRLDAEVPTRYRQLEYNTRNAYTEKSSTGCFSNRGDKMMNNNYDCPLPEEETNPKGSSWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSNGMSQLIGIKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPVLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMTSQPQMAKQYFSNSMLNNVFNLCRNTASSPKAAEAARLLLSDMWASKELQSVLRQQGFDRNMMGNIAGANNLRNFTSRF

Target ORF information:

RefSeq Version	NM_001313701.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus plakophilin 1 (Pkp1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001313701.1

ORF Insert Sequence:

ATGAACCACT CTCCGCTCAA GACCGCGCTG GCGTACGAAT GCTTCCAGGA CCAGGACAAC 
TCCACGCTGG CTTTGCCCTC TGACCAAAAG ATGAAGACCG GCACGTCGGG CAGGCAGCGC 
GTGCAGGAGC AAGTGATGAT GACCGTCAAA CGGCAGAAGT CCAAGTCTTC CCAGTCGTCC 
ACCTTGAGTC ACTCCAACCG AGGTTCCATG TATGATGGGC TGGCTGACAA TTACAACAAC 
TACGGCACCA CGAGCAGAAG CAGCTACTTC TCCAAGTTCC AGGCAGGGAA TGGCTCGTGG 
GGATATCCGA TCTACAATGG GACCCTCAAG CGGGAGCCCG ACAACAGACG CTTCAGCTCC 
TATAGCCAGA TGGAGAACTG GAGCCGGCAC TATCCCCGAG GCAGCTGTGC CACCCCGGGC 
GCTGGCAGTG ACATCTGCTT CATGCAGAAA ATCAAGGCAA GCCGCAGTGA GCCTGACCTC 
TACTGTGACC CAAGGGGCAC ACTGCGCAAG GGCACCCTGG GCAGCAAGGG CCACAAGACC 
ACCCAGAACC GATGCAGCTT CTACAGCACT TGCAGTGGTC AGAAGGCTGT CAAGAAGTGT 
CCCGTGCGGC CGCCCTCCTG CACCTCCAAG CAAGACCCGG TGTATGTGCC GCCTATCTCC 
TGCAACAAGG ACCTGTCCTT CGGCCACTCG AGGGCCAGTT CCAAGATCTG CAGTGAGGAC 
ATTGAGTGTA GTGGGCTGAC CATCCCCAAG GCTGTGCAGT ACCTGTGCTC CCAGGATGAG 
AAGTACCAGG CCATCGGAGC CTATTACATC CAGCACACCT GCTTCCAGGA TGAATCTGCC 
AAGCAACAGG TCTATCAGCT GGGGGGCATC TGCAAGCTGG TGGACCTCCT CCGCAGCCCC 
AATCAGAATG TCCAGCAGGC TGCTGCCGGG GCCCTGCGCA ACCTGGTGTT CAGGAGCACC 
CCCAACAAGC TGGAGACCAG GAGGCAGAAC GGAATCCGTG AAGCTGTCAG CCTCCTGAGG 
AGAAGCGGGA GCACGGAGAT CCAAAAACAG CTGACTGGGC TCCTCTGGAA CCTGTCTTCC 
ACTGATGAGC TGAAGGAGGA GCTGGTGGCC GACGCCCTGC CTGTTCTGAC TGACCGGGTC 
ATCATTCCTT TCTCTGGCTG GTGTGATGGT AACAGCAACA TGTCCCGGGA AGTAGTGGAC 
CCTGAGGTCT TCTTCAATGC TACAGGCTGC TTGAGGAACC TGAGTTCAGC TGATGCTGGC 
CGCCAGACTA TGCGGAACTA CTCTGGGCTC ATTGACTCCC TCATGGCCTA TGTCCAGAAC 
TGCGTGGCTG CCAGCCGCTG CGATGACAAG TCTGTGGAGA ACTGCATGTG TATCCTGCAT 
AACCTCTCCT ACCGCCTGGA CGCCGAGGTG CCCACCCGCT ACCGCCAGCT GGAGTACAAT 
ACCCGCAATG CCTACACCGA GAAGTCCTCC ACTGGCTGCT TCAGCAACAG GGGTGACAAG 
ATGATGAACA ATAACTATGA CTGCCCACTT CCGGAGGAAG AGACCAACCC CAAGGGCAGC 
AGCTGGCTGT ACCACTCAGA TGCCATCCGG ACCTACCTGA ACCTCATGGG AAAGAGCAAG 
AAAGATGCTA CCTTGGAGGC CTGTGCTGGG GCCCTGCAAA ACCTGACAGC CAGCAAGGGG 
CTGATGTCCA ATGGTATGAG TCAGTTAATT GGAATAAAGG AAAAGGGCCT GCCACAAATC 
GCCCGTCTCC TGCAATCTGG CAATTCGGAT GTGGTGCGGT CCGGAGCCTC TCTGCTGAGC 
AACATGTCTC GCCACCCTGT GCTGCACAGA GTGATGGGAA ACCAGGTGTT CCCAGAGGTA 
ACCAGACTCC TCACTAGCCA CACCGGCAAT ACCAGCAACT CTGAAGATAT CTTGTCCTCA 
GCCTGCTACA CTGTGAGGAA CCTGATGACC TCACAGCCTC AGATGGCCAA GCAGTACTTC 
TCCAACAGCA TGCTCAACAA TGTCTTCAAC TTGTGCCGCA ACACTGCCTC CTCACCTAAG 
GCTGCAGAGG CTGCCCGGCT ACTCCTGTCT GACATGTGGG CCAGCAAGGA GCTGCAGAGT 
GTCCTCAGGC AGCAAGGTTT CGATAGGAAT ATGATGGGAA ACATAGCTGG GGCCAACAAC 
CTCAGAAACT TCACCTCCCG GTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pkp1 ( NM_019645.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062619.1 Mus musculus plakophilin 1 (Pkp1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu11243
Clone ID Related Accession (Same CDS sequence)	NM_001313701.1 , NM_019645.3
Accession Version	NM_019645.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2187bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570377600000
Organism	Mus musculus(house mouse)
Product	plakophilin-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK036856.1, AK079429.1, BC139042.1, Y07941.1 and AC162441.11. On Aug 27, 2015 this sequence version replaced NM_019645.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y07941.1, AK036856.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCACT CTCCGCTCAA GACCGCGCTG GCGTACGAAT GCTTCCAGGA CCAGGACAAC 
TCCACGCTGG CTTTGCCCTC TGACCAAAAG ATGAAGACCG GCACGTCGGG CAGGCAGCGC 
GTGCAGGAGC AAGTGATGAT GACCGTCAAA CGGCAGAAGT CCAAGTCTTC CCAGTCGTCC 
ACCTTGAGTC ACTCCAACCG AGGTTCCATG TATGATGGGC TGGCTGACAA TTACAACAAC 
TACGGCACCA CGAGCAGAAG CAGCTACTTC TCCAAGTTCC AGGCAGGGAA TGGCTCGTGG 
GGATATCCGA TCTACAATGG GACCCTCAAG CGGGAGCCCG ACAACAGACG CTTCAGCTCC 
TATAGCCAGA TGGAGAACTG GAGCCGGCAC TATCCCCGAG GCAGCTGTGC CACCCCGGGC 
GCTGGCAGTG ACATCTGCTT CATGCAGAAA ATCAAGGCAA GCCGCAGTGA GCCTGACCTC 
TACTGTGACC CAAGGGGCAC ACTGCGCAAG GGCACCCTGG GCAGCAAGGG CCACAAGACC 
ACCCAGAACC GATGCAGCTT CTACAGCACT TGCAGTGGTC AGAAGGCTGT CAAGAAGTGT 
CCCGTGCGGC CGCCCTCCTG CACCTCCAAG CAAGACCCGG TGTATGTGCC GCCTATCTCC 
TGCAACAAGG ACCTGTCCTT CGGCCACTCG AGGGCCAGTT CCAAGATCTG CAGTGAGGAC 
ATTGAGTGTA GTGGGCTGAC CATCCCCAAG GCTGTGCAGT ACCTGTGCTC CCAGGATGAG 
AAGTACCAGG CCATCGGAGC CTATTACATC CAGCACACCT GCTTCCAGGA TGAATCTGCC 
AAGCAACAGG TCTATCAGCT GGGGGGCATC TGCAAGCTGG TGGACCTCCT CCGCAGCCCC 
AATCAGAATG TCCAGCAGGC TGCTGCCGGG GCCCTGCGCA ACCTGGTGTT CAGGAGCACC 
CCCAACAAGC TGGAGACCAG GAGGCAGAAC GGAATCCGTG AAGCTGTCAG CCTCCTGAGG 
AGAAGCGGGA GCACGGAGAT CCAAAAACAG CTGACTGGGC TCCTCTGGAA CCTGTCTTCC 
ACTGATGAGC TGAAGGAGGA GCTGGTGGCC GACGCCCTGC CTGTTCTGAC TGACCGGGTC 
ATCATTCCTT TCTCTGGCTG GTGTGATGGT AACAGCAACA TGTCCCGGGA AGTAGTGGAC 
CCTGAGGTCT TCTTCAATGC TACAGGCTGC TTGAGGAACC TGAGTTCAGC TGATGCTGGC 
CGCCAGACTA TGCGGAACTA CTCTGGGCTC ATTGACTCCC TCATGGCCTA TGTCCAGAAC 
TGCGTGGCTG CCAGCCGCTG CGATGACAAG TCTGTGGAGA ACTGCATGTG TATCCTGCAT 
AACCTCTCCT ACCGCCTGGA CGCCGAGGTG CCCACCCGCT ACCGCCAGCT GGAGTACAAT 
ACCCGCAATG CCTACACCGA GAAGTCCTCC ACTGGCTGCT TCAGCAACAG GGGTGACAAG 
ATGATGAACA ATAACTATGA CTGCCCACTT CCGGAGGAAG AGACCAACCC CAAGGGCAGC 
AGCTGGCTGT ACCACTCAGA TGCCATCCGG ACCTACCTGA ACCTCATGGG AAAGAGCAAG 
AAAGATGCTA CCTTGGAGGC CTGTGCTGGG GCCCTGCAAA ACCTGACAGC CAGCAAGGGG 
CTGATGTCCA ATGGTATGAG TCAGTTAATT GGAATAAAGG AAAAGGGCCT GCCACAAATC 
GCCCGTCTCC TGCAATCTGG CAATTCGGAT GTGGTGCGGT CCGGAGCCTC TCTGCTGAGC 
AACATGTCTC GCCACCCTGT GCTGCACAGA GTGATGGGAA ACCAGGTGTT CCCAGAGGTA 
ACCAGACTCC TCACTAGCCA CACCGGCAAT ACCAGCAACT CTGAAGATAT CTTGTCCTCA 
GCCTGCTACA CTGTGAGGAA CCTGATGACC TCACAGCCTC AGATGGCCAA GCAGTACTTC 
TCCAACAGCA TGCTCAACAA TGTCTTCAAC TTGTGCCGCA ACACTGCCTC CTCACCTAAG 
GCTGCAGAGG CTGCCCGGCT ACTCCTGTCT GACATGTGGG CCAGCAAGGA GCTGCAGAGT 
GTCCTCAGGC AGCAAGGTTT CGATAGGAAT ATGATGGGAA ACATAGCTGG GGCCAACAAC 
CTCAGAAACT TCACCTCCCG GTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062619.1
CDS	196..2382
Translation	MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHSNRGSMYDGLADNYNNYGTTSRSSYFSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRHYPRGSCATPGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGHKTTQNRCSFYSTCSGQKAVKKCPVRPPSCTSKQDPVYVPPISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLCSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTPNKLETRRQNGIREAVSLLRRSGSTEIQKQLTGLLWNLSSTDELKEELVADALPVLTDRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCILHNLSYRLDAEVPTRYRQLEYNTRNAYTEKSSTGCFSNRGDKMMNNNYDCPLPEEETNPKGSSWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSNGMSQLIGIKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPVLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMTSQPQMAKQYFSNSMLNNVFNLCRNTASSPKAAEAARLLLSDMWASKELQSVLRQQGFDRNMMGNIAGANNLRNFTSRF

Target ORF information:

RefSeq Version	NM_019645.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus plakophilin 1 (Pkp1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019645.3

ORF Insert Sequence:

ATGAACCACT CTCCGCTCAA GACCGCGCTG GCGTACGAAT GCTTCCAGGA CCAGGACAAC 
TCCACGCTGG CTTTGCCCTC TGACCAAAAG ATGAAGACCG GCACGTCGGG CAGGCAGCGC 
GTGCAGGAGC AAGTGATGAT GACCGTCAAA CGGCAGAAGT CCAAGTCTTC CCAGTCGTCC 
ACCTTGAGTC ACTCCAACCG AGGTTCCATG TATGATGGGC TGGCTGACAA TTACAACAAC 
TACGGCACCA CGAGCAGAAG CAGCTACTTC TCCAAGTTCC AGGCAGGGAA TGGCTCGTGG 
GGATATCCGA TCTACAATGG GACCCTCAAG CGGGAGCCCG ACAACAGACG CTTCAGCTCC 
TATAGCCAGA TGGAGAACTG GAGCCGGCAC TATCCCCGAG GCAGCTGTGC CACCCCGGGC 
GCTGGCAGTG ACATCTGCTT CATGCAGAAA ATCAAGGCAA GCCGCAGTGA GCCTGACCTC 
TACTGTGACC CAAGGGGCAC ACTGCGCAAG GGCACCCTGG GCAGCAAGGG CCACAAGACC 
ACCCAGAACC GATGCAGCTT CTACAGCACT TGCAGTGGTC AGAAGGCTGT CAAGAAGTGT 
CCCGTGCGGC CGCCCTCCTG CACCTCCAAG CAAGACCCGG TGTATGTGCC GCCTATCTCC 
TGCAACAAGG ACCTGTCCTT CGGCCACTCG AGGGCCAGTT CCAAGATCTG CAGTGAGGAC 
ATTGAGTGTA GTGGGCTGAC CATCCCCAAG GCTGTGCAGT ACCTGTGCTC CCAGGATGAG 
AAGTACCAGG CCATCGGAGC CTATTACATC CAGCACACCT GCTTCCAGGA TGAATCTGCC 
AAGCAACAGG TCTATCAGCT GGGGGGCATC TGCAAGCTGG TGGACCTCCT CCGCAGCCCC 
AATCAGAATG TCCAGCAGGC TGCTGCCGGG GCCCTGCGCA ACCTGGTGTT CAGGAGCACC 
CCCAACAAGC TGGAGACCAG GAGGCAGAAC GGAATCCGTG AAGCTGTCAG CCTCCTGAGG 
AGAAGCGGGA GCACGGAGAT CCAAAAACAG CTGACTGGGC TCCTCTGGAA CCTGTCTTCC 
ACTGATGAGC TGAAGGAGGA GCTGGTGGCC GACGCCCTGC CTGTTCTGAC TGACCGGGTC 
ATCATTCCTT TCTCTGGCTG GTGTGATGGT AACAGCAACA TGTCCCGGGA AGTAGTGGAC 
CCTGAGGTCT TCTTCAATGC TACAGGCTGC TTGAGGAACC TGAGTTCAGC TGATGCTGGC 
CGCCAGACTA TGCGGAACTA CTCTGGGCTC ATTGACTCCC TCATGGCCTA TGTCCAGAAC 
TGCGTGGCTG CCAGCCGCTG CGATGACAAG TCTGTGGAGA ACTGCATGTG TATCCTGCAT 
AACCTCTCCT ACCGCCTGGA CGCCGAGGTG CCCACCCGCT ACCGCCAGCT GGAGTACAAT 
ACCCGCAATG CCTACACCGA GAAGTCCTCC ACTGGCTGCT TCAGCAACAG GGGTGACAAG 
ATGATGAACA ATAACTATGA CTGCCCACTT CCGGAGGAAG AGACCAACCC CAAGGGCAGC 
AGCTGGCTGT ACCACTCAGA TGCCATCCGG ACCTACCTGA ACCTCATGGG AAAGAGCAAG 
AAAGATGCTA CCTTGGAGGC CTGTGCTGGG GCCCTGCAAA ACCTGACAGC CAGCAAGGGG 
CTGATGTCCA ATGGTATGAG TCAGTTAATT GGAATAAAGG AAAAGGGCCT GCCACAAATC 
GCCCGTCTCC TGCAATCTGG CAATTCGGAT GTGGTGCGGT CCGGAGCCTC TCTGCTGAGC 
AACATGTCTC GCCACCCTGT GCTGCACAGA GTGATGGGAA ACCAGGTGTT CCCAGAGGTA 
ACCAGACTCC TCACTAGCCA CACCGGCAAT ACCAGCAACT CTGAAGATAT CTTGTCCTCA 
GCCTGCTACA CTGTGAGGAA CCTGATGACC TCACAGCCTC AGATGGCCAA GCAGTACTTC 
TCCAACAGCA TGCTCAACAA TGTCTTCAAC TTGTGCCGCA ACACTGCCTC CTCACCTAAG 
GCTGCAGAGG CTGCCCGGCT ACTCCTGTCT GACATGTGGG CCAGCAAGGA GCTGCAGAGT 
GTCCTCAGGC AGCAAGGTTT CGATAGGAAT ATGATGGGAA ACATAGCTGG GGCCAACAAC 
CTCAGAAACT TCACCTCCCG GTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering.
Cellular and molecular life sciences : CMLS76(17)3465-3476(2019 Sep)
Fuchs M,Foresti M,Radeva MY,Kugelmann D,Keil R,Hatzfeld M,Spindler V,Waschke J,Vielmuth F

Coexpression network analysis identified that plakophilin 1 is associated with the metastasis in human melanoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1111234-1242(2019 Mar)
Wang HZ,Wang F,Chen PF,Zhang M,Yu MX,Wang HL,Zhao Q,Liu J

RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.
PLoS genetics15(1)e1007914(2019 01)
Choi YJ,Laclef C,Yang N,Andreu-Cervera A,Lewis J,Mao X,Li L,Snedecor ER,Takemaru KI,Qin C,Schneider-Maunoury S,Shroyer KR,Hannun YA,Koch PJ,Clark RA,Payne AS,Kowalczyk AP,Chen J

Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation.
The Journal of investigative dermatology138(6)1268-1278(2018 06)
Urwyler-Rösselet C,Tanghe G,Leurs K,Gilbert B,De Rycke R,De Bruyne M,Lippens S,Bartunkova S,De Groote P,Niessen C,Haftek M,Vandenabeele P,Declercq W

p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.
PLoS genetics13(6)e1006828(2017 Jun)
Richardson R,Mitchell K,Hammond NL,Mollo MR,Kouwenhoven EN,Wyatt ND,Donaldson IJ,Zeef L,Burgis T,Blance R,van Heeringen SJ,Stunnenberg HG,Zhou H,Missero C,Romano RA,Sinha S,Dixon MJ,Dixon J

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Pkp1 cDNA ORF clone, Mus musculus(house mouse)

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