Mcm4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mcm4
Entrez Gene ID	17217
Full Name	minichromosome maintenance complex component 4
Synonyms	19G,AI325074,AU045576,Cdc21,Mcmd4,mKIAA4003,mcdc21
General protein information	Preferred Names minichromosome maintenance complex component 4 Names DNA replication licensing factor MCM4 CDC21 homolog P1-CDC21 mini chromosome maintenance deficient 4 homolog minichromosome maintenance deficient 4 homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 A2\|16 10.09 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008565.3	NP_032591.3	DNA replication licensing factor MCM4

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	MCM4	XP_424376.2
Arabidopsis thaliana (thale cress)	MCM4	NP_179236.3
Eremothecium gossypii	AGOS_ADL026W	NP_984071.2
Magnaporthe oryzae (rice blast fungus)	MGG_09293	XP_003709942.1
Pan troglodytes (chimpanzee)	MCM4	XP_528129.2
Canis lupus familiaris (dog)	MCM4	XP_535063.3
Mus musculus (house mouse)	Mcm4	NP_032591.3
Rattus norvegicus (Norway rat)	Mcm4	NP_387500.1
Xenopus tropicalis (tropical clawed frog)	mcm4	NP_001005655.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004956	XP_315054.2
Bos taurus (cattle)	MCM4	NP_001068626.1
Schizosaccharomyces pombe (fission yeast)	mcm4	NP_588004.2
Homo sapiens (human)	MCM4	NP_005905.2
Macaca mulatta (Rhesus monkey)	MCM4	XP_002805376.1
Danio rerio (zebrafish)	mcm4	NP_944595.2
Kluyveromyces lactis	KLLA0C17512g	XP_452982.1
Neurospora crassa	NCU02539	XP_965670.1
Drosophila melanogaster (fruit fly)	dpa	NP_477185.1
Caenorhabditis elegans (roundworm)	mcm-4	NP_490962.1
Saccharomyces cerevisiae (baker's yeast)	MCM4	NP_015344.1

Gene Ontology
Bibliography

Related articles in PubMed

Female-biased embryonic death from inflammation induced by genomic instability.
McNairn AJ, Chuang CH, Bloom JC, Wallace MD, Schimenti JC
Nature567(7746)105-108(2019 03)

The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.
O'Driscoll M
The Journal of pathology241(2)192-207(2017 Jan)

The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice.
Kartha N, Shen L, Maskin C, Wallace M, Schimenti JC
Genetics203(4)1601-11(2016 08)

Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.
Wallace MD, Southard TL, Schimenti KJ, Schimenti JC
Oncogene33(28)3688-95(2014 Jul)

Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice.
Pihlajoki M, Gretzinger E, Cochran R, Kyrönlahti A, Schrade A, Hiller T, Sullivan L, Shoykhet M, Schoeller EL, Brooks MD, Heikinheimo M, Wilson DB
Endocrinology154(5)1754-67(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mcm4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mcm4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22627	NM_008565.3 Latest version!	Mus musculus minichromosome maintenance complex component 4 (Mcm4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mcm4 ( NM_008565.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032591.3 Mus musculus minichromosome maintenance complex component 4 (Mcm4), mRNA.

Price & Availability↑

CloneID	OMu22627
Clone ID Related Accession (Same CDS sequence)	NM_008565.3
Accession Version	NM_008565.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2589bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573401600000
Organism	Mus musculus(house mouse)
Product	DNA replication licensing factor MCM4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK141644.1, AK036653.1 and AK151499.1. On Aug 13, 2009 this sequence version replaced NM_008565.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK151499.1, AK036653.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END##

ATGTCGTCCC CGGCATCCAC CCCGAGCCGC CGCAGCAGCC GACGCGGACG AGTCACCCCA 
ACCCAGTCCC TTCGAAGTGA GGAAAGCAGG TCGTCACCCA ATCGGAGACG TAGAGGCGAA 
GATTCTTCCA CCGGAGAGCT ACTGCCAATG CCCACCTCAC CAGGAGCCGA CCTGCAGAGC 
CCACCTGCAC AGAATGCCTT GTTTTCCAGC CCTCCTCAGA TGCATTCTTT AGCTATTCCT 
TTGGACTTTG ATGTTAGTTC ACCATTGACA TATGGCACTC CCAGCTCGCG AGTGGAAGGA 
ACCCCAAGAA GTGGGGTGAG AGGCACACCT GTAAGGCAGA GGCCAGATCT GGGCTCAGCA 
CGAAAGGGTT TGCAGGTGGA TCTGCAGTCT GATGGCGCAG CAGCAGAAGA CATCGTACCA 
AGTGAACAGT CTCTAGGCCA AAAGCTTGTG ATTTGGGGAA CAGATGTGAA TGTGGCAACA 
TGTAAAGAGA ATTTTCAGAG ATTCCTTCAG TGTTTTACTG ATCCTCTGGC CAAAGAAGAA 
GAAAATGTTG GCATAGATAT TACTCAACCT TTGTACATGC AACAACTTGG AGAGATTAAT 
ATTACAGGAG AGCCATTTTT AAATGTGAAC TGCGAACACA TAAAATCATT TAGCAAAAAT 
CTGTATAGAC AGCTCATCTC CTACCCACAG GAGGTTATAC CAACCTTTGA CATGGCTGTC 
AATGAGATCT TCTTTGACCG TTATCCTGAC TCCATCTTAG AACATCAGAT TCAAGTCAGA 
CCTTTTAATG CGTTGAAGAC AAAGAGTATG AGAAACTTGA ATCCAGAAGA CATTGATCAG 
CTCATCACCA TCAGTGGCAT GGTCATCAGA ACATCACAGC TGATTCCGGA GATGCAGGAG 
GCCTTTTTCC AATGCCAAGT CTGTGCCCAC ACCACCCGGG TGGAGATAGA TCGAGGCAGA 
ATTGCTGAGC CCTGCAGTTG TGTGCACTGC CACACTACCC ACAGCATGGC ACTGATCCAC 
AACCGATCAT TCTTCTCTGA CAAGCAAATG ATCAAACTTC AAGAGTCTCC TGAAGACATG 
CCTGCTGGGC AGACACCTCA CACTATTGTC CTTTTTGCCC ACAATGACCT TGTTGACAAG 
GTTCAACCAG GGGACAGAGT GAACGTCACA GGCATATATC GAGCAGTACC AATTCGAGTT 
AATCCAAGAG TGAGCAACGT GAAGTCTGTC TATAAAACCC ACATTGATGT CATTCATTAT 
CGGAAAACGG ATGCAAAACG TCTGCATGGC CTTGATGAAG AAGCAGAACA GAAACTTTTT 
TCAGAGAAAC GTGTGAAATT GCTTAAGGAA CTTTCCAGGA AGCCAGATAT TTATGAGCGG 
CTTGCTTCAG CCTTGGCTCC CAGCATTTAT GAACATGAAG ATATCAAAAA GGGAATCTTA 
CTTCAGCTCT TTGGTGGAAC AAGGAAGGAT TTCAGTCACA CTGGGAGGGG TAAATTCCGT 
GCTGAGATCA ACATCCTTCT GTGTGGGGAC CCTGGCACCA GCAAGTCCCA GCTGCTACAG 
TATGTGTACA ACCTGGTCCC CAGAGGCCAG TACACGTCTG GAAAAGGCTC CAGTGCGGTC 
GGCCTCACCG CCTATGTGAT GAAAGACCCT GAGACCAGGC AGCTTGTCCT CCAGACAGGT 
GCCCTCGTCC TGAGTGACAA TGGGATATGC TGCATCGATG AGTTTGACAA AATGAATGAA 
AGCACAAGGT CTGTGCTGCA TGAGGTCATG GAACAGCAGA CTCTGTCCAT TGCAAAGGCT 
GGGATCATCT GTCAGCTCAA TGCGCGCACC TCTGTCCTGG CAGCAGCAAA TCCTATTGAG 
TCTCAGTGGA ATCCTAAAAA AACAACCATT GAAAATATCC AACTACCGCA CACATTGTTG 
TCAAGGTTTG ATCTCATTTT CCTCATGCTA GACCCTCAGG ATGAGGCATA TGACCGGCGT 
CTAGCTCATC ACCTGGTTTC ATTGTACTAC CAAAGTGAGG AGCAAGTGGA GGAGGAGTTC 
CTGGACATGG CCGTGCTGAA AGACTACATT GCATATGCCC ATAGTACCAT CATGCCCCGA 
CTGAGTGAGG AGGCCAGCCA GGCTCTCATT GAGGCTTATG TAAACATGAG GAAGATTGGG 
AGTAGCCGGG GGATGGTTTC TGCTTACCCT CGACAGCTAG AGTCATTAAT TCGCTTAGCA 
GAAGCCCATG CTAAAGTAAG ATTTTCAAAC AAAGTTGAAG CAATTGATGT GGAAGAGGCA 
AAACGCCTCC ACCGGGAGGC TCTGAAGCAG TCTGCAACTG ACCCTCGTAC TGGCATTGTG 
GATATTTCTA TTCTTACTAC AGGAATGAGT GCCACTTCTC GTAAACGGAA AGAAGAATTA 
GCTGAAGCAT TGAGAAAACT TATTTTATCT AAGGGTAAAA CACCAGCCTT AAAGTACCAA 
CAGCTGTTTG AGGATATTCG GGGACAGTCT GACACAGCAA TTACCAAGGA CATGTTTGAA 
GAAGCCCTGC GAGCTTTGGC TGATGATGAT TTCCTAACAG TGACTGGGAA GACTGTCCGC 
CTGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032591.3
CDS	221..2809
Translation	MSSPASTPSRRSSRRGRVTPTQSLRSEESRSSPNRRRRGEDSSTGELLPMPTSPGADLQSPPAQNALFSSPPQMHSLAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSARKGLQVDLQSDGAAAEDIVPSEQSLGQKLVIWGTDVNVATCKENFQRFLQCFTDPLAKEEENVGIDITQPLYMQQLGEINITGEPFLNVNCEHIKSFSKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKSMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEIDRGRIAEPCSCVHCHTTHSMALIHNRSFFSDKQMIKLQESPEDMPAGQTPHTIVLFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQVEEEFLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVNMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRFSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALRKLILSKGKTPALKYQQLFEDIRGQSDTAITKDMFEEALRALADDDFLTVTGKTVRLL

Target ORF information:

RefSeq Version	NM_008565.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus minichromosome maintenance complex component 4 (Mcm4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008565.3

ORF Insert Sequence:

ATGTCGTCCC CGGCATCCAC CCCGAGCCGC CGCAGCAGCC GACGCGGACG AGTCACCCCA 
ACCCAGTCCC TTCGAAGTGA GGAAAGCAGG TCGTCACCCA ATCGGAGACG TAGAGGCGAA 
GATTCTTCCA CCGGAGAGCT ACTGCCAATG CCCACCTCAC CAGGAGCCGA CCTGCAGAGC 
CCACCTGCAC AGAATGCCTT GTTTTCCAGC CCTCCTCAGA TGCATTCTTT AGCTATTCCT 
TTGGACTTTG ATGTTAGTTC ACCATTGACA TATGGCACTC CCAGCTCGCG AGTGGAAGGA 
ACCCCAAGAA GTGGGGTGAG AGGCACACCT GTAAGGCAGA GGCCAGATCT GGGCTCAGCA 
CGAAAGGGTT TGCAGGTGGA TCTGCAGTCT GATGGCGCAG CAGCAGAAGA CATCGTACCA 
AGTGAACAGT CTCTAGGCCA AAAGCTTGTG ATTTGGGGAA CAGATGTGAA TGTGGCAACA 
TGTAAAGAGA ATTTTCAGAG ATTCCTTCAG TGTTTTACTG ATCCTCTGGC CAAAGAAGAA 
GAAAATGTTG GCATAGATAT TACTCAACCT TTGTACATGC AACAACTTGG AGAGATTAAT 
ATTACAGGAG AGCCATTTTT AAATGTGAAC TGCGAACACA TAAAATCATT TAGCAAAAAT 
CTGTATAGAC AGCTCATCTC CTACCCACAG GAGGTTATAC CAACCTTTGA CATGGCTGTC 
AATGAGATCT TCTTTGACCG TTATCCTGAC TCCATCTTAG AACATCAGAT TCAAGTCAGA 
CCTTTTAATG CGTTGAAGAC AAAGAGTATG AGAAACTTGA ATCCAGAAGA CATTGATCAG 
CTCATCACCA TCAGTGGCAT GGTCATCAGA ACATCACAGC TGATTCCGGA GATGCAGGAG 
GCCTTTTTCC AATGCCAAGT CTGTGCCCAC ACCACCCGGG TGGAGATAGA TCGAGGCAGA 
ATTGCTGAGC CCTGCAGTTG TGTGCACTGC CACACTACCC ACAGCATGGC ACTGATCCAC 
AACCGATCAT TCTTCTCTGA CAAGCAAATG ATCAAACTTC AAGAGTCTCC TGAAGACATG 
CCTGCTGGGC AGACACCTCA CACTATTGTC CTTTTTGCCC ACAATGACCT TGTTGACAAG 
GTTCAACCAG GGGACAGAGT GAACGTCACA GGCATATATC GAGCAGTACC AATTCGAGTT 
AATCCAAGAG TGAGCAACGT GAAGTCTGTC TATAAAACCC ACATTGATGT CATTCATTAT 
CGGAAAACGG ATGCAAAACG TCTGCATGGC CTTGATGAAG AAGCAGAACA GAAACTTTTT 
TCAGAGAAAC GTGTGAAATT GCTTAAGGAA CTTTCCAGGA AGCCAGATAT TTATGAGCGG 
CTTGCTTCAG CCTTGGCTCC CAGCATTTAT GAACATGAAG ATATCAAAAA GGGAATCTTA 
CTTCAGCTCT TTGGTGGAAC AAGGAAGGAT TTCAGTCACA CTGGGAGGGG TAAATTCCGT 
GCTGAGATCA ACATCCTTCT GTGTGGGGAC CCTGGCACCA GCAAGTCCCA GCTGCTACAG 
TATGTGTACA ACCTGGTCCC CAGAGGCCAG TACACGTCTG GAAAAGGCTC CAGTGCGGTC 
GGCCTCACCG CCTATGTGAT GAAAGACCCT GAGACCAGGC AGCTTGTCCT CCAGACAGGT 
GCCCTCGTCC TGAGTGACAA TGGGATATGC TGCATCGATG AGTTTGACAA AATGAATGAA 
AGCACAAGGT CTGTGCTGCA TGAGGTCATG GAACAGCAGA CTCTGTCCAT TGCAAAGGCT 
GGGATCATCT GTCAGCTCAA TGCGCGCACC TCTGTCCTGG CAGCAGCAAA TCCTATTGAG 
TCTCAGTGGA ATCCTAAAAA AACAACCATT GAAAATATCC AACTACCGCA CACATTGTTG 
TCAAGGTTTG ATCTCATTTT CCTCATGCTA GACCCTCAGG ATGAGGCATA TGACCGGCGT 
CTAGCTCATC ACCTGGTTTC ATTGTACTAC CAAAGTGAGG AGCAAGTGGA GGAGGAGTTC 
CTGGACATGG CCGTGCTGAA AGACTACATT GCATATGCCC ATAGTACCAT CATGCCCCGA 
CTGAGTGAGG AGGCCAGCCA GGCTCTCATT GAGGCTTATG TAAACATGAG GAAGATTGGG 
AGTAGCCGGG GGATGGTTTC TGCTTACCCT CGACAGCTAG AGTCATTAAT TCGCTTAGCA 
GAAGCCCATG CTAAAGTAAG ATTTTCAAAC AAAGTTGAAG CAATTGATGT GGAAGAGGCA 
AAACGCCTCC ACCGGGAGGC TCTGAAGCAG TCTGCAACTG ACCCTCGTAC TGGCATTGTG 
GATATTTCTA TTCTTACTAC AGGAATGAGT GCCACTTCTC GTAAACGGAA AGAAGAATTA 
GCTGAAGCAT TGAGAAAACT TATTTTATCT AAGGGTAAAA CACCAGCCTT AAAGTACCAA 
CAGCTGTTTG AGGATATTCG GGGACAGTCT GACACAGCAA TTACCAAGGA CATGTTTGAA 
GAAGCCCTGC GAGCTTTGGC TGATGATGAT TTCCTAACAG TGACTGGGAA GACTGTCCGC 
CTGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Female-biased embryonic death from inflammation induced by genomic instability.
Nature567(7746)105-108(2019 03)
McNairn AJ,Chuang CH,Bloom JC,Wallace MD,Schimenti JC

The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.
The Journal of pathology241(2)192-207(2017 Jan)
O'Driscoll M

The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice.
Genetics203(4)1601-11(2016 08)
Kartha N,Shen L,Maskin C,Wallace M,Schimenti JC

Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.
Oncogene33(28)3688-95(2014 Jul)
Wallace MD,Southard TL,Schimenti KJ,Schimenti JC

Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice.
Endocrinology154(5)1754-67(2013 May)
Pihlajoki M,Gretzinger E,Cochran R,Kyrönlahti A,Schrade A,Hiller T,Sullivan L,Shoykhet M,Schoeller EL,Brooks MD,Heikinheimo M,Wilson DB

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Mcm4 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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