| Gene Symbol | Hpgd |
| Entrez Gene ID | 15446 |
| Full Name | hydroxyprostaglandin dehydrogenase 15 (NAD) |
| Synonyms | 15-PGDH,AV026552 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Hpgd cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Hpgd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hpgd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu01657 Clone ID Related Accession (Same CDS sequence) NM_008278.2 Accession Version NM_008278.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 810bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1568908800000 Organism Mus musculus(house mouse) Product 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB870447.1, AK146038.1 and BY581851.1. On Feb 6, 2007 this sequence version replaced NM_008278.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146038.1, BC021157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGCACGTGA ACGGCAAAGT GGCTCTGGTG ACCGGCGCGG CACAGGGCAT AGGCAAAGCC
TTCGCTGAGG CTCTGCTGCT CCATGGCGCC AAGGTAGCAT TGGTGGATTG GAATCTTGAG
GCAGGTGTAA AATGTAAAGC TGCCCTAGAT GAGCAGTTCG AACCTCAGAA GACACTGTTC
GTCCAGTGTG ATGTGGCTGA CCAGAAACAA CTGAGAGATA CTTTTAGAAA AGTTGTAGAC
CATTTCGGAA GATTGGATAT TTTGGTCAAC AATGCAGGCG TGAACAATGA GAAAAACTGG
GAACAGACTC TACAAATTAA TTTGGTTTCT GTTATCAGTG GGACCTATCT TGGTTTGGAT
TACATGAGTA AGCAAAACGG AGGTGAAGGC GGCATCATCA TCAATATGTC TTCATTAGCA
GGGCTCATGC CTGTTGCGCA GCAACCTGTT TATTGTGCTT CGAAGCACGG CATCATCGGA
TTCACACGCT CAGCAGCGAT GGCTGCTAAC CTCATGAAAA GCGGTGTAAG ACTGAATGTC
ATTTGCCCAG GCTTTGTGGA CACACCCATC CTTGAATCCA TTGAAAAAGA AGAAAATATG
GGCCAATATA TAGAATATAA GGACCAGATC AAGGCTATGA TGAAATTCTA TGGGGTTTTA
CACCCATCAA CCATTGCCAA TGGATTAATA AATCTCATTG AAGATGATGC TCTCAATGGT
GCCATTATGA AGATCACGGC ATCGAAAGGA ATTCATTTTC AAGATTATGA CATCTCTCCA
TTACTCGTAA AAGCTCCATT AACCTCCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_032304.2 CDS 69..878 Translation 
Target ORF information:
RefSeq Version NM_008278.2 Organism Mus musculus(house mouse) Definition Mus musculus hydroxyprostaglandin dehydrogenase 15 (NAD) (Hpgd), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_008278.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGCACGTGA ACGGCAAAGT GGCTCTGGTG ACCGGCGCGG CACAGGGCAT AGGCAAAGCC
TTCGCTGAGG CTCTGCTGCT CCATGGCGCC AAGGTAGCAT TGGTGGATTG GAATCTTGAG
GCAGGTGTAA AATGTAAAGC TGCCCTAGAT GAGCAGTTCG AACCTCAGAA GACACTGTTC
GTCCAGTGTG ATGTGGCTGA CCAGAAACAA CTGAGAGATA CTTTTAGAAA AGTTGTAGAC
CATTTCGGAA GATTGGATAT TTTGGTCAAC AATGCAGGCG TGAACAATGA GAAAAACTGG
GAACAGACTC TACAAATTAA TTTGGTTTCT GTTATCAGTG GGACCTATCT TGGTTTGGAT
TACATGAGTA AGCAAAACGG AGGTGAAGGC GGCATCATCA TCAATATGTC TTCATTAGCA
GGGCTCATGC CTGTTGCGCA GCAACCTGTT TATTGTGCTT CGAAGCACGG CATCATCGGA
TTCACACGCT CAGCAGCGAT GGCTGCTAAC CTCATGAAAA GCGGTGTAAG ACTGAATGTC
ATTTGCCCAG GCTTTGTGGA CACACCCATC CTTGAATCCA TTGAAAAAGA AGAAAATATG
GGCCAATATA TAGAATATAA GGACCAGATC AAGGCTATGA TGAAATTCTA TGGGGTTTTA
CACCCATCAA CCATTGCCAA TGGATTAATA AATCTCATTG AAGATGATGC TCTCAATGGT
GCCATTATGA AGATCACGGC ATCGAAAGGA ATTCATTTTC AAGATTATGA CATCTCTCCA
TTACTCGTAA AAGCTCCATT AACCTCCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.
Oncogene38(8)1211-1224(2019 02)
Arima K,Ohmuraya M,Miyake K,Koiwa M,Uchihara T,Izumi D,Gao F,Yonemura A,Bu L,Okabe H,Imai K,Hashimoto D,Baba Y,Chikamoto A,Yamashita YI,Furukawa T,Araki K,Baba H,Ishimoto T
Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.
Proceedings of the National Academy of Sciences of the United States of America114(31)E6427-E6436(2017 08)
Kishore AH,Liang H,Kanchwala M,Xing C,Ganesh T,Akgul Y,Posner B,Ready JM,Markowitz SD,Word RA
Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis.
Cellular and molecular neurobiology37(3)445-452(2017 Apr)
Miyagishi H,Kosuge Y,Takano A,Endo M,Nango H,Yamagata-Murayama S,Hirose D,Kano R,Tanaka Y,Ishige K,Ito Y
15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury.
PloS one12(4)e0176106(2017)
Yao L,Chen W,Song K,Han C,Gandhi CR,Lim K,Wu T
TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Science (New York, N.Y.)348(6240)aaa2340(2015 Jun)
Zhang Y,Desai A,Yang SY,Bae KB,Antczak MI,Fink SP,Tiwari S,Willis JE,Williams NS,Dawson DM,Wald D,Chen WD,Wang Z,Kasturi L,Larusch GA,He L,Cominelli F,Di Martino L,Djuric Z,Milne GL,Chance M,Sanabria J,Dealwis C,Mikkola D,Naidoo J,Wei S,Tai HH,Gerson SL,Ready JM,Posner B,Willson JK,Markowitz SD
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