| Gene Symbol | Bmp7 |
| Entrez Gene ID | 12162 |
| Full Name | bone morphogenetic protein 7 |
| Synonyms | OP1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Mutation of this gene results in skeletal, kidney, and other developmental defects. [provided by RefSeq, Jul 2016]. |
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Bmp7 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Bmp7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bmp7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu17635 Clone ID Related Accession (Same CDS sequence) NM_007557.3 Accession Version NM_007557.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1293bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577116800000 Organism Mus musculus(house mouse) Product bone morphogenetic protein 7 preproprotein Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF540870.1, CJ094104.1, AL929140.16, CJ164635.1, CA316109.1 and CA451657.1. On Mar 20, 2013 this sequence version replaced NM_007557.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010771.1, SRR1660817.185109.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGCACGTGC GCTCGCTGCG CGCTGCGGCG CCACACAGCT TCGTGGCGCT CTGGGCGCCT
CTGTTCTTGC TGCGCTCCGC CCTGGCCGAT TTCAGCCTGG ACAACGAGGT GCACTCCAGC
TTCATCCACC GGCGCCTCCG CAGCCAGGAG CGGCGGGAGA TGCAGCGGGA GATCCTGTCC
ATCTTAGGGT TGCCCCATCG CCCGCGCCCG CACCTCCAGG GAAAGCATAA TTCGGCGCCC
ATGTTCATGT TGGACCTGTA CAACGCCATG GCGGTGGAGG AGAGCGGGCC GGACGGACAG
GGCTTCTCCT ACCCCTACAA GGCCGTCTTC AGTACCCAGG GCCCCCCTTT AGCCAGCCTG
CAGGACAGCC ACTTCCTCAC TGACGCCGAC ATGGTCATGA GCTTCGTCAA CCTAGTGGAA
CATGACAAAG AATTCTTCCA CCCTCGATAC CACCATCGGG AGTTCCGGTT TGATCTTTCC
AAGATCCCCG AGGGCGAAGC GGTGACCGCA GCCGAATTCA GGATCTATAA GGACTACATC
CGGGAGCGAT TTGACAACGA GACCTTCCAG ATCACAGTCT ATCAGGTGCT CCAGGAGCAC
TCAGGCAGGG AGTCGGACCT CTTCTTGCTG GACAGCCGCA CCATCTGGGC TTCTGAGGAG
GGCTGGTTGG TGTTTGATAT CACAGCCACC AGCAACCACT GGGTGGTCAA CCCTCGGCAC
AACCTGGGCT TACAGCTCTC TGTGGAGACC CTGGATGGGC AGAGCATCAA CCCCAAGTTG
GCAGGCCTGA TTGGACGGCA TGGACCCCAG AACAAGCAAC CCTTCATGGT GGCCTTCTTC
AAGGCCACGG AAGTCCATCT CCGTAGTATC CGGTCCACGG GGGGCAAGCA GCGCAGCCAG
AATCGCTCCA AGACGCCAAA GAACCAAGAG GCCCTGAGGA TGGCCAGTGT GGCAGAAAAC
AGCAGCAGTG ACCAGAGGCA GGCCTGCAAG AAACATGAGC TGTACGTCAG CTTCCGAGAC
CTTGGCTGGC AGGACTGGAT CATTGCACCT GAAGGCTATG CTGCCTACTA CTGTGAGGGA
GAGTGCGCCT TCCCTCTGAA CTCCTACATG AACGCCACCA ACCACGCCAT CGTCCAGACA
CTGGTTCACT TCATCAACCC AGACACAGTA CCCAAGCCCT GCTGTGCGCC CACCCAGCTC
AACGCCATCT CTGTCCTCTA CTTCGACGAC AGCTCTAATG TCATCCTGAA GAAGTACAGA
AACATGGTGG TCCGGGCCTG TGGCTGCCAC TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_031583.2 CDS 253..1545 Translation 
Target ORF information:
RefSeq Version NM_007557.3 Organism Mus musculus(house mouse) Definition Mus musculus bone morphogenetic protein 7 (Bmp7), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_007557.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGCACGTGC GCTCGCTGCG CGCTGCGGCG CCACACAGCT TCGTGGCGCT CTGGGCGCCT
CTGTTCTTGC TGCGCTCCGC CCTGGCCGAT TTCAGCCTGG ACAACGAGGT GCACTCCAGC
TTCATCCACC GGCGCCTCCG CAGCCAGGAG CGGCGGGAGA TGCAGCGGGA GATCCTGTCC
ATCTTAGGGT TGCCCCATCG CCCGCGCCCG CACCTCCAGG GAAAGCATAA TTCGGCGCCC
ATGTTCATGT TGGACCTGTA CAACGCCATG GCGGTGGAGG AGAGCGGGCC GGACGGACAG
GGCTTCTCCT ACCCCTACAA GGCCGTCTTC AGTACCCAGG GCCCCCCTTT AGCCAGCCTG
CAGGACAGCC ACTTCCTCAC TGACGCCGAC ATGGTCATGA GCTTCGTCAA CCTAGTGGAA
CATGACAAAG AATTCTTCCA CCCTCGATAC CACCATCGGG AGTTCCGGTT TGATCTTTCC
AAGATCCCCG AGGGCGAAGC GGTGACCGCA GCCGAATTCA GGATCTATAA GGACTACATC
CGGGAGCGAT TTGACAACGA GACCTTCCAG ATCACAGTCT ATCAGGTGCT CCAGGAGCAC
TCAGGCAGGG AGTCGGACCT CTTCTTGCTG GACAGCCGCA CCATCTGGGC TTCTGAGGAG
GGCTGGTTGG TGTTTGATAT CACAGCCACC AGCAACCACT GGGTGGTCAA CCCTCGGCAC
AACCTGGGCT TACAGCTCTC TGTGGAGACC CTGGATGGGC AGAGCATCAA CCCCAAGTTG
GCAGGCCTGA TTGGACGGCA TGGACCCCAG AACAAGCAAC CCTTCATGGT GGCCTTCTTC
AAGGCCACGG AAGTCCATCT CCGTAGTATC CGGTCCACGG GGGGCAAGCA GCGCAGCCAG
AATCGCTCCA AGACGCCAAA GAACCAAGAG GCCCTGAGGA TGGCCAGTGT GGCAGAAAAC
AGCAGCAGTG ACCAGAGGCA GGCCTGCAAG AAACATGAGC TGTACGTCAG CTTCCGAGAC
CTTGGCTGGC AGGACTGGAT CATTGCACCT GAAGGCTATG CTGCCTACTA CTGTGAGGGA
GAGTGCGCCT TCCCTCTGAA CTCCTACATG AACGCCACCA ACCACGCCAT CGTCCAGACA
CTGGTTCACT TCATCAACCC AGACACAGTA CCCAAGCCCT GCTGTGCGCC CACCCAGCTC
AACGCCATCT CTGTCCTCTA CTTCGACGAC AGCTCTAATG TCATCCTGAA GAAGTACAGA
AACATGGTGG TCCGGGCCTG TGGCTGCCAC TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
BMP-7 inhibits renal fibrosis in diabetic nephropathy via miR-21 downregulation.
Life sciences238116957(2019 Dec)
Liu L,Wang Y,Yan R,Liang L,Zhou X,Liu H,Zhang X,Mao Y,Peng W,Xiao Y,Zhang F,Liu L,Shi M,Guo B
Developmental plasticity of epithelial stem cells in tooth and taste bud renewal.
Proceedings of the National Academy of Sciences of the United States of America116(36)17858-17866(2019 Sep)
Bloomquist RF,Fowler TE,An Z,Yu TY,Abdilleh K,Fraser GJ,Sharpe PT,Streelman JT
Bmp signaling in molar cusp formation.
Gene expression patterns : GEP3267-71(2019 06)
Meguro F,Porntaveetus T,Kawasaki M,Kawasaki K,Yamada A,Kakihara Y,Saeki M,Tabeta K,Kessler JA,Maeda T,Ohazama A
Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos.
Genes to cells : devoted to molecular & cellular mechanisms24(6)436-448(2019 Jun)
Hashimoto K,Yamaguchi Y,Kishi Y,Kikko Y,Takasaki K,Maeda Y,Matsumoto Y,Oka M,Miura M,Ohata S,Katada T,Kontani K
Bone morphogenetic protein 7: a broad-spectrum growth factor with multiple target therapeutic potency.
Cytokine & growth factor reviews22(4)221-9(2011 Aug)
Boon MR,van der Horst G,van der Pluijm G,Tamsma JT,Smit JW,Rensen PC
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