Bloc1s4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bloc1s4
Entrez Gene ID	117197
Full Name	biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino
Synonyms	2610101N07Rik,Blos4,Cno
General protein information	Preferred Names biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino Names biogenesis of lysosome-related organelles complex 1 subunit 4 BLOC-1 subunit 4 biogenesis of organelles complex-1, subunit 4, cappuccino cappuccino protein cappuccino homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_133724.3	NP_598485.1	biogenesis of lysosome-related organelles complex 1 subunit 4

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	BLOC1S4	XP_005618501.1
Macaca mulatta (Rhesus monkey)	CNO	XP_001091640.1
Rattus norvegicus (Norway rat)	Bloc1s4	NP_001094236.1
Danio rerio (zebrafish)	bloc1s4	NP_001003475.1
Xenopus tropicalis (tropical clawed frog)	bloc1s4	NP_001037953.1
Gallus gallus (chicken)	CNO	XP_419086.4
Pan troglodytes (chimpanzee)	CNO	XP_517096.2
Homo sapiens (human)	BLOC1S4	NP_060836.1
Bos taurus (cattle)	CNO	NP_001074200.1
Mus musculus (house mouse)	Bloc1s4	NP_598485.1

Gene Ontology
Bibliography

Related articles in PubMed

The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.
Larimore J, Tornieri K, Ryder PV, Gokhale A, Zlatic SA, Craige B, Lee JD, Talbot K, Pare JF, Smith Y, Faundez V
Molecular biology of the cell22(24)4854-67(2011 Dec)

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.
Ghiani CA, Starcevic M, Rodriguez-Fernandez IA, Nazarian R, Cheli VT, Chan LN, Malvar JS, de Vellis J, Sabatti C, Dell'Angelica EC
Molecular psychiatry15(2)115, 204-15(2010 Feb)

Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.
Newell-Litwa K, Chintala S, Jenkins S, Pare JF, McGaha L, Smith Y, Faundez V
The Journal of neuroscience : the official journal of the Society for Neuroscience30(3)820-31(2010 Jan)

Cappuccino mutation in an autoimmune-prone strain of mice suggests a role of platelet function in the progression of immune complex crescentic glomerulonephritis.
Yoshida M, Saiga K, Hato T, Iwaki S, Niiya T, Arita N, Komori H, Tsubaki T, Furukawa H, Terada M, Maeyama K, Nemoto K, Nose M, Ono M
Arthritis and rheumatism54(9)2934-43(2006 Sep)

Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex.
Gwynn B, Martina JA, Bonifacino JS, Sviderskaya EV, Lamoreux ML, Bennett DC, Moriyama K, Huizing M, Helip-Wooley A, Gahl WA, Webb LS, Lambert AJ, Peters LL
Blood104(10)3181-9(2004 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Bloc1s4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bloc1s4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58334	NM_133724.3 Latest version!	Mus musculus biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino (Bloc1s4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bloc1s4 ( NM_133724.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598485.1 Mus musculus biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino (Bloc1s4), mRNA.

Price & Availability↑

CloneID	OMu58334
Clone ID Related Accession (Same CDS sequence)	NM_133724.3
Accession Version	NM_133724.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Mus musculus(house mouse)
Product	biogenesis of lysosome-related organelles complex 1 subunit 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK129009.1, AK011795.1 and AV291459.1. On Feb 16, 2007 this sequence version replaced NM_133724.2. COMPLETENESS: complete on the 3' end.

ATGGAGGAAG GACCCGCCGT CGGAACCCTG TCTCGAGAGG TCTCTACCGA GGAGGCCGAG 
CCGTTGGGCG CCGCGTGGAG CGGGGACAGC GGCCACGTCT CGCAGAGCCA CAGCAGCGCG 
TCCGGGCCGT GGGACGATGA CGGCCCCGAG GACGCGCCGG GCCGCGACCT GCCGCTGCTG 
CGCCGCGCCG CCTCGGGCTA CGCCTCCAGC CTGCTGCCCA GCGCGGGACC GAGGCCAGAG 
GTGGAGGCGC TGGACGCCAG CCTGGAGGAG CTGCTGGCCA AGGTGGACGA GTTCGTGGGC 
ATGCTGGACA TGATCCGCGG GGACTCGTCG CATGTGGTGG GCGAGGGCGT GCCCCGGATC 
CACGCTAAGG CGGCCGAGAT GAGGCGCATC TACGGCCGGA TCGACAAGCT GGAGGCCTTC 
GTGCGGATGA TCGGGAGCAG CGTGGCCAGG ATGGAGGAGC AGGTCGCCAA GGCCGAAGCC 
GAGCTGGGGA CCTTCCCGCG GGCCTTCCGG AGGCTGCTGC ATACCATCAG CGTCCCCGCT 
CTCTTCAGGT CGGCGCCCAG CGGGCCCCAG CGCGCGGCGT ACGAGCCGCC AGTCCTGTTT 
CGGACCGAGG ACCACTTCCC TGGCTGCGGT GACAGACCGC AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598485.1
CDS	35..682
Translation	MEEGPAVGTLSREVSTEEAEPLGAAWSGDSGHVSQSHSSASGPWDDDGPEDAPGRDLPLLRRAASGYASSLLPSAGPRPEVEALDASLEELLAKVDEFVGMLDMIRGDSSHVVGEGVPRIHAKAAEMRRIYGRIDKLEAFVRMIGSSVARMEEQVAKAEAELGTFPRAFRRLLHTISVPALFRSAPSGPQRAAYEPPVLFRTEDHFPGCGDRPQL

Target ORF information:

RefSeq Version	NM_133724.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino (Bloc1s4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133724.3

ORF Insert Sequence:

ATGGAGGAAG GACCCGCCGT CGGAACCCTG TCTCGAGAGG TCTCTACCGA GGAGGCCGAG 
CCGTTGGGCG CCGCGTGGAG CGGGGACAGC GGCCACGTCT CGCAGAGCCA CAGCAGCGCG 
TCCGGGCCGT GGGACGATGA CGGCCCCGAG GACGCGCCGG GCCGCGACCT GCCGCTGCTG 
CGCCGCGCCG CCTCGGGCTA CGCCTCCAGC CTGCTGCCCA GCGCGGGACC GAGGCCAGAG 
GTGGAGGCGC TGGACGCCAG CCTGGAGGAG CTGCTGGCCA AGGTGGACGA GTTCGTGGGC 
ATGCTGGACA TGATCCGCGG GGACTCGTCG CATGTGGTGG GCGAGGGCGT GCCCCGGATC 
CACGCTAAGG CGGCCGAGAT GAGGCGCATC TACGGCCGGA TCGACAAGCT GGAGGCCTTC 
GTGCGGATGA TCGGGAGCAG CGTGGCCAGG ATGGAGGAGC AGGTCGCCAA GGCCGAAGCC 
GAGCTGGGGA CCTTCCCGCG GGCCTTCCGG AGGCTGCTGC ATACCATCAG CGTCCCCGCT 
CTCTTCAGGT CGGCGCCCAG CGGGCCCCAG CGCGCGGCGT ACGAGCCGCC AGTCCTGTTT 
CGGACCGAGG ACCACTTCCC TGGCTGCGGT GACAGACCGC AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.
Molecular biology of the cell22(24)4854-67(2011 Dec)
Larimore J,Tornieri K,Ryder PV,Gokhale A,Zlatic SA,Craige B,Lee JD,Talbot K,Pare JF,Smith Y,Faundez V

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.
Molecular psychiatry15(2)115, 204-15(2010 Feb)
Ghiani CA,Starcevic M,Rodriguez-Fernandez IA,Nazarian R,Cheli VT,Chan LN,Malvar JS,de Vellis J,Sabatti C,Dell'Angelica EC

Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience30(3)820-31(2010 Jan)
Newell-Litwa K,Chintala S,Jenkins S,Pare JF,McGaha L,Smith Y,Faundez V

Cappuccino mutation in an autoimmune-prone strain of mice suggests a role of platelet function in the progression of immune complex crescentic glomerulonephritis.
Arthritis and rheumatism54(9)2934-43(2006 Sep)
Yoshida M,Saiga K,Hato T,Iwaki S,Niiya T,Arita N,Komori H,Tsubaki T,Furukawa H,Terada M,Maeyama K,Nemoto K,Nose M,Ono M

Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex.
Blood104(10)3181-9(2004 Nov)
Gwynn B,Martina JA,Bonifacino JS,Sviderskaya EV,Lamoreux ML,Bennett DC,Moriyama K,Huizing M,Helip-Wooley A,Gahl WA,Webb LS,Lambert AJ,Peters LL

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Bloc1s4 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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