| Gene Symbol | BLOC1S4 |
| Entrez Gene ID | 55330 |
| Full Name | biogenesis of lysosomal organelles complex 1 subunit 4 |
| Synonyms | BCAS4L,BLOS4,CNO |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and is a model for Hermansky-Pudlak syndrome. The encoded protein may play a role in intracellular vesicular trafficking. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end. |
| Disorder MIM: |
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BLOC1S4 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following BLOC1S4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BLOC1S4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu29396 Clone ID Related Accession (Same CDS sequence) NM_018366.3 , NM_018366.2 Accession Version NM_018366.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 654bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577808000000 Organism Homo sapiens(human) Product biogenesis of lysosome-related organelles complex 1 subunit 4 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK002092.1, BC001818.2, AI679712.1 and AC093323.3. On May 17, 2019 this sequence version replaced NM_018366.2. ##Evidence-Data-START## Transcript is intronless :: BC067815.1, ERR279848.6889.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000320776.5/ ENSP00000318128.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601ATGGAGGGTA GCTTTTCGGA TGGCGGAGCG CTGCCGGAGG GGCTCGCGGA AGAGGCCGAG
CCGCAGGGCG CCGCCTGGAG CGGGGACAGT GGCACTGTTT CCCAGAGCCA CAGCAGCGCC
TCGGGGCCGT GGGAGGACGA GGGCGCGGAG GACGGCGCGC CGGGCCGCGA CCTGCCGCTG
CTTCGCCGCG CCGCTGCGGG CTACGCCGCC TGCCTGCTGC CCGGGGCCGG GGCGCGGCCC
GAGGTCGAGG CCCTGGACGC GAGCCTAGAG GACCTGCTTA CCAGAGTGGA CGAGTTCGTG
GGCATGCTGG ACATGCTTCG CGGCGACTCG TCCCACGTCG TCAGCGAGGG CGTGCCGCGC
ATCCACGCGA AGGCCGCCGA GATGCGGCGC ATCTACAGCA GGATCGACCG GCTGGAGGCC
TTCGTGAGGA TGGTGGGGGG CCGCGTGGCC AGGATGGAGG AGCAGGTCAC CAAGGCCGAG
GCCGAGCTGG GCACCTTCCC CAGGGCGTTC AAGAAGCTCC TGCACACGAT GAACGTGCCC
TCGCTCTTTA GCAAGTCTGC TCCCTCGAGG CCACAGCAAG CCGGCTACGA AGCCCCCGTC
CTGTTTCGGA CCGAAGACTA CTTCCCTTGT TGCAGTGAAA GGCCTCAGCT CTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_060836.1 CDS 37..690 Translation 
Target ORF information:
RefSeq Version NM_018366.3 Organism Homo sapiens(human) Definition Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 4 (BLOC1S4), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_018366.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGGAGGGTA GCTTTTCGGA TGGCGGAGCG CTGCCGGAGG GGCTCGCGGA AGAGGCCGAG
CCGCAGGGCG CCGCCTGGAG CGGGGACAGT GGCACTGTTT CCCAGAGCCA CAGCAGCGCC
TCGGGGCCGT GGGAGGACGA GGGCGCGGAG GACGGCGCGC CGGGCCGCGA CCTGCCGCTG
CTTCGCCGCG CCGCTGCGGG CTACGCCGCC TGCCTGCTGC CCGGGGCCGG GGCGCGGCCC
GAGGTCGAGG CCCTGGACGC GAGCCTAGAG GACCTGCTTA CCAGAGTGGA CGAGTTCGTG
GGCATGCTGG ACATGCTTCG CGGCGACTCG TCCCACGTCG TCAGCGAGGG CGTGCCGCGC
ATCCACGCGA AGGCCGCCGA GATGCGGCGC ATCTACAGCA GGATCGACCG GCTGGAGGCC
TTCGTGAGGA TGGTGGGGGG CCGCGTGGCC AGGATGGAGG AGCAGGTCAC CAAGGCCGAG
GCCGAGCTGG GCACCTTCCC CAGGGCGTTC AAGAAGCTCC TGCACACGAT GAACGTGCCC
TCGCTCTTTA GCAAGTCTGC TCCCTCGAGG CCACAGCAAG CCGGCTACGA AGCCCCCGTC
CTGTTTCGGA CCGAAGACTA CTTCCCTTGT TGCAGTGAAA GGCCTCAGCT CTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu29396 Clone ID Related Accession (Same CDS sequence) NM_018366.3 , NM_018366.2 Accession Version NM_018366.2 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 654bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1550160000000 Organism Homo sapiens(human) Product biogenesis of lysosome-related organelles complex 1 subunit 4 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK002092.1, BC001818.2 and AI679712.1. On Jan 13, 2004 this sequence version replaced NM_018366.1. COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601ATGGAGGGTA GCTTTTCGGA TGGCGGAGCG CTGCCGGAGG GGCTCGCGGA AGAGGCCGAG
CCGCAGGGCG CCGCCTGGAG CGGGGACAGT GGCACTGTTT CCCAGAGCCA CAGCAGCGCC
TCGGGGCCGT GGGAGGACGA GGGCGCGGAG GACGGCGCGC CGGGCCGCGA CCTGCCGCTG
CTTCGCCGCG CCGCTGCGGG CTACGCCGCC TGCCTGCTGC CCGGGGCCGG GGCGCGGCCC
GAGGTCGAGG CCCTGGACGC GAGCCTAGAG GACCTGCTTA CCAGAGTGGA CGAGTTCGTG
GGCATGCTGG ACATGCTTCG CGGCGACTCG TCCCACGTCG TCAGCGAGGG CGTGCCGCGC
ATCCACGCGA AGGCCGCCGA GATGCGGCGC ATCTACAGCA GGATCGACCG GCTGGAGGCC
TTCGTGAGGA TGGTGGGGGG CCGCGTGGCC AGGATGGAGG AGCAGGTCAC CAAGGCCGAG
GCCGAGCTGG GCACCTTCCC CAGGGCGTTC AAGAAGCTCC TGCACACGAT GAACGTGCCC
TCGCTCTTTA GCAAGTCTGC TCCCTCGAGG CCACAGCAAG CCGGCTACGA AGCCCCCGTC
CTGTTTCGGA CCGAAGACTA CTTCCCTTGT TGCAGTGAAA GGCCTCAGCT CTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_060836.1 CDS 96..749 Translation
Target ORF information:
RefSeq Version NM_018366.2 Organism Homo sapiens(human) Definition Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 4 (BLOC1S4), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_018366.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGGAGGGTA GCTTTTCGGA TGGCGGAGCG CTGCCGGAGG GGCTCGCGGA AGAGGCCGAG
CCGCAGGGCG CCGCCTGGAG CGGGGACAGT GGCACTGTTT CCCAGAGCCA CAGCAGCGCC
TCGGGGCCGT GGGAGGACGA GGGCGCGGAG GACGGCGCGC CGGGCCGCGA CCTGCCGCTG
CTTCGCCGCG CCGCTGCGGG CTACGCCGCC TGCCTGCTGC CCGGGGCCGG GGCGCGGCCC
GAGGTCGAGG CCCTGGACGC GAGCCTAGAG GACCTGCTTA CCAGAGTGGA CGAGTTCGTG
GGCATGCTGG ACATGCTTCG CGGCGACTCG TCCCACGTCG TCAGCGAGGG CGTGCCGCGC
ATCCACGCGA AGGCCGCCGA GATGCGGCGC ATCTACAGCA GGATCGACCG GCTGGAGGCC
TTCGTGAGGA TGGTGGGGGG CCGCGTGGCC AGGATGGAGG AGCAGGTCAC CAAGGCCGAG
GCCGAGCTGG GCACCTTCCC CAGGGCGTTC AAGAAGCTCC TGCACACGAT GAACGTGCCC
TCGCTCTTTA GCAAGTCTGC TCCCTCGAGG CCACAGCAAG CCGGCTACGA AGCCCCCGTC
CTGTTTCGGA CCGAAGACTA CTTCCCTTGT TGCAGTGAAA GGCCTCAGCT CTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
The Journal of biological chemistry287(8)5882-90(2012 Feb)
Lee HH,Nemecek D,Schindler C,Smith WJ,Ghirlando R,Steven AC,Bonifacino JS,Hurley JH
Targeting protein-trafficking pathways alters melanoma treatment sensitivity.
Proceedings of the National Academy of Sciences of the United States of America109(2)553-8(2012 Jan)
Huang ZM,Chinen M,Chang PJ,Xie T,Zhong L,Demetriou S,Patel MP,Scherzer R,Sviderskaya EV,Bennett DC,Millhauser GL,Oh DH,Cleaver JE,Wei ML
Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
The Journal of biological chemistry279(27)28393-401(2004 Jul)
Starcevic M,Dell'Angelica EC
Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
Nature genetics35(1)84-9(2003 Sep)
Li W,Zhang Q,Oiso N,Novak EK,Gautam R,O'Brien EP,Tinsley CL,Blake DJ,Spritz RA,Copeland NG,Jenkins NA,Amato D,Roe BA,Starcevic M,Dell'Angelica EC,Elliott RW,Mishra V,Kingsmore SF,Paylor RE,Swank RT
Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1).
Blood101(11)4402-7(2003 Jun)
Ciciotte SL,Gwynn B,Moriyama K,Huizing M,Gahl WA,Bonifacino JS,Peters LL
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