Pld4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pld4
Entrez Gene ID	104759
Full Name	phospholipase D family, member 4
Synonyms	AI132321,thss
General protein information	Preferred Names phospholipase D family, member 4 Names phospholipase D4 PLD 4 choline phosphatase 4 phosphatidylcholine-hydrolyzing phospholipase D4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 F1

mRNA and Protein(s)

mRNA	Protein	Name
NM_178911.4	NP_849242.1	phospholipase D4
XM_017314926.1	XP_017170415.1	phospholipase D4 isoform X1
XM_017314926.2	XP_017170415.1	phospholipase D4 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PLD4	XP_005623935.1
Rattus norvegicus (Norway rat)	Pld4	NP_001119760.1
Caenorhabditis elegans (roundworm)	T05C3.6	NP_001123000.1
Mus musculus (house mouse)	Pld4	NP_849242.1
Danio rerio (zebrafish)	si:dkeyp-110e4.6	XP_005173237.1
Homo sapiens (human)	PLD4	NP_620145.2
Pan troglodytes (chimpanzee)	PLD4	XP_510201.2
Bos taurus (cattle)	PLD4	XP_002696897.2
Macaca mulatta (Rhesus monkey)	PLD4	XP_002805273.1
Gallus gallus (chicken)	PLD4	XP_421399.4

Gene Ontology
Bibliography

Related articles in PubMed

PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes.
Akizuki S, Ishigaki K, Kochi Y, Law SM, Matsuo K, Ohmura K, Suzuki A, Nakayama M, Iizuka Y, Koseki H, Ohara O, Hirata J, Kamatani Y, Matsuda F, Sumida T, Yamamoto K, Okada Y, Mimori T, Terao C
Annals of the rheumatic diseases78(4)509-518(2019 04)

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.
Gavin AL, Huang D, Huber C, Mårtensson A, Tardif V, Skog PD, Blane TR, Thinnes TC, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, Schulz SR, Zarpellon A, Cravatt B, Pang ES, Teijaro J, de la Torre JC, O'Keeffe M, Hochrein H, Damme M, Teyton L, Lawson BR, Nemazee D
Nature immunology19(9)942-953(2018 09)

Targeting Phospholipase D4 Attenuates Kidney Fibrosis.
Trivedi P, Kumar RK, Iyer A, Boswell S, Gerarduzzi C, Dadhania VP, Herbert Z, Joshi N, Luyendyk JP, Humphreys BD, Vaidya VS
Journal of the American Society of Nephrology : JASN28(12)3579-3589(2017 Dec)

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.
Potter PK, Bowl MR, Jeyarajan P, Wisby L, Blease A, Goldsworthy ME, Simon MM, Greenaway S, Michel V, Barnard A, Aguilar C, Agnew T, Banks G, Blake A, Chessum L, Dorning J, Falcone S, Goosey L, Harris S, Haynes A, Heise I, Hillier R, Hough T, Hoslin A, Hutchison M, King R, Kumar S, Lad HV, Law G, MacLaren RE, Morse S, Nicol T, Parker A, Pickford K, Sethi S, Starbuck B, Stelma F, Cheeseman M, Cross SH, Foster RG, Jackson IJ, Peirson SN, Thakker RV, Vincent T, Scudamore C, Wells S, El-Amraoui A, Petit C, Acevedo-Arozena A, Nolan PM, Cox R, Mallon AM, Brown SD
Nature communications712444(2016 08)

Microglial phospholipase D4 deficiency influences myelination during brain development.
Chiba T, Otani Y, Yamaguchi Y, Ishibashi T, Hayashi A, Tanaka KF, Yamazaki M, Sakimura K, Baba H
Proceedings of the Japan Academy. Series B, Physical and biological sciences92(7)237-54(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pld4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pld4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu78123	XM_017314926.2 Latest version!	Mus musculus phospholipase D family, member 4 (Pld4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu20086	NM_178911.4 Latest version!	Mus musculus phospholipase D family, member 4 (Pld4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu78123	XM_017314926.1	Mus musculus phospholipase D family, member 4 (Pld4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pld4 ( XM_017314926.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017170415.1 Mus musculus phospholipase D family, member 4 (Pld4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu78123
Clone ID Related Accession (Same CDS sequence)	XM_017314926.1 , XM_017314926.2
Accession Version	XM_017314926.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1466438400000
Organism	Mus musculus(house mouse)
Product	phospholipase D4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACAAGA AGAAAGAGCA CCCAGAGATG CGGATACCAC TCCAGACAGC AGTGGAGGTC 
TCTGATTGGC CCTGCTCCAC ATCTCATGAT CCACATAGCG GACTTGGCAT GGTACTGGGG 
ATGCTAGCTG TACTGGGACT CAGCTCTGTG ACTCTCATCT TGTTCCTGTG GCAAGGGGCC 
ACTTCTTTCA CCAGTCATCG GATGTTCCCT GAGGAAGTGC CCTCCTGGTC CTGGGAGACC 
CTGAAAGGAG ACGCTGAGCA GCAGAATAAC TCCTGTCAGC TCATCCTTGT GGAAAGCATC 
CCTGAGGACT TGCCATTTGC AGCTGGCAGC CCCACTGCCC AGCCCCTGGC CCAGGCTTGG 
CTGCAGCTTC TTGACACTGC TCGGGAGAGC GTCCACATTG CCTCGTACTA CTGGTCCCTC 
ACTGGACTGG ACATTGGAGT CAATGACTCG TCTTCTCGGC AGGGAGAGGC CCTTCTACAG 
AAGTTCCAAC AGCTTCTTCT CAGGAACATC TCTGTGGTGG TGGCCACCCA CAGCCCAACA 
TTGGCCAAGA CATCCACTGA CCTCCAGGTC TTGGCTGCCC ATGGTGCCCA GATACGACAA 
GTGCCCATGA AACAGCTTAC TGGGGGTGTT CTACACTCCA AATTCTGGGT TGTGGATGGG 
CGACACATCT ACGTGGGCAG TGCCAACATG GACTGGCGGT CCCTGACTCA GCCTATCCTA 
GTCAGCAAGC CCCGGGTCCC AGTGAGAGAT CTTGCCTCAA AAACACAAGA TGGAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017170415.1
CDS	100..879
Translation	MDKKKEHPEMRIPLQTAVEVSDWPCSTSHDPHSGLGMVLGMLAVLGLSSVTLILFLWQGATSFTSHRMFPEEVPSWSWETLKGDAEQQNNSCQLILVESIPEDLPFAAGSPTAQPLAQAWLQLLDTARESVHIASYYWSLTGLDIGVNDSSSRQGEALLQKFQQLLLRNISVVVATHSPTLAKTSTDLQVLAAHGAQIRQVPMKQLTGGVLHSKFWVVDGRHIYVGSANMDWRSLTQPILVSKPRVPVRDLASKTQDGG

Target ORF information:

RefSeq Version	XM_017314926.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus phospholipase D family, member 4 (Pld4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017314926.1

ORF Insert Sequence:

ATGGACAAGA AGAAAGAGCA CCCAGAGATG CGGATACCAC TCCAGACAGC AGTGGAGGTC 
TCTGATTGGC CCTGCTCCAC ATCTCATGAT CCACATAGCG GACTTGGCAT GGTACTGGGG 
ATGCTAGCTG TACTGGGACT CAGCTCTGTG ACTCTCATCT TGTTCCTGTG GCAAGGGGCC 
ACTTCTTTCA CCAGTCATCG GATGTTCCCT GAGGAAGTGC CCTCCTGGTC CTGGGAGACC 
CTGAAAGGAG ACGCTGAGCA GCAGAATAAC TCCTGTCAGC TCATCCTTGT GGAAAGCATC 
CCTGAGGACT TGCCATTTGC AGCTGGCAGC CCCACTGCCC AGCCCCTGGC CCAGGCTTGG 
CTGCAGCTTC TTGACACTGC TCGGGAGAGC GTCCACATTG CCTCGTACTA CTGGTCCCTC 
ACTGGACTGG ACATTGGAGT CAATGACTCG TCTTCTCGGC AGGGAGAGGC CCTTCTACAG 
AAGTTCCAAC AGCTTCTTCT CAGGAACATC TCTGTGGTGG TGGCCACCCA CAGCCCAACA 
TTGGCCAAGA CATCCACTGA CCTCCAGGTC TTGGCTGCCC ATGGTGCCCA GATACGACAA 
GTGCCCATGA AACAGCTTAC TGGGGGTGTT CTACACTCCA AATTCTGGGT TGTGGATGGG 
CGACACATCT ACGTGGGCAG TGCCAACATG GACTGGCGGT CCCTGACTCA GCCTATCCTA 
GTCAGCAAGC CCCGGGTCCC AGTGAGAGAT CTTGCCTCAA AAACACAAGA TGGAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pld4 ( XM_017314926.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017170415.1 Mus musculus phospholipase D family, member 4 (Pld4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu78123
Clone ID Related Accession (Same CDS sequence)	XM_017314926.1 , XM_017314926.2
Accession Version	XM_017314926.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	phospholipase D4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017314926.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACAAGA AGAAAGAGCA CCCAGAGATG CGGATACCAC TCCAGACAGC AGTGGAGGTC 
TCTGATTGGC CCTGCTCCAC ATCTCATGAT CCACATAGCG GACTTGGCAT GGTACTGGGG 
ATGCTAGCTG TACTGGGACT CAGCTCTGTG ACTCTCATCT TGTTCCTGTG GCAAGGGGCC 
ACTTCTTTCA CCAGTCATCG GATGTTCCCT GAGGAAGTGC CCTCCTGGTC CTGGGAGACC 
CTGAAAGGAG ACGCTGAGCA GCAGAATAAC TCCTGTCAGC TCATCCTTGT GGAAAGCATC 
CCTGAGGACT TGCCATTTGC AGCTGGCAGC CCCACTGCCC AGCCCCTGGC CCAGGCTTGG 
CTGCAGCTTC TTGACACTGC TCGGGAGAGC GTCCACATTG CCTCGTACTA CTGGTCCCTC 
ACTGGACTGG ACATTGGAGT CAATGACTCG TCTTCTCGGC AGGGAGAGGC CCTTCTACAG 
AAGTTCCAAC AGCTTCTTCT CAGGAACATC TCTGTGGTGG TGGCCACCCA CAGCCCAACA 
TTGGCCAAGA CATCCACTGA CCTCCAGGTC TTGGCTGCCC ATGGTGCCCA GATACGACAA 
GTGCCCATGA AACAGCTTAC TGGGGGTGTT CTACACTCCA AATTCTGGGT TGTGGATGGG 
CGACACATCT ACGTGGGCAG TGCCAACATG GACTGGCGGT CCCTGACTCA GCCTATCCTA 
GTCAGCAAGC CCCGGGTCCC AGTGAGAGAT CTTGCCTCAA AAACACAAGA TGGAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017170415.1
CDS	312..1091
Translation	MDKKKEHPEMRIPLQTAVEVSDWPCSTSHDPHSGLGMVLGMLAVLGLSSVTLILFLWQGATSFTSHRMFPEEVPSWSWETLKGDAEQQNNSCQLILVESIPEDLPFAAGSPTAQPLAQAWLQLLDTARESVHIASYYWSLTGLDIGVNDSSSRQGEALLQKFQQLLLRNISVVVATHSPTLAKTSTDLQVLAAHGAQIRQVPMKQLTGGVLHSKFWVVDGRHIYVGSANMDWRSLTQPILVSKPRVPVRDLASKTQDGG

Target ORF information:

RefSeq Version	XM_017314926.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus phospholipase D family, member 4 (Pld4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017314926.2

ORF Insert Sequence:

ATGGACAAGA AGAAAGAGCA CCCAGAGATG CGGATACCAC TCCAGACAGC AGTGGAGGTC 
TCTGATTGGC CCTGCTCCAC ATCTCATGAT CCACATAGCG GACTTGGCAT GGTACTGGGG 
ATGCTAGCTG TACTGGGACT CAGCTCTGTG ACTCTCATCT TGTTCCTGTG GCAAGGGGCC 
ACTTCTTTCA CCAGTCATCG GATGTTCCCT GAGGAAGTGC CCTCCTGGTC CTGGGAGACC 
CTGAAAGGAG ACGCTGAGCA GCAGAATAAC TCCTGTCAGC TCATCCTTGT GGAAAGCATC 
CCTGAGGACT TGCCATTTGC AGCTGGCAGC CCCACTGCCC AGCCCCTGGC CCAGGCTTGG 
CTGCAGCTTC TTGACACTGC TCGGGAGAGC GTCCACATTG CCTCGTACTA CTGGTCCCTC 
ACTGGACTGG ACATTGGAGT CAATGACTCG TCTTCTCGGC AGGGAGAGGC CCTTCTACAG 
AAGTTCCAAC AGCTTCTTCT CAGGAACATC TCTGTGGTGG TGGCCACCCA CAGCCCAACA 
TTGGCCAAGA CATCCACTGA CCTCCAGGTC TTGGCTGCCC ATGGTGCCCA GATACGACAA 
GTGCCCATGA AACAGCTTAC TGGGGGTGTT CTACACTCCA AATTCTGGGT TGTGGATGGG 
CGACACATCT ACGTGGGCAG TGCCAACATG GACTGGCGGT CCCTGACTCA GCCTATCCTA 
GTCAGCAAGC CCCGGGTCCC AGTGAGAGAT CTTGCCTCAA AAACACAAGA TGGAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pld4 ( NM_178911.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_849242.1 Mus musculus phospholipase D family, member 4 (Pld4), mRNA.

Price & Availability↑

CloneID	OMu20086
Clone ID Related Accession (Same CDS sequence)	NM_178911.4
Accession Version	NM_178911.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1512bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577462400000
Organism	Mus musculus(house mouse)
Product	phospholipase D4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC124353.5. On May 2, 2007 this sequence version replaced NM_178911.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK079878.1, SRR1660817.291793.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGACAAGA AGAAAGAGCA CCCAGAGATG CGGATACCAC TCCAGACAGC AGTGGAGGTC 
TCTGATTGGC CCTGCTCCAC ATCTCATGAT CCACATAGCG GACTTGGCAT GGTACTGGGG 
ATGCTAGCTG TACTGGGACT CAGCTCTGTG ACTCTCATCT TGTTCCTGTG GCAAGGGGCC 
ACTTCTTTCA CCAGTCATCG GATGTTCCCT GAGGAAGTGC CCTCCTGGTC CTGGGAGACC 
CTGAAAGGAG ACGCTGAGCA GCAGAATAAC TCCTGTCAGC TCATCCTTGT GGAAAGCATC 
CCTGAGGACT TGCCATTTGC AGCTGGCAGC CCCACTGCCC AGCCCCTGGC CCAGGCTTGG 
CTGCAGCTTC TTGACACTGC TCGGGAGAGC GTCCACATTG CCTCGTACTA CTGGTCCCTC 
ACTGGACTGG ACATTGGAGT CAATGACTCG TCTTCTCGGC AGGGAGAGGC CCTTCTACAG 
AAGTTCCAAC AGCTTCTTCT CAGGAACATC TCTGTGGTGG TGGCCACCCA CAGCCCAACA 
TTGGCCAAGA CATCCACTGA CCTCCAGGTC TTGGCTGCCC ATGGTGCCCA GATACGACAA 
GTGCCCATGA AACAGCTTAC TGGGGGTGTT CTACACTCCA AATTCTGGGT TGTGGATGGG 
CGACACATCT ACGTGGGCAG TGCCAACATG GACTGGCGGT CCCTGACTCA GGTGAAGGAA 
CTTGGTGCAA TCATCTACAA CTGCAGCAAC CTGGCTCAAG ACCTTGAGAA AACATTCCAG 
ACCTACTGGG TGCTAGGGAC TCCCCAAGCT GTTCTCCCTA AAACCTGGCC TCGGAACTTC 
TCATCCCACA TCAACCGCTT CCATCCCTTG CGGGGTCCCT TTGATGGGGT TCCCACCACG 
GCCTATTTCT CGGCCTCCCC TCCCTCCCTC TGCCCGCATG GCCGGACCCG GGATCTGGAC 
GCAGTGTTGG GAGTGATGGA GGGTGCTCGC CAGTTCATCT ATGTCTCGGT GATGGAGTAT 
TTCCCTACCA CGCGCTTCAC CCACCATGCC AGGTACTGGC CCGTGCTGGA CAATGCGCTA 
CGGGCAGCGG CCCTCAATAA GGGTGTGCAT GTGCGCTTAC TGGTCAGCTG CTGGTTCAAC 
ACAGACCCCA CCATGTTCGC TTATCTGAGG TCCCTGCAGG CTTTCAGTAA CCCCTCGGCT 
GGCATCTCAG TGGATGTGAA AGTCTTCATC GTGCCTGTGG GAAATCATTC CAACATCCCG 
TTCAGCCGCG TGAACCACAG CAAGTTCATG GTCACAGACA AGACAGCCTA TGTAGGCACC 
TCTAACTGGT CAGAAGACTA CTTCAGCCAC ACCGCTGGTG TGGGCCTGAT TGTCAGCCAG 
AAGACCCCCA GAGCCCAGCC AGGCGCAACC ACCGTGCAGG AGCAGCTGAG GCAACTCTTT 
GAACGAGACT GGAGTTCCCA CTATGCTATG GACCTAGACA GACAAGTCCC GAGCCAGGAC 
TGTGTCTGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_849242.1
CDS	103..1614
Translation	MDKKKEHPEMRIPLQTAVEVSDWPCSTSHDPHSGLGMVLGMLAVLGLSSVTLILFLWQGATSFTSHRMFPEEVPSWSWETLKGDAEQQNNSCQLILVESIPEDLPFAAGSPTAQPLAQAWLQLLDTARESVHIASYYWSLTGLDIGVNDSSSRQGEALLQKFQQLLLRNISVVVATHSPTLAKTSTDLQVLAAHGAQIRQVPMKQLTGGVLHSKFWVVDGRHIYVGSANMDWRSLTQVKELGAIIYNCSNLAQDLEKTFQTYWVLGTPQAVLPKTWPRNFSSHINRFHPLRGPFDGVPTTAYFSASPPSLCPHGRTRDLDAVLGVMEGARQFIYVSVMEYFPTTRFTHHARYWPVLDNALRAAALNKGVHVRLLVSCWFNTDPTMFAYLRSLQAFSNPSAGISVDVKVFIVPVGNHSNIPFSRVNHSKFMVTDKTAYVGTSNWSEDYFSHTAGVGLIVSQKTPRAQPGATTVQEQLRQLFERDWSSHYAMDLDRQVPSQDCVW

Target ORF information:

RefSeq Version	NM_178911.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus phospholipase D family, member 4 (Pld4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178911.4

ORF Insert Sequence:

ATGGACAAGA AGAAAGAGCA CCCAGAGATG CGGATACCAC TCCAGACAGC AGTGGAGGTC 
TCTGATTGGC CCTGCTCCAC ATCTCATGAT CCACATAGCG GACTTGGCAT GGTACTGGGG 
ATGCTAGCTG TACTGGGACT CAGCTCTGTG ACTCTCATCT TGTTCCTGTG GCAAGGGGCC 
ACTTCTTTCA CCAGTCATCG GATGTTCCCT GAGGAAGTGC CCTCCTGGTC CTGGGAGACC 
CTGAAAGGAG ACGCTGAGCA GCAGAATAAC TCCTGTCAGC TCATCCTTGT GGAAAGCATC 
CCTGAGGACT TGCCATTTGC AGCTGGCAGC CCCACTGCCC AGCCCCTGGC CCAGGCTTGG 
CTGCAGCTTC TTGACACTGC TCGGGAGAGC GTCCACATTG CCTCGTACTA CTGGTCCCTC 
ACTGGACTGG ACATTGGAGT CAATGACTCG TCTTCTCGGC AGGGAGAGGC CCTTCTACAG 
AAGTTCCAAC AGCTTCTTCT CAGGAACATC TCTGTGGTGG TGGCCACCCA CAGCCCAACA 
TTGGCCAAGA CATCCACTGA CCTCCAGGTC TTGGCTGCCC ATGGTGCCCA GATACGACAA 
GTGCCCATGA AACAGCTTAC TGGGGGTGTT CTACACTCCA AATTCTGGGT TGTGGATGGG 
CGACACATCT ACGTGGGCAG TGCCAACATG GACTGGCGGT CCCTGACTCA GGTGAAGGAA 
CTTGGTGCAA TCATCTACAA CTGCAGCAAC CTGGCTCAAG ACCTTGAGAA AACATTCCAG 
ACCTACTGGG TGCTAGGGAC TCCCCAAGCT GTTCTCCCTA AAACCTGGCC TCGGAACTTC 
TCATCCCACA TCAACCGCTT CCATCCCTTG CGGGGTCCCT TTGATGGGGT TCCCACCACG 
GCCTATTTCT CGGCCTCCCC TCCCTCCCTC TGCCCGCATG GCCGGACCCG GGATCTGGAC 
GCAGTGTTGG GAGTGATGGA GGGTGCTCGC CAGTTCATCT ATGTCTCGGT GATGGAGTAT 
TTCCCTACCA CGCGCTTCAC CCACCATGCC AGGTACTGGC CCGTGCTGGA CAATGCGCTA 
CGGGCAGCGG CCCTCAATAA GGGTGTGCAT GTGCGCTTAC TGGTCAGCTG CTGGTTCAAC 
ACAGACCCCA CCATGTTCGC TTATCTGAGG TCCCTGCAGG CTTTCAGTAA CCCCTCGGCT 
GGCATCTCAG TGGATGTGAA AGTCTTCATC GTGCCTGTGG GAAATCATTC CAACATCCCG 
TTCAGCCGCG TGAACCACAG CAAGTTCATG GTCACAGACA AGACAGCCTA TGTAGGCACC 
TCTAACTGGT CAGAAGACTA CTTCAGCCAC ACCGCTGGTG TGGGCCTGAT TGTCAGCCAG 
AAGACCCCCA GAGCCCAGCC AGGCGCAACC ACCGTGCAGG AGCAGCTGAG GCAACTCTTT 
GAACGAGACT GGAGTTCCCA CTATGCTATG GACCTAGACA GACAAGTCCC GAGCCAGGAC 
TGTGTCTGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes.
Annals of the rheumatic diseases78(4)509-518(2019 04)
Akizuki S,Ishigaki K,Kochi Y,Law SM,Matsuo K,Ohmura K,Suzuki A,Nakayama M,Iizuka Y,Koseki H,Ohara O,Hirata J,Kamatani Y,Matsuda F,Sumida T,Yamamoto K,Okada Y,Mimori T,Terao C

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.
Nature immunology19(9)942-953(2018 09)
Gavin AL,Huang D,Huber C,Mårtensson A,Tardif V,Skog PD,Blane TR,Thinnes TC,Osborn K,Chong HS,Kargaran F,Kimm P,Zeitjian A,Sielski RL,Briggs M,Schulz SR,Zarpellon A,Cravatt B,Pang ES,Teijaro J,de la Torre JC,O'Keeffe M,Hochrein H,Damme M,Teyton L,Lawson BR,Nemazee D

Targeting Phospholipase D4 Attenuates Kidney Fibrosis.
Journal of the American Society of Nephrology : JASN28(12)3579-3589(2017 Dec)
Trivedi P,Kumar RK,Iyer A,Boswell S,Gerarduzzi C,Dadhania VP,Herbert Z,Joshi N,Luyendyk JP,Humphreys BD,Vaidya VS

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.
Nature communications712444(2016 08)
Potter PK,Bowl MR,Jeyarajan P,Wisby L,Blease A,Goldsworthy ME,Simon MM,Greenaway S,Michel V,Barnard A,Aguilar C,Agnew T,Banks G,Blake A,Chessum L,Dorning J,Falcone S,Goosey L,Harris S,Haynes A,Heise I,Hillier R,Hough T,Hoslin A,Hutchison M,King R,Kumar S,Lad HV,Law G,MacLaren RE,Morse S,Nicol T,Parker A,Pickford K,Sethi S,Starbuck B,Stelma F,Cheeseman M,Cross SH,Foster RG,Jackson IJ,Peirson SN,Thakker RV,Vincent T,Scudamore C,Wells S,El-Amraoui A,Petit C,Acevedo-Arozena A,Nolan PM,Cox R,Mallon AM,Brown SD

Microglial phospholipase D4 deficiency influences myelination during brain development.
Proceedings of the Japan Academy. Series B, Physical and biological sciences92(7)237-54(2016)
Chiba T,Otani Y,Yamaguchi Y,Ishibashi T,Hayashi A,Tanaka KF,Yamazaki M,Sakimura K,Baba H

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Pld4 cDNA ORF clone, Mus musculus(house mouse)

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