Bap1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bap1
Entrez Gene ID	104416
Full Name	Brca1 associated protein 1
Synonyms	2300006C11Rik,AA989761,AW553466,mKIAA0272,uch-x4
General protein information	Preferred Names Brca1 associated protein 1 Names ubiquitin carboxyl-terminal hydrolase BAP1 BRCA1-associated protein 1 ubiquitin C-terminal hydrolase X4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 B

mRNA and Protein(s)

mRNA	Protein	Name
NM_027088.2	NP_081364.1	ubiquitin carboxyl-terminal hydrolase BAP1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Bap1	NP_081364.1
Gallus gallus (chicken)	BAP1	NP_001025761.1
Homo sapiens (human)	BAP1	NP_004647.1
Rattus norvegicus (Norway rat)	Bap1	NP_001100762.1
Bos taurus (cattle)	BAP1	NP_001096019.1
Pan troglodytes (chimpanzee)	BAP1	XP_001171970.1
Danio rerio (zebrafish)	bap1	NP_001157309.1
Drosophila melanogaster (fruit fly)	calypso	NP_788374.1
Macaca mulatta (Rhesus monkey)	BAP1	XP_001089173.1
Canis lupus familiaris (dog)	BAP1	XP_541853.2
Xenopus tropicalis (tropical clawed frog)	bap1	NP_001008206.1

Gene Ontology
Bibliography

Related articles in PubMed

Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1.
He M, Chaurushiya MS, Webster JD, Kummerfeld S, Reja R, Chaudhuri S, Chen YJ, Modrusan Z, Haley B, Dugger DL, Eastham-Anderson J, Lau S, Dey A, Caothien R, Roose-Girma M, Newton K, Dixit VM
Science (New York, N.Y.)364(6437)283-285(2019 Apr)

The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
Webster JD, Pham TH, Wu X, Hughes NW, Li Z, Totpal K, Lee HJ, Calses PC, Chaurushiya MS, Stawiski EW, Modrusan Z, Chang MT, Tran C, Lee WP, Chalasani S, Hung J, Sharma N, Chan S, Hotzel K, Talevich E, Shain A, Xu M, Lill J, Dixit VM, Bastian BC, Dey A
Pigment cell & melanoma research32(2)269-279(2019 03)

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo.
Guo Y, Yang H, Chen S, Zhang P, Li R, Nimer SD, Harbour JW, Xu M, Yang FC
Leukemia32(8)1834-1837(2018 08)

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.
Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T
Nature communications9(1)2733(2018 07)

Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes.
Arenzana TL, Lianoglou S, Seki A, Eidenschenk C, Cheung T, Seshasayee D, Hagenbeek T, Sambandam A, Noubade R, Peng I, Lesch J, DeVoss J, Wu X, Lee WP, Caplazi P, Webster J, Liu J, Pham VC, Arnott D, Lill JR, Modrusan Z, Dey A, Rutz S
Science immunology3(22)(2018 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Bap1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bap1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03586	NM_027088.2 Latest version!	Mus musculus Brca1 associated protein 1 (Bap1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$426.30 $609.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bap1 ( NM_027088.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081364.1 Mus musculus Brca1 associated protein 1 (Bap1), mRNA.

Price & Availability↑

CloneID	OMu03586
Clone ID Related Accession (Same CDS sequence)	NM_027088.2
Accession Version	NM_027088.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2187bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Mus musculus(house mouse)
Product	ubiquitin carboxyl-terminal hydrolase BAP1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK170576.1. On Apr 15, 2006 this sequence version replaced NM_027088.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK079374.1, AK170576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAATAAGG GCTGGCTGGA GCTGGAGAGT GACCCAGGCC TCTTCACCCT CCTGGTGGAA 
GATTTCGGTG TCAAAGGGGT GCAAGTGGAG GAGATCTATG ACCTTCAGAG TAAATGCCAG 
GGGCCTGTGT ATGGATTTAT CTTCCTGTTC AAATGGATCG AAGAGCGCAG GTCCCGCCGC 
AAGGTTTCTA CGTTGGTGGA TGACACGTCT GTGATTGATG ATGATATTGT GAATAACATG 
TTCTTTGCTC ACCAGCTGAT TCCCAACTCT TGTGCCACTC ACGCCTTGCT AAGCGTGCTT 
CTGAACTGCA GCAATGTGGA TCTGGGGCCC ACGCTGAGCC GAATGAAGGA TTTCACCAAA 
GGCTTCAGTC CTGAGAGCAA AGGATATGCA ATTGGCAATG CCCCTGAACT GGCCAAGGCA 
CATAATAGCC ATGCCAGGCC AGAACCACGT CACCTTCCTG AGAAACAGAA TGGCCTCAGT 
GCAGTGCGGA CCATGGAGGC GTTTCATTTT GTCAGCTATG TGCCTATCAC AGGGAGGCTC 
TTTGAATTGG ATGGATTGAA AGTCTACCCA ATTGATCATG GGCCCTGGGG AGAGGACGAG 
GAGTGGACAG ATAAAGCTCG AAGGGTCATC ATGGAGCGAA TCGGTCTTGC TACTGCAGGG 
GAGCCCTATC ATGACATTCG CTTCAACCTG ATGGCAGTGG TGCCTGACCG CAGGATTAAG 
TATGAGACCA GGCTACATGT ACTGAAGGTG AACCGACAAA CAGTCCTGGA GGCCCTGCAG 
CAGCTGATTA GAGTAACCCA GCCGGAGCTG ATTCAGACCC ACAAATCTCA AGAGTCACAG 
CTGCCTGAGG AGAGCAAGCC AGCCAGCAGC AAGTCCCCCC TTGGACTGGA GGCAGGCAGA 
ACCCCAGTGG CCTCTGAGTG CACTCAGACA GATGGTGCAG AGGAGGTGGC TGGTTCGTGC 
CCACAAACTA CAACCCATAG TCCTCCCAGC AAATGTAAGC TGGTGGTGAA GCCTCCAGGG 
AGCAGCCTCA ATGGGGTTCC CCCAAACCCT GCCCCTATTG TCCAGCGGCT GCCAGCCTTC 
CTAGACAATC ACAATTATGC CAAATCCCCT ATGCAGGAGG AGGAAGACCT GGCGGCAGGA 
GTGGGTCGCA GCCGCGTTCC CGTCCGAGCG CCCCAGCAGT ACTCTGAAGA CGAGGATGAC 
TACGAGGATG AGGACGAGGA CGTGCAGAAC ACCAACCCTG CCATCAGATA CAAGCGGAAG 
GGGACAGGGA AGCCAGGATC GTTGAGCAAT TCTTCAGATG GGCAGCTGTC AGTGCTGCAG 
CCCAACACCA TCAATGTCTT AACTGAGAAG CTTCAAGAGT CTCAGAAAGA CCTTTCAGTT 
CCTCTGTCCA TCAAGACTAG CAGTGGGGCT GGGAGTCCAG CTGTGGCTGT GCCCACACAC 
TCGCAACCTT CACCCACCCC TAGCAATGAG AGCACGGACA CAGCCTCTGA GATTGGCAGT 
GCTTTCAACT CACCCTTGCG CTCGCCCATC CGCTCGGCCA ACCCAACACG GCCCTCTAGC 
CCTGTCACCT CTCACATCTC CAAGGTGCTT TTTGGAGAAG ATGACAGCCT ACTTCGTGTT 
GACTGCATAC GCTACAACCG TGCTGTCCGT GACCTGGGTC CTGTCATTAG CACGGGCCTG 
CTGCACCTTG CTGAAGATGG TGTACTGAGT CCCCTGGCAC TCACAGAGGG TGGGAAGGGT 
TCCTCACCTT CTACCAGATC AAGCCAAGGC AGCCAGGGGT CCAGTGGCCT AGAGGAGAAG 
GAGGTGGTGG AAGTCACAGA GAGCAGAGAC AAGCCTGGGC TGAACAGGTC CAGTGAGCCC 
TTGAGTGGAG AGAAGTACTC ACCCAAGGAG CTGCTAGCAC TGCTAAAGTG TGTAGAAGCC 
GAGATTGCAA ACTATGAGGC CTGTCTCAAG GAGGAGGTGG AGAAAAGGAA GAAGTTCAAG 
ATTGATGACC AGCGAAGGAC CCACAACTAT GACGAGTTTA TCTGTACCTT CATATCCATG 
CTGGCTCAGG AAGGAATGCT GGCCAACCTA GTGGAACAGA ACATCTCAGT GCGCCGGCGC 
CAAGGGGTCA GCATTGGGCG GCTTCACAAG CAGCGGAAGC CTGACCGGCG GAAACGCTCT 
CGCCCCTACA AGGCCAAACG CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081364.1
CDS	130..2316
Translation	MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSNVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYETRLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKPASSKSPLGLEAGRTPVASECTQTDGAEEVAGSCPQTTTHSPPSKCKLVVKPPGSSLNGVPPNPAPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRAPQQYSEDEDDYEDEDEDVQNTNPAIRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEKLQESQKDLSVPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSTRSSQGSQGSSGLEEKEVVEVTESRDKPGLNRSSEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ

Target ORF information:

RefSeq Version	NM_027088.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Brca1 associated protein 1 (Bap1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027088.2

ORF Insert Sequence:

ATGAATAAGG GCTGGCTGGA GCTGGAGAGT GACCCAGGCC TCTTCACCCT CCTGGTGGAA 
GATTTCGGTG TCAAAGGGGT GCAAGTGGAG GAGATCTATG ACCTTCAGAG TAAATGCCAG 
GGGCCTGTGT ATGGATTTAT CTTCCTGTTC AAATGGATCG AAGAGCGCAG GTCCCGCCGC 
AAGGTTTCTA CGTTGGTGGA TGACACGTCT GTGATTGATG ATGATATTGT GAATAACATG 
TTCTTTGCTC ACCAGCTGAT TCCCAACTCT TGTGCCACTC ACGCCTTGCT AAGCGTGCTT 
CTGAACTGCA GCAATGTGGA TCTGGGGCCC ACGCTGAGCC GAATGAAGGA TTTCACCAAA 
GGCTTCAGTC CTGAGAGCAA AGGATATGCA ATTGGCAATG CCCCTGAACT GGCCAAGGCA 
CATAATAGCC ATGCCAGGCC AGAACCACGT CACCTTCCTG AGAAACAGAA TGGCCTCAGT 
GCAGTGCGGA CCATGGAGGC GTTTCATTTT GTCAGCTATG TGCCTATCAC AGGGAGGCTC 
TTTGAATTGG ATGGATTGAA AGTCTACCCA ATTGATCATG GGCCCTGGGG AGAGGACGAG 
GAGTGGACAG ATAAAGCTCG AAGGGTCATC ATGGAGCGAA TCGGTCTTGC TACTGCAGGG 
GAGCCCTATC ATGACATTCG CTTCAACCTG ATGGCAGTGG TGCCTGACCG CAGGATTAAG 
TATGAGACCA GGCTACATGT ACTGAAGGTG AACCGACAAA CAGTCCTGGA GGCCCTGCAG 
CAGCTGATTA GAGTAACCCA GCCGGAGCTG ATTCAGACCC ACAAATCTCA AGAGTCACAG 
CTGCCTGAGG AGAGCAAGCC AGCCAGCAGC AAGTCCCCCC TTGGACTGGA GGCAGGCAGA 
ACCCCAGTGG CCTCTGAGTG CACTCAGACA GATGGTGCAG AGGAGGTGGC TGGTTCGTGC 
CCACAAACTA CAACCCATAG TCCTCCCAGC AAATGTAAGC TGGTGGTGAA GCCTCCAGGG 
AGCAGCCTCA ATGGGGTTCC CCCAAACCCT GCCCCTATTG TCCAGCGGCT GCCAGCCTTC 
CTAGACAATC ACAATTATGC CAAATCCCCT ATGCAGGAGG AGGAAGACCT GGCGGCAGGA 
GTGGGTCGCA GCCGCGTTCC CGTCCGAGCG CCCCAGCAGT ACTCTGAAGA CGAGGATGAC 
TACGAGGATG AGGACGAGGA CGTGCAGAAC ACCAACCCTG CCATCAGATA CAAGCGGAAG 
GGGACAGGGA AGCCAGGATC GTTGAGCAAT TCTTCAGATG GGCAGCTGTC AGTGCTGCAG 
CCCAACACCA TCAATGTCTT AACTGAGAAG CTTCAAGAGT CTCAGAAAGA CCTTTCAGTT 
CCTCTGTCCA TCAAGACTAG CAGTGGGGCT GGGAGTCCAG CTGTGGCTGT GCCCACACAC 
TCGCAACCTT CACCCACCCC TAGCAATGAG AGCACGGACA CAGCCTCTGA GATTGGCAGT 
GCTTTCAACT CACCCTTGCG CTCGCCCATC CGCTCGGCCA ACCCAACACG GCCCTCTAGC 
CCTGTCACCT CTCACATCTC CAAGGTGCTT TTTGGAGAAG ATGACAGCCT ACTTCGTGTT 
GACTGCATAC GCTACAACCG TGCTGTCCGT GACCTGGGTC CTGTCATTAG CACGGGCCTG 
CTGCACCTTG CTGAAGATGG TGTACTGAGT CCCCTGGCAC TCACAGAGGG TGGGAAGGGT 
TCCTCACCTT CTACCAGATC AAGCCAAGGC AGCCAGGGGT CCAGTGGCCT AGAGGAGAAG 
GAGGTGGTGG AAGTCACAGA GAGCAGAGAC AAGCCTGGGC TGAACAGGTC CAGTGAGCCC 
TTGAGTGGAG AGAAGTACTC ACCCAAGGAG CTGCTAGCAC TGCTAAAGTG TGTAGAAGCC 
GAGATTGCAA ACTATGAGGC CTGTCTCAAG GAGGAGGTGG AGAAAAGGAA GAAGTTCAAG 
ATTGATGACC AGCGAAGGAC CCACAACTAT GACGAGTTTA TCTGTACCTT CATATCCATG 
CTGGCTCAGG AAGGAATGCT GGCCAACCTA GTGGAACAGA ACATCTCAGT GCGCCGGCGC 
CAAGGGGTCA GCATTGGGCG GCTTCACAAG CAGCGGAAGC CTGACCGGCG GAAACGCTCT 
CGCCCCTACA AGGCCAAACG CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1.
Science (New York, N.Y.)364(6437)283-285(2019 Apr)
He M,Chaurushiya MS,Webster JD,Kummerfeld S,Reja R,Chaudhuri S,Chen YJ,Modrusan Z,Haley B,Dugger DL,Eastham-Anderson J,Lau S,Dey A,Caothien R,Roose-Girma M,Newton K,Dixit VM

The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
Pigment cell & melanoma research32(2)269-279(2019 03)
Webster JD,Pham TH,Wu X,Hughes NW,Li Z,Totpal K,Lee HJ,Calses PC,Chaurushiya MS,Stawiski EW,Modrusan Z,Chang MT,Tran C,Lee WP,Chalasani S,Hung J,Sharma N,Chan S,Hotzel K,Talevich E,Shain A,Xu M,Lill J,Dixit VM,Bastian BC,Dey A

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo.
Leukemia32(8)1834-1837(2018 08)
Guo Y,Yang H,Chen S,Zhang P,Li R,Nimer SD,Harbour JW,Xu M,Yang FC

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.
Nature communications9(1)2733(2018 07)
Asada S,Goyama S,Inoue D,Shikata S,Takeda R,Fukushima T,Yonezawa T,Fujino T,Hayashi Y,Kawabata KC,Fukuyama T,Tanaka Y,Yokoyama A,Yamazaki S,Kozuka-Hata H,Oyama M,Kojima S,Kawazu M,Mano H,Kitamura T

Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes.
Science immunology3(22)(2018 04)
Arenzana TL,Lianoglou S,Seki A,Eidenschenk C,Cheung T,Seshasayee D,Hagenbeek T,Sambandam A,Noubade R,Peng I,Lesch J,DeVoss J,Wu X,Lee WP,Caplazi P,Webster J,Liu J,Pham VC,Arnott D,Lill JR,Modrusan Z,Dey A,Rutz S

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Bap1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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