Acly cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acly
Entrez Gene ID	104112
Full Name	ATP citrate lyase
Synonyms	A730098H14Rik,AW538652
General protein information	Preferred Names ATP citrate lyase Names ATP-citrate synthase ATP-citrate (pro-S-)-lyase citrate cleavage enzyme
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_134037.3	NP_598798.1	ATP-citrate synthase isoform 2
NM_001199296.1	NP_001186225.1	ATP-citrate synthase isoform 1

Pathways from BioSystems

Homologies

Magnaporthe oryzae (rice blast fungus)	MGG_06719	XP_003709430.1
Mus musculus (house mouse)	Acly	NP_001186225.1
Gallus gallus (chicken)	ACLY	NP_001025711.1
Danio rerio (zebrafish)	aclya	NP_001002649.1
Caenorhabditis elegans (roundworm)	acly-2	NP_506267.1
Arabidopsis thaliana (thale cress)	ACLB-2	NP_199757.1
Arabidopsis thaliana (thale cress)	ACLB-1	NP_187317.1
Caenorhabditis elegans (roundworm)	D1005.1	NP_508280.1
Rattus norvegicus (Norway rat)	Acly	NP_058683.2
Xenopus tropicalis (tropical clawed frog)	acly	NP_001008028.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010156	XP_319323.3
Oryza sativa (rice)	Os01g0300200	NP_001042817.1
Macaca mulatta (Rhesus monkey)	ACLY	XP_001108114.2
Bos taurus (cattle)	ACLY	NP_001032534.1
Homo sapiens (human)	ACLY	NP_001087.2
Pan troglodytes (chimpanzee)	ACLY	XP_511495.3
Canis lupus familiaris (dog)	ACLY	XP_850198.1
Drosophila melanogaster (fruit fly)	ATPCL	NP_725514.2
Schizosaccharomyces pombe (fission yeast)	SPBC1703.07	NP_596202.1
Neurospora crassa	NCU06785	XP_963626.1

Gene Ontology
Bibliography

Related articles in PubMed

Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease.
Guo L, Guo YY, Li BY, Peng WQ, Chang XX, Gao X, Tang QQ
The Journal of biological chemistry294(31)11805-11816(2019 Aug)

An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development.
Catela C, Correa E, Wen K, Aburas J, Croci L, Consalez GG, Kratsios P
Neural development14(1)2(2019 01)

Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis.
Scavuzzo MA, Hill MC, Chmielowiec J, Yang D, Teaw J, Sheng K, Kong Y, Bettini M, Zong C, Martin JF, Borowiak M
Nature communications9(1)3356(2018 08)

RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase.
Imamura M, Moon JS, Chung KP, Nakahira K, Muthukumar T, Shingarev R, Ryter SW, Choi AM, Choi ME
JCI insight3(3)(2018 02)

ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation.
Das S, Morvan F, Morozzi G, Jourde B, Minetti GC, Kahle P, Rivet H, Brebbia P, Toussaint G, Glass DJ, Fornaro M
Cell reports21(11)3003-3011(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Acly gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acly cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18269	NM_001199296.1 Latest version!	Mus musculus ATP citrate lyase (Acly), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
OMu18445	NM_134037.3 Latest version!	Mus musculus ATP citrate lyase (Acly), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acly ( NM_001199296.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001186225.1 Mus musculus ATP citrate lyase (Acly), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18269
Clone ID Related Accession (Same CDS sequence)	NM_001199296.1
Accession Version	NM_001199296.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	ATP-citrate synthase isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX842667.2, AK132755.1 and BE623317.1. Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.204662.1, SRR1660817.148380.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END##

ATGTCAGCCA AGGCAATTTC AGAGCAGACC GGCAAAGAAC TCCTGTACAA GTACATCTGC 
ACCACCTCGG CCATCCAGAA CCGGTTCAAG TACGCCCGGG TGACTCCCGA CACAGACTGG 
GCCCATCTGC TGCAGGACCA CCCGTGGCTG CTCAGCCAGA GCTTGGTTGT CAAGCCAGAC 
CAGTTAATCA AACGTCGAGG AAAGCTTGGC CTCGTCGGGG TCAATCTCTC TCTGGATGGA 
GTCAAATCCT GGCTAAAACC TCGCCTGGGA CATGAAGCCA CTGTCGGCAA GGCCAAAGGC 
TTCCTCAAGA ACTTTCTCAT TGAACCCTTC GTCCCCCACA GTCAGGCGGA GGAGTTCTAC 
GTGTGCATCT ATGCTACCCG GGAAGGAGAC TACGTCCTGT TCCACCATGA AGGGGGTGTG 
GATGTGGGCG ATGTGGATGC CAAAGCCCAG AAGCTGCTTG TGGGTGTGGA CGAAAAGCTG 
AATACCGAGG ACATTAAGAG ACACCTGTTG GTCCATGCAC CTGAGGACAA GAAAGAAGTC 
CTGGCCAGCT TCATCTCTGG TCTATTCAAT TTCTACGAGG ATCTGTACTT CACCTACCTT 
GAGATCAACC CCCTTGTGGT GACCAAAGAT GGTGTCTACA TCCTTGACTT GGCGGCCAAG 
GTGGATGCCA CAGCTGACTA CATCTGTAAA GTCAAGTGGG GTGATATAGA GTTCCCTCCC 
CCCTTTGGGC GTGAGGCGTA CCCCGAGGAA GCCTACATTG CAGACCTGGA TGCCAAAAGT 
GGAGCAAGCT TGAAGCTGAC CTTGCTGAAC CCCAAGGGGC GGATCTGGAC CATGGTTGCT 
GGGGGTGGCG CCTCCGTCGT GTACAGTGAC ACCATCTGTG ATCTTGGAGG TGTCAATGAA 
CTGGCGAATT ACGGGGAATA CTCGGGTGCC CCCAGTGAAC AACAGACCTA TGACTATGCC 
AAGACCATCC TCTCACTTAT GACTCGAGAG AAGCACCCAG AAGGCAAGAT CCTCATCATT 
GGAGGCAGCA TTGCAAACTT CACCAATGTG GCCGCCACCT TCAAGGGCAT TGTGAGAGCG 
ATTCGAGATT ACCAGGGTCC CCTGAAGGAG CATGAGGTCA CCATCTTTGT CCGAAGAGGT 
GGCCCCAACT ATCAAGAGGG ATTACGAGTG ATGGGAGAAG TTGGGAAGAC CACTGGGATC 
CCCATCCATG TCTTTGGCAC AGAAACTCAC ATGACGGCCA TTGTGGGCAT GGCCCTGGGC 
CACCGGCCCA TTCCCAACCA GCCACCCACA GCAGCTCACA CTGCCAACTT CCTCCTTAAT 
GCCAGCGGGA GCACATCGAC TCCAGCACCC AGTAGGACAG CATCTTTTTC TGAGTCCCGA 
GCTGATGAAG TGGCACCTGC AAAGAAAGCC AAGCCAGCTA TGCCCCAAGA TTCAGTCCCA 
AGTCCAAGAT CCCTGCAAGG AAAGAGTGCC ACCCTCTTCA GCCGACATAC CAAGGCCATC 
GTGTGGGGCA TGCAGACCCG GGCTGTGCAG GGCATGCTGG ACTTTGACTA CGTGTGTTCC 
CGAGACGAGC CCTCAGTGGC TGCCATGGTC TACCCTTTCA CTGGGGATCA CAAGCAGAAG 
TTTTACTGGG GACACAAGGA AATCCTGATC CCTGTCTTCA AGAACATGGC TGACGCCATG 
AAGAAGCACC CGGAGGTAGA CGTGCTGATC AACTTTGCGT CTCTGCGGTC CGCTTACGAC 
AGCACCATGG AGACCATGAA CTATGCCCAG ATCCGCACCA TAGCCATCAT AGCAGAAGGT 
ATCCCTGAGG CCCTCACACG GAAGCTCATC AAGAAGGCCG ACCAGAAGGG AGTGACCATC 
ATTGGGCCAG CTACGGTTGG GGGCATTAAG CCTGGATGCT TTAAGATCGG GAATACTGGT 
GGAATGCTGG ACAACATCCT GGCCTCCAAA CTGTACCGCC CAGGCAGCGT GGCCTACGTC 
TCACGTTCAG GAGGCATGTC TAATGAACTC AATAACATCA TCTCTCGGAC CACAGATGGT 
GTCTATGAGG GCGTGGCCAT CGGCGGGGAC AGGTACCCTG GGTCCACATT CATGGATCAC 
GTGCTGCGCT ACCAGGACAC TCCAGGAGTC AAGATGATCG TAGTTCTTGG GGAGATAGGG 
GGCACAGAGG AATATAAGAT CTGCCGGGGC ATCAAGGAGG GCCGCCTCAC CAAGCCAGTG 
GTCTGCTGGT GTATCGGGAC CTGTGCCACC ATGTTCTCCT CCGAGGTCCA GTTTGGCCAT 
GCTGGAGCTT GTGCCAACCA GGCTTCTGAA ACTGCAGTAG CCAAGAACCA GGCCTTGAAG 
GAAGCAGGAG TGTTTGTGCC CCGAAGCTTC GATGAGCTTG GAGAAATCAT TCAGTCTGTG 
TATGAAGATC TGGTGGCCAA AGGAGCCATT GTACCTGCCC AGGAAGTGCC ACCTCCAACA 
GTGCCCATGG ACTACTCTTG GGCCAGAGAG CTGGGTTTGA TCCGAAAACC TGCCTCATTC 
ATGACCAGCA TCTGTGATGA GCGAGGGCAG GAGCTCATTT ATGCGGGCAT GCCCATCACC 
GAGGTCTTCA AGGAGGAGAT GGGCATCGGT GGTGTCCTCG GCCTCCTCTG GTTCCAGAGA 
AGGTTGCCCA AGTATTCCTG CCAGTTCATT GAGATGTGTC TGATGGTCAC AGCTGATCAC 
GGGCCAGCTG TCTCTGGAGC CCATAACACC ATCATCTGTG CTCGGGCTGG GAAGGACCTG 
GTCTCCAGCC TCACCTCAGG GCTGCTCACC ATTGGAGACC GGTTTGGGGG TGCCTTGGAT 
GCCGCAGCAA AGATGTTCAG TAAAGCCTTT GACAGCGGCA TCATTCCCAT GGAGTTCGTC 
AACAAGATGA AGAAGGAGGG GAAGCTGATC ATGGGCATCG GCCATCGAGT AAAATCGATA 
AACAACCCAG ACATGCGAGT GCAGATCCTC AAGGACTTCG TCAAACAGCA CTTCCCCGCC 
ACCCCGCTGC TCGACTATGC CCTGGAAGTG GAGAAGATTA CCACCTCCAA GAAGCCAAAT 
CTTATCCTGA ATGTGGACGG CTTCATCGGC GTTGCGTTTG TGGACATGCT CAGGAACTGT 
GGCTCCTTCA CCCGGGAGGA AGCTGATGAA TATGTTGACA TTGGAGCCCT CAATGGCATC 
TTTGTGCTAG GAAGGAGTAT GGGCTTCATT GGGCACTACC TTGACCAGAA GAGGCTGAAG 
CAAGGGCTGT ATCGTCACCC CTGGGATGAC ATTTCCTATG TTCTTCCAGA ACACATGAGC 
ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186225.1
CDS	230..3535
Translation	MSAKAISEQTGKELLYKYICTTSAIQNRFKYARVTPDTDWAHLLQDHPWLLSQSLVVKPDQLIKRRGKLGLVGVNLSLDGVKSWLKPRLGHEATVGKAKGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNTEDIKRHLLVHAPEDKKEVLASFISGLFNFYEDLYFTYLEINPLVVTKDGVYILDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPEGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSATLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMKKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPVVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVAKGAIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQRRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDFVKQHFPATPLLDYALEVEKITTSKKPNLILNVDGFIGVAFVDMLRNCGSFTREEADEYVDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM

Target ORF information:

RefSeq Version	NM_001199296.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ATP citrate lyase (Acly), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199296.1

ORF Insert Sequence:

ATGTCAGCCA AGGCAATTTC AGAGCAGACC GGCAAAGAAC TCCTGTACAA GTACATCTGC 
ACCACCTCGG CCATCCAGAA CCGGTTCAAG TACGCCCGGG TGACTCCCGA CACAGACTGG 
GCCCATCTGC TGCAGGACCA CCCGTGGCTG CTCAGCCAGA GCTTGGTTGT CAAGCCAGAC 
CAGTTAATCA AACGTCGAGG AAAGCTTGGC CTCGTCGGGG TCAATCTCTC TCTGGATGGA 
GTCAAATCCT GGCTAAAACC TCGCCTGGGA CATGAAGCCA CTGTCGGCAA GGCCAAAGGC 
TTCCTCAAGA ACTTTCTCAT TGAACCCTTC GTCCCCCACA GTCAGGCGGA GGAGTTCTAC 
GTGTGCATCT ATGCTACCCG GGAAGGAGAC TACGTCCTGT TCCACCATGA AGGGGGTGTG 
GATGTGGGCG ATGTGGATGC CAAAGCCCAG AAGCTGCTTG TGGGTGTGGA CGAAAAGCTG 
AATACCGAGG ACATTAAGAG ACACCTGTTG GTCCATGCAC CTGAGGACAA GAAAGAAGTC 
CTGGCCAGCT TCATCTCTGG TCTATTCAAT TTCTACGAGG ATCTGTACTT CACCTACCTT 
GAGATCAACC CCCTTGTGGT GACCAAAGAT GGTGTCTACA TCCTTGACTT GGCGGCCAAG 
GTGGATGCCA CAGCTGACTA CATCTGTAAA GTCAAGTGGG GTGATATAGA GTTCCCTCCC 
CCCTTTGGGC GTGAGGCGTA CCCCGAGGAA GCCTACATTG CAGACCTGGA TGCCAAAAGT 
GGAGCAAGCT TGAAGCTGAC CTTGCTGAAC CCCAAGGGGC GGATCTGGAC CATGGTTGCT 
GGGGGTGGCG CCTCCGTCGT GTACAGTGAC ACCATCTGTG ATCTTGGAGG TGTCAATGAA 
CTGGCGAATT ACGGGGAATA CTCGGGTGCC CCCAGTGAAC AACAGACCTA TGACTATGCC 
AAGACCATCC TCTCACTTAT GACTCGAGAG AAGCACCCAG AAGGCAAGAT CCTCATCATT 
GGAGGCAGCA TTGCAAACTT CACCAATGTG GCCGCCACCT TCAAGGGCAT TGTGAGAGCG 
ATTCGAGATT ACCAGGGTCC CCTGAAGGAG CATGAGGTCA CCATCTTTGT CCGAAGAGGT 
GGCCCCAACT ATCAAGAGGG ATTACGAGTG ATGGGAGAAG TTGGGAAGAC CACTGGGATC 
CCCATCCATG TCTTTGGCAC AGAAACTCAC ATGACGGCCA TTGTGGGCAT GGCCCTGGGC 
CACCGGCCCA TTCCCAACCA GCCACCCACA GCAGCTCACA CTGCCAACTT CCTCCTTAAT 
GCCAGCGGGA GCACATCGAC TCCAGCACCC AGTAGGACAG CATCTTTTTC TGAGTCCCGA 
GCTGATGAAG TGGCACCTGC AAAGAAAGCC AAGCCAGCTA TGCCCCAAGA TTCAGTCCCA 
AGTCCAAGAT CCCTGCAAGG AAAGAGTGCC ACCCTCTTCA GCCGACATAC CAAGGCCATC 
GTGTGGGGCA TGCAGACCCG GGCTGTGCAG GGCATGCTGG ACTTTGACTA CGTGTGTTCC 
CGAGACGAGC CCTCAGTGGC TGCCATGGTC TACCCTTTCA CTGGGGATCA CAAGCAGAAG 
TTTTACTGGG GACACAAGGA AATCCTGATC CCTGTCTTCA AGAACATGGC TGACGCCATG 
AAGAAGCACC CGGAGGTAGA CGTGCTGATC AACTTTGCGT CTCTGCGGTC CGCTTACGAC 
AGCACCATGG AGACCATGAA CTATGCCCAG ATCCGCACCA TAGCCATCAT AGCAGAAGGT 
ATCCCTGAGG CCCTCACACG GAAGCTCATC AAGAAGGCCG ACCAGAAGGG AGTGACCATC 
ATTGGGCCAG CTACGGTTGG GGGCATTAAG CCTGGATGCT TTAAGATCGG GAATACTGGT 
GGAATGCTGG ACAACATCCT GGCCTCCAAA CTGTACCGCC CAGGCAGCGT GGCCTACGTC 
TCACGTTCAG GAGGCATGTC TAATGAACTC AATAACATCA TCTCTCGGAC CACAGATGGT 
GTCTATGAGG GCGTGGCCAT CGGCGGGGAC AGGTACCCTG GGTCCACATT CATGGATCAC 
GTGCTGCGCT ACCAGGACAC TCCAGGAGTC AAGATGATCG TAGTTCTTGG GGAGATAGGG 
GGCACAGAGG AATATAAGAT CTGCCGGGGC ATCAAGGAGG GCCGCCTCAC CAAGCCAGTG 
GTCTGCTGGT GTATCGGGAC CTGTGCCACC ATGTTCTCCT CCGAGGTCCA GTTTGGCCAT 
GCTGGAGCTT GTGCCAACCA GGCTTCTGAA ACTGCAGTAG CCAAGAACCA GGCCTTGAAG 
GAAGCAGGAG TGTTTGTGCC CCGAAGCTTC GATGAGCTTG GAGAAATCAT TCAGTCTGTG 
TATGAAGATC TGGTGGCCAA AGGAGCCATT GTACCTGCCC AGGAAGTGCC ACCTCCAACA 
GTGCCCATGG ACTACTCTTG GGCCAGAGAG CTGGGTTTGA TCCGAAAACC TGCCTCATTC 
ATGACCAGCA TCTGTGATGA GCGAGGGCAG GAGCTCATTT ATGCGGGCAT GCCCATCACC 
GAGGTCTTCA AGGAGGAGAT GGGCATCGGT GGTGTCCTCG GCCTCCTCTG GTTCCAGAGA 
AGGTTGCCCA AGTATTCCTG CCAGTTCATT GAGATGTGTC TGATGGTCAC AGCTGATCAC 
GGGCCAGCTG TCTCTGGAGC CCATAACACC ATCATCTGTG CTCGGGCTGG GAAGGACCTG 
GTCTCCAGCC TCACCTCAGG GCTGCTCACC ATTGGAGACC GGTTTGGGGG TGCCTTGGAT 
GCCGCAGCAA AGATGTTCAG TAAAGCCTTT GACAGCGGCA TCATTCCCAT GGAGTTCGTC 
AACAAGATGA AGAAGGAGGG GAAGCTGATC ATGGGCATCG GCCATCGAGT AAAATCGATA 
AACAACCCAG ACATGCGAGT GCAGATCCTC AAGGACTTCG TCAAACAGCA CTTCCCCGCC 
ACCCCGCTGC TCGACTATGC CCTGGAAGTG GAGAAGATTA CCACCTCCAA GAAGCCAAAT 
CTTATCCTGA ATGTGGACGG CTTCATCGGC GTTGCGTTTG TGGACATGCT CAGGAACTGT 
GGCTCCTTCA CCCGGGAGGA AGCTGATGAA TATGTTGACA TTGGAGCCCT CAATGGCATC 
TTTGTGCTAG GAAGGAGTAT GGGCTTCATT GGGCACTACC TTGACCAGAA GAGGCTGAAG 
CAAGGGCTGT ATCGTCACCC CTGGGATGAC ATTTCCTATG TTCTTCCAGA ACACATGAGC 
ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Acly ( NM_134037.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598798.1 Mus musculus ATP citrate lyase (Acly), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu18445
Clone ID Related Accession (Same CDS sequence)	NM_134037.3
Accession Version	NM_134037.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	ATP-citrate synthase isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX842667.2, BC056378.1 and BE623317.1. On Dec 2, 2010 this sequence version replaced NM_134037.2. Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the middle of the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.13826.1, SRR1660817.39173.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END##

ATGTCAGCCA AGGCAATTTC AGAGCAGACC GGCAAAGAAC TCCTGTACAA GTACATCTGC 
ACCACCTCGG CCATCCAGAA CCGGTTCAAG TACGCCCGGG TGACTCCCGA CACAGACTGG 
GCCCATCTGC TGCAGGACCA CCCGTGGCTG CTCAGCCAGA GCTTGGTTGT CAAGCCAGAC 
CAGTTAATCA AACGTCGAGG AAAGCTTGGC CTCGTCGGGG TCAATCTCTC TCTGGATGGA 
GTCAAATCCT GGCTAAAACC TCGCCTGGGA CATGAAGCCA CTGTCGGCAA GGCCAAAGGC 
TTCCTCAAGA ACTTTCTCAT TGAACCCTTC GTCCCCCACA GTCAGGCGGA GGAGTTCTAC 
GTGTGCATCT ATGCTACCCG GGAAGGAGAC TACGTCCTGT TCCACCATGA AGGGGGTGTG 
GATGTGGGCG ATGTGGATGC CAAAGCCCAG AAGCTGCTTG TGGGTGTGGA CGAAAAGCTG 
AATACCGAGG ACATTAAGAG ACACCTGTTG GTCCATGCAC CTGAGGACAA GAAAGAAGTC 
CTGGCCAGCT TCATCTCTGG TCTATTCAAT TTCTACGAGG ATCTGTACTT CACCTACCTT 
GAGATCAACC CCCTTGTGGT GACCAAAGAT GGTGTCTACA TCCTTGACTT GGCGGCCAAG 
GTGGATGCCA CAGCTGACTA CATCTGTAAA GTCAAGTGGG GTGATATAGA GTTCCCTCCC 
CCCTTTGGGC GTGAGGCGTA CCCCGAGGAA GCCTACATTG CAGACCTGGA TGCCAAAAGT 
GGAGCAAGCT TGAAGCTGAC CTTGCTGAAC CCCAAGGGGC GGATCTGGAC CATGGTTGCT 
GGGGGTGGCG CCTCCGTCGT GTACAGTGAC ACCATCTGTG ATCTTGGAGG TGTCAATGAA 
CTGGCGAATT ACGGGGAATA CTCGGGTGCC CCCAGTGAAC AACAGACCTA TGACTATGCC 
AAGACCATCC TCTCACTTAT GACTCGAGAG AAGCACCCAG AAGGCAAGAT CCTCATCATT 
GGAGGCAGCA TTGCAAACTT CACCAATGTG GCCGCCACCT TCAAGGGCAT TGTGAGAGCG 
ATTCGAGATT ACCAGGGTCC CCTGAAGGAG CATGAGGTCA CCATCTTTGT CCGAAGAGGT 
GGCCCCAACT ATCAAGAGGG ATTACGAGTG ATGGGAGAAG TTGGGAAGAC CACTGGGATC 
CCCATCCATG TCTTTGGCAC AGAAACTCAC ATGACGGCCA TTGTGGGCAT GGCCCTGGGC 
CACCGGCCCA TTCCCAACCA GCCACCCACA GCAGCTCACA CTGCCAACTT CCTCCTTAAT 
GCCAGCGGGA GCACATCGAC TCCAGCACCC AGTAGGACAG CATCTTTTTC TGAGTCCCGA 
GCTGATGAAG TGGCACCTGC AAAGAAAGCC AAGCCAGCTA TGCCCCAAGG AAAGAGTGCC 
ACCCTCTTCA GCCGACATAC CAAGGCCATC GTGTGGGGCA TGCAGACCCG GGCTGTGCAG 
GGCATGCTGG ACTTTGACTA CGTGTGTTCC CGAGACGAGC CCTCAGTGGC TGCCATGGTC 
TACCCTTTCA CTGGGGATCA CAAGCAGAAG TTTTACTGGG GACACAAGGA AATCCTGATC 
CCTGTCTTCA AGAACATGGC TGACGCCATG AAGAAGCACC CGGAGGTAGA CGTGCTGATC 
AACTTTGCGT CTCTGCGGTC CGCTTACGAC AGCACCATGG AGACCATGAA CTATGCCCAG 
ATCCGCACCA TAGCCATCAT AGCAGAAGGT ATCCCTGAGG CCCTCACACG GAAGCTCATC 
AAGAAGGCCG ACCAGAAGGG AGTGACCATC ATTGGGCCAG CTACGGTTGG GGGCATTAAG 
CCTGGATGCT TTAAGATCGG GAATACTGGT GGAATGCTGG ACAACATCCT GGCCTCCAAA 
CTGTACCGCC CAGGCAGCGT GGCCTACGTC TCACGTTCAG GAGGCATGTC TAATGAACTC 
AATAACATCA TCTCTCGGAC CACAGATGGT GTCTATGAGG GCGTGGCCAT CGGCGGGGAC 
AGGTACCCTG GGTCCACATT CATGGATCAC GTGCTGCGCT ACCAGGACAC TCCAGGAGTC 
AAGATGATCG TAGTTCTTGG GGAGATAGGG GGCACAGAGG AATATAAGAT CTGCCGGGGC 
ATCAAGGAGG GCCGCCTCAC CAAGCCAGTG GTCTGCTGGT GTATCGGGAC CTGTGCCACC 
ATGTTCTCCT CCGAGGTCCA GTTTGGCCAT GCTGGAGCTT GTGCCAACCA GGCTTCTGAA 
ACTGCAGTAG CCAAGAACCA GGCCTTGAAG GAAGCAGGAG TGTTTGTGCC CCGAAGCTTC 
GATGAGCTTG GAGAAATCAT TCAGTCTGTG TATGAAGATC TGGTGGCCAA AGGAGCCATT 
GTACCTGCCC AGGAAGTGCC ACCTCCAACA GTGCCCATGG ACTACTCTTG GGCCAGAGAG 
CTGGGTTTGA TCCGAAAACC TGCCTCATTC ATGACCAGCA TCTGTGATGA GCGAGGGCAG 
GAGCTCATTT ATGCGGGCAT GCCCATCACC GAGGTCTTCA AGGAGGAGAT GGGCATCGGT 
GGTGTCCTCG GCCTCCTCTG GTTCCAGAGA AGGTTGCCCA AGTATTCCTG CCAGTTCATT 
GAGATGTGTC TGATGGTCAC AGCTGATCAC GGGCCAGCTG TCTCTGGAGC CCATAACACC 
ATCATCTGTG CTCGGGCTGG GAAGGACCTG GTCTCCAGCC TCACCTCAGG GCTGCTCACC 
ATTGGAGACC GGTTTGGGGG TGCCTTGGAT GCCGCAGCAA AGATGTTCAG TAAAGCCTTT 
GACAGCGGCA TCATTCCCAT GGAGTTCGTC AACAAGATGA AGAAGGAGGG GAAGCTGATC 
ATGGGCATCG GCCATCGAGT AAAATCGATA AACAACCCAG ACATGCGAGT GCAGATCCTC 
AAGGACTTCG TCAAACAGCA CTTCCCCGCC ACCCCGCTGC TCGACTATGC CCTGGAAGTG 
GAGAAGATTA CCACCTCCAA GAAGCCAAAT CTTATCCTGA ATGTGGACGG CTTCATCGGC 
GTTGCGTTTG TGGACATGCT CAGGAACTGT GGCTCCTTCA CCCGGGAGGA AGCTGATGAA 
TATGTTGACA TTGGAGCCCT CAATGGCATC TTTGTGCTAG GAAGGAGTAT GGGCTTCATT 
GGGCACTACC TTGACCAGAA GAGGCTGAAG CAAGGGCTGT ATCGTCACCC CTGGGATGAC 
ATTTCCTATG TTCTTCCAGA ACACATGAGC ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598798.1
CDS	230..3505
Translation	MSAKAISEQTGKELLYKYICTTSAIQNRFKYARVTPDTDWAHLLQDHPWLLSQSLVVKPDQLIKRRGKLGLVGVNLSLDGVKSWLKPRLGHEATVGKAKGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNTEDIKRHLLVHAPEDKKEVLASFISGLFNFYEDLYFTYLEINPLVVTKDGVYILDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPEGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSATLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMKKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPVVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVAKGAIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQRRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDFVKQHFPATPLLDYALEVEKITTSKKPNLILNVDGFIGVAFVDMLRNCGSFTREEADEYVDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM

Target ORF information:

RefSeq Version	NM_134037.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ATP citrate lyase (Acly), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134037.3

ORF Insert Sequence:

ATGTCAGCCA AGGCAATTTC AGAGCAGACC GGCAAAGAAC TCCTGTACAA GTACATCTGC 
ACCACCTCGG CCATCCAGAA CCGGTTCAAG TACGCCCGGG TGACTCCCGA CACAGACTGG 
GCCCATCTGC TGCAGGACCA CCCGTGGCTG CTCAGCCAGA GCTTGGTTGT CAAGCCAGAC 
CAGTTAATCA AACGTCGAGG AAAGCTTGGC CTCGTCGGGG TCAATCTCTC TCTGGATGGA 
GTCAAATCCT GGCTAAAACC TCGCCTGGGA CATGAAGCCA CTGTCGGCAA GGCCAAAGGC 
TTCCTCAAGA ACTTTCTCAT TGAACCCTTC GTCCCCCACA GTCAGGCGGA GGAGTTCTAC 
GTGTGCATCT ATGCTACCCG GGAAGGAGAC TACGTCCTGT TCCACCATGA AGGGGGTGTG 
GATGTGGGCG ATGTGGATGC CAAAGCCCAG AAGCTGCTTG TGGGTGTGGA CGAAAAGCTG 
AATACCGAGG ACATTAAGAG ACACCTGTTG GTCCATGCAC CTGAGGACAA GAAAGAAGTC 
CTGGCCAGCT TCATCTCTGG TCTATTCAAT TTCTACGAGG ATCTGTACTT CACCTACCTT 
GAGATCAACC CCCTTGTGGT GACCAAAGAT GGTGTCTACA TCCTTGACTT GGCGGCCAAG 
GTGGATGCCA CAGCTGACTA CATCTGTAAA GTCAAGTGGG GTGATATAGA GTTCCCTCCC 
CCCTTTGGGC GTGAGGCGTA CCCCGAGGAA GCCTACATTG CAGACCTGGA TGCCAAAAGT 
GGAGCAAGCT TGAAGCTGAC CTTGCTGAAC CCCAAGGGGC GGATCTGGAC CATGGTTGCT 
GGGGGTGGCG CCTCCGTCGT GTACAGTGAC ACCATCTGTG ATCTTGGAGG TGTCAATGAA 
CTGGCGAATT ACGGGGAATA CTCGGGTGCC CCCAGTGAAC AACAGACCTA TGACTATGCC 
AAGACCATCC TCTCACTTAT GACTCGAGAG AAGCACCCAG AAGGCAAGAT CCTCATCATT 
GGAGGCAGCA TTGCAAACTT CACCAATGTG GCCGCCACCT TCAAGGGCAT TGTGAGAGCG 
ATTCGAGATT ACCAGGGTCC CCTGAAGGAG CATGAGGTCA CCATCTTTGT CCGAAGAGGT 
GGCCCCAACT ATCAAGAGGG ATTACGAGTG ATGGGAGAAG TTGGGAAGAC CACTGGGATC 
CCCATCCATG TCTTTGGCAC AGAAACTCAC ATGACGGCCA TTGTGGGCAT GGCCCTGGGC 
CACCGGCCCA TTCCCAACCA GCCACCCACA GCAGCTCACA CTGCCAACTT CCTCCTTAAT 
GCCAGCGGGA GCACATCGAC TCCAGCACCC AGTAGGACAG CATCTTTTTC TGAGTCCCGA 
GCTGATGAAG TGGCACCTGC AAAGAAAGCC AAGCCAGCTA TGCCCCAAGG AAAGAGTGCC 
ACCCTCTTCA GCCGACATAC CAAGGCCATC GTGTGGGGCA TGCAGACCCG GGCTGTGCAG 
GGCATGCTGG ACTTTGACTA CGTGTGTTCC CGAGACGAGC CCTCAGTGGC TGCCATGGTC 
TACCCTTTCA CTGGGGATCA CAAGCAGAAG TTTTACTGGG GACACAAGGA AATCCTGATC 
CCTGTCTTCA AGAACATGGC TGACGCCATG AAGAAGCACC CGGAGGTAGA CGTGCTGATC 
AACTTTGCGT CTCTGCGGTC CGCTTACGAC AGCACCATGG AGACCATGAA CTATGCCCAG 
ATCCGCACCA TAGCCATCAT AGCAGAAGGT ATCCCTGAGG CCCTCACACG GAAGCTCATC 
AAGAAGGCCG ACCAGAAGGG AGTGACCATC ATTGGGCCAG CTACGGTTGG GGGCATTAAG 
CCTGGATGCT TTAAGATCGG GAATACTGGT GGAATGCTGG ACAACATCCT GGCCTCCAAA 
CTGTACCGCC CAGGCAGCGT GGCCTACGTC TCACGTTCAG GAGGCATGTC TAATGAACTC 
AATAACATCA TCTCTCGGAC CACAGATGGT GTCTATGAGG GCGTGGCCAT CGGCGGGGAC 
AGGTACCCTG GGTCCACATT CATGGATCAC GTGCTGCGCT ACCAGGACAC TCCAGGAGTC 
AAGATGATCG TAGTTCTTGG GGAGATAGGG GGCACAGAGG AATATAAGAT CTGCCGGGGC 
ATCAAGGAGG GCCGCCTCAC CAAGCCAGTG GTCTGCTGGT GTATCGGGAC CTGTGCCACC 
ATGTTCTCCT CCGAGGTCCA GTTTGGCCAT GCTGGAGCTT GTGCCAACCA GGCTTCTGAA 
ACTGCAGTAG CCAAGAACCA GGCCTTGAAG GAAGCAGGAG TGTTTGTGCC CCGAAGCTTC 
GATGAGCTTG GAGAAATCAT TCAGTCTGTG TATGAAGATC TGGTGGCCAA AGGAGCCATT 
GTACCTGCCC AGGAAGTGCC ACCTCCAACA GTGCCCATGG ACTACTCTTG GGCCAGAGAG 
CTGGGTTTGA TCCGAAAACC TGCCTCATTC ATGACCAGCA TCTGTGATGA GCGAGGGCAG 
GAGCTCATTT ATGCGGGCAT GCCCATCACC GAGGTCTTCA AGGAGGAGAT GGGCATCGGT 
GGTGTCCTCG GCCTCCTCTG GTTCCAGAGA AGGTTGCCCA AGTATTCCTG CCAGTTCATT 
GAGATGTGTC TGATGGTCAC AGCTGATCAC GGGCCAGCTG TCTCTGGAGC CCATAACACC 
ATCATCTGTG CTCGGGCTGG GAAGGACCTG GTCTCCAGCC TCACCTCAGG GCTGCTCACC 
ATTGGAGACC GGTTTGGGGG TGCCTTGGAT GCCGCAGCAA AGATGTTCAG TAAAGCCTTT 
GACAGCGGCA TCATTCCCAT GGAGTTCGTC AACAAGATGA AGAAGGAGGG GAAGCTGATC 
ATGGGCATCG GCCATCGAGT AAAATCGATA AACAACCCAG ACATGCGAGT GCAGATCCTC 
AAGGACTTCG TCAAACAGCA CTTCCCCGCC ACCCCGCTGC TCGACTATGC CCTGGAAGTG 
GAGAAGATTA CCACCTCCAA GAAGCCAAAT CTTATCCTGA ATGTGGACGG CTTCATCGGC 
GTTGCGTTTG TGGACATGCT CAGGAACTGT GGCTCCTTCA CCCGGGAGGA AGCTGATGAA 
TATGTTGACA TTGGAGCCCT CAATGGCATC TTTGTGCTAG GAAGGAGTAT GGGCTTCATT 
GGGCACTACC TTGACCAGAA GAGGCTGAAG CAAGGGCTGT ATCGTCACCC CTGGGATGAC 
ATTTCCTATG TTCTTCCAGA ACACATGAGC ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease.
The Journal of biological chemistry294(31)11805-11816(2019 Aug)
Guo L,Guo YY,Li BY,Peng WQ,Chang XX,Gao X,Tang QQ

An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development.
Neural development14(1)2(2019 01)
Catela C,Correa E,Wen K,Aburas J,Croci L,Consalez GG,Kratsios P

Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis.
Nature communications9(1)3356(2018 08)
Scavuzzo MA,Hill MC,Chmielowiec J,Yang D,Teaw J,Sheng K,Kong Y,Bettini M,Zong C,Martin JF,Borowiak M

RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase.
JCI insight3(3)(2018 02)
Imamura M,Moon JS,Chung KP,Nakahira K,Muthukumar T,Shingarev R,Ryter SW,Choi AM,Choi ME

ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation.
Cell reports21(11)3003-3011(2017 Dec)
Das S,Morvan F,Morozzi G,Jourde B,Minetti GC,Kahle P,Rivet H,Brebbia P,Toussaint G,Glass DJ,Fornaro M

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Acly cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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