Cd276 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd276
Entrez Gene ID	102657
Full Name	CD276 antigen
Synonyms	6030411F23Rik,AU016588,B7RP-2,B7h3
General protein information	Preferred Names CD276 antigen Names CD276 antigen B7 homolog 3 B7-H3 costimulatory molecule
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 B

mRNA and Protein(s)

mRNA	Protein	Name
NM_133983.4	NP_598744.1	CD276 antigen precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CD276	NP_001019907.1
Macaca mulatta (Rhesus monkey)	CD276	XP_001094177.1
Bos taurus (cattle)	CD276	XP_002690541.1
Mus musculus (house mouse)	Cd276	NP_598744.1
Gallus gallus (chicken)	CD276	XP_413702.2
Xenopus tropicalis (tropical clawed frog)	cd276	XP_004916023.1
Rattus norvegicus (Norway rat)	Cd276	NP_877976.1
Danio rerio (zebrafish)	cd276	NP_001074091.1
Pan troglodytes (chimpanzee)	CD276	XP_523213.2
Canis lupus familiaris (dog)	CD276	XP_854204.2

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function.
Lee YH, Martin-Orozco N, Zheng P, Li J, Zhang P, Tan H, Park HJ, Jeong M, Chang SH, Kim BS, Xiong W, Zang W, Guo L, Liu Y, Dong ZJ, Overwijk WW, Hwu P, Yi Q, Kwak L, Yang Z, Mak TW, Li W, Radvanyi LG, Ni L, Liu D, Dong C
Cell research27(8)1034-1045(2017 Aug)

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Seaman S, Zhu Z, Saha S, Zhang XM, Yang MY, Hilton MB, Morris K, Szot C, Morris H, Swing DA, Tessarollo L, Smith SW, Degrado S, Borkin D, Jain N, Scheiermann J, Feng Y, Wang Y, Li J, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Klarmann KD, Keller JR, Dimitrov DS, St Croix B
Cancer cell31(4)501-515.e8(2017 04)

B7-H3 Augments Inflammatory Responses and Exacerbates Brain Damage via Amplifying NF-κB p65 and MAPK p38 Activation during Experimental Pneumococcal Meningitis.
Chen X, Li Y, Blankson S, Liu M, Huang D, Redmond HP, Huang J, Wang JH, Wang J
PloS one12(1)e0171146(2017)

B7-H3 participates in the development of Asthma by augmentation of the inflammatory response independent of TLR2 pathway.
Gu W, Zhang X, Yan Y, Wang Y, Huang L, Wang M, Shao X, Chen Z, Ji W
Scientific reports740398(2017 01)

B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration.
Li Y, Huang J, Foley NM, Xu Y, Li YP, Pan J, Redmond HP, Wang JH, Wang J
Scientific reports631284(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cd276 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd276 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23158	NM_133983.4 Latest version!	Mus musculus CD276 antigen (Cd276), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd276 ( NM_133983.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598744.1 Mus musculus CD276 antigen (Cd276), mRNA.

Price & Availability↑

CloneID	OMu23158
Clone ID Related Accession (Same CDS sequence)	NM_133983.4
Accession Version	NM_133983.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 951bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568995200000
Organism	Mus musculus(house mouse)
Product	CD276 antigen precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CT030640.9. On Aug 22, 2007 this sequence version replaced NM_133983.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ832276.1, SRR1660813.48690.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGCTTCGAG GATGGGGTGG CCCCAGTGTG GGTGTGTGTG TGCGCACAGC ACTGGGGGTG 
CTGTGCCTCT GCCTCACAGG AGCTGTGGAA GTCCAGGTCT CTGAAGACCC CGTGGTGGCC 
CTGGTGGACA CGGATGCCAC CCTACGCTGC TCCTTTTCCC CAGAGCCTGG CTTCAGTCTG 
GCACAGCTCA ACCTCATCTG GCAGCTGACA GACACCAAAC AGCTGGTGCA CAGCTTCACG 
GAGGGCCGGG ACCAAGGCAG TGCCTACTCC AACCGCACAG CGCTCTTCCC TGACCTGTTG 
GTGCAAGGCA ATGCGTCCTT GAGGCTGCAG CGCGTCCGAG TAACCGACGA GGGCAGCTAC 
ACCTGCTTTG TGAGCATCCA GGACTTTGAC AGCGCTGCTG TTAGCCTGCA GGTGGCCGCC 
CCCTACTCGA AGCCCAGCAT GACCCTGGAG CCCAACAAGG ACCTACGTCC AGGGAACATG 
GTGACCATCA CGTGCTCTAG CTACCAGGGC TATCCGGAGG CCGAGGTGTT CTGGAAGGAT 
GGACAGGGAG TGCCCTTGAC TGGCAATGTG ACCACATCCC AGATGGCCAA CGAGCGGGGC 
TTGTTCGATG TTCACAGCGT GCTGAGGGTG GTGCTGGGTG CTAACGGCAC CTACAGCTGC 
CTGGTACGCA ACCCGGTGTT GCAGCAAGAT GCTCACGGCT CAGTCACCAT CACAGGGCAG 
CCCCTGACAT TCCCCCCTGA GGCTCTGTGG GTAACCGTGG GGCTCTCTGT CTGTCTTGTG 
GTACTACTGG TGGCCCTGGC TTTCGTGTGC TGGAGAAAGA TCAAGCAGAG CTGCGAGGAG 
GAGAATGCAG GTGCCGAGGA CCAGGATGGA GATGGAGAAG GATCCAAGAC AGCTCTACGG 
CCTCTGAAAC CCTCTGAAAA CAAAGAAGAT GACGGACAAG AAATTGCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598744.1
CDS	208..1158
Translation	MLRGWGGPSVGVCVRTALGVLCLCLTGAVEVQVSEDPVVALVDTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYSNRTALFPDLLVQGNASLRLQRVRVTDEGSYTCFVSIQDFDSAAVSLQVAAPYSKPSMTLEPNKDLRPGNMVTITCSSYQGYPEAEVFWKDGQGVPLTGNVTTSQMANERGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPLTFPPEALWVTVGLSVCLVVLLVALAFVCWRKIKQSCEEENAGAEDQDGDGEGSKTALRPLKPSENKEDDGQEIA

Target ORF information:

RefSeq Version	NM_133983.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD276 antigen (Cd276), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133983.4

ORF Insert Sequence:

ATGCTTCGAG GATGGGGTGG CCCCAGTGTG GGTGTGTGTG TGCGCACAGC ACTGGGGGTG 
CTGTGCCTCT GCCTCACAGG AGCTGTGGAA GTCCAGGTCT CTGAAGACCC CGTGGTGGCC 
CTGGTGGACA CGGATGCCAC CCTACGCTGC TCCTTTTCCC CAGAGCCTGG CTTCAGTCTG 
GCACAGCTCA ACCTCATCTG GCAGCTGACA GACACCAAAC AGCTGGTGCA CAGCTTCACG 
GAGGGCCGGG ACCAAGGCAG TGCCTACTCC AACCGCACAG CGCTCTTCCC TGACCTGTTG 
GTGCAAGGCA ATGCGTCCTT GAGGCTGCAG CGCGTCCGAG TAACCGACGA GGGCAGCTAC 
ACCTGCTTTG TGAGCATCCA GGACTTTGAC AGCGCTGCTG TTAGCCTGCA GGTGGCCGCC 
CCCTACTCGA AGCCCAGCAT GACCCTGGAG CCCAACAAGG ACCTACGTCC AGGGAACATG 
GTGACCATCA CGTGCTCTAG CTACCAGGGC TATCCGGAGG CCGAGGTGTT CTGGAAGGAT 
GGACAGGGAG TGCCCTTGAC TGGCAATGTG ACCACATCCC AGATGGCCAA CGAGCGGGGC 
TTGTTCGATG TTCACAGCGT GCTGAGGGTG GTGCTGGGTG CTAACGGCAC CTACAGCTGC 
CTGGTACGCA ACCCGGTGTT GCAGCAAGAT GCTCACGGCT CAGTCACCAT CACAGGGCAG 
CCCCTGACAT TCCCCCCTGA GGCTCTGTGG GTAACCGTGG GGCTCTCTGT CTGTCTTGTG 
GTACTACTGG TGGCCCTGGC TTTCGTGTGC TGGAGAAAGA TCAAGCAGAG CTGCGAGGAG 
GAGAATGCAG GTGCCGAGGA CCAGGATGGA GATGGAGAAG GATCCAAGAC AGCTCTACGG 
CCTCTGAAAC CCTCTGAAAA CAAAGAAGAT GACGGACAAG AAATTGCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function.
Cell research27(8)1034-1045(2017 Aug)
Lee YH,Martin-Orozco N,Zheng P,Li J,Zhang P,Tan H,Park HJ,Jeong M,Chang SH,Kim BS,Xiong W,Zang W,Guo L,Liu Y,Dong ZJ,Overwijk WW,Hwu P,Yi Q,Kwak L,Yang Z,Mak TW,Li W,Radvanyi LG,Ni L,Liu D,Dong C

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Cancer cell31(4)501-515.e8(2017 04)
Seaman S,Zhu Z,Saha S,Zhang XM,Yang MY,Hilton MB,Morris K,Szot C,Morris H,Swing DA,Tessarollo L,Smith SW,Degrado S,Borkin D,Jain N,Scheiermann J,Feng Y,Wang Y,Li J,Welsch D,DeCrescenzo G,Chaudhary A,Zudaire E,Klarmann KD,Keller JR,Dimitrov DS,St Croix B

B7-H3 Augments Inflammatory Responses and Exacerbates Brain Damage via Amplifying NF-κB p65 and MAPK p38 Activation during Experimental Pneumococcal Meningitis.
PloS one12(1)e0171146(2017)
Chen X,Li Y,Blankson S,Liu M,Huang D,Redmond HP,Huang J,Wang JH,Wang J

B7-H3 participates in the development of Asthma by augmentation of the inflammatory response independent of TLR2 pathway.
Scientific reports740398(2017 01)
Gu W,Zhang X,Yan Y,Wang Y,Huang L,Wang M,Shao X,Chen Z,Ji W

B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration.
Scientific reports631284(2016 08)
Li Y,Huang J,Foley NM,Xu Y,Li YP,Pan J,Redmond HP,Wang JH,Wang J