HDAC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HDAC3
Entrez Gene ID	8841
Full Name	histone deacetylase 3
Synonyms	HD3,RPD3,RPD3-2
General protein information	Preferred Names histone deacetylase 3 Names histone deacetylase 3 SMAP45
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.3
Summary	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	605166

mRNA and Protein(s)

mRNA	Protein	Name
XM_011537697.2	XP_011535999.1	histone deacetylase 3 isoform X1
NM_003883.3	NP_003874.2	histone deacetylase 3 isoform 2
NM_003883.4	NP_003874.2	histone deacetylase 3 isoform 2
NM_001355040.1	NP_001341969.1	histone deacetylase 3 isoform 3
NM_001355039.2	NP_001341968.1	histone deacetylase 3 isoform 1
NM_001355041.1	NP_001341970.1	histone deacetylase 3 isoform 4
NM_001355039.1	NP_001341968.1	histone deacetylase 3 isoform 1

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os04g0409600	NP_001052725.1
Xenopus tropicalis (tropical clawed frog)	hdac3	NP_001016883.1
Canis lupus familiaris (dog)	HDAC3	XP_535219.2
Macaca mulatta (Rhesus monkey)	HDAC3	XP_001094295.1
Homo sapiens (human)	HDAC3	NP_003874.2
Gallus gallus (chicken)	HDAC3	NP_990078.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001143	XP_322018.5
Bos taurus (cattle)	HDAC3	NP_001193172.1
Mus musculus (house mouse)	Hdac3	NP_034541.2
Drosophila melanogaster (fruit fly)	Hdac3	NP_651978.2
Arabidopsis thaliana (thale cress)	HDA9	NP_190054.2
Pan troglodytes (chimpanzee)	HDAC3	XP_001151495.1
Rattus norvegicus (Norway rat)	Hdac3	NP_445900.1
Danio rerio (zebrafish)	hdac3	NP_957284.1

Gene Ontology
Bibliography

Related articles in PubMed

PPARβ/δ recruits NCOR and regulates transcription reinitiation of ANGPTL4.
Legrand N, Bretscher CL, Zielke S, Wilke B, Daude M, Fritz B, Diederich WE, Adhikary T
Nucleic acids research47(18)9573-9591(2019 10)

PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure.
Hervera A, Zhou L, Palmisano I, McLachlan E, Kong G, Hutson TH, Danzi MC, Lemmon VP, Bixby JL, Matamoros-Angles A, Forsberg K, De Virgiliis F, Matheos DP, Kwapis J, Wood MA, Puttagunta R, Del Río JA, Di Giovanni S
The EMBO journal38(13)e101032(2019 07)

Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis.
Zhang M, Pan Y, Tang D, Dorfman RG, Xu L, Zhou Q, Zhou L, Wang Y, Li Y, Yin Y, Kong B, Friess H, Zhao S, Wu JL, Wang L, Zou X
Cell communication and signaling : CCS17(1)23(2019 03)

The HDAC3-SMARCA4-miR-27a axis promotes expression of the
Bharathy N, Berlow NE, Wang E, Abraham J, Settelmeyer TP, Hooper JE, Svalina MN, Ishikawa Y, Zientek K, Bajwa Z, Goros MW, Hernandez BS, Wolff JE, Rudek MA, Xu L, Anders NM, Pal R, Harrold AP, Davies AM, Ashok A, Bushby D, Mancini M, Noakes C, Goodwin NC, Ordentlich P, Keck J, Hawkins DS, Rudzinski ER, Chatterjee B, Bächinger HP, Barr FG, Liddle J, Garcia BA, Mansoor A, Perkins TJ, Vakoc CR, Michalek JE, Keller C
Science signaling11(557)(2018 11)

Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis.
Li Y, Zhou M, Lv X, Song L, Zhang D, He Y, Wang M, Zhao X, Yuan X, Shi G, Wang D
Journal of immunology research20187313515(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HDAC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HDAC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu102816	NM_001355040.1 Latest version!	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu102842	NM_001355039.2 Latest version!	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu62237	NM_001355041.1 Latest version!	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu62237	XM_011537697.2 Latest version!	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu25621	NM_003883.4 Latest version!	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu25621	NM_003883.3	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu102842	NM_001355039.1	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HDAC3 ( NM_001355040.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001341969.1 Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 3, mRNA.

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CloneID	OHu102816
Clone ID Related Accession (Same CDS sequence)	NM_001355040.1
Accession Version	NM_001355040.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Homo sapiens(human)
Product	histone deacetylase 3 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008781.7 and KC877130.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.351166.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAAGAA GTTTGAGGTA CCACCCTCGG GTGCTCTACA TTGACATTGA CATCCACCAT 
GGTGACGGGG TTCAAGAAGC TTTCTACCTC ACTGACCGGG TCATGACGGT GTCCTTCCAC 
AAATACGGAA ATTACTTCTT CCCTGGCACA GGTGACATGT ATGAAGTCGG GGCAGAGAGT 
GGCCGCTACT ACTGTCTGAA CGTGCCCCTG CGGGATGGCA TTGATGACCA GAGTTACAAG 
CACCTTTTCC AGCCGGTTAT CAACCAGGTA GTGGACTTCT ACCAACCCAC GTGCATTGTG 
CTCCAGTGTG GAGCTGACTC TCTGGGCTGT GATCGATTGG GCTGCTTTAA CCTCAGCATC 
CGAGGGCATG GGGAATGCGT TGAATATGTC AAGAGCTTCA ATATCCCTCT ACTCGTGCTG 
GGTGGTGGTG GTTATACTGT CCGAAATGTT GCCCGCTGCT GGACATATGA GACATCGCTG 
CTGGTAGAAG AGGCCATTAG TGAGGAGCTT CCCTATAGTG AATACTTCGA GTACTTTGCC 
CCAGACTTCA CACTTCATCC AGATGTCAGC ACCCGCATCG AGAATCAGAA CTCACGCCAG 
TATCTGGACC AGATCCGCCA GACAATCTTT GAAAACCTGA AGATGCTGAA CCATGCACCT 
AGTGTCCAGA TTCATGACGT GCCTGCAGAC CTCCTGACCT ATGACAGGAC TGATGAGGCT 
GATGCAGAGG AGAGGGGTCC TGAGGAGAAC TATAGCAGGC CAGAGGCACC CAATGAGTTC 
TATGATGGAG ACCATGACAA TGACAAGGAA AGCGATGTGG AGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001341969.1
CDS	327..1154
Translation	MPRSLRYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI

Target ORF information:

RefSeq Version	NM_001355040.1
Organism	Homo sapiens(human)
Definition	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001355040.1

ORF Insert Sequence:

ATGCCAAGAA GTTTGAGGTA CCACCCTCGG GTGCTCTACA TTGACATTGA CATCCACCAT 
GGTGACGGGG TTCAAGAAGC TTTCTACCTC ACTGACCGGG TCATGACGGT GTCCTTCCAC 
AAATACGGAA ATTACTTCTT CCCTGGCACA GGTGACATGT ATGAAGTCGG GGCAGAGAGT 
GGCCGCTACT ACTGTCTGAA CGTGCCCCTG CGGGATGGCA TTGATGACCA GAGTTACAAG 
CACCTTTTCC AGCCGGTTAT CAACCAGGTA GTGGACTTCT ACCAACCCAC GTGCATTGTG 
CTCCAGTGTG GAGCTGACTC TCTGGGCTGT GATCGATTGG GCTGCTTTAA CCTCAGCATC 
CGAGGGCATG GGGAATGCGT TGAATATGTC AAGAGCTTCA ATATCCCTCT ACTCGTGCTG 
GGTGGTGGTG GTTATACTGT CCGAAATGTT GCCCGCTGCT GGACATATGA GACATCGCTG 
CTGGTAGAAG AGGCCATTAG TGAGGAGCTT CCCTATAGTG AATACTTCGA GTACTTTGCC 
CCAGACTTCA CACTTCATCC AGATGTCAGC ACCCGCATCG AGAATCAGAA CTCACGCCAG 
TATCTGGACC AGATCCGCCA GACAATCTTT GAAAACCTGA AGATGCTGAA CCATGCACCT 
AGTGTCCAGA TTCATGACGT GCCTGCAGAC CTCCTGACCT ATGACAGGAC TGATGAGGCT 
GATGCAGAGG AGAGGGGTCC TGAGGAGAAC TATAGCAGGC CAGAGGCACC CAATGAGTTC 
TATGATGGAG ACCATGACAA TGACAAGGAA AGCGATGTGG AGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HDAC3 ( NM_001355039.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001341968.1 Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu102842
Clone ID Related Accession (Same CDS sequence)	NM_001355039.2 , NM_001355039.1
Accession Version	NM_001355039.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1305bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577980800000
Organism	Homo sapiens(human)
Product	histone deacetylase 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008781.7 and KC877130.1. On May 31, 2019 this sequence version replaced NM_001355039.1. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1100234.1, SRR3476690.327845.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAGA CCGTGGCCTA TTTCTACGAC CCCGACGTGG GCAACTTCCA CTACGGAGCT 
GGACACCCTA TGAAGCCCCA TCGCCTGGCA TTGACCCATA GCCTGGTCCT GCATTACGGT 
CTCTATAAGA AGATGATCGT CTTCAAGCCA TACCAGGCCT CCCAACATGA CATGTGCCGC 
TTCCACTCCG AGGACTACAT TGACTTCCTG CAGAGAGTCA GCCCCACCAA TATGCAAGGC 
TTCACCAAGA GTCTTAATGC CTTCAACGTA GGCGATGACT GCCCAGTGTT TCCCGGGCTC 
TTTGAGTTCT GCTCGCGTTA CACAGGCGCA TCTCTGCAAG GAGCAACCCA GCTGAACAAC 
AAGATCTGTG ATATTGCCAT TAACTGGGCT GGTGGTCTGC ACCATGCCAA GAAGTTTGAG 
GCCTCTGGCT TCTGCTATGT CAACGACATT GTGATTGGCA TCCTGGAGCT GCTCAAGTAC 
CACCCTCGGG TGCTCTACAT TGACATTGAC ATCCACCATG GTGACGGGGT TCAAGAAGCT 
TTCTACCTCA CTGACCGGGT CATGACGGTG TCCTTCCACA AATACGGAAA TTACTTCTTC 
CCTGGCACAG GTGACATGTA TGAAGTCGGG GCAGAGAGTG GCCGCTACTA CTGTCTGAAC 
GTGCCCCTGC GGGATGGCAT TGATGACCAG AGTTACAAGC ACCTTTTCCA GCCGGTTATC 
AACCAGGTAG TGGACTTCTA CCAACCCACG TGCATTGTGC TCCAGTGTGG AGCTGACTCT 
CTGGGCTGTG ATCGATTGGG CTGCTTTAAC CTCAGCATCC GAGGGCATGG GGAATGCGTT 
GAATATGTCA AGAGCTTCAA TATCCCTCTA CTCGTGCTGG GTGGTGGTGG TTATACTGTC 
CGAAATGTTG CCCGCTGCTG GACATATGAG ACATCGCTGC TGGTAGAAGA GGCCATTAGT 
GAGGAGCTTC CCTATAGTGA ATACTTCGAG TACTTTGCCC CAGACTTCAC ACTTCATCCA 
GATGTCAGCA CCCGCATCGA GAATCAGAAC TCACGCCAGT ATCTGGACCA GATCCGCCAG 
ACAATCTTTG AAAACCTGAA GATGCTGAAC CATGCACCTA GTGTCCAGAT TCATGACGTG 
CCTGCAGACC TCCTGACCTA TGACAGGACT GATGAGGCTG ATGCAGAGGA GAGGGGTCCT 
GAGGAGAACT ATAGCAGGTC TGGGAGCAGG GACTTCAGCC TACTTTCAAT AGGCTTGCTG 
GGGAGGTTTA AAAGGGAAAA AGTAAATGGG AAGGTATTAG TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001341968.1
CDS	60..1364
Translation	MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRSGSRDFSLLSIGLLGRFKREKVNGKVLV

Target ORF information:

RefSeq Version	NM_001355039.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001355039.2

ORF Insert Sequence:

ATGGCCAAGA CCGTGGCCTA TTTCTACGAC CCCGACGTGG GCAACTTCCA CTACGGAGCT 
GGACACCCTA TGAAGCCCCA TCGCCTGGCA TTGACCCATA GCCTGGTCCT GCATTACGGT 
CTCTATAAGA AGATGATCGT CTTCAAGCCA TACCAGGCCT CCCAACATGA CATGTGCCGC 
TTCCACTCCG AGGACTACAT TGACTTCCTG CAGAGAGTCA GCCCCACCAA TATGCAAGGC 
TTCACCAAGA GTCTTAATGC CTTCAACGTA GGCGATGACT GCCCAGTGTT TCCCGGGCTC 
TTTGAGTTCT GCTCGCGTTA CACAGGCGCA TCTCTGCAAG GAGCAACCCA GCTGAACAAC 
AAGATCTGTG ATATTGCCAT TAACTGGGCT GGTGGTCTGC ACCATGCCAA GAAGTTTGAG 
GCCTCTGGCT TCTGCTATGT CAACGACATT GTGATTGGCA TCCTGGAGCT GCTCAAGTAC 
CACCCTCGGG TGCTCTACAT TGACATTGAC ATCCACCATG GTGACGGGGT TCAAGAAGCT 
TTCTACCTCA CTGACCGGGT CATGACGGTG TCCTTCCACA AATACGGAAA TTACTTCTTC 
CCTGGCACAG GTGACATGTA TGAAGTCGGG GCAGAGAGTG GCCGCTACTA CTGTCTGAAC 
GTGCCCCTGC GGGATGGCAT TGATGACCAG AGTTACAAGC ACCTTTTCCA GCCGGTTATC 
AACCAGGTAG TGGACTTCTA CCAACCCACG TGCATTGTGC TCCAGTGTGG AGCTGACTCT 
CTGGGCTGTG ATCGATTGGG CTGCTTTAAC CTCAGCATCC GAGGGCATGG GGAATGCGTT 
GAATATGTCA AGAGCTTCAA TATCCCTCTA CTCGTGCTGG GTGGTGGTGG TTATACTGTC 
CGAAATGTTG CCCGCTGCTG GACATATGAG ACATCGCTGC TGGTAGAAGA GGCCATTAGT 
GAGGAGCTTC CCTATAGTGA ATACTTCGAG TACTTTGCCC CAGACTTCAC ACTTCATCCA 
GATGTCAGCA CCCGCATCGA GAATCAGAAC TCACGCCAGT ATCTGGACCA GATCCGCCAG 
ACAATCTTTG AAAACCTGAA GATGCTGAAC CATGCACCTA GTGTCCAGAT TCATGACGTG 
CCTGCAGACC TCCTGACCTA TGACAGGACT GATGAGGCTG ATGCAGAGGA GAGGGGTCCT 
GAGGAGAACT ATAGCAGGTC TGGGAGCAGG GACTTCAGCC TACTTTCAAT AGGCTTGCTG 
GGGAGGTTTA AAAGGGAAAA AGTAAATGGG AAGGTATTAG TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HDAC3 ( NM_001355039.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001341968.1 Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu102842
Clone ID Related Accession (Same CDS sequence)	NM_001355039.2 , NM_001355039.1
Accession Version	NM_001355039.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1305bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550505600000
Organism	Homo sapiens(human)
Product	histone deacetylase 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008781.7 and KC877130.1. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.154269.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAGA CCGTGGCCTA TTTCTACGAC CCCGACGTGG GCAACTTCCA CTACGGAGCT 
GGACACCCTA TGAAGCCCCA TCGCCTGGCA TTGACCCATA GCCTGGTCCT GCATTACGGT 
CTCTATAAGA AGATGATCGT CTTCAAGCCA TACCAGGCCT CCCAACATGA CATGTGCCGC 
TTCCACTCCG AGGACTACAT TGACTTCCTG CAGAGAGTCA GCCCCACCAA TATGCAAGGC 
TTCACCAAGA GTCTTAATGC CTTCAACGTA GGCGATGACT GCCCAGTGTT TCCCGGGCTC 
TTTGAGTTCT GCTCGCGTTA CACAGGCGCA TCTCTGCAAG GAGCAACCCA GCTGAACAAC 
AAGATCTGTG ATATTGCCAT TAACTGGGCT GGTGGTCTGC ACCATGCCAA GAAGTTTGAG 
GCCTCTGGCT TCTGCTATGT CAACGACATT GTGATTGGCA TCCTGGAGCT GCTCAAGTAC 
CACCCTCGGG TGCTCTACAT TGACATTGAC ATCCACCATG GTGACGGGGT TCAAGAAGCT 
TTCTACCTCA CTGACCGGGT CATGACGGTG TCCTTCCACA AATACGGAAA TTACTTCTTC 
CCTGGCACAG GTGACATGTA TGAAGTCGGG GCAGAGAGTG GCCGCTACTA CTGTCTGAAC 
GTGCCCCTGC GGGATGGCAT TGATGACCAG AGTTACAAGC ACCTTTTCCA GCCGGTTATC 
AACCAGGTAG TGGACTTCTA CCAACCCACG TGCATTGTGC TCCAGTGTGG AGCTGACTCT 
CTGGGCTGTG ATCGATTGGG CTGCTTTAAC CTCAGCATCC GAGGGCATGG GGAATGCGTT 
GAATATGTCA AGAGCTTCAA TATCCCTCTA CTCGTGCTGG GTGGTGGTGG TTATACTGTC 
CGAAATGTTG CCCGCTGCTG GACATATGAG ACATCGCTGC TGGTAGAAGA GGCCATTAGT 
GAGGAGCTTC CCTATAGTGA ATACTTCGAG TACTTTGCCC CAGACTTCAC ACTTCATCCA 
GATGTCAGCA CCCGCATCGA GAATCAGAAC TCACGCCAGT ATCTGGACCA GATCCGCCAG 
ACAATCTTTG AAAACCTGAA GATGCTGAAC CATGCACCTA GTGTCCAGAT TCATGACGTG 
CCTGCAGACC TCCTGACCTA TGACAGGACT GATGAGGCTG ATGCAGAGGA GAGGGGTCCT 
GAGGAGAACT ATAGCAGGTC TGGGAGCAGG GACTTCAGCC TACTTTCAAT AGGCTTGCTG 
GGGAGGTTTA AAAGGGAAAA AGTAAATGGG AAGGTATTAG TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001341968.1
CDS	67..1371
Translation	MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRSGSRDFSLLSIGLLGRFKREKVNGKVLV

Target ORF information:

RefSeq Version	NM_001355039.1
Organism	Homo sapiens(human)
Definition	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001355039.1

ORF Insert Sequence:

ATGGCCAAGA CCGTGGCCTA TTTCTACGAC CCCGACGTGG GCAACTTCCA CTACGGAGCT 
GGACACCCTA TGAAGCCCCA TCGCCTGGCA TTGACCCATA GCCTGGTCCT GCATTACGGT 
CTCTATAAGA AGATGATCGT CTTCAAGCCA TACCAGGCCT CCCAACATGA CATGTGCCGC 
TTCCACTCCG AGGACTACAT TGACTTCCTG CAGAGAGTCA GCCCCACCAA TATGCAAGGC 
TTCACCAAGA GTCTTAATGC CTTCAACGTA GGCGATGACT GCCCAGTGTT TCCCGGGCTC 
TTTGAGTTCT GCTCGCGTTA CACAGGCGCA TCTCTGCAAG GAGCAACCCA GCTGAACAAC 
AAGATCTGTG ATATTGCCAT TAACTGGGCT GGTGGTCTGC ACCATGCCAA GAAGTTTGAG 
GCCTCTGGCT TCTGCTATGT CAACGACATT GTGATTGGCA TCCTGGAGCT GCTCAAGTAC 
CACCCTCGGG TGCTCTACAT TGACATTGAC ATCCACCATG GTGACGGGGT TCAAGAAGCT 
TTCTACCTCA CTGACCGGGT CATGACGGTG TCCTTCCACA AATACGGAAA TTACTTCTTC 
CCTGGCACAG GTGACATGTA TGAAGTCGGG GCAGAGAGTG GCCGCTACTA CTGTCTGAAC 
GTGCCCCTGC GGGATGGCAT TGATGACCAG AGTTACAAGC ACCTTTTCCA GCCGGTTATC 
AACCAGGTAG TGGACTTCTA CCAACCCACG TGCATTGTGC TCCAGTGTGG AGCTGACTCT 
CTGGGCTGTG ATCGATTGGG CTGCTTTAAC CTCAGCATCC GAGGGCATGG GGAATGCGTT 
GAATATGTCA AGAGCTTCAA TATCCCTCTA CTCGTGCTGG GTGGTGGTGG TTATACTGTC 
CGAAATGTTG CCCGCTGCTG GACATATGAG ACATCGCTGC TGGTAGAAGA GGCCATTAGT 
GAGGAGCTTC CCTATAGTGA ATACTTCGAG TACTTTGCCC CAGACTTCAC ACTTCATCCA 
GATGTCAGCA CCCGCATCGA GAATCAGAAC TCACGCCAGT ATCTGGACCA GATCCGCCAG 
ACAATCTTTG AAAACCTGAA GATGCTGAAC CATGCACCTA GTGTCCAGAT TCATGACGTG 
CCTGCAGACC TCCTGACCTA TGACAGGACT GATGAGGCTG ATGCAGAGGA GAGGGGTCCT 
GAGGAGAACT ATAGCAGGTC TGGGAGCAGG GACTTCAGCC TACTTTCAAT AGGCTTGCTG 
GGGAGGTTTA AAAGGGAAAA AGTAAATGGG AAGGTATTAG TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HDAC3 ( NM_001355041.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001341970.1 Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 4, mRNA.

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CloneID	OHu62237
Clone ID Related Accession (Same CDS sequence)	XM_011537697.2 , NM_001355041.1
Accession Version	NM_001355041.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577721600000
Organism	Homo sapiens(human)
Product	histone deacetylase 3 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008781.7 and KC877130.1. On Sep 2, 2017 this sequence version replaced XM_011537697.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.1401.1, SRR1660803.251990.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGGTGT CCTTCCACAA ATACGGAAAT TACTTCTTCC CTGGCACAGG TGACATGTAT 
GAAGTCGGGG CAGAGAGTGG CCGCTACTAC TGTCTGAACG TGCCCCTGCG GGATGGCATT 
GATGACCAGA GTTACAAGCA CCTTTTCCAG CCGGTTATCA ACCAGGTAGT GGACTTCTAC 
CAACCCACGT GCATTGTGCT CCAGTGTGGA GCTGACTCTC TGGGCTGTGA TCGATTGGGC 
TGCTTTAACC TCAGCATCCG AGGGCATGGG GAATGCGTTG AATATGTCAA GAGCTTCAAT 
ATCCCTCTAC TCGTGCTGGG TGGTGGTGGT TATACTGTCC GAAATGTTGC CCGCTGCTGG 
ACATATGAGA CATCGCTGCT GGTAGAAGAG GCCATTAGTG AGGAGCTTCC CTATAGTGAA 
TACTTCGAGT ACTTTGCCCC AGACTTCACA CTTCATCCAG ATGTCAGCAC CCGCATCGAG 
AATCAGAACT CACGCCAGTA TCTGGACCAG ATCCGCCAGA CAATCTTTGA AAACCTGAAG 
ATGCTGAACC ATGCACCTAG TGTCCAGATT CATGACGTGC CTGCAGACCT CCTGACCTAT 
GACAGGACTG ATGAGGCTGA TGCAGAGGAG AGGGGTCCTG AGGAGAACTA TAGCAGGCCA 
GAGGCACCCA ATGAGTTCTA TGATGGAGAC CATGACAATG ACAAGGAAAG CGATGTGGAG 
ATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001341970.1
CDS	485..1210
Translation	MTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI

Target ORF information:

RefSeq Version	NM_001355041.1
Organism	Homo sapiens(human)
Definition	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001355041.1

ORF Insert Sequence:

ATGACGGTGT CCTTCCACAA ATACGGAAAT TACTTCTTCC CTGGCACAGG TGACATGTAT 
GAAGTCGGGG CAGAGAGTGG CCGCTACTAC TGTCTGAACG TGCCCCTGCG GGATGGCATT 
GATGACCAGA GTTACAAGCA CCTTTTCCAG CCGGTTATCA ACCAGGTAGT GGACTTCTAC 
CAACCCACGT GCATTGTGCT CCAGTGTGGA GCTGACTCTC TGGGCTGTGA TCGATTGGGC 
TGCTTTAACC TCAGCATCCG AGGGCATGGG GAATGCGTTG AATATGTCAA GAGCTTCAAT 
ATCCCTCTAC TCGTGCTGGG TGGTGGTGGT TATACTGTCC GAAATGTTGC CCGCTGCTGG 
ACATATGAGA CATCGCTGCT GGTAGAAGAG GCCATTAGTG AGGAGCTTCC CTATAGTGAA 
TACTTCGAGT ACTTTGCCCC AGACTTCACA CTTCATCCAG ATGTCAGCAC CCGCATCGAG 
AATCAGAACT CACGCCAGTA TCTGGACCAG ATCCGCCAGA CAATCTTTGA AAACCTGAAG 
ATGCTGAACC ATGCACCTAG TGTCCAGATT CATGACGTGC CTGCAGACCT CCTGACCTAT 
GACAGGACTG ATGAGGCTGA TGCAGAGGAG AGGGGTCCTG AGGAGAACTA TAGCAGGCCA 
GAGGCACCCA ATGAGTTCTA TGATGGAGAC CATGACAATG ACAAGGAAAG CGATGTGGAG 
ATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HDAC3 ( XM_011537697.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011535999.1 Homo sapiens histone deacetylase 3 (HDAC3), transcript variant X2, mRNA.

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CloneID	OHu62237
Clone ID Related Accession (Same CDS sequence)	XM_011537697.2 , NM_001355041.1
Accession Version	XM_011537697.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(Human)
Product	histone deacetylase 3 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011537697.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGGTGT CCTTCCACAA ATACGGAAAT TACTTCTTCC CTGGCACAGG TGACATGTAT 
GAAGTCGGGG CAGAGAGTGG CCGCTACTAC TGTCTGAACG TGCCCCTGCG GGATGGCATT 
GATGACCAGA GTTACAAGCA CCTTTTCCAG CCGGTTATCA ACCAGGTAGT GGACTTCTAC 
CAACCCACGT GCATTGTGCT CCAGTGTGGA GCTGACTCTC TGGGCTGTGA TCGATTGGGC 
TGCTTTAACC TCAGCATCCG AGGGCATGGG GAATGCGTTG AATATGTCAA GAGCTTCAAT 
ATCCCTCTAC TCGTGCTGGG TGGTGGTGGT TATACTGTCC GAAATGTTGC CCGCTGCTGG 
ACATATGAGA CATCGCTGCT GGTAGAAGAG GCCATTAGTG AGGAGCTTCC CTATAGTGAA 
TACTTCGAGT ACTTTGCCCC AGACTTCACA CTTCATCCAG ATGTCAGCAC CCGCATCGAG 
AATCAGAACT CACGCCAGTA TCTGGACCAG ATCCGCCAGA CAATCTTTGA AAACCTGAAG 
ATGCTGAACC ATGCACCTAG TGTCCAGATT CATGACGTGC CTGCAGACCT CCTGACCTAT 
GACAGGACTG ATGAGGCTGA TGCAGAGGAG AGGGGTCCTG AGGAGAACTA TAGCAGGCCA 
GAGGCACCCA ATGAGTTCTA TGATGGAGAC CATGACAATG ACAAGGAAAG CGATGTGGAG 
ATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011535999.1
CDS	480..1205
Translation	MTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI

Target ORF information:

RefSeq Version	XM_011537697.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011537697.2

ORF Insert Sequence:

ATGACGGTGT CCTTCCACAA ATACGGAAAT TACTTCTTCC CTGGCACAGG TGACATGTAT 
GAAGTCGGGG CAGAGAGTGG CCGCTACTAC TGTCTGAACG TGCCCCTGCG GGATGGCATT 
GATGACCAGA GTTACAAGCA CCTTTTCCAG CCGGTTATCA ACCAGGTAGT GGACTTCTAC 
CAACCCACGT GCATTGTGCT CCAGTGTGGA GCTGACTCTC TGGGCTGTGA TCGATTGGGC 
TGCTTTAACC TCAGCATCCG AGGGCATGGG GAATGCGTTG AATATGTCAA GAGCTTCAAT 
ATCCCTCTAC TCGTGCTGGG TGGTGGTGGT TATACTGTCC GAAATGTTGC CCGCTGCTGG 
ACATATGAGA CATCGCTGCT GGTAGAAGAG GCCATTAGTG AGGAGCTTCC CTATAGTGAA 
TACTTCGAGT ACTTTGCCCC AGACTTCACA CTTCATCCAG ATGTCAGCAC CCGCATCGAG 
AATCAGAACT CACGCCAGTA TCTGGACCAG ATCCGCCAGA CAATCTTTGA AAACCTGAAG 
ATGCTGAACC ATGCACCTAG TGTCCAGATT CATGACGTGC CTGCAGACCT CCTGACCTAT 
GACAGGACTG ATGAGGCTGA TGCAGAGGAG AGGGGTCCTG AGGAGAACTA TAGCAGGCCA 
GAGGCACCCA ATGAGTTCTA TGATGGAGAC CATGACAATG ACAAGGAAAG CGATGTGGAG 
ATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HDAC3 ( NM_003883.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003874.2 Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 2, mRNA.

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CloneID	OHu25621
Clone ID Related Accession (Same CDS sequence)	NM_003883.3 , NM_003883.4
Accession Version	NM_003883.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514649600000
Organism	Homo sapiens(human)
Product	histone deacetylase 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB456387.1, BM461585.1, BC000614.1 and U66914.1. This sequence is a reference standard in the RefSeqGene project. On Sep 14, 2007 this sequence version replaced NM_003883.2. Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U75697.1, BC000614.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAGA CCGTGGCCTA TTTCTACGAC CCCGACGTGG GCAACTTCCA CTACGGAGCT 
GGACACCCTA TGAAGCCCCA TCGCCTGGCA TTGACCCATA GCCTGGTCCT GCATTACGGT 
CTCTATAAGA AGATGATCGT CTTCAAGCCA TACCAGGCCT CCCAACATGA CATGTGCCGC 
TTCCACTCCG AGGACTACAT TGACTTCCTG CAGAGAGTCA GCCCCACCAA TATGCAAGGC 
TTCACCAAGA GTCTTAATGC CTTCAACGTA GGCGATGACT GCCCAGTGTT TCCCGGGCTC 
TTTGAGTTCT GCTCGCGTTA CACAGGCGCA TCTCTGCAAG GAGCAACCCA GCTGAACAAC 
AAGATCTGTG ATATTGCCAT TAACTGGGCT GGTGGTCTGC ACCATGCCAA GAAGTTTGAG 
GCCTCTGGCT TCTGCTATGT CAACGACATT GTGATTGGCA TCCTGGAGCT GCTCAAGTAC 
CACCCTCGGG TGCTCTACAT TGACATTGAC ATCCACCATG GTGACGGGGT TCAAGAAGCT 
TTCTACCTCA CTGACCGGGT CATGACGGTG TCCTTCCACA AATACGGAAA TTACTTCTTC 
CCTGGCACAG GTGACATGTA TGAAGTCGGG GCAGAGAGTG GCCGCTACTA CTGTCTGAAC 
GTGCCCCTGC GGGATGGCAT TGATGACCAG AGTTACAAGC ACCTTTTCCA GCCGGTTATC 
AACCAGGTAG TGGACTTCTA CCAACCCACG TGCATTGTGC TCCAGTGTGG AGCTGACTCT 
CTGGGCTGTG ATCGATTGGG CTGCTTTAAC CTCAGCATCC GAGGGCATGG GGAATGCGTT 
GAATATGTCA AGAGCTTCAA TATCCCTCTA CTCGTGCTGG GTGGTGGTGG TTATACTGTC 
CGAAATGTTG CCCGCTGCTG GACATATGAG ACATCGCTGC TGGTAGAAGA GGCCATTAGT 
GAGGAGCTTC CCTATAGTGA ATACTTCGAG TACTTTGCCC CAGACTTCAC ACTTCATCCA 
GATGTCAGCA CCCGCATCGA GAATCAGAAC TCACGCCAGT ATCTGGACCA GATCCGCCAG 
ACAATCTTTG AAAACCTGAA GATGCTGAAC CATGCACCTA GTGTCCAGAT TCATGACGTG 
CCTGCAGACC TCCTGACCTA TGACAGGACT GATGAGGCTG ATGCAGAGGA GAGGGGTCCT 
GAGGAGAACT ATAGCAGGCC AGAGGCACCC AATGAGTTCT ATGATGGAGA CCATGACAAT 
GACAAGGAAA GCGATGTGGA GATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003874.2
CDS	67..1353
Translation	MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI

Target ORF information:

RefSeq Version	NM_003883.3
Organism	Homo sapiens(human)
Definition	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003883.3

ORF Insert Sequence:

ATGGCCAAGA CCGTGGCCTA TTTCTACGAC CCCGACGTGG GCAACTTCCA CTACGGAGCT 
GGACACCCTA TGAAGCCCCA TCGCCTGGCA TTGACCCATA GCCTGGTCCT GCATTACGGT 
CTCTATAAGA AGATGATCGT CTTCAAGCCA TACCAGGCCT CCCAACATGA CATGTGCCGC 
TTCCACTCCG AGGACTACAT TGACTTCCTG CAGAGAGTCA GCCCCACCAA TATGCAAGGC 
TTCACCAAGA GTCTTAATGC CTTCAACGTA GGCGATGACT GCCCAGTGTT TCCCGGGCTC 
TTTGAGTTCT GCTCGCGTTA CACAGGCGCA TCTCTGCAAG GAGCAACCCA GCTGAACAAC 
AAGATCTGTG ATATTGCCAT TAACTGGGCT GGTGGTCTGC ACCATGCCAA GAAGTTTGAG 
GCCTCTGGCT TCTGCTATGT CAACGACATT GTGATTGGCA TCCTGGAGCT GCTCAAGTAC 
CACCCTCGGG TGCTCTACAT TGACATTGAC ATCCACCATG GTGACGGGGT TCAAGAAGCT 
TTCTACCTCA CTGACCGGGT CATGACGGTG TCCTTCCACA AATACGGAAA TTACTTCTTC 
CCTGGCACAG GTGACATGTA TGAAGTCGGG GCAGAGAGTG GCCGCTACTA CTGTCTGAAC 
GTGCCCCTGC GGGATGGCAT TGATGACCAG AGTTACAAGC ACCTTTTCCA GCCGGTTATC 
AACCAGGTAG TGGACTTCTA CCAACCCACG TGCATTGTGC TCCAGTGTGG AGCTGACTCT 
CTGGGCTGTG ATCGATTGGG CTGCTTTAAC CTCAGCATCC GAGGGCATGG GGAATGCGTT 
GAATATGTCA AGAGCTTCAA TATCCCTCTA CTCGTGCTGG GTGGTGGTGG TTATACTGTC 
CGAAATGTTG CCCGCTGCTG GACATATGAG ACATCGCTGC TGGTAGAAGA GGCCATTAGT 
GAGGAGCTTC CCTATAGTGA ATACTTCGAG TACTTTGCCC CAGACTTCAC ACTTCATCCA 
GATGTCAGCA CCCGCATCGA GAATCAGAAC TCACGCCAGT ATCTGGACCA GATCCGCCAG 
ACAATCTTTG AAAACCTGAA GATGCTGAAC CATGCACCTA GTGTCCAGAT TCATGACGTG 
CCTGCAGACC TCCTGACCTA TGACAGGACT GATGAGGCTG ATGCAGAGGA GAGGGGTCCT 
GAGGAGAACT ATAGCAGGCC AGAGGCACCC AATGAGTTCT ATGATGGAGA CCATGACAAT 
GACAAGGAAA GCGATGTGGA GATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HDAC3 ( NM_003883.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003874.2 Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu25621
Clone ID Related Accession (Same CDS sequence)	NM_003883.3 , NM_003883.4
Accession Version	NM_003883.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577721600000
Organism	Homo sapiens(human)
Product	histone deacetylase 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB456387.1, BM461585.1 and BC000614.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003883.3. Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1140268.1, SRR3476690.46193.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000305264.8/ ENSP00000302967.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAAGA CCGTGGCCTA TTTCTACGAC CCCGACGTGG GCAACTTCCA CTACGGAGCT 
GGACACCCTA TGAAGCCCCA TCGCCTGGCA TTGACCCATA GCCTGGTCCT GCATTACGGT 
CTCTATAAGA AGATGATCGT CTTCAAGCCA TACCAGGCCT CCCAACATGA CATGTGCCGC 
TTCCACTCCG AGGACTACAT TGACTTCCTG CAGAGAGTCA GCCCCACCAA TATGCAAGGC 
TTCACCAAGA GTCTTAATGC CTTCAACGTA GGCGATGACT GCCCAGTGTT TCCCGGGCTC 
TTTGAGTTCT GCTCGCGTTA CACAGGCGCA TCTCTGCAAG GAGCAACCCA GCTGAACAAC 
AAGATCTGTG ATATTGCCAT TAACTGGGCT GGTGGTCTGC ACCATGCCAA GAAGTTTGAG 
GCCTCTGGCT TCTGCTATGT CAACGACATT GTGATTGGCA TCCTGGAGCT GCTCAAGTAC 
CACCCTCGGG TGCTCTACAT TGACATTGAC ATCCACCATG GTGACGGGGT TCAAGAAGCT 
TTCTACCTCA CTGACCGGGT CATGACGGTG TCCTTCCACA AATACGGAAA TTACTTCTTC 
CCTGGCACAG GTGACATGTA TGAAGTCGGG GCAGAGAGTG GCCGCTACTA CTGTCTGAAC 
GTGCCCCTGC GGGATGGCAT TGATGACCAG AGTTACAAGC ACCTTTTCCA GCCGGTTATC 
AACCAGGTAG TGGACTTCTA CCAACCCACG TGCATTGTGC TCCAGTGTGG AGCTGACTCT 
CTGGGCTGTG ATCGATTGGG CTGCTTTAAC CTCAGCATCC GAGGGCATGG GGAATGCGTT 
GAATATGTCA AGAGCTTCAA TATCCCTCTA CTCGTGCTGG GTGGTGGTGG TTATACTGTC 
CGAAATGTTG CCCGCTGCTG GACATATGAG ACATCGCTGC TGGTAGAAGA GGCCATTAGT 
GAGGAGCTTC CCTATAGTGA ATACTTCGAG TACTTTGCCC CAGACTTCAC ACTTCATCCA 
GATGTCAGCA CCCGCATCGA GAATCAGAAC TCACGCCAGT ATCTGGACCA GATCCGCCAG 
ACAATCTTTG AAAACCTGAA GATGCTGAAC CATGCACCTA GTGTCCAGAT TCATGACGTG 
CCTGCAGACC TCCTGACCTA TGACAGGACT GATGAGGCTG ATGCAGAGGA GAGGGGTCCT 
GAGGAGAACT ATAGCAGGCC AGAGGCACCC AATGAGTTCT ATGATGGAGA CCATGACAAT 
GACAAGGAAA GCGATGTGGA GATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003874.2
CDS	60..1346
Translation	MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI

Target ORF information:

RefSeq Version	NM_003883.4
Organism	Homo sapiens(human)
Definition	Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003883.4

ORF Insert Sequence:

ATGGCCAAGA CCGTGGCCTA TTTCTACGAC CCCGACGTGG GCAACTTCCA CTACGGAGCT 
GGACACCCTA TGAAGCCCCA TCGCCTGGCA TTGACCCATA GCCTGGTCCT GCATTACGGT 
CTCTATAAGA AGATGATCGT CTTCAAGCCA TACCAGGCCT CCCAACATGA CATGTGCCGC 
TTCCACTCCG AGGACTACAT TGACTTCCTG CAGAGAGTCA GCCCCACCAA TATGCAAGGC 
TTCACCAAGA GTCTTAATGC CTTCAACGTA GGCGATGACT GCCCAGTGTT TCCCGGGCTC 
TTTGAGTTCT GCTCGCGTTA CACAGGCGCA TCTCTGCAAG GAGCAACCCA GCTGAACAAC 
AAGATCTGTG ATATTGCCAT TAACTGGGCT GGTGGTCTGC ACCATGCCAA GAAGTTTGAG 
GCCTCTGGCT TCTGCTATGT CAACGACATT GTGATTGGCA TCCTGGAGCT GCTCAAGTAC 
CACCCTCGGG TGCTCTACAT TGACATTGAC ATCCACCATG GTGACGGGGT TCAAGAAGCT 
TTCTACCTCA CTGACCGGGT CATGACGGTG TCCTTCCACA AATACGGAAA TTACTTCTTC 
CCTGGCACAG GTGACATGTA TGAAGTCGGG GCAGAGAGTG GCCGCTACTA CTGTCTGAAC 
GTGCCCCTGC GGGATGGCAT TGATGACCAG AGTTACAAGC ACCTTTTCCA GCCGGTTATC 
AACCAGGTAG TGGACTTCTA CCAACCCACG TGCATTGTGC TCCAGTGTGG AGCTGACTCT 
CTGGGCTGTG ATCGATTGGG CTGCTTTAAC CTCAGCATCC GAGGGCATGG GGAATGCGTT 
GAATATGTCA AGAGCTTCAA TATCCCTCTA CTCGTGCTGG GTGGTGGTGG TTATACTGTC 
CGAAATGTTG CCCGCTGCTG GACATATGAG ACATCGCTGC TGGTAGAAGA GGCCATTAGT 
GAGGAGCTTC CCTATAGTGA ATACTTCGAG TACTTTGCCC CAGACTTCAC ACTTCATCCA 
GATGTCAGCA CCCGCATCGA GAATCAGAAC TCACGCCAGT ATCTGGACCA GATCCGCCAG 
ACAATCTTTG AAAACCTGAA GATGCTGAAC CATGCACCTA GTGTCCAGAT TCATGACGTG 
CCTGCAGACC TCCTGACCTA TGACAGGACT GATGAGGCTG ATGCAGAGGA GAGGGGTCCT 
GAGGAGAACT ATAGCAGGCC AGAGGCACCC AATGAGTTCT ATGATGGAGA CCATGACAAT 
GACAAGGAAA GCGATGTGGA GATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PPARβ/δ recruits NCOR and regulates transcription reinitiation of ANGPTL4.
Nucleic acids research47(18)9573-9591(2019 10)
Legrand N,Bretscher CL,Zielke S,Wilke B,Daude M,Fritz B,Diederich WE,Adhikary T

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