| Gene Symbol | CBR3 |
| Entrez Gene ID | 874 |
| Full Name | carbonyl reductase 3 |
| Synonyms | HEL-S-25,SDR21C2,hCBR3 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
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CBR3 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following CBR3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CBR3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu56680 Clone ID Related Accession (Same CDS sequence) XM_011529772.2 Accession Version XM_011529772.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 438bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1575475200000 Organism Homo sapiens(human) Product carbonyl reductase [NADPH] 3 isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000021.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011529772.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361
421ATGTCGTCCT GCAGCCGCGT GGCGCTGGTG ACCGGGGCCA ACAGGGGCAT CGGCTTGGCC
ATCGCGCGCG AACTGTGCCG ACAGTTCTCT GGGGATGTGG TGCTCACCGC GCGGGACGTG
GCGCGGGGCC AGGCGGCCGT GCAGCAGCTG CAGGCGGAGG GCCTGAGCCC GCGCTTCCAC
CAACTGGACA TCGACGACTT GCAGAGCATC CGCGCCCTGC GCGACTTCCT GCGCAAGGAG
TACGGGGGGC TCAACGTACT GGTCAACAAC GCGGCCGTCG CCTTCAAGAG TGATGATCCA
ATGCCCTTTG ACATTAAAGC TGAGATGACA CTGAAGACAA ATTTTTTTGC CACTAGAAAC
ATGTGCAACG AGTTACTGCC GATAATGAAA CCTCATGCCG CCAAGTTTCT GAGAACAAAG
CTGTTTAGAA AGCAATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_011528074.1 CDS 293..730 Translation 
Target ORF information:
RefSeq Version XM_011529772.2 Organism Homo sapiens(human) Definition Homo sapiens carbonyl reductase 3 (CBR3), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
XM_011529772.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGTCGTCCT GCAGCCGCGT GGCGCTGGTG ACCGGGGCCA ACAGGGGCAT CGGCTTGGCC
ATCGCGCGCG AACTGTGCCG ACAGTTCTCT GGGGATGTGG TGCTCACCGC GCGGGACGTG
GCGCGGGGCC AGGCGGCCGT GCAGCAGCTG CAGGCGGAGG GCCTGAGCCC GCGCTTCCAC
CAACTGGACA TCGACGACTT GCAGAGCATC CGCGCCCTGC GCGACTTCCT GCGCAAGGAG
TACGGGGGGC TCAACGTACT GGTCAACAAC GCGGCCGTCG CCTTCAAGAG TGATGATCCA
ATGCCCTTTG ACATTAAAGC TGAGATGACA CTGAAGACAA ATTTTTTTGC CACTAGAAAC
ATGTGCAACG AGTTACTGCC GATAATGAAA CCTCATGCCG CCAAGTTTCT GAGAACAAAG
CTGTTTAGAA AGCAATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu29525 Clone ID Related Accession (Same CDS sequence) NM_001236.4 , NM_001236.3 Accession Version NM_001236.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577635200000 Organism Homo sapiens(human) Product carbonyl reductase [NADPH] 3 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB041012.1 and BC002812.2. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001236.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223429.1, AB041012.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000290354.6/ ENSP00000290354.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGTCGTCCT GCAGCCGCGT GGCGCTGGTG ACCGGGGCCA ACAGGGGCAT CGGCTTGGCC
ATCGCGCGCG AACTGTGCCG ACAGTTCTCT GGGGATGTGG TGCTCACCGC GCGGGACGTG
GCGCGGGGCC AGGCGGCCGT GCAGCAGCTG CAGGCGGAGG GCCTGAGCCC GCGCTTCCAC
CAACTGGACA TCGACGACTT GCAGAGCATC CGCGCCCTGC GCGACTTCCT GCGCAAGGAG
TACGGGGGGC TCAACGTACT GGTCAACAAC GCGGCCGTCG CCTTCAAGAG TGATGATCCA
ATGCCCTTTG ACATTAAAGC TGAGATGACA CTGAAGACAA ATTTTTTTGC CACTAGAAAC
ATGTGCAACG AGTTACTGCC GATAATGAAA CCTCATGGGA GAGTGGTGAA TATCAGTAGT
TTGCAGTGTT TAAGGGCTTT TGAAAACTGC AGTGAAGATC TGCAGGAAAG GTTCCACAGT
GAGACACTCA CAGAAGGAGA CCTGGTGGAT CTCATGAAAA AGTTTGTGGA GGACACAAAA
AATGAGGTGC ATGAGAGGGA AGGCTGGCCC AACTCACCTT ATGGGGTGTC CAAGTTGGGG
GTCACGGTCT TATCGAGGAT CCTGGCCAGG CGTCTGGATG AGAAGAGGAA AGCTGACAGG
ATTCTGGTGA ATGCGTGCTG CCCAGGACCA GTGAAGACAG ACATGGATGG GAAAGACAGC
ATCAGGACTG TGGAGGAGGG GGCTGAGACC CCTGTCTACT TGGCCCTCTT GCCTCCAGAT
GCCACTGAGC CACAAGGCCA GTTGGTCCAT GACAAAGTTG TGCAAAACTG GTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001227.1 CDS 115..948 Translation
Target ORF information:
RefSeq Version NM_001236.4 Organism Homo sapiens(human) Definition Homo sapiens carbonyl reductase 3 (CBR3), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001236.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGTCGTCCT GCAGCCGCGT GGCGCTGGTG ACCGGGGCCA ACAGGGGCAT CGGCTTGGCC
ATCGCGCGCG AACTGTGCCG ACAGTTCTCT GGGGATGTGG TGCTCACCGC GCGGGACGTG
GCGCGGGGCC AGGCGGCCGT GCAGCAGCTG CAGGCGGAGG GCCTGAGCCC GCGCTTCCAC
CAACTGGACA TCGACGACTT GCAGAGCATC CGCGCCCTGC GCGACTTCCT GCGCAAGGAG
TACGGGGGGC TCAACGTACT GGTCAACAAC GCGGCCGTCG CCTTCAAGAG TGATGATCCA
ATGCCCTTTG ACATTAAAGC TGAGATGACA CTGAAGACAA ATTTTTTTGC CACTAGAAAC
ATGTGCAACG AGTTACTGCC GATAATGAAA CCTCATGGGA GAGTGGTGAA TATCAGTAGT
TTGCAGTGTT TAAGGGCTTT TGAAAACTGC AGTGAAGATC TGCAGGAAAG GTTCCACAGT
GAGACACTCA CAGAAGGAGA CCTGGTGGAT CTCATGAAAA AGTTTGTGGA GGACACAAAA
AATGAGGTGC ATGAGAGGGA AGGCTGGCCC AACTCACCTT ATGGGGTGTC CAAGTTGGGG
GTCACGGTCT TATCGAGGAT CCTGGCCAGG CGTCTGGATG AGAAGAGGAA AGCTGACAGG
ATTCTGGTGA ATGCGTGCTG CCCAGGACCA GTGAAGACAG ACATGGATGG GAAAGACAGC
ATCAGGACTG TGGAGGAGGG GGCTGAGACC CCTGTCTACT TGGCCCTCTT GCCTCCAGAT
GCCACTGAGC CACAAGGCCA GTTGGTCCAT GACAAAGTTG TGCAAAACTG GTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu29525 Clone ID Related Accession (Same CDS sequence) NM_001236.4 , NM_001236.3 Accession Version NM_001236.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506700800000 Organism Homo sapiens(human) Product carbonyl reductase [NADPH] 3 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB041012.1 and BC002812.2. This sequence is a reference standard in the RefSeqGene project. On Apr 6, 2005 this sequence version replaced NM_001236.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279826.8581.1, AB041012.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGTCGTCCT GCAGCCGCGT GGCGCTGGTG ACCGGGGCCA ACAGGGGCAT CGGCTTGGCC
ATCGCGCGCG AACTGTGCCG ACAGTTCTCT GGGGATGTGG TGCTCACCGC GCGGGACGTG
GCGCGGGGCC AGGCGGCCGT GCAGCAGCTG CAGGCGGAGG GCCTGAGCCC GCGCTTCCAC
CAACTGGACA TCGACGACTT GCAGAGCATC CGCGCCCTGC GCGACTTCCT GCGCAAGGAG
TACGGGGGGC TCAACGTACT GGTCAACAAC GCGGCCGTCG CCTTCAAGAG TGATGATCCA
ATGCCCTTTG ACATTAAAGC TGAGATGACA CTGAAGACAA ATTTTTTTGC CACTAGAAAC
ATGTGCAACG AGTTACTGCC GATAATGAAA CCTCATGGGA GAGTGGTGAA TATCAGTAGT
TTGCAGTGTT TAAGGGCTTT TGAAAACTGC AGTGAAGATC TGCAGGAAAG GTTCCACAGT
GAGACACTCA CAGAAGGAGA CCTGGTGGAT CTCATGAAAA AGTTTGTGGA GGACACAAAA
AATGAGGTGC ATGAGAGGGA AGGCTGGCCC AACTCACCTT ATGGGGTGTC CAAGTTGGGG
GTCACGGTCT TATCGAGGAT CCTGGCCAGG CGTCTGGATG AGAAGAGGAA AGCTGACAGG
ATTCTGGTGA ATGCGTGCTG CCCAGGACCA GTGAAGACAG ACATGGATGG GAAAGACAGC
ATCAGGACTG TGGAGGAGGG GGCTGAGACC CCTGTCTACT TGGCCCTCTT GCCTCCAGAT
GCCACTGAGC CACAAGGCCA GTTGGTCCAT GACAAAGTTG TGCAAAACTG GTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001227.1 CDS 229..1062 Translation
Target ORF information:
RefSeq Version NM_001236.3 Organism Homo sapiens(human) Definition Homo sapiens carbonyl reductase 3 (CBR3), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001236.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGTCGTCCT GCAGCCGCGT GGCGCTGGTG ACCGGGGCCA ACAGGGGCAT CGGCTTGGCC
ATCGCGCGCG AACTGTGCCG ACAGTTCTCT GGGGATGTGG TGCTCACCGC GCGGGACGTG
GCGCGGGGCC AGGCGGCCGT GCAGCAGCTG CAGGCGGAGG GCCTGAGCCC GCGCTTCCAC
CAACTGGACA TCGACGACTT GCAGAGCATC CGCGCCCTGC GCGACTTCCT GCGCAAGGAG
TACGGGGGGC TCAACGTACT GGTCAACAAC GCGGCCGTCG CCTTCAAGAG TGATGATCCA
ATGCCCTTTG ACATTAAAGC TGAGATGACA CTGAAGACAA ATTTTTTTGC CACTAGAAAC
ATGTGCAACG AGTTACTGCC GATAATGAAA CCTCATGGGA GAGTGGTGAA TATCAGTAGT
TTGCAGTGTT TAAGGGCTTT TGAAAACTGC AGTGAAGATC TGCAGGAAAG GTTCCACAGT
GAGACACTCA CAGAAGGAGA CCTGGTGGAT CTCATGAAAA AGTTTGTGGA GGACACAAAA
AATGAGGTGC ATGAGAGGGA AGGCTGGCCC AACTCACCTT ATGGGGTGTC CAAGTTGGGG
GTCACGGTCT TATCGAGGAT CCTGGCCAGG CGTCTGGATG AGAAGAGGAA AGCTGACAGG
ATTCTGGTGA ATGCGTGCTG CCCAGGACCA GTGAAGACAG ACATGGATGG GAAAGACAGC
ATCAGGACTG TGGAGGAGGG GGCTGAGACC CCTGTCTACT TGGCCCTCTT GCCTCCAGAT
GCCACTGAGC CACAAGGCCA GTTGGTCCAT GACAAAGTTG TGCAAAACTG GTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
PlncRNA-1 is overexpressed in retinoblastoma and regulates retinoblastoma cell proliferation and motility through modulating CBR3.
IUBMB life70(10)969-975(2018 10)
Wang S,Liu J,Yang Y,Hao F,Zhang L
NOS3 895G>T and CBR3 730G>A Are Associated with Recurrence Risk in Non-Muscle-Invasive Bladder Cancer with Intravesical Instillations of THP.
Chemotherapy63(4)191-197(2018)
Zhou Q,Ding W,Weng Y,Ding G,Xia G,Xu J,Xu K,Ding Q
Risk factors for anthracycline-associated cardiotoxicity.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer24(5)2173-2180(2016 May)
Reinbolt RE,Patel R,Pan X,Timmers CD,Pilarski R,Shapiro CL,Lustberg MB
Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines.
Pharmacogenomics17(3)231-40(2016 Feb)
Hertz DL,Caram MV,Kidwell KM,Thibert JN,Gersch C,Seewald NJ,Smerage J,Rubenfire M,Henry NL,Cooney KA,Leja M,Griggs JJ,Rae JM
Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kovács IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barabási AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M
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