PARD6G cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PARD6G
Entrez Gene ID	84552
Full Name	par-6 family cell polarity regulator gamma
Synonyms	PAR-6G,PAR6gamma
General protein information	Preferred Names par-6 family cell polarity regulator gamma Names partitioning defective 6 homolog gamma PAR-6 gamma protein PAR6D par-6 partitioning defective 6 homolog gamma
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q23
Disorder MIM:	608976

mRNA and Protein(s)

mRNA	Protein	Name
NM_032510.3	NP_115899.1	partitioning defective 6 homolog gamma
NM_032510.4	NP_115899.1	partitioning defective 6 homolog gamma

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PARD6G	XP_001145392.1
Rattus norvegicus (Norway rat)	Pard6g	NP_001094443.1
Gallus gallus (chicken)	PARD6G	XP_426065.4
Homo sapiens (human)	PARD6G	NP_115899.1
Xenopus tropicalis (tropical clawed frog)	pard6g	NP_001017338.1
Macaca mulatta (Rhesus monkey)	PARD6G	XP_001090088.1
Bos taurus (cattle)	PARD6G	NP_001091569.1
Mus musculus (house mouse)	Pard6g	NP_444347.3
Drosophila melanogaster (fruit fly)	par-6	NP_573238.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010494	XP_314468.4
Canis lupus familiaris (dog)	PARD6G	XP_541043.2
Danio rerio (zebrafish)	pard6gb	NP_997728.1
Caenorhabditis elegans (roundworm)	par-6	NP_001040687.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers.
Marques E, Englund JI, Tervonen TA, Virkunen E, Laakso M, Myllynen M, Mäkelä A, Ahvenainen M, Lepikhova T, Monni O, Hautaniemi S, Klefström J
Oncogene35(11)1386-98(2016 Mar)

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K
Science signaling8(371)rs3(2015 Apr)

Par6γ is at the mother centriole and controls centrosomal protein composition through a Par6α-dependent pathway.
Dormoy V, Tormanen K, Sütterlin C
Journal of cell science126(Pt 3)860-70(2013 Feb)

A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells.
Iden S, Rehder D, August B, Suzuki A, Wolburg-Buchholz K, Wolburg H, Ohno S, Behrens J, Vestweber D, Ebnet K
EMBO reports7(12)1239-46(2006 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PARD6G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PARD6G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05031	NM_032510.4 Latest version!	Homo sapiens par-6 family cell polarity regulator gamma (PARD6G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu05031	NM_032510.3	Homo sapiens par-6 family cell polarity regulator gamma (PARD6G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PARD6G ( NM_032510.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115899.1 Homo sapiens par-6 family cell polarity regulator gamma (PARD6G), mRNA.

Price & Availability↑

CloneID	OHu05031
Clone ID Related Accession (Same CDS sequence)	NM_032510.3 , NM_032510.4
Accession Version	NM_032510.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1131bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	partitioning defective 6 homolog gamma
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC060797.1, AC139100.4 and AA502508.1. On Oct 3, 2006 this sequence version replaced NM_032510.2. ##Evidence-Data-START## Transcript exon combination :: BC060797.1, SRR1163655.155917.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END##

ATGAACCGAA GTTTTCACAA GTCTCAGACC TTGCGATTCT ACGATTGCAG CGCAGTGGAA 
GTCAAGAGCA AGTTTGGGGC GGAATTCCGA AGGTTCTCTC TGGACCGTCA TAAGCCTGGG 
AAGTTTGAAG ATTTCTACAA GCTGGTTGTG CACACCCACC ATATCTCCAA CAGTGATGTA 
ACTATTGGCT ATGCAGATGT GCACGGAGAC CTGCTGCCCA TCAACAATGA TGACAACTTC 
TGCAAGGCGG TTTCTAGTGC AAATCCCCTG CTCAGGGTCT TCATCCAGAA ACGAGAGGAG 
GCCGAGCGTG GCAGCCTCGG CGCGGGCTCG CTGTGCAGGC GGAGGCGGGC GCTGGGCGCG 
CTGCGTGATG AAGGACCCCG GCGGCGTGCA CACCTGGACA TCGGCCTCCC GCGCGACTTC 
CGCCCCGTAT CATCCATCAT CGATGTGGAC CTGGTCCCCG AGACGCACCG GCGAGTGCGG 
CTGCACCGGC ACGGCTGCGA GAAGCCGCTG GGCTTCTACA TCCGCGATGG CGCCAGCGTG 
CGCGTGACCC CGCACGGGCT GGAGAAGGTG CCCGGCATCT TCATCTCGCG CATGGTACCC 
GGGGGCCTGG CGGAGAGCAC CGGGCTGCTG GCTGTGAATG ACGAGGTCCT GGAGGTGAAC 
GGCATTGAGG TGGCCGGGAA GACGCTGGAC CAGGTCACGG ACATGATGAT CGCCAACAGC 
CACAACCTCA TCGTCACCGT CAAGCCCGCC AACCAGCGCA ACAACGTGGT GCGCGGCGGC 
CGCGCGTTGG GCAGCTCGGG ACCGCCCTCG GACGGCACCG CGGGCTTCGT GGGTCCCCCC 
GCCCCGCGCG TCCTGCAGAA CTTCCACCCC GACGAGGCGG AGAGCGATGA GGACAACGAC 
GTCGTCATCG AGGGCACACT GGAGCCTGCA CGTCCCCCCC AGACCCCGGG CGCGCCCGCA 
GGCAGCCTCT CCCGGGTCAA TGGCGCGGGC CTGGCGCAGC GGCTGCAGCG GGACCTGGCC 
CTGGACGGCG GCCTCCAGCG GCTGCTCAGC TCCCTGCGGG CCGACCCCCG TCACAGCCTG 
GCGCTGCCGC CAGGCGGCGT GGAGGAGCAC GGGCCCGCGG TCACGCTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115899.1
CDS	167..1297
Translation	MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVTL

Target ORF information:

RefSeq Version	NM_032510.3
Organism	Homo sapiens(human)
Definition	Homo sapiens par-6 family cell polarity regulator gamma (PARD6G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032510.3

ORF Insert Sequence:

ATGAACCGAA GTTTTCACAA GTCTCAGACC TTGCGATTCT ACGATTGCAG CGCAGTGGAA 
GTCAAGAGCA AGTTTGGGGC GGAATTCCGA AGGTTCTCTC TGGACCGTCA TAAGCCTGGG 
AAGTTTGAAG ATTTCTACAA GCTGGTTGTG CACACCCACC ATATCTCCAA CAGTGATGTA 
ACTATTGGCT ATGCAGATGT GCACGGAGAC CTGCTGCCCA TCAACAATGA TGACAACTTC 
TGCAAGGCGG TTTCTAGTGC AAATCCCCTG CTCAGGGTCT TCATCCAGAA ACGAGAGGAG 
GCCGAGCGTG GCAGCCTCGG CGCGGGCTCG CTGTGCAGGC GGAGGCGGGC GCTGGGCGCG 
CTGCGTGATG AAGGACCCCG GCGGCGTGCA CACCTGGACA TCGGCCTCCC GCGCGACTTC 
CGCCCCGTAT CATCCATCAT CGATGTGGAC CTGGTCCCCG AGACGCACCG GCGAGTGCGG 
CTGCACCGGC ACGGCTGCGA GAAGCCGCTG GGCTTCTACA TCCGCGATGG CGCCAGCGTG 
CGCGTGACCC CGCACGGGCT GGAGAAGGTG CCCGGCATCT TCATCTCGCG CATGGTACCC 
GGGGGCCTGG CGGAGAGCAC CGGGCTGCTG GCTGTGAATG ACGAGGTCCT GGAGGTGAAC 
GGCATTGAGG TGGCCGGGAA GACGCTGGAC CAGGTCACGG ACATGATGAT CGCCAACAGC 
CACAACCTCA TCGTCACCGT CAAGCCCGCC AACCAGCGCA ACAACGTGGT GCGCGGCGGC 
CGCGCGTTGG GCAGCTCGGG ACCGCCCTCG GACGGCACCG CGGGCTTCGT GGGTCCCCCC 
GCCCCGCGCG TCCTGCAGAA CTTCCACCCC GACGAGGCGG AGAGCGATGA GGACAACGAC 
GTCGTCATCG AGGGCACACT GGAGCCTGCA CGTCCCCCCC AGACCCCGGG CGCGCCCGCA 
GGCAGCCTCT CCCGGGTCAA TGGCGCGGGC CTGGCGCAGC GGCTGCAGCG GGACCTGGCC 
CTGGACGGCG GCCTCCAGCG GCTGCTCAGC TCCCTGCGGG CCGACCCCCG TCACAGCCTG 
GCGCTGCCGC CAGGCGGCGT GGAGGAGCAC GGGCCCGCGG TCACGCTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PARD6G ( NM_032510.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_115899.1 Homo sapiens par-6 family cell polarity regulator gamma (PARD6G), mRNA.

Price & Availability↑

CloneID	OHu05031
Clone ID Related Accession (Same CDS sequence)	NM_032510.3 , NM_032510.4
Accession Version	NM_032510.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1131bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577548800000
Organism	Homo sapiens(human)
Product	partitioning defective 6 homolog gamma
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC060797.1, AC139100.4 and AA502508.1. On Nov 23, 2018 this sequence version replaced NM_032510.3. ##Evidence-Data-START## Transcript exon combination :: BC060797.1, SRR1163655.155917.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000353265.8/ ENSP00000343144.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACCGAA GTTTTCACAA GTCTCAGACC TTGCGATTCT ACGATTGCAG CGCAGTGGAA 
GTCAAGAGCA AGTTTGGGGC GGAATTCCGA AGGTTCTCTC TGGACCGTCA TAAGCCTGGG 
AAGTTTGAAG ATTTCTACAA GCTGGTTGTG CACACCCACC ATATCTCCAA CAGTGATGTA 
ACTATTGGCT ATGCAGATGT GCACGGAGAC CTGCTGCCCA TCAACAATGA TGACAACTTC 
TGCAAGGCGG TTTCTAGTGC AAATCCCCTG CTCAGGGTCT TCATCCAGAA ACGAGAGGAG 
GCCGAGCGTG GCAGCCTCGG CGCGGGCTCG CTGTGCAGGC GGAGGCGGGC GCTGGGCGCG 
CTGCGTGATG AAGGACCCCG GCGGCGTGCA CACCTGGACA TCGGCCTCCC GCGCGACTTC 
CGCCCCGTAT CATCCATCAT CGATGTGGAC CTGGTCCCCG AGACGCACCG GCGAGTGCGG 
CTGCACCGGC ACGGCTGCGA GAAGCCGCTG GGCTTCTACA TCCGCGATGG CGCCAGCGTG 
CGCGTGACCC CGCACGGGCT GGAGAAGGTG CCCGGCATCT TCATCTCGCG CATGGTACCC 
GGGGGCCTGG CGGAGAGCAC CGGGCTGCTG GCTGTGAATG ACGAGGTCCT GGAGGTGAAC 
GGCATTGAGG TGGCCGGGAA GACGCTGGAC CAGGTCACGG ACATGATGAT CGCCAACAGC 
CACAACCTCA TCGTCACCGT CAAGCCCGCC AACCAGCGCA ACAACGTGGT GCGCGGCGGC 
CGCGCGTTGG GCAGCTCGGG ACCGCCCTCG GACGGCACCG CGGGCTTCGT GGGTCCCCCC 
GCCCCGCGCG TCCTGCAGAA CTTCCACCCC GACGAGGCGG AGAGCGATGA GGACAACGAC 
GTCGTCATCG AGGGCACACT GGAGCCTGCA CGTCCCCCCC AGACCCCGGG CGCGCCCGCA 
GGCAGCCTCT CCCGGGTCAA TGGCGCGGGC CTGGCGCAGC GGCTGCAGCG GGACCTGGCC 
CTGGACGGCG GCCTCCAGCG GCTGCTCAGC TCCCTGCGGG CCGACCCCCG TCACAGCCTG 
GCGCTGCCGC CAGGCGGCGT GGAGGAGCAC GGGCCCGCGG TCACGCTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115899.1
CDS	167..1297
Translation	MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVTL

Target ORF information:

RefSeq Version	NM_032510.4
Organism	Homo sapiens(human)
Definition	Homo sapiens par-6 family cell polarity regulator gamma (PARD6G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032510.4

ORF Insert Sequence:

ATGAACCGAA GTTTTCACAA GTCTCAGACC TTGCGATTCT ACGATTGCAG CGCAGTGGAA 
GTCAAGAGCA AGTTTGGGGC GGAATTCCGA AGGTTCTCTC TGGACCGTCA TAAGCCTGGG 
AAGTTTGAAG ATTTCTACAA GCTGGTTGTG CACACCCACC ATATCTCCAA CAGTGATGTA 
ACTATTGGCT ATGCAGATGT GCACGGAGAC CTGCTGCCCA TCAACAATGA TGACAACTTC 
TGCAAGGCGG TTTCTAGTGC AAATCCCCTG CTCAGGGTCT TCATCCAGAA ACGAGAGGAG 
GCCGAGCGTG GCAGCCTCGG CGCGGGCTCG CTGTGCAGGC GGAGGCGGGC GCTGGGCGCG 
CTGCGTGATG AAGGACCCCG GCGGCGTGCA CACCTGGACA TCGGCCTCCC GCGCGACTTC 
CGCCCCGTAT CATCCATCAT CGATGTGGAC CTGGTCCCCG AGACGCACCG GCGAGTGCGG 
CTGCACCGGC ACGGCTGCGA GAAGCCGCTG GGCTTCTACA TCCGCGATGG CGCCAGCGTG 
CGCGTGACCC CGCACGGGCT GGAGAAGGTG CCCGGCATCT TCATCTCGCG CATGGTACCC 
GGGGGCCTGG CGGAGAGCAC CGGGCTGCTG GCTGTGAATG ACGAGGTCCT GGAGGTGAAC 
GGCATTGAGG TGGCCGGGAA GACGCTGGAC CAGGTCACGG ACATGATGAT CGCCAACAGC 
CACAACCTCA TCGTCACCGT CAAGCCCGCC AACCAGCGCA ACAACGTGGT GCGCGGCGGC 
CGCGCGTTGG GCAGCTCGGG ACCGCCCTCG GACGGCACCG CGGGCTTCGT GGGTCCCCCC 
GCCCCGCGCG TCCTGCAGAA CTTCCACCCC GACGAGGCGG AGAGCGATGA GGACAACGAC 
GTCGTCATCG AGGGCACACT GGAGCCTGCA CGTCCCCCCC AGACCCCGGG CGCGCCCGCA 
GGCAGCCTCT CCCGGGTCAA TGGCGCGGGC CTGGCGCAGC GGCTGCAGCG GGACCTGGCC 
CTGGACGGCG GCCTCCAGCG GCTGCTCAGC TCCCTGCGGG CCGACCCCCG TCACAGCCTG 
GCGCTGCCGC CAGGCGGCGT GGAGGAGCAC GGGCCCGCGG TCACGCTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers.
Oncogene35(11)1386-98(2016 Mar)
Marques E,Englund JI,Tervonen TA,Virkunen E,Laakso M,Myllynen M,Mäkelä A,Ahvenainen M,Lepikhova T,Monni O,Hautaniemi S,Klefström J

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Science signaling8(371)rs3(2015 Apr)
So J,Pasculescu A,Dai AY,Williton K,James A,Nguyen V,Creixell P,Schoof EM,Sinclair J,Barrios-Rodiles M,Gu J,Krizus A,Williams R,Olhovsky M,Dennis JW,Wrana JL,Linding R,Jorgensen C,Pawson T,Colwill K

Par6γ is at the mother centriole and controls centrosomal protein composition through a Par6α-dependent pathway.
Journal of cell science126(Pt 3)860-70(2013 Feb)
Dormoy V,Tormanen K,Sütterlin C

A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells.
EMBO reports7(12)1239-46(2006 Dec)
Iden S,Rehder D,August B,Suzuki A,Wolburg-Buchholz K,Wolburg H,Ohno S,Behrens J,Vestweber D,Ebnet K

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PARD6G cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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