DOT1L cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DOT1L
Entrez Gene ID	84444
Full Name	DOT1 like histone lysine methyltransferase
Synonyms	DOT1,KMT4
General protein information	Preferred Names DOT1 like histone lysine methyltransferase Names histone-lysine N-methyltransferase, H3 lysine-79 specific DOT1 like histone H3K79 methyltransferase DOT1-like histone methyltransferase DOT1-like protein DOT1-like, histone H3 methyltransferase H3-K79-HMTase histone H3-K79 methyltransferase histone methyltransferase DOT1L lysine N-methyltransferase 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011].
Disorder MIM:	607375

mRNA and Protein(s)

mRNA	Protein	Name
XM_011528360.1	XP_011526662.1	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3
NM_032482.3	NP_115871.1	histone-lysine N-methyltransferase, H3 lysine-79 specific
XM_005259660.3	XP_005259717.1	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
XM_011528361.2	XP_011526663.1	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X5
NM_032482.2	NP_115871.1	histone-lysine N-methyltransferase, H3 lysine-79 specific
XM_017027366.1	XP_016882855.1	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X4
XM_011528359.2	XP_011526661.1	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2
XM_005259659.3	XP_005259716.1	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DOT1L	XP_003953365.1
Canis lupus familiaris (dog)	DOT1L	XP_005633296.1
Homo sapiens (human)	DOT1L	NP_115871.1
Macaca mulatta (Rhesus monkey)	DOT1L	XP_001097213.2
Xenopus tropicalis (tropical clawed frog)	dot1l	XP_002937984.2
Bos taurus (cattle)	DOT1L	XP_005209126.1
Mus musculus (house mouse)	Dot1l	NP_955354.1
Rattus norvegicus (Norway rat)	Dot1l	NP_001102203.1
Gallus gallus (chicken)	DOT1L	XP_004948823.1
Danio rerio (zebrafish)	dot1l	XP_005170590.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase.
Jang S, Kang C, Yang HS, Jung T, Hebert H, Chung KY, Kim SJ, Hohng S, Song JJ
Genes & development33(11-12)620-625(2019 06)

Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination.
Valencia-Sánchez MI, De Ioannes P, Wang M, Vasilyev N, Chen R, Nudler E, Armache JP, Armache KJ
Molecular cell74(5)1010-1019.e6(2019 06)

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness.
Kari V, Raul SK, Henck JM, Kitz J, Kramer F, Kosinsky RL, Übelmesser N, Mansour WY, Eggert J, Spitzner M, Najafova Z, Bastians H, Grade M, Gaedcke J, Wegwitz F, Johnsen SA
Clinical epigenetics11(1)4(2019 01)

Selective DOT1L, LSD1, and HDAC Class I Inhibitors Reduce HOXA9 Expression in MLL-AF9 Rearranged Leukemia Cells, But Dysregulate the Expression of Many Histone-Modifying Enzymes.
Lillico R, Lawrence CK, Lakowski TM
Journal of proteome research17(8)2657-2667(2018 08)

Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage.
Pursani V, Bhartiya D, Tanavde V, Bashir M, Sampath P
Stem cell research & therapy9(1)97(2018 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DOT1L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DOT1L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu73529	XM_011528361.2 Latest version!	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$727.30 $1039.00
OHu51864	XM_005259659.3 Latest version!	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00
OHu51864	XM_005259660.3 Latest version!	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00
OHu51865	XM_017027366.1 Latest version!	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$811.30 $1159.00
OHu73527	XM_011528359.2 Latest version!	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00
OHu73528	XM_011528360.1 Latest version!	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00
OHu18464	NM_032482.3 Latest version!	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$811.30 $1159.00
View Old Accession Versions >>
OHu18464	NM_032482.2	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$811.30 $1159.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DOT1L ( XM_011528361.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526663.1 Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X6, mRNA.

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CloneID	OHu73529
Clone ID Related Accession (Same CDS sequence)	XM_011528361.2
Accession Version	XM_011528361.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X5
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011528361.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG GGCTCGGTGT CGTGGACGGG GAAGCCAGTC 
TCCTACTACC TGCACACTAT CGACCGCACC ATACTTGAAA ACTATTTTTC TAGTCTGAAA 
AACCCAAAAC TCAGGGAGGA ACAGGAGGCA GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG 
AGCAACGCGG CCACGCCCAC TAAGGGCCCA GAGGGCAAGG TGGCCGGCCC CGCCGACGCC 
CCCATGGACT CTGGTGCTGA GGAAGAGAAG GCGGGAGCAG CCACCGTGAA GAAGCCGTCT 
CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC AAGAAGGGGA GGAAGATGGC TGGCCGCAAG 
CGCGGGCGCC CCAAGAAGAT GAACACTGCG AACCCCGAGC GGAAGCCCAA GAAGAACCAA 
ACTGCACTGG ATGCCCTGCA CGCTCAGACC GTGTCTCAGA CGGCGGCCTC CTCACCCCAG 
GATGCCTACA GATCCCCTCA CAGCCCGTTC TACCAGCTAC CTCCGAGCGT GCAGCGGCAC 
TCCCCCAACC CGCTGCTGGT GGCGCCCACC CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC 
TTCAAGATCC AGTACCTGCA GTTCCTGGCA TACACAAAGA CCCCCCAGTA CAAGGCCAGC 
CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG AAGAACGCCC AGCTCCTGGG TGCGGCTCAG 
CAGCTCCTCA GCCACTGCCA GGCCCAGAAG GAGGAGATCA GGAGGCTGTT TCAGCAAAAA 
TTGGATGAGC TGGGTGTGAA GGCGCTGACC TACAACGACC TGATTCAAGC GCAGAAGGAG 
ATCTCCGCCC ATAACCAGCA GCTGCGGGAG CAGTCGGAGC AGCTGGAGCA GGACAACCGC 
GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC 
TGGGCCACGC TGTCGCTGGA GAAGCTGTTG AAGGAGAAGC AGGCCCTGAA GAGCCAGATC 
TCGGAGAAGC AGAGGCACTG CCTGGAGCTG CAGATCAGCA TTGTGGAGCT AGAGAAGAGC 
CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG TCCTGTGTGC CGCCTGACGA CGCCCTGTCC 
CTGCACCTGC GTGGGAAGGG CGCCCTGGGC CGCGAGCTGG AGCCTGACGC CAGCCGGCTG 
CACCTGGAGC TGGACTGCAC CAAGTTCTCG CTGCCTCACT TGAGCAGCAT GAGCCCGGAG 
CTCTCCATGA ACGGCCAGGC TGCTGGCTAT GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG 
TCGAAGCAGA ACACGCCCCA GTACCTGGCC TCACCCCTGG ACCAGGAGGT GGTGCCCTGT 
ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG GAGAAGCTGT CTGGCCTAGC CGCACCCGAC 
TACACTAGGC TGTCCCCGGC CAAGATTGTG CTGAGGCGGC ACCTGAGCCA GGACCACACG 
GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG CATTCGAGAG CTGAGCACAC CAAGGAGAAC 
GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT GGCAGCATGA AGCTGAGCCC TCAGGACCCG 
CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG 
AGAGAGCGCG CCTACGGCAG CAGCGGGGAG CTCATCACCA GCCTGCCCAT CAGCATCCCG 
CTCAGCACCG TGCAGCCCAA CAAGCTCCCG GTCAGCATTC CCCTGGCCAG CGTGGTGCTG 
CCCAGCCGCG CCGAGAGGGC GAGGAGCACC CCCAGTCCCG TGCTGCAGCC CCGTGACCCC 
TCGTCCACAC TTGAAAAGCA GATTGGTGCT AATGCCCACG GTGCTGGGAG CAGAAGCCTT 
GCCCTGGCCC CCGCAGGCTT CTCCTACGCT GGCTCGGTGG CCATCAGCGG GGCCTTGGCG 
GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC GAGCCGGCCA CCTTGGATGA GTCCTCCAGC 
TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC CGCAGCTCCA CGCCACAGCA CCCCCTGCTG 
CTGGCACAGC CCCGGAACTC GCTTCCTGCC TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC 
CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC 
GATTCCGGCT TCTCAGATCC TGAGAGTGAA GCCAAGAGGA GGATTGTGTT CACCATCACC 
ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC TCCAGCAAGC ACAGCCCCCT GACCGCCAGC 
GCCCGTGGGG ACTGTGTGCC GAGCCACGGG CAGGACAGTC GCAGGCGCGG CCGGCGGAAG 
CGAGCATCTG CGGGGACGCC CAGCTTGAGC GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG 
CCGTCCGTCG CTGGCCTTTT CACACAGCCT TCGGGGTCTC CCCTCAACCT CAACTCCATG 
GTCAGTAACA TCAACCAGCC CCTGGAGATT ACAGCCATCT CGTCCCCGGA GACCTCCCTG 
AAGAGCTCCC CTGTGCCCTA CCAGGACCAC GACCAGCCCC CCGTGCTCAA GAAGGAGCGG 
CCTCTGAGCC AGACCAATGG GGCACACTAC TCCCCACTCA CCTCAGACGA GGAGCCAGGC 
TCTGAGGACG AGCCCAGCAG TGCTCGAATT GAGAGAAAAA TTGCAACAAT CTCCTTAGAA 
AGCAAATCTC CCCCGAAAAC CTTGGAAAAT GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG 
CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG TGGAAGTCCA CCTTCTCGCC CATCTCCGAC 
ATCGGCCTGG CCAAGTCGGC GGACAGCCCG CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC 
TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG GAGCCCTCTG CCGATGCCAA GCTGGCCGCT 
CACCCCAGGA AAGGCTTTCC CGGCTCCCTG TCGGGGGCTG ACGGACTCAG CCCGGGCACC 
AACCCTGCCA ACGGCTGCAC CTTCGGCGGG GGCCTGGCCG CGGACCTGAG TTTACACAGC 
TTCAGTGATG GTGCTTCTCT TCCCCACAAG GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG 
CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG GGCTCGGACG CCAACCCTTT CCTGAGCAAG 
AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG 
GAGGGCGGCC TACCGCTGTG CGGGCCCACG GACAAGACCC CACTGCTGAG CGGCAAGGCC 
GCCAAGGCCC GGGACCGCGA GGTCGACCTC AAGAATGGCC ACAACCTCTT CATCTCTGCG 
GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC 
GCAGGCGGCG CGGCGTCCTC CGCCCAGACG CACCGGTCCT TCCTGGGCCC CTTCCCGCCG 
GGACCGCAGT TCGCGCTCGG CCCCATGTCC CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC 
TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT GTGCCGGCCG CCGCAGGCCT GGTGCACGTG 
TCGTCCGCTG CCACCAGACT GACCAACTCG CACGCCATGG GCAGCTTTTC CGGGGTGGCA 
GGCGGCACAG TTGGAGGTGT CTTTAACCAC GCGGTGCCCT CCGCCTCTGC TCATCCGTTT 
GGAGCCCGTG TCGGCCGCGG GGCTGCATGT GGCAGCGCCA CACTGGGCCC GAGCCCGCTG 
CAGGCGGCGG CCAGCGCCTC GGCCTCTTCC TTTCAGGCCC CGGCCTCGGT TGAGACCCGG 
CCGCCCCCTC CGCCTCCGCC TCCGCCTCCC CCGCTGCCCC CGCCTGCGCA CCTGGGCCGG 
TCCCCCGCGG GGCCGCCCGT CCTCCACGCC CCCCCTCCAC CTAACGCCGC CTTGCCTCCT 
CCCCCAACGC TGCTGGCCTC TAACCCTGAG CCCGCGCTTC TGCAGAGCCT CGCGTCCCTC 
CCGCCTAACC AAGCTTTCTT GCCCCCCACC TCTGCTGCCT CTCTGCCGCC TGCTAACGCC 
TCTTTGTCTA TCAAGCTCAC CTCCCTCCCG CACAAGGGCG CCCGCCCCTC CTTCACGGTG 
CACCACCAGC CCCTGCCCCG GCTGGCCCTG GCCCAGGCCG CGCCCGGGAT CCCACAGGCC 
AGCGCCACGG GGCCGTCCGC GGTGTGGGTG TCCCTCGGCA TGCCGCCTCC CTATGCCGCG 
CACCTTTCGG GGGTTAAGCC GCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526663.1
CDS	312..4658
Translation	MRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGVFNHAVPSASAHPFGARVGRGAACGSATLGPSPLQAAASASASSFQAPASVETRPPPPPPPPPPPLPPPAHLGRSPAGPPVLHAPPPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLPPTSAASLPPANASLSIKLTSLPHKGARPSFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSGVKPR

Target ORF information:

RefSeq Version	XM_011528361.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528361.2

ORF Insert Sequence:

ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG GGCTCGGTGT CGTGGACGGG GAAGCCAGTC 
TCCTACTACC TGCACACTAT CGACCGCACC ATACTTGAAA ACTATTTTTC TAGTCTGAAA 
AACCCAAAAC TCAGGGAGGA ACAGGAGGCA GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG 
AGCAACGCGG CCACGCCCAC TAAGGGCCCA GAGGGCAAGG TGGCCGGCCC CGCCGACGCC 
CCCATGGACT CTGGTGCTGA GGAAGAGAAG GCGGGAGCAG CCACCGTGAA GAAGCCGTCT 
CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC AAGAAGGGGA GGAAGATGGC TGGCCGCAAG 
CGCGGGCGCC CCAAGAAGAT GAACACTGCG AACCCCGAGC GGAAGCCCAA GAAGAACCAA 
ACTGCACTGG ATGCCCTGCA CGCTCAGACC GTGTCTCAGA CGGCGGCCTC CTCACCCCAG 
GATGCCTACA GATCCCCTCA CAGCCCGTTC TACCAGCTAC CTCCGAGCGT GCAGCGGCAC 
TCCCCCAACC CGCTGCTGGT GGCGCCCACC CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC 
TTCAAGATCC AGTACCTGCA GTTCCTGGCA TACACAAAGA CCCCCCAGTA CAAGGCCAGC 
CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG AAGAACGCCC AGCTCCTGGG TGCGGCTCAG 
CAGCTCCTCA GCCACTGCCA GGCCCAGAAG GAGGAGATCA GGAGGCTGTT TCAGCAAAAA 
TTGGATGAGC TGGGTGTGAA GGCGCTGACC TACAACGACC TGATTCAAGC GCAGAAGGAG 
ATCTCCGCCC ATAACCAGCA GCTGCGGGAG CAGTCGGAGC AGCTGGAGCA GGACAACCGC 
GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC 
TGGGCCACGC TGTCGCTGGA GAAGCTGTTG AAGGAGAAGC AGGCCCTGAA GAGCCAGATC 
TCGGAGAAGC AGAGGCACTG CCTGGAGCTG CAGATCAGCA TTGTGGAGCT AGAGAAGAGC 
CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG TCCTGTGTGC CGCCTGACGA CGCCCTGTCC 
CTGCACCTGC GTGGGAAGGG CGCCCTGGGC CGCGAGCTGG AGCCTGACGC CAGCCGGCTG 
CACCTGGAGC TGGACTGCAC CAAGTTCTCG CTGCCTCACT TGAGCAGCAT GAGCCCGGAG 
CTCTCCATGA ACGGCCAGGC TGCTGGCTAT GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG 
TCGAAGCAGA ACACGCCCCA GTACCTGGCC TCACCCCTGG ACCAGGAGGT GGTGCCCTGT 
ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG GAGAAGCTGT CTGGCCTAGC CGCACCCGAC 
TACACTAGGC TGTCCCCGGC CAAGATTGTG CTGAGGCGGC ACCTGAGCCA GGACCACACG 
GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG CATTCGAGAG CTGAGCACAC CAAGGAGAAC 
GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT GGCAGCATGA AGCTGAGCCC TCAGGACCCG 
CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG 
AGAGAGCGCG CCTACGGCAG CAGCGGGGAG CTCATCACCA GCCTGCCCAT CAGCATCCCG 
CTCAGCACCG TGCAGCCCAA CAAGCTCCCG GTCAGCATTC CCCTGGCCAG CGTGGTGCTG 
CCCAGCCGCG CCGAGAGGGC GAGGAGCACC CCCAGTCCCG TGCTGCAGCC CCGTGACCCC 
TCGTCCACAC TTGAAAAGCA GATTGGTGCT AATGCCCACG GTGCTGGGAG CAGAAGCCTT 
GCCCTGGCCC CCGCAGGCTT CTCCTACGCT GGCTCGGTGG CCATCAGCGG GGCCTTGGCG 
GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC GAGCCGGCCA CCTTGGATGA GTCCTCCAGC 
TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC CGCAGCTCCA CGCCACAGCA CCCCCTGCTG 
CTGGCACAGC CCCGGAACTC GCTTCCTGCC TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC 
CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC 
GATTCCGGCT TCTCAGATCC TGAGAGTGAA GCCAAGAGGA GGATTGTGTT CACCATCACC 
ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC TCCAGCAAGC ACAGCCCCCT GACCGCCAGC 
GCCCGTGGGG ACTGTGTGCC GAGCCACGGG CAGGACAGTC GCAGGCGCGG CCGGCGGAAG 
CGAGCATCTG CGGGGACGCC CAGCTTGAGC GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG 
CCGTCCGTCG CTGGCCTTTT CACACAGCCT TCGGGGTCTC CCCTCAACCT CAACTCCATG 
GTCAGTAACA TCAACCAGCC CCTGGAGATT ACAGCCATCT CGTCCCCGGA GACCTCCCTG 
AAGAGCTCCC CTGTGCCCTA CCAGGACCAC GACCAGCCCC CCGTGCTCAA GAAGGAGCGG 
CCTCTGAGCC AGACCAATGG GGCACACTAC TCCCCACTCA CCTCAGACGA GGAGCCAGGC 
TCTGAGGACG AGCCCAGCAG TGCTCGAATT GAGAGAAAAA TTGCAACAAT CTCCTTAGAA 
AGCAAATCTC CCCCGAAAAC CTTGGAAAAT GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG 
CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG TGGAAGTCCA CCTTCTCGCC CATCTCCGAC 
ATCGGCCTGG CCAAGTCGGC GGACAGCCCG CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC 
TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG GAGCCCTCTG CCGATGCCAA GCTGGCCGCT 
CACCCCAGGA AAGGCTTTCC CGGCTCCCTG TCGGGGGCTG ACGGACTCAG CCCGGGCACC 
AACCCTGCCA ACGGCTGCAC CTTCGGCGGG GGCCTGGCCG CGGACCTGAG TTTACACAGC 
TTCAGTGATG GTGCTTCTCT TCCCCACAAG GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG 
CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG GGCTCGGACG CCAACCCTTT CCTGAGCAAG 
AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG 
GAGGGCGGCC TACCGCTGTG CGGGCCCACG GACAAGACCC CACTGCTGAG CGGCAAGGCC 
GCCAAGGCCC GGGACCGCGA GGTCGACCTC AAGAATGGCC ACAACCTCTT CATCTCTGCG 
GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC 
GCAGGCGGCG CGGCGTCCTC CGCCCAGACG CACCGGTCCT TCCTGGGCCC CTTCCCGCCG 
GGACCGCAGT TCGCGCTCGG CCCCATGTCC CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC 
TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT GTGCCGGCCG CCGCAGGCCT GGTGCACGTG 
TCGTCCGCTG CCACCAGACT GACCAACTCG CACGCCATGG GCAGCTTTTC CGGGGTGGCA 
GGCGGCACAG TTGGAGGTGT CTTTAACCAC GCGGTGCCCT CCGCCTCTGC TCATCCGTTT 
GGAGCCCGTG TCGGCCGCGG GGCTGCATGT GGCAGCGCCA CACTGGGCCC GAGCCCGCTG 
CAGGCGGCGG CCAGCGCCTC GGCCTCTTCC TTTCAGGCCC CGGCCTCGGT TGAGACCCGG 
CCGCCCCCTC CGCCTCCGCC TCCGCCTCCC CCGCTGCCCC CGCCTGCGCA CCTGGGCCGG 
TCCCCCGCGG GGCCGCCCGT CCTCCACGCC CCCCCTCCAC CTAACGCCGC CTTGCCTCCT 
CCCCCAACGC TGCTGGCCTC TAACCCTGAG CCCGCGCTTC TGCAGAGCCT CGCGTCCCTC 
CCGCCTAACC AAGCTTTCTT GCCCCCCACC TCTGCTGCCT CTCTGCCGCC TGCTAACGCC 
TCTTTGTCTA TCAAGCTCAC CTCCCTCCCG CACAAGGGCG CCCGCCCCTC CTTCACGGTG 
CACCACCAGC CCCTGCCCCG GCTGGCCCTG GCCCAGGCCG CGCCCGGGAT CCCACAGGCC 
AGCGCCACGG GGCCGTCCGC GGTGTGGGTG TCCCTCGGCA TGCCGCCTCC CTATGCCGCG 
CACCTTTCGG GGGTTAAGCC GCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOT1L ( XM_005259660.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005259717.1 Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X2, mRNA.

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CloneID	OHu51864
Clone ID Related Accession (Same CDS sequence)	XM_005259660.3 , XM_005259659.3
Accession Version	XM_005259660.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005259660.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGAGA AGCTGGAGCT GAGACTGAAG TCGCCCGTGG GGGCTGAGCC CGCCGTCTAC 
CCGTGGCCGC TGCCGGTCTA CGATAAACAT CACGATGCTG CTCATGAAAT CATCGAGACC 
ATCCGATGGG TCTGTGAAGA AATCCCGGAT CTCAAGCTCG CTATGGAGAA TTACGTTTTA 
ATTGACTATG ACACCAAAAG CTTCGAGAGC ATGCAGAGGC TCTGCGACAA GTACAACCGT 
GCCATCGACA GCATCCACCA GCTGTGGAAG GGCACCACGC AGCCCATGAA GCTGAACACG 
CGGCCGTCCA CTGGACTCCT GCGCCATATC CTGCAGCAGG TCTACAACCA CTCGGTGACC 
GACCCCGAGA AGCTCAACAA CTACGAGCCC TTCTCCCCCG AGGTGTACGG GGAGACCTCC 
TTCGACCTGG TGGCCCAGAT GATTGATGAG ATCAAGATGA CCGACGACGA CCTGTTTGTG 
GACTTGGGGA GCGGTGTGGG CCAGGTCGTG CTCCAGGTTG CTGCTGCCAC CAACTGCAAA 
CATCACTATG GCGTCGAGAA AGCAGACATC CCGGCCAAGT ATGCGGAGAC CATGGACCGC 
GAGTTCAGGA AGTGGATGAA ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA 
GGCGATTTCC TCTCAGAAGA GTGGAGGGAG CGAATCGCCA ACACGAGTGT TATATTTGTG 
AATAATTTTG CCTTTGGTCC TGAGGTGGAT CACCAGCTGA AGGAGCGGTT TGCAAACATG 
AAGGAAGGTG GCAGAATCGT GTCCTCGAAA CCCTTTGCAC CTCTGAACTT CAGAATAAAC 
AGTAGAAACT TGAGTGACAT CGGCACCATC ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG 
GGCTCGGTGT CGTGGACGGG GAAGCCAGTC TCCTACTACC TGCACACTAT CGACCGCACC 
ATACTTGAAA ACTATTTTTC TAGTCTGAAA AACCCAAAAC TCAGGGAGGA ACAGGAGGCA 
GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG AGCAACGCGG CCACGCCCAC TAAGGGCCCA 
GAGGGCAAGG TGGCCGGCCC CGCCGACGCC CCCATGGACT CTGGTGCTGA GGAAGAGAAG 
GCGGGAGCAG CCACCGTGAA GAAGCCGTCT CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC 
AAGAAGGGGA GGAAGATGGC TGGCCGCAAG CGCGGGCGCC CCAAGAAGAT GAACACTGCG 
AACCCCGAGC GGAAGCCCAA GAAGAACCAA ACTGCACTGG ATGCCCTGCA CGCTCAGACC 
GTGTCTCAGA CGGCGGCCTC CTCACCCCAG GATGCCTACA GATCCCCTCA CAGCCCGTTC 
TACCAGCTAC CTCCGAGCGT GCAGCGGCAC TCCCCCAACC CGCTGCTGGT GGCGCCCACC 
CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC TTCAAGATCC AGTACCTGCA GTTCCTGGCA 
TACACAAAGA CCCCCCAGTA CAAGGCCAGC CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG 
AAGAACGCCC AGCTCCTGGG TGCGGCTCAG CAGCTCCTCA GCCACTGCCA GGCCCAGAAG 
GAGGAGATCA GGAGGCTGTT TCAGCAAAAA TTGGATGAGC TGGGTGTGAA GGCGCTGACC 
TACAACGACC TGATTCAAGC GCAGAAGGAG ATCTCCGCCC ATAACCAGCA GCTGCGGGAG 
CAGTCGGAGC AGCTGGAGCA GGACAACCGC GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC 
AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC TGGGCCACGC TGTCGCTGGA GAAGCTGTTG 
AAGGAGAAGC AGGCCCTGAA GAGCCAGATC TCGGAGAAGC AGAGGCACTG CCTGGAGCTG 
CAGATCAGCA TTGTGGAGCT AGAGAAGAGC CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG 
TCCTGTGTGC CGCCTGACGA CGCCCTGTCC CTGCACCTGC GTGGGAAGGG CGCCCTGGGC 
CGCGAGCTGG AGCCTGACGC CAGCCGGCTG CACCTGGAGC TGGACTGCAC CAAGTTCTCG 
CTGCCTCACT TGAGCAGCAT GAGCCCGGAG CTCTCCATGA ACGGCCAGGC TGCTGGCTAT 
GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG TCGAAGCAGA ACACGCCCCA GTACCTGGCC 
TCACCCCTGG ACCAGGAGGT GGTGCCCTGT ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG 
GAGAAGCTGT CTGGCCTAGC CGCACCCGAC TACACTAGGC TGTCCCCGGC CAAGATTGTG 
CTGAGGCGGC ACCTGAGCCA GGACCACACG GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG 
CATTCGAGAG CTGAGCACAC CAAGGAGAAC GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT 
GGCAGCATGA AGCTGAGCCC TCAGGACCCG CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT 
GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG AGAGAGCGCG CCTACGGCAG CAGCGGGGAG 
CTCATCACCA GCCTGCCCAT CAGCATCCCG CTCAGCACCG TGCAGCCCAA CAAGCTCCCG 
GTCAGCATTC CCCTGGCCAG CGTGGTGCTG CCCAGCCGCG CCGAGAGGGC GAGGAGCACC 
CCCAGTCCCG TGCTGCAGCC CCGTGACCCC TCGTCCACAC TTGAAAAGCA GATTGGTGCT 
AATGCCCACG GTGCTGGGAG CAGAAGCCTT GCCCTGGCCC CCGCAGGCTT CTCCTACGCT 
GGCTCGGTGG CCATCAGCGG GGCCTTGGCG GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC 
GAGCCGGCCA CCTTGGATGA GTCCTCCAGC TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC 
CGCAGCTCCA CGCCACAGCA CCCCCTGCTG CTGGCACAGC CCCGGAACTC GCTTCCTGCC 
TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG 
CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC GATTCCGGCT TCTCAGATCC TGAGAGTGAA 
GCCAAGAGGA GGATTGTGTT CACCATCACC ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC 
TCCAGCAAGC ACAGCCCCCT GACCGCCAGC GCCCGTGGGG ACTGTGTGCC GAGCCACGGG 
CAGGACAGTC GCAGGCGCGG CCGGCGGAAG CGAGCATCTG CGGGGACGCC CAGCTTGAGC 
GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG CCGTCCGTCG CTGGCCTTTT CACACAGCCT 
TCGGGGTCTC CCCTCAACCT CAACTCCATG GTCAGTAACA TCAACCAGCC CCTGGAGATT 
ACAGCCATCT CGTCCCCGGA GACCTCCCTG AAGAGCTCCC CTGTGCCCTA CCAGGACCAC 
GACCAGCCCC CCGTGCTCAA GAAGGAGCGG CCTCTGAGCC AGACCAATGG GGCACACTAC 
TCCCCACTCA CCTCAGACGA GGAGCCAGGC TCTGAGGACG AGCCCAGCAG TGCTCGAATT 
GAGAGAAAAA TTGCAACAAT CTCCTTAGAA AGCAAATCTC CCCCGAAAAC CTTGGAAAAT 
GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG 
TGGAAGTCCA CCTTCTCGCC CATCTCCGAC ATCGGCCTGG CCAAGTCGGC GGACAGCCCG 
CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG 
GAGCCCTCTG CCGATGCCAA GCTGGCCGCT CACCCCAGGA AAGGCTTTCC CGGCTCCCTG 
TCGGGGGCTG ACGGACTCAG CCCGGGCACC AACCCTGCCA ACGGCTGCAC CTTCGGCGGG 
GGCCTGGCCG CGGACCTGAG TTTACACAGC TTCAGTGATG GTGCTTCTCT TCCCCACAAG 
GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG 
GGCTCGGACG CCAACCCTTT CCTGAGCAAG AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG 
GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG GAGGGCGGCC TACCGCTGTG CGGGCCCACG 
GACAAGACCC CACTGCTGAG CGGCAAGGCC GCCAAGGCCC GGGACCGCGA GGTCGACCTC 
AAGAATGGCC ACAACCTCTT CATCTCTGCG GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC 
GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC GCAGGCGGCG CGGCGTCCTC CGCCCAGACG 
CACCGGTCCT TCCTGGGCCC CTTCCCGCCG GGACCGCAGT TCGCGCTCGG CCCCATGTCC 
CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT 
GTGCCGGCCG CCGCAGGCCT GGTGCACGTG TCGTCCGCTG CCACCAGACT GACCAACTCG 
CACGCCATGG GCAGCTTTTC CGGGGTGGCA GGCGGCACAG TTGGAGGTGT CTTTAACCAC 
GCGGTGCCCT CCGCCTCTGC TCATCCGTTT GGAGCCCGTG TCGGCCGCGG GGCTGCATGT 
GGCAGCGCCA CACTGGGCCC GAGCCCGCTG CAGGCGGCGG CCAGCGCCTC GGCCTCTTCC 
TTTCAGGCCC CGGCCTCGGT TGAGACCCGG CCGCCCCCTC CGCCTCCGCC TCCGCCTCCC 
CCGCTGCCCC CGCCTGCGCA CCTGGGCCGG TCCCCCGCGG GGCCGCCCGT CCTCCACGCC 
CCCCCTCCAC CTAACGCCGC CTTGCCTCCT CCCCCAACGC TGCTGGCCTC TAACCCTGAG 
CCCGCGCTTC TGCAGAGCCT CGCGTCCCTC CCGCCTAACC AAGCTTTCTT GCCCCCCACC 
TCTGCTGCCT CTCTGCCGCC TGCTAACGCC TCTTTGTCTA TCAAGCTCAC CTCCCTCCCG 
CACAAGGGCG CCCGCCCCTC CTTCACGGTG CACCACCAGC CCCTGCCCCG GCTGGCCCTG 
GCCCAGGCCG CGCCCGGGAT CCCACAGGCC AGCGCCACGG GGCCGTCCGC GGTGTGGGTG 
TCCCTCGGCA TGCCGCCTCC CTATGCCGCG CACCTTTCGG GGGTTAAGCC GCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005259717.1
CDS	223..5439
Translation	MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGVFNHAVPSASAHPFGARVGRGAACGSATLGPSPLQAAASASASSFQAPASVETRPPPPPPPPPPPLPPPAHLGRSPAGPPVLHAPPPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLPPTSAASLPPANASLSIKLTSLPHKGARPSFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSGVKPR

Target ORF information:

RefSeq Version	XM_005259660.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005259660.3

ORF Insert Sequence:

ATGGGGGAGA AGCTGGAGCT GAGACTGAAG TCGCCCGTGG GGGCTGAGCC CGCCGTCTAC 
CCGTGGCCGC TGCCGGTCTA CGATAAACAT CACGATGCTG CTCATGAAAT CATCGAGACC 
ATCCGATGGG TCTGTGAAGA AATCCCGGAT CTCAAGCTCG CTATGGAGAA TTACGTTTTA 
ATTGACTATG ACACCAAAAG CTTCGAGAGC ATGCAGAGGC TCTGCGACAA GTACAACCGT 
GCCATCGACA GCATCCACCA GCTGTGGAAG GGCACCACGC AGCCCATGAA GCTGAACACG 
CGGCCGTCCA CTGGACTCCT GCGCCATATC CTGCAGCAGG TCTACAACCA CTCGGTGACC 
GACCCCGAGA AGCTCAACAA CTACGAGCCC TTCTCCCCCG AGGTGTACGG GGAGACCTCC 
TTCGACCTGG TGGCCCAGAT GATTGATGAG ATCAAGATGA CCGACGACGA CCTGTTTGTG 
GACTTGGGGA GCGGTGTGGG CCAGGTCGTG CTCCAGGTTG CTGCTGCCAC CAACTGCAAA 
CATCACTATG GCGTCGAGAA AGCAGACATC CCGGCCAAGT ATGCGGAGAC CATGGACCGC 
GAGTTCAGGA AGTGGATGAA ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA 
GGCGATTTCC TCTCAGAAGA GTGGAGGGAG CGAATCGCCA ACACGAGTGT TATATTTGTG 
AATAATTTTG CCTTTGGTCC TGAGGTGGAT CACCAGCTGA AGGAGCGGTT TGCAAACATG 
AAGGAAGGTG GCAGAATCGT GTCCTCGAAA CCCTTTGCAC CTCTGAACTT CAGAATAAAC 
AGTAGAAACT TGAGTGACAT CGGCACCATC ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG 
GGCTCGGTGT CGTGGACGGG GAAGCCAGTC TCCTACTACC TGCACACTAT CGACCGCACC 
ATACTTGAAA ACTATTTTTC TAGTCTGAAA AACCCAAAAC TCAGGGAGGA ACAGGAGGCA 
GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG AGCAACGCGG CCACGCCCAC TAAGGGCCCA 
GAGGGCAAGG TGGCCGGCCC CGCCGACGCC CCCATGGACT CTGGTGCTGA GGAAGAGAAG 
GCGGGAGCAG CCACCGTGAA GAAGCCGTCT CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC 
AAGAAGGGGA GGAAGATGGC TGGCCGCAAG CGCGGGCGCC CCAAGAAGAT GAACACTGCG 
AACCCCGAGC GGAAGCCCAA GAAGAACCAA ACTGCACTGG ATGCCCTGCA CGCTCAGACC 
GTGTCTCAGA CGGCGGCCTC CTCACCCCAG GATGCCTACA GATCCCCTCA CAGCCCGTTC 
TACCAGCTAC CTCCGAGCGT GCAGCGGCAC TCCCCCAACC CGCTGCTGGT GGCGCCCACC 
CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC TTCAAGATCC AGTACCTGCA GTTCCTGGCA 
TACACAAAGA CCCCCCAGTA CAAGGCCAGC CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG 
AAGAACGCCC AGCTCCTGGG TGCGGCTCAG CAGCTCCTCA GCCACTGCCA GGCCCAGAAG 
GAGGAGATCA GGAGGCTGTT TCAGCAAAAA TTGGATGAGC TGGGTGTGAA GGCGCTGACC 
TACAACGACC TGATTCAAGC GCAGAAGGAG ATCTCCGCCC ATAACCAGCA GCTGCGGGAG 
CAGTCGGAGC AGCTGGAGCA GGACAACCGC GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC 
AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC TGGGCCACGC TGTCGCTGGA GAAGCTGTTG 
AAGGAGAAGC AGGCCCTGAA GAGCCAGATC TCGGAGAAGC AGAGGCACTG CCTGGAGCTG 
CAGATCAGCA TTGTGGAGCT AGAGAAGAGC CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG 
TCCTGTGTGC CGCCTGACGA CGCCCTGTCC CTGCACCTGC GTGGGAAGGG CGCCCTGGGC 
CGCGAGCTGG AGCCTGACGC CAGCCGGCTG CACCTGGAGC TGGACTGCAC CAAGTTCTCG 
CTGCCTCACT TGAGCAGCAT GAGCCCGGAG CTCTCCATGA ACGGCCAGGC TGCTGGCTAT 
GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG TCGAAGCAGA ACACGCCCCA GTACCTGGCC 
TCACCCCTGG ACCAGGAGGT GGTGCCCTGT ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG 
GAGAAGCTGT CTGGCCTAGC CGCACCCGAC TACACTAGGC TGTCCCCGGC CAAGATTGTG 
CTGAGGCGGC ACCTGAGCCA GGACCACACG GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG 
CATTCGAGAG CTGAGCACAC CAAGGAGAAC GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT 
GGCAGCATGA AGCTGAGCCC TCAGGACCCG CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT 
GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG AGAGAGCGCG CCTACGGCAG CAGCGGGGAG 
CTCATCACCA GCCTGCCCAT CAGCATCCCG CTCAGCACCG TGCAGCCCAA CAAGCTCCCG 
GTCAGCATTC CCCTGGCCAG CGTGGTGCTG CCCAGCCGCG CCGAGAGGGC GAGGAGCACC 
CCCAGTCCCG TGCTGCAGCC CCGTGACCCC TCGTCCACAC TTGAAAAGCA GATTGGTGCT 
AATGCCCACG GTGCTGGGAG CAGAAGCCTT GCCCTGGCCC CCGCAGGCTT CTCCTACGCT 
GGCTCGGTGG CCATCAGCGG GGCCTTGGCG GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC 
GAGCCGGCCA CCTTGGATGA GTCCTCCAGC TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC 
CGCAGCTCCA CGCCACAGCA CCCCCTGCTG CTGGCACAGC CCCGGAACTC GCTTCCTGCC 
TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG 
CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC GATTCCGGCT TCTCAGATCC TGAGAGTGAA 
GCCAAGAGGA GGATTGTGTT CACCATCACC ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC 
TCCAGCAAGC ACAGCCCCCT GACCGCCAGC GCCCGTGGGG ACTGTGTGCC GAGCCACGGG 
CAGGACAGTC GCAGGCGCGG CCGGCGGAAG CGAGCATCTG CGGGGACGCC CAGCTTGAGC 
GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG CCGTCCGTCG CTGGCCTTTT CACACAGCCT 
TCGGGGTCTC CCCTCAACCT CAACTCCATG GTCAGTAACA TCAACCAGCC CCTGGAGATT 
ACAGCCATCT CGTCCCCGGA GACCTCCCTG AAGAGCTCCC CTGTGCCCTA CCAGGACCAC 
GACCAGCCCC CCGTGCTCAA GAAGGAGCGG CCTCTGAGCC AGACCAATGG GGCACACTAC 
TCCCCACTCA CCTCAGACGA GGAGCCAGGC TCTGAGGACG AGCCCAGCAG TGCTCGAATT 
GAGAGAAAAA TTGCAACAAT CTCCTTAGAA AGCAAATCTC CCCCGAAAAC CTTGGAAAAT 
GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG 
TGGAAGTCCA CCTTCTCGCC CATCTCCGAC ATCGGCCTGG CCAAGTCGGC GGACAGCCCG 
CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG 
GAGCCCTCTG CCGATGCCAA GCTGGCCGCT CACCCCAGGA AAGGCTTTCC CGGCTCCCTG 
TCGGGGGCTG ACGGACTCAG CCCGGGCACC AACCCTGCCA ACGGCTGCAC CTTCGGCGGG 
GGCCTGGCCG CGGACCTGAG TTTACACAGC TTCAGTGATG GTGCTTCTCT TCCCCACAAG 
GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG 
GGCTCGGACG CCAACCCTTT CCTGAGCAAG AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG 
GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG GAGGGCGGCC TACCGCTGTG CGGGCCCACG 
GACAAGACCC CACTGCTGAG CGGCAAGGCC GCCAAGGCCC GGGACCGCGA GGTCGACCTC 
AAGAATGGCC ACAACCTCTT CATCTCTGCG GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC 
GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC GCAGGCGGCG CGGCGTCCTC CGCCCAGACG 
CACCGGTCCT TCCTGGGCCC CTTCCCGCCG GGACCGCAGT TCGCGCTCGG CCCCATGTCC 
CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT 
GTGCCGGCCG CCGCAGGCCT GGTGCACGTG TCGTCCGCTG CCACCAGACT GACCAACTCG 
CACGCCATGG GCAGCTTTTC CGGGGTGGCA GGCGGCACAG TTGGAGGTGT CTTTAACCAC 
GCGGTGCCCT CCGCCTCTGC TCATCCGTTT GGAGCCCGTG TCGGCCGCGG GGCTGCATGT 
GGCAGCGCCA CACTGGGCCC GAGCCCGCTG CAGGCGGCGG CCAGCGCCTC GGCCTCTTCC 
TTTCAGGCCC CGGCCTCGGT TGAGACCCGG CCGCCCCCTC CGCCTCCGCC TCCGCCTCCC 
CCGCTGCCCC CGCCTGCGCA CCTGGGCCGG TCCCCCGCGG GGCCGCCCGT CCTCCACGCC 
CCCCCTCCAC CTAACGCCGC CTTGCCTCCT CCCCCAACGC TGCTGGCCTC TAACCCTGAG 
CCCGCGCTTC TGCAGAGCCT CGCGTCCCTC CCGCCTAACC AAGCTTTCTT GCCCCCCACC 
TCTGCTGCCT CTCTGCCGCC TGCTAACGCC TCTTTGTCTA TCAAGCTCAC CTCCCTCCCG 
CACAAGGGCG CCCGCCCCTC CTTCACGGTG CACCACCAGC CCCTGCCCCG GCTGGCCCTG 
GCCCAGGCCG CGCCCGGGAT CCCACAGGCC AGCGCCACGG GGCCGTCCGC GGTGTGGGTG 
TCCCTCGGCA TGCCGCCTCC CTATGCCGCG CACCTTTCGG GGGTTAAGCC GCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOT1L ( XM_005259659.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005259716.1 Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu51864
Clone ID Related Accession (Same CDS sequence)	XM_005259660.3 , XM_005259659.3
Accession Version	XM_005259659.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005259659.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGAGA AGCTGGAGCT GAGACTGAAG TCGCCCGTGG GGGCTGAGCC CGCCGTCTAC 
CCGTGGCCGC TGCCGGTCTA CGATAAACAT CACGATGCTG CTCATGAAAT CATCGAGACC 
ATCCGATGGG TCTGTGAAGA AATCCCGGAT CTCAAGCTCG CTATGGAGAA TTACGTTTTA 
ATTGACTATG ACACCAAAAG CTTCGAGAGC ATGCAGAGGC TCTGCGACAA GTACAACCGT 
GCCATCGACA GCATCCACCA GCTGTGGAAG GGCACCACGC AGCCCATGAA GCTGAACACG 
CGGCCGTCCA CTGGACTCCT GCGCCATATC CTGCAGCAGG TCTACAACCA CTCGGTGACC 
GACCCCGAGA AGCTCAACAA CTACGAGCCC TTCTCCCCCG AGGTGTACGG GGAGACCTCC 
TTCGACCTGG TGGCCCAGAT GATTGATGAG ATCAAGATGA CCGACGACGA CCTGTTTGTG 
GACTTGGGGA GCGGTGTGGG CCAGGTCGTG CTCCAGGTTG CTGCTGCCAC CAACTGCAAA 
CATCACTATG GCGTCGAGAA AGCAGACATC CCGGCCAAGT ATGCGGAGAC CATGGACCGC 
GAGTTCAGGA AGTGGATGAA ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA 
GGCGATTTCC TCTCAGAAGA GTGGAGGGAG CGAATCGCCA ACACGAGTGT TATATTTGTG 
AATAATTTTG CCTTTGGTCC TGAGGTGGAT CACCAGCTGA AGGAGCGGTT TGCAAACATG 
AAGGAAGGTG GCAGAATCGT GTCCTCGAAA CCCTTTGCAC CTCTGAACTT CAGAATAAAC 
AGTAGAAACT TGAGTGACAT CGGCACCATC ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG 
GGCTCGGTGT CGTGGACGGG GAAGCCAGTC TCCTACTACC TGCACACTAT CGACCGCACC 
ATACTTGAAA ACTATTTTTC TAGTCTGAAA AACCCAAAAC TCAGGGAGGA ACAGGAGGCA 
GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG AGCAACGCGG CCACGCCCAC TAAGGGCCCA 
GAGGGCAAGG TGGCCGGCCC CGCCGACGCC CCCATGGACT CTGGTGCTGA GGAAGAGAAG 
GCGGGAGCAG CCACCGTGAA GAAGCCGTCT CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC 
AAGAAGGGGA GGAAGATGGC TGGCCGCAAG CGCGGGCGCC CCAAGAAGAT GAACACTGCG 
AACCCCGAGC GGAAGCCCAA GAAGAACCAA ACTGCACTGG ATGCCCTGCA CGCTCAGACC 
GTGTCTCAGA CGGCGGCCTC CTCACCCCAG GATGCCTACA GATCCCCTCA CAGCCCGTTC 
TACCAGCTAC CTCCGAGCGT GCAGCGGCAC TCCCCCAACC CGCTGCTGGT GGCGCCCACC 
CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC TTCAAGATCC AGTACCTGCA GTTCCTGGCA 
TACACAAAGA CCCCCCAGTA CAAGGCCAGC CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG 
AAGAACGCCC AGCTCCTGGG TGCGGCTCAG CAGCTCCTCA GCCACTGCCA GGCCCAGAAG 
GAGGAGATCA GGAGGCTGTT TCAGCAAAAA TTGGATGAGC TGGGTGTGAA GGCGCTGACC 
TACAACGACC TGATTCAAGC GCAGAAGGAG ATCTCCGCCC ATAACCAGCA GCTGCGGGAG 
CAGTCGGAGC AGCTGGAGCA GGACAACCGC GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC 
AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC TGGGCCACGC TGTCGCTGGA GAAGCTGTTG 
AAGGAGAAGC AGGCCCTGAA GAGCCAGATC TCGGAGAAGC AGAGGCACTG CCTGGAGCTG 
CAGATCAGCA TTGTGGAGCT AGAGAAGAGC CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG 
TCCTGTGTGC CGCCTGACGA CGCCCTGTCC CTGCACCTGC GTGGGAAGGG CGCCCTGGGC 
CGCGAGCTGG AGCCTGACGC CAGCCGGCTG CACCTGGAGC TGGACTGCAC CAAGTTCTCG 
CTGCCTCACT TGAGCAGCAT GAGCCCGGAG CTCTCCATGA ACGGCCAGGC TGCTGGCTAT 
GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG TCGAAGCAGA ACACGCCCCA GTACCTGGCC 
TCACCCCTGG ACCAGGAGGT GGTGCCCTGT ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG 
GAGAAGCTGT CTGGCCTAGC CGCACCCGAC TACACTAGGC TGTCCCCGGC CAAGATTGTG 
CTGAGGCGGC ACCTGAGCCA GGACCACACG GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG 
CATTCGAGAG CTGAGCACAC CAAGGAGAAC GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT 
GGCAGCATGA AGCTGAGCCC TCAGGACCCG CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT 
GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG AGAGAGCGCG CCTACGGCAG CAGCGGGGAG 
CTCATCACCA GCCTGCCCAT CAGCATCCCG CTCAGCACCG TGCAGCCCAA CAAGCTCCCG 
GTCAGCATTC CCCTGGCCAG CGTGGTGCTG CCCAGCCGCG CCGAGAGGGC GAGGAGCACC 
CCCAGTCCCG TGCTGCAGCC CCGTGACCCC TCGTCCACAC TTGAAAAGCA GATTGGTGCT 
AATGCCCACG GTGCTGGGAG CAGAAGCCTT GCCCTGGCCC CCGCAGGCTT CTCCTACGCT 
GGCTCGGTGG CCATCAGCGG GGCCTTGGCG GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC 
GAGCCGGCCA CCTTGGATGA GTCCTCCAGC TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC 
CGCAGCTCCA CGCCACAGCA CCCCCTGCTG CTGGCACAGC CCCGGAACTC GCTTCCTGCC 
TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG 
CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC GATTCCGGCT TCTCAGATCC TGAGAGTGAA 
GCCAAGAGGA GGATTGTGTT CACCATCACC ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC 
TCCAGCAAGC ACAGCCCCCT GACCGCCAGC GCCCGTGGGG ACTGTGTGCC GAGCCACGGG 
CAGGACAGTC GCAGGCGCGG CCGGCGGAAG CGAGCATCTG CGGGGACGCC CAGCTTGAGC 
GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG CCGTCCGTCG CTGGCCTTTT CACACAGCCT 
TCGGGGTCTC CCCTCAACCT CAACTCCATG GTCAGTAACA TCAACCAGCC CCTGGAGATT 
ACAGCCATCT CGTCCCCGGA GACCTCCCTG AAGAGCTCCC CTGTGCCCTA CCAGGACCAC 
GACCAGCCCC CCGTGCTCAA GAAGGAGCGG CCTCTGAGCC AGACCAATGG GGCACACTAC 
TCCCCACTCA CCTCAGACGA GGAGCCAGGC TCTGAGGACG AGCCCAGCAG TGCTCGAATT 
GAGAGAAAAA TTGCAACAAT CTCCTTAGAA AGCAAATCTC CCCCGAAAAC CTTGGAAAAT 
GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG 
TGGAAGTCCA CCTTCTCGCC CATCTCCGAC ATCGGCCTGG CCAAGTCGGC GGACAGCCCG 
CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG 
GAGCCCTCTG CCGATGCCAA GCTGGCCGCT CACCCCAGGA AAGGCTTTCC CGGCTCCCTG 
TCGGGGGCTG ACGGACTCAG CCCGGGCACC AACCCTGCCA ACGGCTGCAC CTTCGGCGGG 
GGCCTGGCCG CGGACCTGAG TTTACACAGC TTCAGTGATG GTGCTTCTCT TCCCCACAAG 
GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG 
GGCTCGGACG CCAACCCTTT CCTGAGCAAG AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG 
GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG GAGGGCGGCC TACCGCTGTG CGGGCCCACG 
GACAAGACCC CACTGCTGAG CGGCAAGGCC GCCAAGGCCC GGGACCGCGA GGTCGACCTC 
AAGAATGGCC ACAACCTCTT CATCTCTGCG GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC 
GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC GCAGGCGGCG CGGCGTCCTC CGCCCAGACG 
CACCGGTCCT TCCTGGGCCC CTTCCCGCCG GGACCGCAGT TCGCGCTCGG CCCCATGTCC 
CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT 
GTGCCGGCCG CCGCAGGCCT GGTGCACGTG TCGTCCGCTG CCACCAGACT GACCAACTCG 
CACGCCATGG GCAGCTTTTC CGGGGTGGCA GGCGGCACAG TTGGAGGTGT CTTTAACCAC 
GCGGTGCCCT CCGCCTCTGC TCATCCGTTT GGAGCCCGTG TCGGCCGCGG GGCTGCATGT 
GGCAGCGCCA CACTGGGCCC GAGCCCGCTG CAGGCGGCGG CCAGCGCCTC GGCCTCTTCC 
TTTCAGGCCC CGGCCTCGGT TGAGACCCGG CCGCCCCCTC CGCCTCCGCC TCCGCCTCCC 
CCGCTGCCCC CGCCTGCGCA CCTGGGCCGG TCCCCCGCGG GGCCGCCCGT CCTCCACGCC 
CCCCCTCCAC CTAACGCCGC CTTGCCTCCT CCCCCAACGC TGCTGGCCTC TAACCCTGAG 
CCCGCGCTTC TGCAGAGCCT CGCGTCCCTC CCGCCTAACC AAGCTTTCTT GCCCCCCACC 
TCTGCTGCCT CTCTGCCGCC TGCTAACGCC TCTTTGTCTA TCAAGCTCAC CTCCCTCCCG 
CACAAGGGCG CCCGCCCCTC CTTCACGGTG CACCACCAGC CCCTGCCCCG GCTGGCCCTG 
GCCCAGGCCG CGCCCGGGAT CCCACAGGCC AGCGCCACGG GGCCGTCCGC GGTGTGGGTG 
TCCCTCGGCA TGCCGCCTCC CTATGCCGCG CACCTTTCGG GGGTTAAGCC GCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005259716.1
CDS	223..5439
Translation	MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGVFNHAVPSASAHPFGARVGRGAACGSATLGPSPLQAAASASASSFQAPASVETRPPPPPPPPPPPLPPPAHLGRSPAGPPVLHAPPPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLPPTSAASLPPANASLSIKLTSLPHKGARPSFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSGVKPR

Target ORF information:

RefSeq Version	XM_005259659.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005259659.3

ORF Insert Sequence:

ATGGGGGAGA AGCTGGAGCT GAGACTGAAG TCGCCCGTGG GGGCTGAGCC CGCCGTCTAC 
CCGTGGCCGC TGCCGGTCTA CGATAAACAT CACGATGCTG CTCATGAAAT CATCGAGACC 
ATCCGATGGG TCTGTGAAGA AATCCCGGAT CTCAAGCTCG CTATGGAGAA TTACGTTTTA 
ATTGACTATG ACACCAAAAG CTTCGAGAGC ATGCAGAGGC TCTGCGACAA GTACAACCGT 
GCCATCGACA GCATCCACCA GCTGTGGAAG GGCACCACGC AGCCCATGAA GCTGAACACG 
CGGCCGTCCA CTGGACTCCT GCGCCATATC CTGCAGCAGG TCTACAACCA CTCGGTGACC 
GACCCCGAGA AGCTCAACAA CTACGAGCCC TTCTCCCCCG AGGTGTACGG GGAGACCTCC 
TTCGACCTGG TGGCCCAGAT GATTGATGAG ATCAAGATGA CCGACGACGA CCTGTTTGTG 
GACTTGGGGA GCGGTGTGGG CCAGGTCGTG CTCCAGGTTG CTGCTGCCAC CAACTGCAAA 
CATCACTATG GCGTCGAGAA AGCAGACATC CCGGCCAAGT ATGCGGAGAC CATGGACCGC 
GAGTTCAGGA AGTGGATGAA ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA 
GGCGATTTCC TCTCAGAAGA GTGGAGGGAG CGAATCGCCA ACACGAGTGT TATATTTGTG 
AATAATTTTG CCTTTGGTCC TGAGGTGGAT CACCAGCTGA AGGAGCGGTT TGCAAACATG 
AAGGAAGGTG GCAGAATCGT GTCCTCGAAA CCCTTTGCAC CTCTGAACTT CAGAATAAAC 
AGTAGAAACT TGAGTGACAT CGGCACCATC ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG 
GGCTCGGTGT CGTGGACGGG GAAGCCAGTC TCCTACTACC TGCACACTAT CGACCGCACC 
ATACTTGAAA ACTATTTTTC TAGTCTGAAA AACCCAAAAC TCAGGGAGGA ACAGGAGGCA 
GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG AGCAACGCGG CCACGCCCAC TAAGGGCCCA 
GAGGGCAAGG TGGCCGGCCC CGCCGACGCC CCCATGGACT CTGGTGCTGA GGAAGAGAAG 
GCGGGAGCAG CCACCGTGAA GAAGCCGTCT CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC 
AAGAAGGGGA GGAAGATGGC TGGCCGCAAG CGCGGGCGCC CCAAGAAGAT GAACACTGCG 
AACCCCGAGC GGAAGCCCAA GAAGAACCAA ACTGCACTGG ATGCCCTGCA CGCTCAGACC 
GTGTCTCAGA CGGCGGCCTC CTCACCCCAG GATGCCTACA GATCCCCTCA CAGCCCGTTC 
TACCAGCTAC CTCCGAGCGT GCAGCGGCAC TCCCCCAACC CGCTGCTGGT GGCGCCCACC 
CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC TTCAAGATCC AGTACCTGCA GTTCCTGGCA 
TACACAAAGA CCCCCCAGTA CAAGGCCAGC CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG 
AAGAACGCCC AGCTCCTGGG TGCGGCTCAG CAGCTCCTCA GCCACTGCCA GGCCCAGAAG 
GAGGAGATCA GGAGGCTGTT TCAGCAAAAA TTGGATGAGC TGGGTGTGAA GGCGCTGACC 
TACAACGACC TGATTCAAGC GCAGAAGGAG ATCTCCGCCC ATAACCAGCA GCTGCGGGAG 
CAGTCGGAGC AGCTGGAGCA GGACAACCGC GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC 
AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC TGGGCCACGC TGTCGCTGGA GAAGCTGTTG 
AAGGAGAAGC AGGCCCTGAA GAGCCAGATC TCGGAGAAGC AGAGGCACTG CCTGGAGCTG 
CAGATCAGCA TTGTGGAGCT AGAGAAGAGC CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG 
TCCTGTGTGC CGCCTGACGA CGCCCTGTCC CTGCACCTGC GTGGGAAGGG CGCCCTGGGC 
CGCGAGCTGG AGCCTGACGC CAGCCGGCTG CACCTGGAGC TGGACTGCAC CAAGTTCTCG 
CTGCCTCACT TGAGCAGCAT GAGCCCGGAG CTCTCCATGA ACGGCCAGGC TGCTGGCTAT 
GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG TCGAAGCAGA ACACGCCCCA GTACCTGGCC 
TCACCCCTGG ACCAGGAGGT GGTGCCCTGT ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG 
GAGAAGCTGT CTGGCCTAGC CGCACCCGAC TACACTAGGC TGTCCCCGGC CAAGATTGTG 
CTGAGGCGGC ACCTGAGCCA GGACCACACG GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG 
CATTCGAGAG CTGAGCACAC CAAGGAGAAC GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT 
GGCAGCATGA AGCTGAGCCC TCAGGACCCG CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT 
GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG AGAGAGCGCG CCTACGGCAG CAGCGGGGAG 
CTCATCACCA GCCTGCCCAT CAGCATCCCG CTCAGCACCG TGCAGCCCAA CAAGCTCCCG 
GTCAGCATTC CCCTGGCCAG CGTGGTGCTG CCCAGCCGCG CCGAGAGGGC GAGGAGCACC 
CCCAGTCCCG TGCTGCAGCC CCGTGACCCC TCGTCCACAC TTGAAAAGCA GATTGGTGCT 
AATGCCCACG GTGCTGGGAG CAGAAGCCTT GCCCTGGCCC CCGCAGGCTT CTCCTACGCT 
GGCTCGGTGG CCATCAGCGG GGCCTTGGCG GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC 
GAGCCGGCCA CCTTGGATGA GTCCTCCAGC TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC 
CGCAGCTCCA CGCCACAGCA CCCCCTGCTG CTGGCACAGC CCCGGAACTC GCTTCCTGCC 
TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG 
CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC GATTCCGGCT TCTCAGATCC TGAGAGTGAA 
GCCAAGAGGA GGATTGTGTT CACCATCACC ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC 
TCCAGCAAGC ACAGCCCCCT GACCGCCAGC GCCCGTGGGG ACTGTGTGCC GAGCCACGGG 
CAGGACAGTC GCAGGCGCGG CCGGCGGAAG CGAGCATCTG CGGGGACGCC CAGCTTGAGC 
GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG CCGTCCGTCG CTGGCCTTTT CACACAGCCT 
TCGGGGTCTC CCCTCAACCT CAACTCCATG GTCAGTAACA TCAACCAGCC CCTGGAGATT 
ACAGCCATCT CGTCCCCGGA GACCTCCCTG AAGAGCTCCC CTGTGCCCTA CCAGGACCAC 
GACCAGCCCC CCGTGCTCAA GAAGGAGCGG CCTCTGAGCC AGACCAATGG GGCACACTAC 
TCCCCACTCA CCTCAGACGA GGAGCCAGGC TCTGAGGACG AGCCCAGCAG TGCTCGAATT 
GAGAGAAAAA TTGCAACAAT CTCCTTAGAA AGCAAATCTC CCCCGAAAAC CTTGGAAAAT 
GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG 
TGGAAGTCCA CCTTCTCGCC CATCTCCGAC ATCGGCCTGG CCAAGTCGGC GGACAGCCCG 
CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG 
GAGCCCTCTG CCGATGCCAA GCTGGCCGCT CACCCCAGGA AAGGCTTTCC CGGCTCCCTG 
TCGGGGGCTG ACGGACTCAG CCCGGGCACC AACCCTGCCA ACGGCTGCAC CTTCGGCGGG 
GGCCTGGCCG CGGACCTGAG TTTACACAGC TTCAGTGATG GTGCTTCTCT TCCCCACAAG 
GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG 
GGCTCGGACG CCAACCCTTT CCTGAGCAAG AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG 
GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG GAGGGCGGCC TACCGCTGTG CGGGCCCACG 
GACAAGACCC CACTGCTGAG CGGCAAGGCC GCCAAGGCCC GGGACCGCGA GGTCGACCTC 
AAGAATGGCC ACAACCTCTT CATCTCTGCG GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC 
GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC GCAGGCGGCG CGGCGTCCTC CGCCCAGACG 
CACCGGTCCT TCCTGGGCCC CTTCCCGCCG GGACCGCAGT TCGCGCTCGG CCCCATGTCC 
CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT 
GTGCCGGCCG CCGCAGGCCT GGTGCACGTG TCGTCCGCTG CCACCAGACT GACCAACTCG 
CACGCCATGG GCAGCTTTTC CGGGGTGGCA GGCGGCACAG TTGGAGGTGT CTTTAACCAC 
GCGGTGCCCT CCGCCTCTGC TCATCCGTTT GGAGCCCGTG TCGGCCGCGG GGCTGCATGT 
GGCAGCGCCA CACTGGGCCC GAGCCCGCTG CAGGCGGCGG CCAGCGCCTC GGCCTCTTCC 
TTTCAGGCCC CGGCCTCGGT TGAGACCCGG CCGCCCCCTC CGCCTCCGCC TCCGCCTCCC 
CCGCTGCCCC CGCCTGCGCA CCTGGGCCGG TCCCCCGCGG GGCCGCCCGT CCTCCACGCC 
CCCCCTCCAC CTAACGCCGC CTTGCCTCCT CCCCCAACGC TGCTGGCCTC TAACCCTGAG 
CCCGCGCTTC TGCAGAGCCT CGCGTCCCTC CCGCCTAACC AAGCTTTCTT GCCCCCCACC 
TCTGCTGCCT CTCTGCCGCC TGCTAACGCC TCTTTGTCTA TCAAGCTCAC CTCCCTCCCG 
CACAAGGGCG CCCGCCCCTC CTTCACGGTG CACCACCAGC CCCTGCCCCG GCTGGCCCTG 
GCCCAGGCCG CGCCCGGGAT CCCACAGGCC AGCGCCACGG GGCCGTCCGC GGTGTGGGTG 
TCCCTCGGCA TGCCGCCTCC CTATGCCGCG CACCTTTCGG GGGTTAAGCC GCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOT1L ( XM_017027366.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882855.1 Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X5, mRNA.

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CloneID	OHu51865
Clone ID Related Accession (Same CDS sequence)	XM_017027366.1
Accession Version	XM_017027366.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4560bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA GGCGATTTCC TCTCAGAAGA 
GTGGAGGGAG CGAATCGCCA ACACGAGGTG GATCACCAGC TGAAGGAGCG GTTTGCAAAC 
ATGAAGGAAG GTGGCAGAAT CGTGTCCTCG AAACCCTTTG CACCTCTGAA CTTCAGAATA 
AACAGTAGAA ACTTGAGTGA CATCGGCACC ATCATGCGCG TGGTGGAGCT CTCGCCCCTG 
AAGGGCTCGG TGTCGTGGAC GGGGAAGCCA GTCTCCTACT ACCTGCACAC TATCGACCGC 
ACCATACTTG AAAACTATTT TTCTAGTCTG AAAAACCCAA AACTCAGGGA GGAACAGGAG 
GCAGCCCGGC GCCGCCAGCA GCGCGAGAGC AAGAGCAACG CGGCCACGCC CACTAAGGGC 
CCAGAGGGCA AGGTGGCCGG CCCCGCCGAC GCCCCCATGG ACTCTGGTGC TGAGGAAGAG 
AAGGCGGGAG CAGCCACCGT GAAGAAGCCG TCTCCCTCCA AAGCCCGCAA GAAGAAGCTA 
AACAAGAAGG GGAGGAAGAT GGCTGGCCGC AAGCGCGGGC GCCCCAAGAA GATGAACACT 
GCGAACCCCG AGCGGAAGCC CAAGAAGAAC CAAACTGCAC TGGATGCCCT GCACGCTCAG 
ACCGTGTCTC AGACGGCGGC CTCCTCACCC CAGGATGCCT ACAGATCCCC TCACAGCCCG 
TTCTACCAGC TACCTCCGAG CGTGCAGCGG CACTCCCCCA ACCCGCTGCT GGTGGCGCCC 
ACCCCGCCCG CGCTGCAGAA GCTTCTAGAG TCCTTCAAGA TCCAGTACCT GCAGTTCCTG 
GCATACACAA AGACCCCCCA GTACAAGGCC AGCCTGCAGG AGCTGCTGGG CCAGGAGAAG 
GAGAAGAACG CCCAGCTCCT GGGTGCGGCT CAGCAGCTCC TCAGCCACTG CCAGGCCCAG 
AAGGAGGAGA TCAGGAGGCT GTTTCAGCAA AAATTGGATG AGCTGGGTGT GAAGGCGCTG 
ACCTACAACG ACCTGATTCA AGCGCAGAAG GAGATCTCCG CCCATAACCA GCAGCTGCGG 
GAGCAGTCGG AGCAGCTGGA GCAGGACAAC CGCGCGCTCC GCGGCCAGAG CTTGCAGCTG 
CTCAAGGCTC GCTGCGAGGA GCTGCAGCTG GACTGGGCCA CGCTGTCGCT GGAGAAGCTG 
TTGAAGGAGA AGCAGGCCCT GAAGAGCCAG ATCTCGGAGA AGCAGAGGCA CTGCCTGGAG 
CTGCAGATCA GCATTGTGGA GCTAGAGAAG AGCCAGCGGC AGCAGGAGCT CCTGCAGCTC 
AAGTCCTGTG TGCCGCCTGA CGACGCCCTG TCCCTGCACC TGCGTGGGAA GGGCGCCCTG 
GGCCGCGAGC TGGAGCCTGA CGCCAGCCGG CTGCACCTGG AGCTGGACTG CACCAAGTTC 
TCGCTGCCTC ACTTGAGCAG CATGAGCCCG GAGCTCTCCA TGAACGGCCA GGCTGCTGGC 
TATGAGCTCT GCGGTGTGCT GAGCCGGCCT TCGTCGAAGC AGAACACGCC CCAGTACCTG 
GCCTCACCCC TGGACCAGGA GGTGGTGCCC TGTACCCCTA GCCACGTCGG CCGGCCGCGC 
CTGGAGAAGC TGTCTGGCCT AGCCGCACCC GACTACACTA GGCTGTCCCC GGCCAAGATT 
GTGCTGAGGC GGCACCTGAG CCAGGACCAC ACGGTGCCCG GCAGGCCGGC TGCCAGTGAG 
CTGCATTCGA GAGCTGAGCA CACCAAGGAG AACGGCCTTC CCTACCAGAG CCCCAGCGTG 
CCTGGCAGCA TGAAGCTGAG CCCTCAGGAC CCGCGGCCCC TGTCCCCTGG GGCCTTGCAG 
CTTGCTGGAG AGAAGAGCAG TGAGAAGGGC CTGAGAGAGC GCGCCTACGG CAGCAGCGGG 
GAGCTCATCA CCAGCCTGCC CATCAGCATC CCGCTCAGCA CCGTGCAGCC CAACAAGCTC 
CCGGTCAGCA TTCCCCTGGC CAGCGTGGTG CTGCCCAGCC GCGCCGAGAG GGCGAGGAGC 
ACCCCCAGTC CCGTGCTGCA GCCCCGTGAC CCCTCGTCCA CACTTGAAAA GCAGATTGGT 
GCTAATGCCC ACGGTGCTGG GAGCAGAAGC CTTGCCCTGG CCCCCGCAGG CTTCTCCTAC 
GCTGGCTCGG TGGCCATCAG CGGGGCCTTG GCGGGCAGCC CGGCCTCTCT CACACCTGGA 
GCCGAGCCGG CCACCTTGGA TGAGTCCTCC AGCTCTGGGA GCCTTTTTGC CACCGTGGGG 
TCCCGCAGCT CCACGCCACA GCACCCCCTG CTGCTGGCAC AGCCCCGGAA CTCGCTTCCT 
GCCTCTCCCG CCCACCAGCT CTCCTCCAGT CCCCGGCTTG GTGGGGCCGC CCAGGGCCCG 
TTGCCCGAGG CCAGCAAGGG AGACCTGCCC TCCGATTCCG GCTTCTCAGA TCCTGAGAGT 
GAAGCCAAGA GGAGGATTGT GTTCACCATC ACCACTGGTG CGGGCAGTGC CAAGCAGTCG 
CCCTCCAGCA AGCACAGCCC CCTGACCGCC AGCGCCCGTG GGGACTGTGT GCCGAGCCAC 
GGGCAGGACA GTCGCAGGCG CGGCCGGCGG AAGCGAGCAT CTGCGGGGAC GCCCAGCTTG 
AGCGCAGGCG TGTCCCCCAA GCGCCGAGCC CTGCCGTCCG TCGCTGGCCT TTTCACACAG 
CCTTCGGGGT CTCCCCTCAA CCTCAACTCC ATGGTCAGTA ACATCAACCA GCCCCTGGAG 
ATTACAGCCA TCTCGTCCCC GGAGACCTCC CTGAAGAGCT CCCCTGTGCC CTACCAGGAC 
CACGACCAGC CCCCCGTGCT CAAGAAGGAG CGGCCTCTGA GCCAGACCAA TGGGGCACAC 
TACTCCCCAC TCACCTCAGA CGAGGAGCCA GGCTCTGAGG ACGAGCCCAG CAGTGCTCGA 
ATTGAGAGAA AAATTGCAAC AATCTCCTTA GAAAGCAAAT CTCCCCCGAA AACCTTGGAA 
AATGGTGGTG GCTTGGCGGG AAGGAAGCCC GCGCCCGCCG GCGAGCCAGT CAATAGCAGC 
AAGTGGAAGT CCACCTTCTC GCCCATCTCC GACATCGGCC TGGCCAAGTC GGCGGACAGC 
CCGCTGCAGG CCAGCTCCGC CCTCAGCCAG AACTCCCTGT TCACGTTCCG GCCCGCCCTG 
GAGGAGCCCT CTGCCGATGC CAAGCTGGCC GCTCACCCCA GGAAAGGCTT TCCCGGCTCC 
CTGTCGGGGG CTGACGGACT CAGCCCGGGC ACCAACCCTG CCAACGGCTG CACCTTCGGC 
GGGGGCCTGG CCGCGGACCT GAGTTTACAC AGCTTCAGTG ATGGTGCTTC TCTTCCCCAC 
AAGGGCCCCG AGGCGGCCGG CCTGAGCTCC CCGCTGAGCT TCCCCTCGCA GCGCGGCAAG 
GAGGGCTCGG ACGCCAACCC TTTCCTGAGC AAGAGGCAGC TGGACGGCCT GGCTGGGCTG 
AAGGGCGAGG GCAGCCGCGG CAAGGAGGCA GGGGAGGGCG GCCTACCGCT GTGCGGGCCC 
ACGGACAAGA CCCCACTGCT GAGCGGCAAG GCCGCCAAGG CCCGGGACCG CGAGGTCGAC 
CTCAAGAATG GCCACAACCT CTTCATCTCT GCGGCGGCCG TGCCTCCCGG AAGCCTCCTC 
AGCGGCCCCG GCCTGGCCCC GGCGGCGTCC TCCGCAGGCG GCGCGGCGTC CTCCGCCCAG 
ACGCACCGGT CCTTCCTGGG CCCCTTCCCG CCGGGACCGC AGTTCGCGCT CGGCCCCATG 
TCCCTGCAGG CCAACCTCGG CTCCGTGGCC GGCTCCTCCG TGCTGCAGTC GCTGTTCAGC 
TCTGTGCCGG CCGCCGCAGG CCTGGTGCAC GTGTCGTCCG CTGCCACCAG ACTGACCAAC 
TCGCACGCCA TGGGCAGCTT TTCCGGGGTG GCAGGCGGCA CAGTTGGAGG TGTCTTTAAC 
CACGCGGTGC CCTCCGCCTC TGCTCATCCG TTTGGAGCCC GTGTCGGCCG CGGGGCTGCA 
TGTGGCAGCG CCACACTGGG CCCGAGCCCG CTGCAGGCGG CGGCCAGCGC CTCGGCCTCT 
TCCTTTCAGG CCCCGGCCTC GGTTGAGACC CGGCCGCCCC CTCCGCCTCC GCCTCCGCCT 
CCCCCGCTGC CCCCGCCTGC GCACCTGGGC CGGTCCCCCG CGGGGCCGCC CGTCCTCCAC 
GCCCCCCCTC CACCTAACGC CGCCTTGCCT CCTCCCCCAA CGCTGCTGGC CTCTAACCCT 
GAGCCCGCGC TTCTGCAGAG CCTCGCGTCC CTCCCGCCTA ACCAAGCTTT CTTGCCCCCC 
ACCTCTGCTG CCTCTCTGCC GCCTGCTAAC GCCTCTTTGT CTATCAAGCT CACCTCCCTC 
CCGCACAAGG GCGCCCGCCC CTCCTTCACG GTGCACCACC AGCCCCTGCC CCGGCTGGCC 
CTGGCCCAGG CCGCGCCCGG GATCCCACAG GCCAGCGCCA CGGGGCCGTC CGCGGTGTGG 
GTGTCCCTCG GCATGCCGCC TCCCTATGCC GCGCACCTTT CGGGGGTTAA GCCGCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882855.1
CDS	843..5402
Translation	MVWKKACRIHIGERRFPLRRVEGANRQHEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGVFNHAVPSASAHPFGARVGRGAACGSATLGPSPLQAAASASASSFQAPASVETRPPPPPPPPPPPLPPPAHLGRSPAGPPVLHAPPPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLPPTSAASLPPANASLSIKLTSLPHKGARPSFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSGVKPR

Target ORF information:

RefSeq Version	XM_017027366.1
Organism	Homo sapiens(human)
Definition	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027366.1

ORF Insert Sequence:

ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA GGCGATTTCC TCTCAGAAGA 
GTGGAGGGAG CGAATCGCCA ACACGAGGTG GATCACCAGC TGAAGGAGCG GTTTGCAAAC 
ATGAAGGAAG GTGGCAGAAT CGTGTCCTCG AAACCCTTTG CACCTCTGAA CTTCAGAATA 
AACAGTAGAA ACTTGAGTGA CATCGGCACC ATCATGCGCG TGGTGGAGCT CTCGCCCCTG 
AAGGGCTCGG TGTCGTGGAC GGGGAAGCCA GTCTCCTACT ACCTGCACAC TATCGACCGC 
ACCATACTTG AAAACTATTT TTCTAGTCTG AAAAACCCAA AACTCAGGGA GGAACAGGAG 
GCAGCCCGGC GCCGCCAGCA GCGCGAGAGC AAGAGCAACG CGGCCACGCC CACTAAGGGC 
CCAGAGGGCA AGGTGGCCGG CCCCGCCGAC GCCCCCATGG ACTCTGGTGC TGAGGAAGAG 
AAGGCGGGAG CAGCCACCGT GAAGAAGCCG TCTCCCTCCA AAGCCCGCAA GAAGAAGCTA 
AACAAGAAGG GGAGGAAGAT GGCTGGCCGC AAGCGCGGGC GCCCCAAGAA GATGAACACT 
GCGAACCCCG AGCGGAAGCC CAAGAAGAAC CAAACTGCAC TGGATGCCCT GCACGCTCAG 
ACCGTGTCTC AGACGGCGGC CTCCTCACCC CAGGATGCCT ACAGATCCCC TCACAGCCCG 
TTCTACCAGC TACCTCCGAG CGTGCAGCGG CACTCCCCCA ACCCGCTGCT GGTGGCGCCC 
ACCCCGCCCG CGCTGCAGAA GCTTCTAGAG TCCTTCAAGA TCCAGTACCT GCAGTTCCTG 
GCATACACAA AGACCCCCCA GTACAAGGCC AGCCTGCAGG AGCTGCTGGG CCAGGAGAAG 
GAGAAGAACG CCCAGCTCCT GGGTGCGGCT CAGCAGCTCC TCAGCCACTG CCAGGCCCAG 
AAGGAGGAGA TCAGGAGGCT GTTTCAGCAA AAATTGGATG AGCTGGGTGT GAAGGCGCTG 
ACCTACAACG ACCTGATTCA AGCGCAGAAG GAGATCTCCG CCCATAACCA GCAGCTGCGG 
GAGCAGTCGG AGCAGCTGGA GCAGGACAAC CGCGCGCTCC GCGGCCAGAG CTTGCAGCTG 
CTCAAGGCTC GCTGCGAGGA GCTGCAGCTG GACTGGGCCA CGCTGTCGCT GGAGAAGCTG 
TTGAAGGAGA AGCAGGCCCT GAAGAGCCAG ATCTCGGAGA AGCAGAGGCA CTGCCTGGAG 
CTGCAGATCA GCATTGTGGA GCTAGAGAAG AGCCAGCGGC AGCAGGAGCT CCTGCAGCTC 
AAGTCCTGTG TGCCGCCTGA CGACGCCCTG TCCCTGCACC TGCGTGGGAA GGGCGCCCTG 
GGCCGCGAGC TGGAGCCTGA CGCCAGCCGG CTGCACCTGG AGCTGGACTG CACCAAGTTC 
TCGCTGCCTC ACTTGAGCAG CATGAGCCCG GAGCTCTCCA TGAACGGCCA GGCTGCTGGC 
TATGAGCTCT GCGGTGTGCT GAGCCGGCCT TCGTCGAAGC AGAACACGCC CCAGTACCTG 
GCCTCACCCC TGGACCAGGA GGTGGTGCCC TGTACCCCTA GCCACGTCGG CCGGCCGCGC 
CTGGAGAAGC TGTCTGGCCT AGCCGCACCC GACTACACTA GGCTGTCCCC GGCCAAGATT 
GTGCTGAGGC GGCACCTGAG CCAGGACCAC ACGGTGCCCG GCAGGCCGGC TGCCAGTGAG 
CTGCATTCGA GAGCTGAGCA CACCAAGGAG AACGGCCTTC CCTACCAGAG CCCCAGCGTG 
CCTGGCAGCA TGAAGCTGAG CCCTCAGGAC CCGCGGCCCC TGTCCCCTGG GGCCTTGCAG 
CTTGCTGGAG AGAAGAGCAG TGAGAAGGGC CTGAGAGAGC GCGCCTACGG CAGCAGCGGG 
GAGCTCATCA CCAGCCTGCC CATCAGCATC CCGCTCAGCA CCGTGCAGCC CAACAAGCTC 
CCGGTCAGCA TTCCCCTGGC CAGCGTGGTG CTGCCCAGCC GCGCCGAGAG GGCGAGGAGC 
ACCCCCAGTC CCGTGCTGCA GCCCCGTGAC CCCTCGTCCA CACTTGAAAA GCAGATTGGT 
GCTAATGCCC ACGGTGCTGG GAGCAGAAGC CTTGCCCTGG CCCCCGCAGG CTTCTCCTAC 
GCTGGCTCGG TGGCCATCAG CGGGGCCTTG GCGGGCAGCC CGGCCTCTCT CACACCTGGA 
GCCGAGCCGG CCACCTTGGA TGAGTCCTCC AGCTCTGGGA GCCTTTTTGC CACCGTGGGG 
TCCCGCAGCT CCACGCCACA GCACCCCCTG CTGCTGGCAC AGCCCCGGAA CTCGCTTCCT 
GCCTCTCCCG CCCACCAGCT CTCCTCCAGT CCCCGGCTTG GTGGGGCCGC CCAGGGCCCG 
TTGCCCGAGG CCAGCAAGGG AGACCTGCCC TCCGATTCCG GCTTCTCAGA TCCTGAGAGT 
GAAGCCAAGA GGAGGATTGT GTTCACCATC ACCACTGGTG CGGGCAGTGC CAAGCAGTCG 
CCCTCCAGCA AGCACAGCCC CCTGACCGCC AGCGCCCGTG GGGACTGTGT GCCGAGCCAC 
GGGCAGGACA GTCGCAGGCG CGGCCGGCGG AAGCGAGCAT CTGCGGGGAC GCCCAGCTTG 
AGCGCAGGCG TGTCCCCCAA GCGCCGAGCC CTGCCGTCCG TCGCTGGCCT TTTCACACAG 
CCTTCGGGGT CTCCCCTCAA CCTCAACTCC ATGGTCAGTA ACATCAACCA GCCCCTGGAG 
ATTACAGCCA TCTCGTCCCC GGAGACCTCC CTGAAGAGCT CCCCTGTGCC CTACCAGGAC 
CACGACCAGC CCCCCGTGCT CAAGAAGGAG CGGCCTCTGA GCCAGACCAA TGGGGCACAC 
TACTCCCCAC TCACCTCAGA CGAGGAGCCA GGCTCTGAGG ACGAGCCCAG CAGTGCTCGA 
ATTGAGAGAA AAATTGCAAC AATCTCCTTA GAAAGCAAAT CTCCCCCGAA AACCTTGGAA 
AATGGTGGTG GCTTGGCGGG AAGGAAGCCC GCGCCCGCCG GCGAGCCAGT CAATAGCAGC 
AAGTGGAAGT CCACCTTCTC GCCCATCTCC GACATCGGCC TGGCCAAGTC GGCGGACAGC 
CCGCTGCAGG CCAGCTCCGC CCTCAGCCAG AACTCCCTGT TCACGTTCCG GCCCGCCCTG 
GAGGAGCCCT CTGCCGATGC CAAGCTGGCC GCTCACCCCA GGAAAGGCTT TCCCGGCTCC 
CTGTCGGGGG CTGACGGACT CAGCCCGGGC ACCAACCCTG CCAACGGCTG CACCTTCGGC 
GGGGGCCTGG CCGCGGACCT GAGTTTACAC AGCTTCAGTG ATGGTGCTTC TCTTCCCCAC 
AAGGGCCCCG AGGCGGCCGG CCTGAGCTCC CCGCTGAGCT TCCCCTCGCA GCGCGGCAAG 
GAGGGCTCGG ACGCCAACCC TTTCCTGAGC AAGAGGCAGC TGGACGGCCT GGCTGGGCTG 
AAGGGCGAGG GCAGCCGCGG CAAGGAGGCA GGGGAGGGCG GCCTACCGCT GTGCGGGCCC 
ACGGACAAGA CCCCACTGCT GAGCGGCAAG GCCGCCAAGG CCCGGGACCG CGAGGTCGAC 
CTCAAGAATG GCCACAACCT CTTCATCTCT GCGGCGGCCG TGCCTCCCGG AAGCCTCCTC 
AGCGGCCCCG GCCTGGCCCC GGCGGCGTCC TCCGCAGGCG GCGCGGCGTC CTCCGCCCAG 
ACGCACCGGT CCTTCCTGGG CCCCTTCCCG CCGGGACCGC AGTTCGCGCT CGGCCCCATG 
TCCCTGCAGG CCAACCTCGG CTCCGTGGCC GGCTCCTCCG TGCTGCAGTC GCTGTTCAGC 
TCTGTGCCGG CCGCCGCAGG CCTGGTGCAC GTGTCGTCCG CTGCCACCAG ACTGACCAAC 
TCGCACGCCA TGGGCAGCTT TTCCGGGGTG GCAGGCGGCA CAGTTGGAGG TGTCTTTAAC 
CACGCGGTGC CCTCCGCCTC TGCTCATCCG TTTGGAGCCC GTGTCGGCCG CGGGGCTGCA 
TGTGGCAGCG CCACACTGGG CCCGAGCCCG CTGCAGGCGG CGGCCAGCGC CTCGGCCTCT 
TCCTTTCAGG CCCCGGCCTC GGTTGAGACC CGGCCGCCCC CTCCGCCTCC GCCTCCGCCT 
CCCCCGCTGC CCCCGCCTGC GCACCTGGGC CGGTCCCCCG CGGGGCCGCC CGTCCTCCAC 
GCCCCCCCTC CACCTAACGC CGCCTTGCCT CCTCCCCCAA CGCTGCTGGC CTCTAACCCT 
GAGCCCGCGC TTCTGCAGAG CCTCGCGTCC CTCCCGCCTA ACCAAGCTTT CTTGCCCCCC 
ACCTCTGCTG CCTCTCTGCC GCCTGCTAAC GCCTCTTTGT CTATCAAGCT CACCTCCCTC 
CCGCACAAGG GCGCCCGCCC CTCCTTCACG GTGCACCACC AGCCCCTGCC CCGGCTGGCC 
CTGGCCCAGG CCGCGCCCGG GATCCCACAG GCCAGCGCCA CGGGGCCGTC CGCGGTGTGG 
GTGTCCCTCG GCATGCCGCC TCCCTATGCC GCGCACCTTT CGGGGGTTAA GCCGCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOT1L ( XM_011528359.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526661.1 Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X3, mRNA.

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CloneID	OHu73527
Clone ID Related Accession (Same CDS sequence)	XM_011528359.2
Accession Version	XM_011528359.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5070bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011528359.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGAGA AGCTGGAGCT GAGACTGAAG TCGCCCGTGG GGGCTGAGCC CGCCGTCTAC 
CCGTGGCCGC TGCCGGTCTA CGATAAACAT CACGATGCTG CTCATGAAAT CATCGAGACC 
ATCCGATGGG TCTGTGAAGA AATCCCGGAT CTCAAGCTCG CTATGGAGAA TTACGTTTTA 
ATTGACTATG ACACCAAAAG CTTCGAGAGC ATGCAGAGGC TCTGCGACAA GTACAACCGT 
GCCATCGACA GCATCCACCA GCTGTGGAAG GGCACCACGC AGCCCATGAA GCTGAACACG 
CGGCCGTCCA CTGGACTCCT GCGCCATATC CTGCAGCAGG TCTACAACCA CTCGGTGACC 
GACCCCGAGA AGCTCAACAA CTACGAGCCC TTCTCCCCCG AGGTGTACGG GGAGACCTCC 
TTCGACCTGG TGGCCCAGAT GATTGATGAG ATCAAGATGA CCGACGACGA CCTGTTTGTG 
GACTTGGGGA GCGGTGTGGG CCAGGTCGTG CTCCAGGTTG CTGCTGCCAC CAACTGCAAA 
CATCACTATG GCGTCGAGAA AGCAGACATC CCGGCCAAGT ATGCGGAGAC CATGGACCGC 
GAGTTCAGGA AGTGGATGAA ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA 
GGCGATTTCC TCTCAGAAGA GTGGAGGGAG CGAATCGCCA ACACGAGTGT TATATTTGTG 
AATAATTTTG CCTTTGGTCC TGAGGTGGAT CACCAGCTGA AGGAGCGGTT TGCAAACATG 
AAGGAAGGTG GCAGAATCGT GTCCTCGAAA CCCTTTGCAC CTCTGAACTT CAGAATAAAC 
AGTAGAAACT TGAGTGACAT CGGCACCATC ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG 
GGCTCGGTGT CGTGGACGGG GAAGCCAGTC TCCTACTACC TGCACACTAT CGACCGCACC 
ATACTTGAAA ACTATTTTTC TAGTCTGAAA AACCCAAAAC TCAGGGAGGA ACAGGAGGCA 
GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG AGCAACGCGG CCACGCCCAC TAAGGGCCCA 
GAGGGCAAGG TGGCCGGCCC CGCCGACGCC CCCATGGACT CTGGTGCTGA GGAAGAGAAG 
GCGGGAGCAG CCACCGTGAA GAAGCCGTCT CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC 
AAGAAGGGGA GGAAGATGGC TGGCCGCAAG CGCGGGCGCC CCAAGAAGAT GAACACTGCG 
AACCCCGAGC GGAAGCCCAA GAAGAACCAA ACTGCACTGG ATGCCCTGCA CGCTCAGACC 
GTGTCTCAGA CGGCGGCCTC CTCACCCCAG GATGCCTACA GATCCCCTCA CAGCCCGTTC 
TACCAGCTAC CTCCGAGCGT GCAGCGGCAC TCCCCCAACC CGCTGCTGGT GGCGCCCACC 
CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC TTCAAGATCC AGTACCTGCA GTTCCTGGCA 
TACACAAAGA CCCCCCAGTA CAAGGCCAGC CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG 
AAGAACGCCC AGCTCCTGGG TGCGGCTCAG CAGCTCCTCA GCCACTGCCA GGCCCAGAAG 
GAGGAGATCA GGAGGCTGTT TCAGCAAAAA TTGGATGAGC TGGGTGTGAA GGCGCTGACC 
TACAACGACC TGATTCAAGC GCAGAAGGAG ATCTCCGCCC ATAACCAGCA GCTGCGGGAG 
CAGTCGGAGC AGCTGGAGCA GGACAACCGC GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC 
AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC TGGGCCACGC TGTCGCTGGA GAAGCTGTTG 
AAGGAGAAGC AGGCCCTGAA GAGCCAGATC TCGGAGAAGC AGAGGCACTG CCTGGAGCTG 
CAGATCAGCA TTGTGGAGCT AGAGAAGAGC CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG 
TCCTGTGTGC CGCCTGACGA CGCCCTGTCC CTGCACCTGC GTGGGAAGGG CGCCCTGGGC 
CGCGAGCTGG AGCCTGACGC CAGCCGGCTG CACCTGGAGC TGGACTGCAC CAAGTTCTCG 
CTGCCTCACT TGAGCAGCAT GAGCCCGGAG CTCTCCATGA ACGGCCAGGC TGCTGGCTAT 
GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG TCGAAGCAGA ACACGCCCCA GTACCTGGCC 
TCACCCCTGG ACCAGGAGGT GGTGCCCTGT ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG 
GAGAAGCTGT CTGGCCTAGC CGCACCCGAC TACACTAGGC TGTCCCCGGC CAAGATTGTG 
CTGAGGCGGC ACCTGAGCCA GGACCACACG GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG 
CATTCGAGAG CTGAGCACAC CAAGGAGAAC GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT 
GGCAGCATGA AGCTGAGCCC TCAGGACCCG CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT 
GCTGGAGAGA AGAGCAGTGA GAAGAGGAGC ACCCCCAGTC CCGTGCTGCA GCCCCGTGAC 
CCCTCGTCCA CACTTGAAAA GCAGATTGGT GCTAATGCCC ACGGTGCTGG GAGCAGAAGC 
CTTGCCCTGG CCCCCGCAGG CTTCTCCTAC GCTGGCTCGG TGGCCATCAG CGGGGCCTTG 
GCGGGCAGCC CGGCCTCTCT CACACCTGGA GCCGAGCCGG CCACCTTGGA TGAGTCCTCC 
AGCTCTGGGA GCCTTTTTGC CACCGTGGGG TCCCGCAGCT CCACGCCACA GCACCCCCTG 
CTGCTGGCAC AGCCCCGGAA CTCGCTTCCT GCCTCTCCCG CCCACCAGCT CTCCTCCAGT 
CCCCGGCTTG GTGGGGCCGC CCAGGGCCCG TTGCCCGAGG CCAGCAAGGG AGACCTGCCC 
TCCGATTCCG GCTTCTCAGA TCCTGAGAGT GAAGCCAAGA GGAGGATTGT GTTCACCATC 
ACCACTGGTG CGGGCAGTGC CAAGCAGTCG CCCTCCAGCA AGCACAGCCC CCTGACCGCC 
AGCGCCCGTG GGGACTGTGT GCCGAGCCAC GGGCAGGACA GTCGCAGGCG CGGCCGGCGG 
AAGCGAGCAT CTGCGGGGAC GCCCAGCTTG AGCGCAGGCG TGTCCCCCAA GCGCCGAGCC 
CTGCCGTCCG TCGCTGGCCT TTTCACACAG CCTTCGGGGT CTCCCCTCAA CCTCAACTCC 
ATGGTCAGTA ACATCAACCA GCCCCTGGAG ATTACAGCCA TCTCGTCCCC GGAGACCTCC 
CTGAAGAGCT CCCCTGTGCC CTACCAGGAC CACGACCAGC CCCCCGTGCT CAAGAAGGAG 
CGGCCTCTGA GCCAGACCAA TGGGGCACAC TACTCCCCAC TCACCTCAGA CGAGGAGCCA 
GGCTCTGAGG ACGAGCCCAG CAGTGCTCGA ATTGAGAGAA AAATTGCAAC AATCTCCTTA 
GAAAGCAAAT CTCCCCCGAA AACCTTGGAA AATGGTGGTG GCTTGGCGGG AAGGAAGCCC 
GCGCCCGCCG GCGAGCCAGT CAATAGCAGC AAGTGGAAGT CCACCTTCTC GCCCATCTCC 
GACATCGGCC TGGCCAAGTC GGCGGACAGC CCGCTGCAGG CCAGCTCCGC CCTCAGCCAG 
AACTCCCTGT TCACGTTCCG GCCCGCCCTG GAGGAGCCCT CTGCCGATGC CAAGCTGGCC 
GCTCACCCCA GGAAAGGCTT TCCCGGCTCC CTGTCGGGGG CTGACGGACT CAGCCCGGGC 
ACCAACCCTG CCAACGGCTG CACCTTCGGC GGGGGCCTGG CCGCGGACCT GAGTTTACAC 
AGCTTCAGTG ATGGTGCTTC TCTTCCCCAC AAGGGCCCCG AGGCGGCCGG CCTGAGCTCC 
CCGCTGAGCT TCCCCTCGCA GCGCGGCAAG GAGGGCTCGG ACGCCAACCC TTTCCTGAGC 
AAGAGGCAGC TGGACGGCCT GGCTGGGCTG AAGGGCGAGG GCAGCCGCGG CAAGGAGGCA 
GGGGAGGGCG GCCTACCGCT GTGCGGGCCC ACGGACAAGA CCCCACTGCT GAGCGGCAAG 
GCCGCCAAGG CCCGGGACCG CGAGGTCGAC CTCAAGAATG GCCACAACCT CTTCATCTCT 
GCGGCGGCCG TGCCTCCCGG AAGCCTCCTC AGCGGCCCCG GCCTGGCCCC GGCGGCGTCC 
TCCGCAGGCG GCGCGGCGTC CTCCGCCCAG ACGCACCGGT CCTTCCTGGG CCCCTTCCCG 
CCGGGACCGC AGTTCGCGCT CGGCCCCATG TCCCTGCAGG CCAACCTCGG CTCCGTGGCC 
GGCTCCTCCG TGCTGCAGTC GCTGTTCAGC TCTGTGCCGG CCGCCGCAGG CCTGGTGCAC 
GTGTCGTCCG CTGCCACCAG ACTGACCAAC TCGCACGCCA TGGGCAGCTT TTCCGGGGTG 
GCAGGCGGCA CAGTTGGAGG TGTCTTTAAC CACGCGGTGC CCTCCGCCTC TGCTCATCCG 
TTTGGAGCCC GTGTCGGCCG CGGGGCTGCA TGTGGCAGCG CCACACTGGG CCCGAGCCCG 
CTGCAGGCGG CGGCCAGCGC CTCGGCCTCT TCCTTTCAGG CCCCGGCCTC GGTTGAGACC 
CGGCCGCCCC CTCCGCCTCC GCCTCCGCCT CCCCCGCTGC CCCCGCCTGC GCACCTGGGC 
CGGTCCCCCG CGGGGCCGCC CGTCCTCCAC GCCCCCCCTC CACCTAACGC CGCCTTGCCT 
CCTCCCCCAA CGCTGCTGGC CTCTAACCCT GAGCCCGCGC TTCTGCAGAG CCTCGCGTCC 
CTCCCGCCTA ACCAAGCTTT CTTGCCCCCC ACCTCTGCTG CCTCTCTGCC GCCTGCTAAC 
GCCTCTTTGT CTATCAAGCT CACCTCCCTC CCGCACAAGG GCGCCCGCCC CTCCTTCACG 
GTGCACCACC AGCCCCTGCC CCGGCTGGCC CTGGCCCAGG CCGCGCCCGG GATCCCACAG 
GCCAGCGCCA CGGGGCCGTC CGCGGTGTGG GTGTCCCTCG GCATGCCGCC TCCCTATGCC 
GCGCACCTTT CGGGGGTTAA GCCGCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526661.1
CDS	223..5292
Translation	MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKRSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGVFNHAVPSASAHPFGARVGRGAACGSATLGPSPLQAAASASASSFQAPASVETRPPPPPPPPPPPLPPPAHLGRSPAGPPVLHAPPPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLPPTSAASLPPANASLSIKLTSLPHKGARPSFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSGVKPR

Target ORF information:

RefSeq Version	XM_011528359.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528359.2

ORF Insert Sequence:

ATGGGGGAGA AGCTGGAGCT GAGACTGAAG TCGCCCGTGG GGGCTGAGCC CGCCGTCTAC 
CCGTGGCCGC TGCCGGTCTA CGATAAACAT CACGATGCTG CTCATGAAAT CATCGAGACC 
ATCCGATGGG TCTGTGAAGA AATCCCGGAT CTCAAGCTCG CTATGGAGAA TTACGTTTTA 
ATTGACTATG ACACCAAAAG CTTCGAGAGC ATGCAGAGGC TCTGCGACAA GTACAACCGT 
GCCATCGACA GCATCCACCA GCTGTGGAAG GGCACCACGC AGCCCATGAA GCTGAACACG 
CGGCCGTCCA CTGGACTCCT GCGCCATATC CTGCAGCAGG TCTACAACCA CTCGGTGACC 
GACCCCGAGA AGCTCAACAA CTACGAGCCC TTCTCCCCCG AGGTGTACGG GGAGACCTCC 
TTCGACCTGG TGGCCCAGAT GATTGATGAG ATCAAGATGA CCGACGACGA CCTGTTTGTG 
GACTTGGGGA GCGGTGTGGG CCAGGTCGTG CTCCAGGTTG CTGCTGCCAC CAACTGCAAA 
CATCACTATG GCGTCGAGAA AGCAGACATC CCGGCCAAGT ATGCGGAGAC CATGGACCGC 
GAGTTCAGGA AGTGGATGAA ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA 
GGCGATTTCC TCTCAGAAGA GTGGAGGGAG CGAATCGCCA ACACGAGTGT TATATTTGTG 
AATAATTTTG CCTTTGGTCC TGAGGTGGAT CACCAGCTGA AGGAGCGGTT TGCAAACATG 
AAGGAAGGTG GCAGAATCGT GTCCTCGAAA CCCTTTGCAC CTCTGAACTT CAGAATAAAC 
AGTAGAAACT TGAGTGACAT CGGCACCATC ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG 
GGCTCGGTGT CGTGGACGGG GAAGCCAGTC TCCTACTACC TGCACACTAT CGACCGCACC 
ATACTTGAAA ACTATTTTTC TAGTCTGAAA AACCCAAAAC TCAGGGAGGA ACAGGAGGCA 
GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG AGCAACGCGG CCACGCCCAC TAAGGGCCCA 
GAGGGCAAGG TGGCCGGCCC CGCCGACGCC CCCATGGACT CTGGTGCTGA GGAAGAGAAG 
GCGGGAGCAG CCACCGTGAA GAAGCCGTCT CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC 
AAGAAGGGGA GGAAGATGGC TGGCCGCAAG CGCGGGCGCC CCAAGAAGAT GAACACTGCG 
AACCCCGAGC GGAAGCCCAA GAAGAACCAA ACTGCACTGG ATGCCCTGCA CGCTCAGACC 
GTGTCTCAGA CGGCGGCCTC CTCACCCCAG GATGCCTACA GATCCCCTCA CAGCCCGTTC 
TACCAGCTAC CTCCGAGCGT GCAGCGGCAC TCCCCCAACC CGCTGCTGGT GGCGCCCACC 
CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC TTCAAGATCC AGTACCTGCA GTTCCTGGCA 
TACACAAAGA CCCCCCAGTA CAAGGCCAGC CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG 
AAGAACGCCC AGCTCCTGGG TGCGGCTCAG CAGCTCCTCA GCCACTGCCA GGCCCAGAAG 
GAGGAGATCA GGAGGCTGTT TCAGCAAAAA TTGGATGAGC TGGGTGTGAA GGCGCTGACC 
TACAACGACC TGATTCAAGC GCAGAAGGAG ATCTCCGCCC ATAACCAGCA GCTGCGGGAG 
CAGTCGGAGC AGCTGGAGCA GGACAACCGC GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC 
AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC TGGGCCACGC TGTCGCTGGA GAAGCTGTTG 
AAGGAGAAGC AGGCCCTGAA GAGCCAGATC TCGGAGAAGC AGAGGCACTG CCTGGAGCTG 
CAGATCAGCA TTGTGGAGCT AGAGAAGAGC CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG 
TCCTGTGTGC CGCCTGACGA CGCCCTGTCC CTGCACCTGC GTGGGAAGGG CGCCCTGGGC 
CGCGAGCTGG AGCCTGACGC CAGCCGGCTG CACCTGGAGC TGGACTGCAC CAAGTTCTCG 
CTGCCTCACT TGAGCAGCAT GAGCCCGGAG CTCTCCATGA ACGGCCAGGC TGCTGGCTAT 
GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG TCGAAGCAGA ACACGCCCCA GTACCTGGCC 
TCACCCCTGG ACCAGGAGGT GGTGCCCTGT ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG 
GAGAAGCTGT CTGGCCTAGC CGCACCCGAC TACACTAGGC TGTCCCCGGC CAAGATTGTG 
CTGAGGCGGC ACCTGAGCCA GGACCACACG GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG 
CATTCGAGAG CTGAGCACAC CAAGGAGAAC GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT 
GGCAGCATGA AGCTGAGCCC TCAGGACCCG CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT 
GCTGGAGAGA AGAGCAGTGA GAAGAGGAGC ACCCCCAGTC CCGTGCTGCA GCCCCGTGAC 
CCCTCGTCCA CACTTGAAAA GCAGATTGGT GCTAATGCCC ACGGTGCTGG GAGCAGAAGC 
CTTGCCCTGG CCCCCGCAGG CTTCTCCTAC GCTGGCTCGG TGGCCATCAG CGGGGCCTTG 
GCGGGCAGCC CGGCCTCTCT CACACCTGGA GCCGAGCCGG CCACCTTGGA TGAGTCCTCC 
AGCTCTGGGA GCCTTTTTGC CACCGTGGGG TCCCGCAGCT CCACGCCACA GCACCCCCTG 
CTGCTGGCAC AGCCCCGGAA CTCGCTTCCT GCCTCTCCCG CCCACCAGCT CTCCTCCAGT 
CCCCGGCTTG GTGGGGCCGC CCAGGGCCCG TTGCCCGAGG CCAGCAAGGG AGACCTGCCC 
TCCGATTCCG GCTTCTCAGA TCCTGAGAGT GAAGCCAAGA GGAGGATTGT GTTCACCATC 
ACCACTGGTG CGGGCAGTGC CAAGCAGTCG CCCTCCAGCA AGCACAGCCC CCTGACCGCC 
AGCGCCCGTG GGGACTGTGT GCCGAGCCAC GGGCAGGACA GTCGCAGGCG CGGCCGGCGG 
AAGCGAGCAT CTGCGGGGAC GCCCAGCTTG AGCGCAGGCG TGTCCCCCAA GCGCCGAGCC 
CTGCCGTCCG TCGCTGGCCT TTTCACACAG CCTTCGGGGT CTCCCCTCAA CCTCAACTCC 
ATGGTCAGTA ACATCAACCA GCCCCTGGAG ATTACAGCCA TCTCGTCCCC GGAGACCTCC 
CTGAAGAGCT CCCCTGTGCC CTACCAGGAC CACGACCAGC CCCCCGTGCT CAAGAAGGAG 
CGGCCTCTGA GCCAGACCAA TGGGGCACAC TACTCCCCAC TCACCTCAGA CGAGGAGCCA 
GGCTCTGAGG ACGAGCCCAG CAGTGCTCGA ATTGAGAGAA AAATTGCAAC AATCTCCTTA 
GAAAGCAAAT CTCCCCCGAA AACCTTGGAA AATGGTGGTG GCTTGGCGGG AAGGAAGCCC 
GCGCCCGCCG GCGAGCCAGT CAATAGCAGC AAGTGGAAGT CCACCTTCTC GCCCATCTCC 
GACATCGGCC TGGCCAAGTC GGCGGACAGC CCGCTGCAGG CCAGCTCCGC CCTCAGCCAG 
AACTCCCTGT TCACGTTCCG GCCCGCCCTG GAGGAGCCCT CTGCCGATGC CAAGCTGGCC 
GCTCACCCCA GGAAAGGCTT TCCCGGCTCC CTGTCGGGGG CTGACGGACT CAGCCCGGGC 
ACCAACCCTG CCAACGGCTG CACCTTCGGC GGGGGCCTGG CCGCGGACCT GAGTTTACAC 
AGCTTCAGTG ATGGTGCTTC TCTTCCCCAC AAGGGCCCCG AGGCGGCCGG CCTGAGCTCC 
CCGCTGAGCT TCCCCTCGCA GCGCGGCAAG GAGGGCTCGG ACGCCAACCC TTTCCTGAGC 
AAGAGGCAGC TGGACGGCCT GGCTGGGCTG AAGGGCGAGG GCAGCCGCGG CAAGGAGGCA 
GGGGAGGGCG GCCTACCGCT GTGCGGGCCC ACGGACAAGA CCCCACTGCT GAGCGGCAAG 
GCCGCCAAGG CCCGGGACCG CGAGGTCGAC CTCAAGAATG GCCACAACCT CTTCATCTCT 
GCGGCGGCCG TGCCTCCCGG AAGCCTCCTC AGCGGCCCCG GCCTGGCCCC GGCGGCGTCC 
TCCGCAGGCG GCGCGGCGTC CTCCGCCCAG ACGCACCGGT CCTTCCTGGG CCCCTTCCCG 
CCGGGACCGC AGTTCGCGCT CGGCCCCATG TCCCTGCAGG CCAACCTCGG CTCCGTGGCC 
GGCTCCTCCG TGCTGCAGTC GCTGTTCAGC TCTGTGCCGG CCGCCGCAGG CCTGGTGCAC 
GTGTCGTCCG CTGCCACCAG ACTGACCAAC TCGCACGCCA TGGGCAGCTT TTCCGGGGTG 
GCAGGCGGCA CAGTTGGAGG TGTCTTTAAC CACGCGGTGC CCTCCGCCTC TGCTCATCCG 
TTTGGAGCCC GTGTCGGCCG CGGGGCTGCA TGTGGCAGCG CCACACTGGG CCCGAGCCCG 
CTGCAGGCGG CGGCCAGCGC CTCGGCCTCT TCCTTTCAGG CCCCGGCCTC GGTTGAGACC 
CGGCCGCCCC CTCCGCCTCC GCCTCCGCCT CCCCCGCTGC CCCCGCCTGC GCACCTGGGC 
CGGTCCCCCG CGGGGCCGCC CGTCCTCCAC GCCCCCCCTC CACCTAACGC CGCCTTGCCT 
CCTCCCCCAA CGCTGCTGGC CTCTAACCCT GAGCCCGCGC TTCTGCAGAG CCTCGCGTCC 
CTCCCGCCTA ACCAAGCTTT CTTGCCCCCC ACCTCTGCTG CCTCTCTGCC GCCTGCTAAC 
GCCTCTTTGT CTATCAAGCT CACCTCCCTC CCGCACAAGG GCGCCCGCCC CTCCTTCACG 
GTGCACCACC AGCCCCTGCC CCGGCTGGCC CTGGCCCAGG CCGCGCCCGG GATCCCACAG 
GCCAGCGCCA CGGGGCCGTC CGCGGTGTGG GTGTCCCTCG GCATGCCGCC TCCCTATGCC 
GCGCACCTTT CGGGGGTTAA GCCGCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOT1L ( XM_011528360.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526662.1 Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X4, mRNA.

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CloneID	OHu73528
Clone ID Related Accession (Same CDS sequence)	XM_011528360.1
Accession Version	XM_011528360.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5007bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGAGGC TCTGCGACAA GTACAACCGT GCCATCGACA GCATCCACCA GCTGTGGAAG 
GGCACCACGC AGCCCATGAA GCTGAACACG CGGCCGTCCA CTGGACTCCT GCGCCATATC 
CTGCAGCAGG TCTACAACCA CTCGGTGACC GACCCCGAGA AGCTCAACAA CTACGAGCCC 
TTCTCCCCCG AGGTGTACGG GGAGACCTCC TTCGACCTGG TGGCCCAGAT GATTGATGAG 
ATCAAGATGA CCGACGACGA CCTGTTTGTG GACTTGGGGA GCGGTGTGGG CCAGGTCGTG 
CTCCAGGTTG CTGCTGCCAC CAACTGCAAA CATCACTATG GCGTCGAGAA AGCAGACATC 
CCGGCCAAGT ATGCGGAGAC CATGGACCGC GAGTTCAGGA AGTGGATGAA ATGGTATGGA 
AAAAAGCATG CAGAATACAC ATTGGAGAGA GGCGATTTCC TCTCAGAAGA GTGGAGGGAG 
CGAATCGCCA ACACGAGTGT TATATTTGTG AATAATTTTG CCTTTGGTCC TGAGGTGGAT 
CACCAGCTGA AGGAGCGGTT TGCAAACATG AAGGAAGGTG GCAGAATCGT GTCCTCGAAA 
CCCTTTGCAC CTCTGAACTT CAGAATAAAC AGTAGAAACT TGAGTGACAT CGGCACCATC 
ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG GGCTCGGTGT CGTGGACGGG GAAGCCAGTC 
TCCTACTACC TGCACACTAT CGACCGCACC ATACTTGAAA ACTATTTTTC TAGTCTGAAA 
AACCCAAAAC TCAGGGAGGA ACAGGAGGCA GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG 
AGCAACGCGG CCACGCCCAC TAAGGGCCCA GAGGGCAAGG TGGCCGGCCC CGCCGACGCC 
CCCATGGACT CTGGTGCTGA GGAAGAGAAG GCGGGAGCAG CCACCGTGAA GAAGCCGTCT 
CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC AAGAAGGGGA GGAAGATGGC TGGCCGCAAG 
CGCGGGCGCC CCAAGAAGAT GAACACTGCG AACCCCGAGC GGAAGCCCAA GAAGAACCAA 
ACTGCACTGG ATGCCCTGCA CGCTCAGACC GTGTCTCAGA CGGCGGCCTC CTCACCCCAG 
GATGCCTACA GATCCCCTCA CAGCCCGTTC TACCAGCTAC CTCCGAGCGT GCAGCGGCAC 
TCCCCCAACC CGCTGCTGGT GGCGCCCACC CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC 
TTCAAGATCC AGTACCTGCA GTTCCTGGCA TACACAAAGA CCCCCCAGTA CAAGGCCAGC 
CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG AAGAACGCCC AGCTCCTGGG TGCGGCTCAG 
CAGCTCCTCA GCCACTGCCA GGCCCAGAAG GAGGAGATCA GGAGGCTGTT TCAGCAAAAA 
TTGGATGAGC TGGGTGTGAA GGCGCTGACC TACAACGACC TGATTCAAGC GCAGAAGGAG 
ATCTCCGCCC ATAACCAGCA GCTGCGGGAG CAGTCGGAGC AGCTGGAGCA GGACAACCGC 
GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC 
TGGGCCACGC TGTCGCTGGA GAAGCTGTTG AAGGAGAAGC AGGCCCTGAA GAGCCAGATC 
TCGGAGAAGC AGAGGCACTG CCTGGAGCTG CAGATCAGCA TTGTGGAGCT AGAGAAGAGC 
CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG TCCTGTGTGC CGCCTGACGA CGCCCTGTCC 
CTGCACCTGC GTGGGAAGGG CGCCCTGGGC CGCGAGCTGG AGCCTGACGC CAGCCGGCTG 
CACCTGGAGC TGGACTGCAC CAAGTTCTCG CTGCCTCACT TGAGCAGCAT GAGCCCGGAG 
CTCTCCATGA ACGGCCAGGC TGCTGGCTAT GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG 
TCGAAGCAGA ACACGCCCCA GTACCTGGCC TCACCCCTGG ACCAGGAGGT GGTGCCCTGT 
ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG GAGAAGCTGT CTGGCCTAGC CGCACCCGAC 
TACACTAGGC TGTCCCCGGC CAAGATTGTG CTGAGGCGGC ACCTGAGCCA GGACCACACG 
GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG CATTCGAGAG CTGAGCACAC CAAGGAGAAC 
GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT GGCAGCATGA AGCTGAGCCC TCAGGACCCG 
CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG 
AGAGAGCGCG CCTACGGCAG CAGCGGGGAG CTCATCACCA GCCTGCCCAT CAGCATCCCG 
CTCAGCACCG TGCAGCCCAA CAAGCTCCCG GTCAGCATTC CCCTGGCCAG CGTGGTGCTG 
CCCAGCCGCG CCGAGAGGGC GAGGAGCACC CCCAGTCCCG TGCTGCAGCC CCGTGACCCC 
TCGTCCACAC TTGAAAAGCA GATTGGTGCT AATGCCCACG GTGCTGGGAG CAGAAGCCTT 
GCCCTGGCCC CCGCAGGCTT CTCCTACGCT GGCTCGGTGG CCATCAGCGG GGCCTTGGCG 
GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC GAGCCGGCCA CCTTGGATGA GTCCTCCAGC 
TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC CGCAGCTCCA CGCCACAGCA CCCCCTGCTG 
CTGGCACAGC CCCGGAACTC GCTTCCTGCC TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC 
CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC 
GATTCCGGCT TCTCAGATCC TGAGAGTGAA GCCAAGAGGA GGATTGTGTT CACCATCACC 
ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC TCCAGCAAGC ACAGCCCCCT GACCGCCAGC 
GCCCGTGGGG ACTGTGTGCC GAGCCACGGG CAGGACAGTC GCAGGCGCGG CCGGCGGAAG 
CGAGCATCTG CGGGGACGCC CAGCTTGAGC GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG 
CCGTCCGTCG CTGGCCTTTT CACACAGCCT TCGGGGTCTC CCCTCAACCT CAACTCCATG 
GTCAGTAACA TCAACCAGCC CCTGGAGATT ACAGCCATCT CGTCCCCGGA GACCTCCCTG 
AAGAGCTCCC CTGTGCCCTA CCAGGACCAC GACCAGCCCC CCGTGCTCAA GAAGGAGCGG 
CCTCTGAGCC AGACCAATGG GGCACACTAC TCCCCACTCA CCTCAGACGA GGAGCCAGGC 
TCTGAGGACG AGCCCAGCAG TGCTCGAATT GAGAGAAAAA TTGCAACAAT CTCCTTAGAA 
AGCAAATCTC CCCCGAAAAC CTTGGAAAAT GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG 
CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG TGGAAGTCCA CCTTCTCGCC CATCTCCGAC 
ATCGGCCTGG CCAAGTCGGC GGACAGCCCG CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC 
TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG GAGCCCTCTG CCGATGCCAA GCTGGCCGCT 
CACCCCAGGA AAGGCTTTCC CGGCTCCCTG TCGGGGGCTG ACGGACTCAG CCCGGGCACC 
AACCCTGCCA ACGGCTGCAC CTTCGGCGGG GGCCTGGCCG CGGACCTGAG TTTACACAGC 
TTCAGTGATG GTGCTTCTCT TCCCCACAAG GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG 
CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG GGCTCGGACG CCAACCCTTT CCTGAGCAAG 
AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG 
GAGGGCGGCC TACCGCTGTG CGGGCCCACG GACAAGACCC CACTGCTGAG CGGCAAGGCC 
GCCAAGGCCC GGGACCGCGA GGTCGACCTC AAGAATGGCC ACAACCTCTT CATCTCTGCG 
GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC 
GCAGGCGGCG CGGCGTCCTC CGCCCAGACG CACCGGTCCT TCCTGGGCCC CTTCCCGCCG 
GGACCGCAGT TCGCGCTCGG CCCCATGTCC CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC 
TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT GTGCCGGCCG CCGCAGGCCT GGTGCACGTG 
TCGTCCGCTG CCACCAGACT GACCAACTCG CACGCCATGG GCAGCTTTTC CGGGGTGGCA 
GGCGGCACAG TTGGAGGTGT CTTTAACCAC GCGGTGCCCT CCGCCTCTGC TCATCCGTTT 
GGAGCCCGTG TCGGCCGCGG GGCTGCATGT GGCAGCGCCA CACTGGGCCC GAGCCCGCTG 
CAGGCGGCGG CCAGCGCCTC GGCCTCTTCC TTTCAGGCCC CGGCCTCGGT TGAGACCCGG 
CCGCCCCCTC CGCCTCCGCC TCCGCCTCCC CCGCTGCCCC CGCCTGCGCA CCTGGGCCGG 
TCCCCCGCGG GGCCGCCCGT CCTCCACGCC CCCCCTCCAC CTAACGCCGC CTTGCCTCCT 
CCCCCAACGC TGCTGGCCTC TAACCCTGAG CCCGCGCTTC TGCAGAGCCT CGCGTCCCTC 
CCGCCTAACC AAGCTTTCTT GCCCCCCACC TCTGCTGCCT CTCTGCCGCC TGCTAACGCC 
TCTTTGTCTA TCAAGCTCAC CTCCCTCCCG CACAAGGGCG CCCGCCCCTC CTTCACGGTG 
CACCACCAGC CCCTGCCCCG GCTGGCCCTG GCCCAGGCCG CGCCCGGGAT CCCACAGGCC 
AGCGCCACGG GGCCGTCCGC GGTGTGGGTG TCCCTCGGCA TGCCGCCTCC CTATGCCGCG 
CACCTTTCGG GGGTTAAGCC GCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526662.1
CDS	291..5297
Translation	MQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGVFNHAVPSASAHPFGARVGRGAACGSATLGPSPLQAAASASASSFQAPASVETRPPPPPPPPPPPLPPPAHLGRSPAGPPVLHAPPPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLPPTSAASLPPANASLSIKLTSLPHKGARPSFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSGVKPR

Target ORF information:

RefSeq Version	XM_011528360.1
Organism	Homo sapiens(human)
Definition	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528360.1

ORF Insert Sequence:

ATGCAGAGGC TCTGCGACAA GTACAACCGT GCCATCGACA GCATCCACCA GCTGTGGAAG 
GGCACCACGC AGCCCATGAA GCTGAACACG CGGCCGTCCA CTGGACTCCT GCGCCATATC 
CTGCAGCAGG TCTACAACCA CTCGGTGACC GACCCCGAGA AGCTCAACAA CTACGAGCCC 
TTCTCCCCCG AGGTGTACGG GGAGACCTCC TTCGACCTGG TGGCCCAGAT GATTGATGAG 
ATCAAGATGA CCGACGACGA CCTGTTTGTG GACTTGGGGA GCGGTGTGGG CCAGGTCGTG 
CTCCAGGTTG CTGCTGCCAC CAACTGCAAA CATCACTATG GCGTCGAGAA AGCAGACATC 
CCGGCCAAGT ATGCGGAGAC CATGGACCGC GAGTTCAGGA AGTGGATGAA ATGGTATGGA 
AAAAAGCATG CAGAATACAC ATTGGAGAGA GGCGATTTCC TCTCAGAAGA GTGGAGGGAG 
CGAATCGCCA ACACGAGTGT TATATTTGTG AATAATTTTG CCTTTGGTCC TGAGGTGGAT 
CACCAGCTGA AGGAGCGGTT TGCAAACATG AAGGAAGGTG GCAGAATCGT GTCCTCGAAA 
CCCTTTGCAC CTCTGAACTT CAGAATAAAC AGTAGAAACT TGAGTGACAT CGGCACCATC 
ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG GGCTCGGTGT CGTGGACGGG GAAGCCAGTC 
TCCTACTACC TGCACACTAT CGACCGCACC ATACTTGAAA ACTATTTTTC TAGTCTGAAA 
AACCCAAAAC TCAGGGAGGA ACAGGAGGCA GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG 
AGCAACGCGG CCACGCCCAC TAAGGGCCCA GAGGGCAAGG TGGCCGGCCC CGCCGACGCC 
CCCATGGACT CTGGTGCTGA GGAAGAGAAG GCGGGAGCAG CCACCGTGAA GAAGCCGTCT 
CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC AAGAAGGGGA GGAAGATGGC TGGCCGCAAG 
CGCGGGCGCC CCAAGAAGAT GAACACTGCG AACCCCGAGC GGAAGCCCAA GAAGAACCAA 
ACTGCACTGG ATGCCCTGCA CGCTCAGACC GTGTCTCAGA CGGCGGCCTC CTCACCCCAG 
GATGCCTACA GATCCCCTCA CAGCCCGTTC TACCAGCTAC CTCCGAGCGT GCAGCGGCAC 
TCCCCCAACC CGCTGCTGGT GGCGCCCACC CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC 
TTCAAGATCC AGTACCTGCA GTTCCTGGCA TACACAAAGA CCCCCCAGTA CAAGGCCAGC 
CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG AAGAACGCCC AGCTCCTGGG TGCGGCTCAG 
CAGCTCCTCA GCCACTGCCA GGCCCAGAAG GAGGAGATCA GGAGGCTGTT TCAGCAAAAA 
TTGGATGAGC TGGGTGTGAA GGCGCTGACC TACAACGACC TGATTCAAGC GCAGAAGGAG 
ATCTCCGCCC ATAACCAGCA GCTGCGGGAG CAGTCGGAGC AGCTGGAGCA GGACAACCGC 
GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC 
TGGGCCACGC TGTCGCTGGA GAAGCTGTTG AAGGAGAAGC AGGCCCTGAA GAGCCAGATC 
TCGGAGAAGC AGAGGCACTG CCTGGAGCTG CAGATCAGCA TTGTGGAGCT AGAGAAGAGC 
CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG TCCTGTGTGC CGCCTGACGA CGCCCTGTCC 
CTGCACCTGC GTGGGAAGGG CGCCCTGGGC CGCGAGCTGG AGCCTGACGC CAGCCGGCTG 
CACCTGGAGC TGGACTGCAC CAAGTTCTCG CTGCCTCACT TGAGCAGCAT GAGCCCGGAG 
CTCTCCATGA ACGGCCAGGC TGCTGGCTAT GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG 
TCGAAGCAGA ACACGCCCCA GTACCTGGCC TCACCCCTGG ACCAGGAGGT GGTGCCCTGT 
ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG GAGAAGCTGT CTGGCCTAGC CGCACCCGAC 
TACACTAGGC TGTCCCCGGC CAAGATTGTG CTGAGGCGGC ACCTGAGCCA GGACCACACG 
GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG CATTCGAGAG CTGAGCACAC CAAGGAGAAC 
GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT GGCAGCATGA AGCTGAGCCC TCAGGACCCG 
CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG 
AGAGAGCGCG CCTACGGCAG CAGCGGGGAG CTCATCACCA GCCTGCCCAT CAGCATCCCG 
CTCAGCACCG TGCAGCCCAA CAAGCTCCCG GTCAGCATTC CCCTGGCCAG CGTGGTGCTG 
CCCAGCCGCG CCGAGAGGGC GAGGAGCACC CCCAGTCCCG TGCTGCAGCC CCGTGACCCC 
TCGTCCACAC TTGAAAAGCA GATTGGTGCT AATGCCCACG GTGCTGGGAG CAGAAGCCTT 
GCCCTGGCCC CCGCAGGCTT CTCCTACGCT GGCTCGGTGG CCATCAGCGG GGCCTTGGCG 
GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC GAGCCGGCCA CCTTGGATGA GTCCTCCAGC 
TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC CGCAGCTCCA CGCCACAGCA CCCCCTGCTG 
CTGGCACAGC CCCGGAACTC GCTTCCTGCC TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC 
CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC 
GATTCCGGCT TCTCAGATCC TGAGAGTGAA GCCAAGAGGA GGATTGTGTT CACCATCACC 
ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC TCCAGCAAGC ACAGCCCCCT GACCGCCAGC 
GCCCGTGGGG ACTGTGTGCC GAGCCACGGG CAGGACAGTC GCAGGCGCGG CCGGCGGAAG 
CGAGCATCTG CGGGGACGCC CAGCTTGAGC GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG 
CCGTCCGTCG CTGGCCTTTT CACACAGCCT TCGGGGTCTC CCCTCAACCT CAACTCCATG 
GTCAGTAACA TCAACCAGCC CCTGGAGATT ACAGCCATCT CGTCCCCGGA GACCTCCCTG 
AAGAGCTCCC CTGTGCCCTA CCAGGACCAC GACCAGCCCC CCGTGCTCAA GAAGGAGCGG 
CCTCTGAGCC AGACCAATGG GGCACACTAC TCCCCACTCA CCTCAGACGA GGAGCCAGGC 
TCTGAGGACG AGCCCAGCAG TGCTCGAATT GAGAGAAAAA TTGCAACAAT CTCCTTAGAA 
AGCAAATCTC CCCCGAAAAC CTTGGAAAAT GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG 
CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG TGGAAGTCCA CCTTCTCGCC CATCTCCGAC 
ATCGGCCTGG CCAAGTCGGC GGACAGCCCG CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC 
TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG GAGCCCTCTG CCGATGCCAA GCTGGCCGCT 
CACCCCAGGA AAGGCTTTCC CGGCTCCCTG TCGGGGGCTG ACGGACTCAG CCCGGGCACC 
AACCCTGCCA ACGGCTGCAC CTTCGGCGGG GGCCTGGCCG CGGACCTGAG TTTACACAGC 
TTCAGTGATG GTGCTTCTCT TCCCCACAAG GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG 
CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG GGCTCGGACG CCAACCCTTT CCTGAGCAAG 
AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG 
GAGGGCGGCC TACCGCTGTG CGGGCCCACG GACAAGACCC CACTGCTGAG CGGCAAGGCC 
GCCAAGGCCC GGGACCGCGA GGTCGACCTC AAGAATGGCC ACAACCTCTT CATCTCTGCG 
GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC 
GCAGGCGGCG CGGCGTCCTC CGCCCAGACG CACCGGTCCT TCCTGGGCCC CTTCCCGCCG 
GGACCGCAGT TCGCGCTCGG CCCCATGTCC CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC 
TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT GTGCCGGCCG CCGCAGGCCT GGTGCACGTG 
TCGTCCGCTG CCACCAGACT GACCAACTCG CACGCCATGG GCAGCTTTTC CGGGGTGGCA 
GGCGGCACAG TTGGAGGTGT CTTTAACCAC GCGGTGCCCT CCGCCTCTGC TCATCCGTTT 
GGAGCCCGTG TCGGCCGCGG GGCTGCATGT GGCAGCGCCA CACTGGGCCC GAGCCCGCTG 
CAGGCGGCGG CCAGCGCCTC GGCCTCTTCC TTTCAGGCCC CGGCCTCGGT TGAGACCCGG 
CCGCCCCCTC CGCCTCCGCC TCCGCCTCCC CCGCTGCCCC CGCCTGCGCA CCTGGGCCGG 
TCCCCCGCGG GGCCGCCCGT CCTCCACGCC CCCCCTCCAC CTAACGCCGC CTTGCCTCCT 
CCCCCAACGC TGCTGGCCTC TAACCCTGAG CCCGCGCTTC TGCAGAGCCT CGCGTCCCTC 
CCGCCTAACC AAGCTTTCTT GCCCCCCACC TCTGCTGCCT CTCTGCCGCC TGCTAACGCC 
TCTTTGTCTA TCAAGCTCAC CTCCCTCCCG CACAAGGGCG CCCGCCCCTC CTTCACGGTG 
CACCACCAGC CCCTGCCCCG GCTGGCCCTG GCCCAGGCCG CGCCCGGGAT CCCACAGGCC 
AGCGCCACGG GGCCGTCCGC GGTGTGGGTG TCCCTCGGCA TGCCGCCTCC CTATGCCGCG 
CACCTTTCGG GGGTTAAGCC GCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOT1L ( NM_032482.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115871.1 Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), mRNA.

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CloneID	OHu18464
Clone ID Related Accession (Same CDS sequence)	NM_032482.3 , NM_032482.2
Accession Version	NM_032482.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572105600000
Organism	Homo sapiens(human)
Product	histone-lysine N-methyltransferase, H3 lysine-79 specific
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005257.1, AF509504.1, AC005263.1 and AL080221.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_032482.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF509504.1, KX792913.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000398665.8/ ENSP00000381657.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGGAGA AGCTGGAGCT GAGACTGAAG TCGCCCGTGG GGGCTGAGCC CGCCGTCTAC 
CCGTGGCCGC TGCCGGTCTA CGATAAACAT CACGATGCTG CTCATGAAAT CATCGAGACC 
ATCCGATGGG TCTGTGAAGA AATCCCGGAT CTCAAGCTCG CTATGGAGAA TTACGTTTTA 
ATTGACTATG ACACCAAAAG CTTCGAGAGC ATGCAGAGGC TCTGCGACAA GTACAACCGT 
GCCATCGACA GCATCCACCA GCTGTGGAAG GGCACCACGC AGCCCATGAA GCTGAACACG 
CGGCCGTCCA CTGGACTCCT GCGCCATATC CTGCAGCAGG TCTACAACCA CTCGGTGACC 
GACCCCGAGA AGCTCAACAA CTACGAGCCC TTCTCCCCCG AGGTGTACGG GGAGACCTCC 
TTCGACCTGG TGGCCCAGAT GATTGATGAG ATCAAGATGA CCGACGACGA CCTGTTTGTG 
GACTTGGGGA GCGGTGTGGG CCAGGTCGTG CTCCAGGTTG CTGCTGCCAC CAACTGCAAA 
CATCACTATG GCGTCGAGAA AGCAGACATC CCGGCCAAGT ATGCGGAGAC CATGGACCGC 
GAGTTCAGGA AGTGGATGAA ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA 
GGCGATTTCC TCTCAGAAGA GTGGAGGGAG CGAATCGCCA ACACGAGTGT TATATTTGTG 
AATAATTTTG CCTTTGGTCC TGAGGTGGAT CACCAGCTGA AGGAGCGGTT TGCAAACATG 
AAGGAAGGTG GCAGAATCGT GTCCTCGAAA CCCTTTGCAC CTCTGAACTT CAGAATAAAC 
AGTAGAAACT TGAGTGACAT CGGCACCATC ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG 
GGCTCGGTGT CGTGGACGGG GAAGCCAGTC TCCTACTACC TGCACACTAT CGACCGCACC 
ATACTTGAAA ACTATTTTTC TAGTCTGAAA AACCCAAAAC TCAGGGAGGA ACAGGAGGCA 
GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG AGCAACGCGG CCACGCCCAC TAAGGGCCCA 
GAGGGCAAGG TGGCCGGCCC CGCCGACGCC CCCATGGACT CTGGTGCTGA GGAAGAGAAG 
GCGGGAGCAG CCACCGTGAA GAAGCCGTCT CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC 
AAGAAGGGGA GGAAGATGGC TGGCCGCAAG CGCGGGCGCC CCAAGAAGAT GAACACTGCG 
AACCCCGAGC GGAAGCCCAA GAAGAACCAA ACTGCACTGG ATGCCCTGCA CGCTCAGACC 
GTGTCTCAGA CGGCGGCCTC CTCACCCCAG GATGCCTACA GATCCCCTCA CAGCCCGTTC 
TACCAGCTAC CTCCGAGCGT GCAGCGGCAC TCCCCCAACC CGCTGCTGGT GGCGCCCACC 
CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC TTCAAGATCC AGTACCTGCA GTTCCTGGCA 
TACACAAAGA CCCCCCAGTA CAAGGCCAGC CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG 
AAGAACGCCC AGCTCCTGGG TGCGGCTCAG CAGCTCCTCA GCCACTGCCA GGCCCAGAAG 
GAGGAGATCA GGAGGCTGTT TCAGCAAAAA TTGGATGAGC TGGGTGTGAA GGCGCTGACC 
TACAACGACC TGATTCAAGC GCAGAAGGAG ATCTCCGCCC ATAACCAGCA GCTGCGGGAG 
CAGTCGGAGC AGCTGGAGCA GGACAACCGC GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC 
AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC TGGGCCACGC TGTCGCTGGA GAAGCTGTTG 
AAGGAGAAGC AGGCCCTGAA GAGCCAGATC TCGGAGAAGC AGAGGCACTG CCTGGAGCTG 
CAGATCAGCA TTGTGGAGCT AGAGAAGAGC CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG 
TCCTGTGTGC CGCCTGACGA CGCCCTGTCC CTGCACCTGC GTGGGAAGGG CGCCCTGGGC 
CGCGAGCTGG AGCCTGACGC CAGCCGGCTG CACCTGGAGC TGGACTGCAC CAAGTTCTCG 
CTGCCTCACT TGAGCAGCAT GAGCCCGGAG CTCTCCATGA ACGGCCAGGC TGCTGGCTAT 
GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG TCGAAGCAGA ACACGCCCCA GTACCTGGCC 
TCACCCCTGG ACCAGGAGGT GGTGCCCTGT ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG 
GAGAAGCTGT CTGGCCTAGC CGCACCCGAC TACACTAGGC TGTCCCCGGC CAAGATTGTG 
CTGAGGCGGC ACCTGAGCCA GGACCACACG GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG 
CATTCGAGAG CTGAGCACAC CAAGGAGAAC GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT 
GGCAGCATGA AGCTGAGCCC TCAGGACCCG CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT 
GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG AGAGAGCGCG CCTACGGCAG CAGCGGGGAG 
CTCATCACCA GCCTGCCCAT CAGCATCCCG CTCAGCACCG TGCAGCCCAA CAAGCTCCCG 
GTCAGCATTC CCCTGGCCAG CGTGGTGCTG CCCAGCCGCG CCGAGAGGGC GAGGAGCACC 
CCCAGTCCCG TGCTGCAGCC CCGTGACCCC TCGTCCACAC TTGAAAAGCA GATTGGTGCT 
AATGCCCACG GTGCTGGGAG CAGAAGCCTT GCCCTGGCCC CCGCAGGCTT CTCCTACGCT 
GGCTCGGTGG CCATCAGCGG GGCCTTGGCG GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC 
GAGCCGGCCA CCTTGGATGA GTCCTCCAGC TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC 
CGCAGCTCCA CGCCACAGCA CCCCCTGCTG CTGGCACAGC CCCGGAACTC GCTTCCTGCC 
TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG 
CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC GATTCCGGCT TCTCAGATCC TGAGAGTGAA 
GCCAAGAGGA GGATTGTGTT CACCATCACC ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC 
TCCAGCAAGC ACAGCCCCCT GACCGCCAGC GCCCGTGGGG ACTGTGTGCC GAGCCACGGG 
CAGGACAGTC GCAGGCGCGG CCGGCGGAAG CGAGCATCTG CGGGGACGCC CAGCTTGAGC 
GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG CCGTCCGTCG CTGGCCTTTT CACACAGCCT 
TCGGGGTCTC CCCTCAACCT CAACTCCATG GTCAGTAACA TCAACCAGCC CCTGGAGATT 
ACAGCCATCT CGTCCCCGGA GACCTCCCTG AAGAGCTCCC CTGTGCCCTA CCAGGACCAC 
GACCAGCCCC CCGTGCTCAA GAAGGAGCGG CCTCTGAGCC AGACCAATGG GGCACACTAC 
TCCCCACTCA CCTCAGACGA GGAGCCAGGC TCTGAGGACG AGCCCAGCAG TGCTCGAATT 
GAGAGAAAAA TTGCAACAAT CTCCTTAGAA AGCAAATCTC CCCCGAAAAC CTTGGAAAAT 
GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG 
TGGAAGTCCA CCTTCTCGCC CATCTCCGAC ATCGGCCTGG CCAAGTCGGC GGACAGCCCG 
CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG 
GAGCCCTCTG CCGATGCCAA GCTGGCCGCT CACCCCAGGA AAGGCTTTCC CGGCTCCCTG 
TCGGGGGCTG ACGGACTCAG CCCGGGCACC AACCCTGCCA ACGGCTGCAC CTTCGGCGGG 
GGCCTGGCCG CGGACCTGAG TTTACACAGC TTCAGTGATG GTGCTTCTCT TCCCCACAAG 
GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG 
GGCTCGGACG CCAACCCTTT CCTGAGCAAG AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG 
GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG GAGGGCGGCC TACCGCTGTG CGGGCCCACG 
GACAAGACCC CACTGCTGAG CGGCAAGGCC GCCAAGGCCC GGGACCGCGA GGTCGACCTC 
AAGAATGGCC ACAACCTCTT CATCTCTGCG GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC 
GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC GCAGGCGGCG CGGCGTCCTC CGCCCAGACG 
CACCGGTCCT TCCTGGGCCC CTTCCCGCCG GGACCGCAGT TCGCGCTCGG CCCCATGTCC 
CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT 
GTGCCGGCCG CCGCAGGCCT GGTGCACGTG TCGTCCGCTG CCACCAGACT GACCAACTCG 
CACGCCATGG GCAGCTTTTC CGGGGTGGCA GGCGGCACAG TTGGAGGTAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115871.1
CDS	253..4866
Translation	MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN

Target ORF information:

RefSeq Version	NM_032482.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032482.3

ORF Insert Sequence:

ATGGGGGAGA AGCTGGAGCT GAGACTGAAG TCGCCCGTGG GGGCTGAGCC CGCCGTCTAC 
CCGTGGCCGC TGCCGGTCTA CGATAAACAT CACGATGCTG CTCATGAAAT CATCGAGACC 
ATCCGATGGG TCTGTGAAGA AATCCCGGAT CTCAAGCTCG CTATGGAGAA TTACGTTTTA 
ATTGACTATG ACACCAAAAG CTTCGAGAGC ATGCAGAGGC TCTGCGACAA GTACAACCGT 
GCCATCGACA GCATCCACCA GCTGTGGAAG GGCACCACGC AGCCCATGAA GCTGAACACG 
CGGCCGTCCA CTGGACTCCT GCGCCATATC CTGCAGCAGG TCTACAACCA CTCGGTGACC 
GACCCCGAGA AGCTCAACAA CTACGAGCCC TTCTCCCCCG AGGTGTACGG GGAGACCTCC 
TTCGACCTGG TGGCCCAGAT GATTGATGAG ATCAAGATGA CCGACGACGA CCTGTTTGTG 
GACTTGGGGA GCGGTGTGGG CCAGGTCGTG CTCCAGGTTG CTGCTGCCAC CAACTGCAAA 
CATCACTATG GCGTCGAGAA AGCAGACATC CCGGCCAAGT ATGCGGAGAC CATGGACCGC 
GAGTTCAGGA AGTGGATGAA ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA 
GGCGATTTCC TCTCAGAAGA GTGGAGGGAG CGAATCGCCA ACACGAGTGT TATATTTGTG 
AATAATTTTG CCTTTGGTCC TGAGGTGGAT CACCAGCTGA AGGAGCGGTT TGCAAACATG 
AAGGAAGGTG GCAGAATCGT GTCCTCGAAA CCCTTTGCAC CTCTGAACTT CAGAATAAAC 
AGTAGAAACT TGAGTGACAT CGGCACCATC ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG 
GGCTCGGTGT CGTGGACGGG GAAGCCAGTC TCCTACTACC TGCACACTAT CGACCGCACC 
ATACTTGAAA ACTATTTTTC TAGTCTGAAA AACCCAAAAC TCAGGGAGGA ACAGGAGGCA 
GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG AGCAACGCGG CCACGCCCAC TAAGGGCCCA 
GAGGGCAAGG TGGCCGGCCC CGCCGACGCC CCCATGGACT CTGGTGCTGA GGAAGAGAAG 
GCGGGAGCAG CCACCGTGAA GAAGCCGTCT CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC 
AAGAAGGGGA GGAAGATGGC TGGCCGCAAG CGCGGGCGCC CCAAGAAGAT GAACACTGCG 
AACCCCGAGC GGAAGCCCAA GAAGAACCAA ACTGCACTGG ATGCCCTGCA CGCTCAGACC 
GTGTCTCAGA CGGCGGCCTC CTCACCCCAG GATGCCTACA GATCCCCTCA CAGCCCGTTC 
TACCAGCTAC CTCCGAGCGT GCAGCGGCAC TCCCCCAACC CGCTGCTGGT GGCGCCCACC 
CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC TTCAAGATCC AGTACCTGCA GTTCCTGGCA 
TACACAAAGA CCCCCCAGTA CAAGGCCAGC CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG 
AAGAACGCCC AGCTCCTGGG TGCGGCTCAG CAGCTCCTCA GCCACTGCCA GGCCCAGAAG 
GAGGAGATCA GGAGGCTGTT TCAGCAAAAA TTGGATGAGC TGGGTGTGAA GGCGCTGACC 
TACAACGACC TGATTCAAGC GCAGAAGGAG ATCTCCGCCC ATAACCAGCA GCTGCGGGAG 
CAGTCGGAGC AGCTGGAGCA GGACAACCGC GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC 
AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC TGGGCCACGC TGTCGCTGGA GAAGCTGTTG 
AAGGAGAAGC AGGCCCTGAA GAGCCAGATC TCGGAGAAGC AGAGGCACTG CCTGGAGCTG 
CAGATCAGCA TTGTGGAGCT AGAGAAGAGC CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG 
TCCTGTGTGC CGCCTGACGA CGCCCTGTCC CTGCACCTGC GTGGGAAGGG CGCCCTGGGC 
CGCGAGCTGG AGCCTGACGC CAGCCGGCTG CACCTGGAGC TGGACTGCAC CAAGTTCTCG 
CTGCCTCACT TGAGCAGCAT GAGCCCGGAG CTCTCCATGA ACGGCCAGGC TGCTGGCTAT 
GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG TCGAAGCAGA ACACGCCCCA GTACCTGGCC 
TCACCCCTGG ACCAGGAGGT GGTGCCCTGT ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG 
GAGAAGCTGT CTGGCCTAGC CGCACCCGAC TACACTAGGC TGTCCCCGGC CAAGATTGTG 
CTGAGGCGGC ACCTGAGCCA GGACCACACG GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG 
CATTCGAGAG CTGAGCACAC CAAGGAGAAC GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT 
GGCAGCATGA AGCTGAGCCC TCAGGACCCG CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT 
GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG AGAGAGCGCG CCTACGGCAG CAGCGGGGAG 
CTCATCACCA GCCTGCCCAT CAGCATCCCG CTCAGCACCG TGCAGCCCAA CAAGCTCCCG 
GTCAGCATTC CCCTGGCCAG CGTGGTGCTG CCCAGCCGCG CCGAGAGGGC GAGGAGCACC 
CCCAGTCCCG TGCTGCAGCC CCGTGACCCC TCGTCCACAC TTGAAAAGCA GATTGGTGCT 
AATGCCCACG GTGCTGGGAG CAGAAGCCTT GCCCTGGCCC CCGCAGGCTT CTCCTACGCT 
GGCTCGGTGG CCATCAGCGG GGCCTTGGCG GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC 
GAGCCGGCCA CCTTGGATGA GTCCTCCAGC TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC 
CGCAGCTCCA CGCCACAGCA CCCCCTGCTG CTGGCACAGC CCCGGAACTC GCTTCCTGCC 
TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG 
CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC GATTCCGGCT TCTCAGATCC TGAGAGTGAA 
GCCAAGAGGA GGATTGTGTT CACCATCACC ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC 
TCCAGCAAGC ACAGCCCCCT GACCGCCAGC GCCCGTGGGG ACTGTGTGCC GAGCCACGGG 
CAGGACAGTC GCAGGCGCGG CCGGCGGAAG CGAGCATCTG CGGGGACGCC CAGCTTGAGC 
GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG CCGTCCGTCG CTGGCCTTTT CACACAGCCT 
TCGGGGTCTC CCCTCAACCT CAACTCCATG GTCAGTAACA TCAACCAGCC CCTGGAGATT 
ACAGCCATCT CGTCCCCGGA GACCTCCCTG AAGAGCTCCC CTGTGCCCTA CCAGGACCAC 
GACCAGCCCC CCGTGCTCAA GAAGGAGCGG CCTCTGAGCC AGACCAATGG GGCACACTAC 
TCCCCACTCA CCTCAGACGA GGAGCCAGGC TCTGAGGACG AGCCCAGCAG TGCTCGAATT 
GAGAGAAAAA TTGCAACAAT CTCCTTAGAA AGCAAATCTC CCCCGAAAAC CTTGGAAAAT 
GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG 
TGGAAGTCCA CCTTCTCGCC CATCTCCGAC ATCGGCCTGG CCAAGTCGGC GGACAGCCCG 
CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG 
GAGCCCTCTG CCGATGCCAA GCTGGCCGCT CACCCCAGGA AAGGCTTTCC CGGCTCCCTG 
TCGGGGGCTG ACGGACTCAG CCCGGGCACC AACCCTGCCA ACGGCTGCAC CTTCGGCGGG 
GGCCTGGCCG CGGACCTGAG TTTACACAGC TTCAGTGATG GTGCTTCTCT TCCCCACAAG 
GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG 
GGCTCGGACG CCAACCCTTT CCTGAGCAAG AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG 
GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG GAGGGCGGCC TACCGCTGTG CGGGCCCACG 
GACAAGACCC CACTGCTGAG CGGCAAGGCC GCCAAGGCCC GGGACCGCGA GGTCGACCTC 
AAGAATGGCC ACAACCTCTT CATCTCTGCG GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC 
GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC GCAGGCGGCG CGGCGTCCTC CGCCCAGACG 
CACCGGTCCT TCCTGGGCCC CTTCCCGCCG GGACCGCAGT TCGCGCTCGG CCCCATGTCC 
CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT 
GTGCCGGCCG CCGCAGGCCT GGTGCACGTG TCGTCCGCTG CCACCAGACT GACCAACTCG 
CACGCCATGG GCAGCTTTTC CGGGGTGGCA GGCGGCACAG TTGGAGGTAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DOT1L ( NM_032482.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115871.1 Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), mRNA.

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CloneID	OHu18464
Clone ID Related Accession (Same CDS sequence)	NM_032482.3 , NM_032482.2
Accession Version	NM_032482.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512403200000
Organism	Homo sapiens(human)
Product	histone-lysine N-methyltransferase, H3 lysine-79 specific
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF509504.1, AC005263.1 and AL080221.1. This sequence is a reference standard in the RefSeqGene project. On Dec 29, 2007 this sequence version replaced NM_032482.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF509504.1, KX792913.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAGA AGCTGGAGCT GAGACTGAAG TCGCCCGTGG GGGCTGAGCC CGCCGTCTAC 
CCGTGGCCGC TGCCGGTCTA CGATAAACAT CACGATGCTG CTCATGAAAT CATCGAGACC 
ATCCGATGGG TCTGTGAAGA AATCCCGGAT CTCAAGCTCG CTATGGAGAA TTACGTTTTA 
ATTGACTATG ACACCAAAAG CTTCGAGAGC ATGCAGAGGC TCTGCGACAA GTACAACCGT 
GCCATCGACA GCATCCACCA GCTGTGGAAG GGCACCACGC AGCCCATGAA GCTGAACACG 
CGGCCGTCCA CTGGACTCCT GCGCCATATC CTGCAGCAGG TCTACAACCA CTCGGTGACC 
GACCCCGAGA AGCTCAACAA CTACGAGCCC TTCTCCCCCG AGGTGTACGG GGAGACCTCC 
TTCGACCTGG TGGCCCAGAT GATTGATGAG ATCAAGATGA CCGACGACGA CCTGTTTGTG 
GACTTGGGGA GCGGTGTGGG CCAGGTCGTG CTCCAGGTTG CTGCTGCCAC CAACTGCAAA 
CATCACTATG GCGTCGAGAA AGCAGACATC CCGGCCAAGT ATGCGGAGAC CATGGACCGC 
GAGTTCAGGA AGTGGATGAA ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA 
GGCGATTTCC TCTCAGAAGA GTGGAGGGAG CGAATCGCCA ACACGAGTGT TATATTTGTG 
AATAATTTTG CCTTTGGTCC TGAGGTGGAT CACCAGCTGA AGGAGCGGTT TGCAAACATG 
AAGGAAGGTG GCAGAATCGT GTCCTCGAAA CCCTTTGCAC CTCTGAACTT CAGAATAAAC 
AGTAGAAACT TGAGTGACAT CGGCACCATC ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG 
GGCTCGGTGT CGTGGACGGG GAAGCCAGTC TCCTACTACC TGCACACTAT CGACCGCACC 
ATACTTGAAA ACTATTTTTC TAGTCTGAAA AACCCAAAAC TCAGGGAGGA ACAGGAGGCA 
GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG AGCAACGCGG CCACGCCCAC TAAGGGCCCA 
GAGGGCAAGG TGGCCGGCCC CGCCGACGCC CCCATGGACT CTGGTGCTGA GGAAGAGAAG 
GCGGGAGCAG CCACCGTGAA GAAGCCGTCT CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC 
AAGAAGGGGA GGAAGATGGC TGGCCGCAAG CGCGGGCGCC CCAAGAAGAT GAACACTGCG 
AACCCCGAGC GGAAGCCCAA GAAGAACCAA ACTGCACTGG ATGCCCTGCA CGCTCAGACC 
GTGTCTCAGA CGGCGGCCTC CTCACCCCAG GATGCCTACA GATCCCCTCA CAGCCCGTTC 
TACCAGCTAC CTCCGAGCGT GCAGCGGCAC TCCCCCAACC CGCTGCTGGT GGCGCCCACC 
CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC TTCAAGATCC AGTACCTGCA GTTCCTGGCA 
TACACAAAGA CCCCCCAGTA CAAGGCCAGC CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG 
AAGAACGCCC AGCTCCTGGG TGCGGCTCAG CAGCTCCTCA GCCACTGCCA GGCCCAGAAG 
GAGGAGATCA GGAGGCTGTT TCAGCAAAAA TTGGATGAGC TGGGTGTGAA GGCGCTGACC 
TACAACGACC TGATTCAAGC GCAGAAGGAG ATCTCCGCCC ATAACCAGCA GCTGCGGGAG 
CAGTCGGAGC AGCTGGAGCA GGACAACCGC GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC 
AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC TGGGCCACGC TGTCGCTGGA GAAGCTGTTG 
AAGGAGAAGC AGGCCCTGAA GAGCCAGATC TCGGAGAAGC AGAGGCACTG CCTGGAGCTG 
CAGATCAGCA TTGTGGAGCT AGAGAAGAGC CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG 
TCCTGTGTGC CGCCTGACGA CGCCCTGTCC CTGCACCTGC GTGGGAAGGG CGCCCTGGGC 
CGCGAGCTGG AGCCTGACGC CAGCCGGCTG CACCTGGAGC TGGACTGCAC CAAGTTCTCG 
CTGCCTCACT TGAGCAGCAT GAGCCCGGAG CTCTCCATGA ACGGCCAGGC TGCTGGCTAT 
GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG TCGAAGCAGA ACACGCCCCA GTACCTGGCC 
TCACCCCTGG ACCAGGAGGT GGTGCCCTGT ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG 
GAGAAGCTGT CTGGCCTAGC CGCACCCGAC TACACTAGGC TGTCCCCGGC CAAGATTGTG 
CTGAGGCGGC ACCTGAGCCA GGACCACACG GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG 
CATTCGAGAG CTGAGCACAC CAAGGAGAAC GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT 
GGCAGCATGA AGCTGAGCCC TCAGGACCCG CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT 
GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG AGAGAGCGCG CCTACGGCAG CAGCGGGGAG 
CTCATCACCA GCCTGCCCAT CAGCATCCCG CTCAGCACCG TGCAGCCCAA CAAGCTCCCG 
GTCAGCATTC CCCTGGCCAG CGTGGTGCTG CCCAGCCGCG CCGAGAGGGC GAGGAGCACC 
CCCAGTCCCG TGCTGCAGCC CCGTGACCCC TCGTCCACAC TTGAAAAGCA GATTGGTGCT 
AATGCCCACG GTGCTGGGAG CAGAAGCCTT GCCCTGGCCC CCGCAGGCTT CTCCTACGCT 
GGCTCGGTGG CCATCAGCGG GGCCTTGGCG GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC 
GAGCCGGCCA CCTTGGATGA GTCCTCCAGC TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC 
CGCAGCTCCA CGCCACAGCA CCCCCTGCTG CTGGCACAGC CCCGGAACTC GCTTCCTGCC 
TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG 
CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC GATTCCGGCT TCTCAGATCC TGAGAGTGAA 
GCCAAGAGGA GGATTGTGTT CACCATCACC ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC 
TCCAGCAAGC ACAGCCCCCT GACCGCCAGC GCCCGTGGGG ACTGTGTGCC GAGCCACGGG 
CAGGACAGTC GCAGGCGCGG CCGGCGGAAG CGAGCATCTG CGGGGACGCC CAGCTTGAGC 
GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG CCGTCCGTCG CTGGCCTTTT CACACAGCCT 
TCGGGGTCTC CCCTCAACCT CAACTCCATG GTCAGTAACA TCAACCAGCC CCTGGAGATT 
ACAGCCATCT CGTCCCCGGA GACCTCCCTG AAGAGCTCCC CTGTGCCCTA CCAGGACCAC 
GACCAGCCCC CCGTGCTCAA GAAGGAGCGG CCTCTGAGCC AGACCAATGG GGCACACTAC 
TCCCCACTCA CCTCAGACGA GGAGCCAGGC TCTGAGGACG AGCCCAGCAG TGCTCGAATT 
GAGAGAAAAA TTGCAACAAT CTCCTTAGAA AGCAAATCTC CCCCGAAAAC CTTGGAAAAT 
GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG 
TGGAAGTCCA CCTTCTCGCC CATCTCCGAC ATCGGCCTGG CCAAGTCGGC GGACAGCCCG 
CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG 
GAGCCCTCTG CCGATGCCAA GCTGGCCGCT CACCCCAGGA AAGGCTTTCC CGGCTCCCTG 
TCGGGGGCTG ACGGACTCAG CCCGGGCACC AACCCTGCCA ACGGCTGCAC CTTCGGCGGG 
GGCCTGGCCG CGGACCTGAG TTTACACAGC TTCAGTGATG GTGCTTCTCT TCCCCACAAG 
GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG 
GGCTCGGACG CCAACCCTTT CCTGAGCAAG AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG 
GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG GAGGGCGGCC TACCGCTGTG CGGGCCCACG 
GACAAGACCC CACTGCTGAG CGGCAAGGCC GCCAAGGCCC GGGACCGCGA GGTCGACCTC 
AAGAATGGCC ACAACCTCTT CATCTCTGCG GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC 
GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC GCAGGCGGCG CGGCGTCCTC CGCCCAGACG 
CACCGGTCCT TCCTGGGCCC CTTCCCGCCG GGACCGCAGT TCGCGCTCGG CCCCATGTCC 
CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT 
GTGCCGGCCG CCGCAGGCCT GGTGCACGTG TCGTCCGCTG CCACCAGACT GACCAACTCG 
CACGCCATGG GCAGCTTTTC CGGGGTGGCA GGCGGCACAG TTGGAGGTAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115871.1
CDS	37..4650
Translation	MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN

Target ORF information:

RefSeq Version	NM_032482.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032482.2

ORF Insert Sequence:

ATGGGGGAGA AGCTGGAGCT GAGACTGAAG TCGCCCGTGG GGGCTGAGCC CGCCGTCTAC 
CCGTGGCCGC TGCCGGTCTA CGATAAACAT CACGATGCTG CTCATGAAAT CATCGAGACC 
ATCCGATGGG TCTGTGAAGA AATCCCGGAT CTCAAGCTCG CTATGGAGAA TTACGTTTTA 
ATTGACTATG ACACCAAAAG CTTCGAGAGC ATGCAGAGGC TCTGCGACAA GTACAACCGT 
GCCATCGACA GCATCCACCA GCTGTGGAAG GGCACCACGC AGCCCATGAA GCTGAACACG 
CGGCCGTCCA CTGGACTCCT GCGCCATATC CTGCAGCAGG TCTACAACCA CTCGGTGACC 
GACCCCGAGA AGCTCAACAA CTACGAGCCC TTCTCCCCCG AGGTGTACGG GGAGACCTCC 
TTCGACCTGG TGGCCCAGAT GATTGATGAG ATCAAGATGA CCGACGACGA CCTGTTTGTG 
GACTTGGGGA GCGGTGTGGG CCAGGTCGTG CTCCAGGTTG CTGCTGCCAC CAACTGCAAA 
CATCACTATG GCGTCGAGAA AGCAGACATC CCGGCCAAGT ATGCGGAGAC CATGGACCGC 
GAGTTCAGGA AGTGGATGAA ATGGTATGGA AAAAAGCATG CAGAATACAC ATTGGAGAGA 
GGCGATTTCC TCTCAGAAGA GTGGAGGGAG CGAATCGCCA ACACGAGTGT TATATTTGTG 
AATAATTTTG CCTTTGGTCC TGAGGTGGAT CACCAGCTGA AGGAGCGGTT TGCAAACATG 
AAGGAAGGTG GCAGAATCGT GTCCTCGAAA CCCTTTGCAC CTCTGAACTT CAGAATAAAC 
AGTAGAAACT TGAGTGACAT CGGCACCATC ATGCGCGTGG TGGAGCTCTC GCCCCTGAAG 
GGCTCGGTGT CGTGGACGGG GAAGCCAGTC TCCTACTACC TGCACACTAT CGACCGCACC 
ATACTTGAAA ACTATTTTTC TAGTCTGAAA AACCCAAAAC TCAGGGAGGA ACAGGAGGCA 
GCCCGGCGCC GCCAGCAGCG CGAGAGCAAG AGCAACGCGG CCACGCCCAC TAAGGGCCCA 
GAGGGCAAGG TGGCCGGCCC CGCCGACGCC CCCATGGACT CTGGTGCTGA GGAAGAGAAG 
GCGGGAGCAG CCACCGTGAA GAAGCCGTCT CCCTCCAAAG CCCGCAAGAA GAAGCTAAAC 
AAGAAGGGGA GGAAGATGGC TGGCCGCAAG CGCGGGCGCC CCAAGAAGAT GAACACTGCG 
AACCCCGAGC GGAAGCCCAA GAAGAACCAA ACTGCACTGG ATGCCCTGCA CGCTCAGACC 
GTGTCTCAGA CGGCGGCCTC CTCACCCCAG GATGCCTACA GATCCCCTCA CAGCCCGTTC 
TACCAGCTAC CTCCGAGCGT GCAGCGGCAC TCCCCCAACC CGCTGCTGGT GGCGCCCACC 
CCGCCCGCGC TGCAGAAGCT TCTAGAGTCC TTCAAGATCC AGTACCTGCA GTTCCTGGCA 
TACACAAAGA CCCCCCAGTA CAAGGCCAGC CTGCAGGAGC TGCTGGGCCA GGAGAAGGAG 
AAGAACGCCC AGCTCCTGGG TGCGGCTCAG CAGCTCCTCA GCCACTGCCA GGCCCAGAAG 
GAGGAGATCA GGAGGCTGTT TCAGCAAAAA TTGGATGAGC TGGGTGTGAA GGCGCTGACC 
TACAACGACC TGATTCAAGC GCAGAAGGAG ATCTCCGCCC ATAACCAGCA GCTGCGGGAG 
CAGTCGGAGC AGCTGGAGCA GGACAACCGC GCGCTCCGCG GCCAGAGCTT GCAGCTGCTC 
AAGGCTCGCT GCGAGGAGCT GCAGCTGGAC TGGGCCACGC TGTCGCTGGA GAAGCTGTTG 
AAGGAGAAGC AGGCCCTGAA GAGCCAGATC TCGGAGAAGC AGAGGCACTG CCTGGAGCTG 
CAGATCAGCA TTGTGGAGCT AGAGAAGAGC CAGCGGCAGC AGGAGCTCCT GCAGCTCAAG 
TCCTGTGTGC CGCCTGACGA CGCCCTGTCC CTGCACCTGC GTGGGAAGGG CGCCCTGGGC 
CGCGAGCTGG AGCCTGACGC CAGCCGGCTG CACCTGGAGC TGGACTGCAC CAAGTTCTCG 
CTGCCTCACT TGAGCAGCAT GAGCCCGGAG CTCTCCATGA ACGGCCAGGC TGCTGGCTAT 
GAGCTCTGCG GTGTGCTGAG CCGGCCTTCG TCGAAGCAGA ACACGCCCCA GTACCTGGCC 
TCACCCCTGG ACCAGGAGGT GGTGCCCTGT ACCCCTAGCC ACGTCGGCCG GCCGCGCCTG 
GAGAAGCTGT CTGGCCTAGC CGCACCCGAC TACACTAGGC TGTCCCCGGC CAAGATTGTG 
CTGAGGCGGC ACCTGAGCCA GGACCACACG GTGCCCGGCA GGCCGGCTGC CAGTGAGCTG 
CATTCGAGAG CTGAGCACAC CAAGGAGAAC GGCCTTCCCT ACCAGAGCCC CAGCGTGCCT 
GGCAGCATGA AGCTGAGCCC TCAGGACCCG CGGCCCCTGT CCCCTGGGGC CTTGCAGCTT 
GCTGGAGAGA AGAGCAGTGA GAAGGGCCTG AGAGAGCGCG CCTACGGCAG CAGCGGGGAG 
CTCATCACCA GCCTGCCCAT CAGCATCCCG CTCAGCACCG TGCAGCCCAA CAAGCTCCCG 
GTCAGCATTC CCCTGGCCAG CGTGGTGCTG CCCAGCCGCG CCGAGAGGGC GAGGAGCACC 
CCCAGTCCCG TGCTGCAGCC CCGTGACCCC TCGTCCACAC TTGAAAAGCA GATTGGTGCT 
AATGCCCACG GTGCTGGGAG CAGAAGCCTT GCCCTGGCCC CCGCAGGCTT CTCCTACGCT 
GGCTCGGTGG CCATCAGCGG GGCCTTGGCG GGCAGCCCGG CCTCTCTCAC ACCTGGAGCC 
GAGCCGGCCA CCTTGGATGA GTCCTCCAGC TCTGGGAGCC TTTTTGCCAC CGTGGGGTCC 
CGCAGCTCCA CGCCACAGCA CCCCCTGCTG CTGGCACAGC CCCGGAACTC GCTTCCTGCC 
TCTCCCGCCC ACCAGCTCTC CTCCAGTCCC CGGCTTGGTG GGGCCGCCCA GGGCCCGTTG 
CCCGAGGCCA GCAAGGGAGA CCTGCCCTCC GATTCCGGCT TCTCAGATCC TGAGAGTGAA 
GCCAAGAGGA GGATTGTGTT CACCATCACC ACTGGTGCGG GCAGTGCCAA GCAGTCGCCC 
TCCAGCAAGC ACAGCCCCCT GACCGCCAGC GCCCGTGGGG ACTGTGTGCC GAGCCACGGG 
CAGGACAGTC GCAGGCGCGG CCGGCGGAAG CGAGCATCTG CGGGGACGCC CAGCTTGAGC 
GCAGGCGTGT CCCCCAAGCG CCGAGCCCTG CCGTCCGTCG CTGGCCTTTT CACACAGCCT 
TCGGGGTCTC CCCTCAACCT CAACTCCATG GTCAGTAACA TCAACCAGCC CCTGGAGATT 
ACAGCCATCT CGTCCCCGGA GACCTCCCTG AAGAGCTCCC CTGTGCCCTA CCAGGACCAC 
GACCAGCCCC CCGTGCTCAA GAAGGAGCGG CCTCTGAGCC AGACCAATGG GGCACACTAC 
TCCCCACTCA CCTCAGACGA GGAGCCAGGC TCTGAGGACG AGCCCAGCAG TGCTCGAATT 
GAGAGAAAAA TTGCAACAAT CTCCTTAGAA AGCAAATCTC CCCCGAAAAC CTTGGAAAAT 
GGTGGTGGCT TGGCGGGAAG GAAGCCCGCG CCCGCCGGCG AGCCAGTCAA TAGCAGCAAG 
TGGAAGTCCA CCTTCTCGCC CATCTCCGAC ATCGGCCTGG CCAAGTCGGC GGACAGCCCG 
CTGCAGGCCA GCTCCGCCCT CAGCCAGAAC TCCCTGTTCA CGTTCCGGCC CGCCCTGGAG 
GAGCCCTCTG CCGATGCCAA GCTGGCCGCT CACCCCAGGA AAGGCTTTCC CGGCTCCCTG 
TCGGGGGCTG ACGGACTCAG CCCGGGCACC AACCCTGCCA ACGGCTGCAC CTTCGGCGGG 
GGCCTGGCCG CGGACCTGAG TTTACACAGC TTCAGTGATG GTGCTTCTCT TCCCCACAAG 
GGCCCCGAGG CGGCCGGCCT GAGCTCCCCG CTGAGCTTCC CCTCGCAGCG CGGCAAGGAG 
GGCTCGGACG CCAACCCTTT CCTGAGCAAG AGGCAGCTGG ACGGCCTGGC TGGGCTGAAG 
GGCGAGGGCA GCCGCGGCAA GGAGGCAGGG GAGGGCGGCC TACCGCTGTG CGGGCCCACG 
GACAAGACCC CACTGCTGAG CGGCAAGGCC GCCAAGGCCC GGGACCGCGA GGTCGACCTC 
AAGAATGGCC ACAACCTCTT CATCTCTGCG GCGGCCGTGC CTCCCGGAAG CCTCCTCAGC 
GGCCCCGGCC TGGCCCCGGC GGCGTCCTCC GCAGGCGGCG CGGCGTCCTC CGCCCAGACG 
CACCGGTCCT TCCTGGGCCC CTTCCCGCCG GGACCGCAGT TCGCGCTCGG CCCCATGTCC 
CTGCAGGCCA ACCTCGGCTC CGTGGCCGGC TCCTCCGTGC TGCAGTCGCT GTTCAGCTCT 
GTGCCGGCCG CCGCAGGCCT GGTGCACGTG TCGTCCGCTG CCACCAGACT GACCAACTCG 
CACGCCATGG GCAGCTTTTC CGGGGTGGCA GGCGGCACAG TTGGAGGTAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase.
Genes & development33(11-12)620-625(2019 06)
Jang S,Kang C,Yang HS,Jung T,Hebert H,Chung KY,Kim SJ,Hohng S,Song JJ

Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination.
Molecular cell74(5)1010-1019.e6(2019 06)
Valencia-Sánchez MI,De Ioannes P,Wang M,Vasilyev N,Chen R,Nudler E,Armache JP,Armache KJ

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness.
Clinical epigenetics11(1)4(2019 01)
Kari V,Raul SK,Henck JM,Kitz J,Kramer F,Kosinsky RL,Übelmesser N,Mansour WY,Eggert J,Spitzner M,Najafova Z,Bastians H,Grade M,Gaedcke J,Wegwitz F,Johnsen SA

Selective DOT1L, LSD1, and HDAC Class I Inhibitors Reduce HOXA9 Expression in MLL-AF9 Rearranged Leukemia Cells, But Dysregulate the Expression of Many Histone-Modifying Enzymes.
Journal of proteome research17(8)2657-2667(2018 08)
Lillico R,Lawrence CK,Lakowski TM

Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage.
Stem cell research & therapy9(1)97(2018 04)
Pursani V,Bhartiya D,Tanavde V,Bashir M,Sampath P

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DOT1L cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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