CCDC115 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCDC115
Entrez Gene ID	84317
Full Name	coiled-coil domain containing 115
Synonyms	CDG2O,ccp1
General protein information	Preferred Names coiled-coil domain containing 115 Names coiled-coil domain-containing protein 115
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q21.1
Summary	The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) vesicles in some human cells. The encoded protein shares some homology with the yeast V-ATPase assembly factor Vma22p, and the orthologous protein in mouse promotes cell proliferation and suppresses cell death. Defects in this gene are a cause of congenital disorder of glycosylation, type IIo in humans. [provided by RefSeq, Mar 2016].
Disorder MIM:	613734
Disorder Html:	Congenital disorder of glycosylation, type IIo, 616828 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_032357.4	NP_115733.2	coiled-coil domain-containing protein 115 isoform a
NM_032357.3	NP_115733.2	coiled-coil domain-containing protein 115 isoform a
NM_001321119.1	NP_001308048.1	coiled-coil domain-containing protein 115 isoform c
NM_001321119.2	NP_001308048.2	coiled-coil domain-containing protein 115 isoform d
NM_001321118.1	NP_001308047.1	coiled-coil domain-containing protein 115 isoform b

Pathways from BioSystems

Homologies

Homo sapiens (human)	CCDC115	NP_115733.2
Pan troglodytes (chimpanzee)	CCDC115	XP_001142734.1
Canis lupus familiaris (dog)	CCDC115	XP_005635680.1
Macaca mulatta (Rhesus monkey)	LOC702032	XP_001093120.2
Rattus norvegicus (Norway rat)	Ccdc115	NP_001102263.1
Bos taurus (cattle)	CCDC115	NP_001029616.1
Danio rerio (zebrafish)	zgc:113121	NP_001013313.1
Bos taurus (cattle)	LOC614882	XP_002696395.1
Mus musculus (house mouse)	Ccdc115	NP_081435.1

Gene Ontology
Bibliography

Related articles in PubMed

CCDC115-CDG: A new rare and misleading inherited cause of liver disease.
Girard M, Poujois A, Fabre M, Lacaille F, Debray D, Rio M, Fenaille F, Cholet S, Ruel C, Caussé E, Selves J, Bridoux-Henno L, Woimant F, Dupré T, Vuillaumier-Barrot S, Seta N, Alric L, de Lonlay P, Bruneel A
Molecular genetics and metabolism124(3)228-235(2018 07)

Modifier locus mapping of a transgenic F2 mouse population identifies CCDC115 as a novel aggressive prostate cancer modifier gene in humans.
Winter JM, Curry NL, Gildea DM, Williams KA, Lee M, Hu Y, Crawford NPS
BMC genomics19(1)450(2018 Jun)

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels.
Miles AL, Burr SP, Grice GL, Nathan JA
eLife6(2017 03)

CCDC115 Deficiency Causes a Disorder of Golgi Homeostasis with Abnormal Protein Glycosylation.
Jansen JC, Cirak S, van Scherpenzeel M, Timal S, Reunert J, Rust S, Pérez B, Vicogne D, Krawitz P, Wada Y, Ashikov A, Pérez-Cerdá C, Medrano C, Arnoldy A, Hoischen A, Huijben K, Steenbergen G, Quelhas D, Diogo L, Rymen D, Jaeken J, Guffon N, Cheillan D, van den Heuvel LP, Maeda Y, Kaiser O, Schara U, Gerner P, van den Boogert MA, Holleboom AG, Nassogne MC, Sokal E, Salomon J, van den Bogaart G, Drenth JP, Huynen MA, Veltman JA, Wevers RA, Morava E, Matthijs G, Foulquier F, Marquardt T, Lefeber DJ
American journal of human genetics98(2)310-21(2016 Feb)

Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene.
Pellicano F, Thomson RE, Inman GJ, Iwata T
BMC cancer10657(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CCDC115 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCDC115 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu102748	NM_001321119.1 Latest version!	Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu108775	NM_001321119.2 Latest version!	Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu36688	NM_001321118.1 Latest version!	Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu04982	NM_032357.4 Latest version!	Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu04982	NM_032357.3	Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCDC115 ( NM_001321119.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001308048.1 Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu102748
Clone ID Related Accession (Same CDS sequence)	NM_001321119.1
Accession Version	NM_001321119.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1552233600000
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 115 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG179982.1, BC006429.1 and AA831631.1. ##Evidence-Data-START## Transcript exon combination :: BG179982.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCGCCA AGTCGGTAGG GCCCCTGCAG TATGCTTCCC ACATGGAGCC CCAGGTCTGC 
CTCCACGCCA GCGAGGCCCA GGAGGGACTC CAGAAGTTCA AGGTGGTGAG AGCTGGTGTC 
CACGCCCCAG AGGAGGTGGG GCCTCGCGAA GCAGGTCTGC GGAGGCGCAA GGGCCCCACT 
AAGACCCCAG AACCGGAGTC CTCTGAGGCC CCTCAGGACC CCCTGAACTG GTTTGGAATC 
CTAGTTCCTC ACAGTCTACG TCAGGCTCAA GCAAGCTTCC GGGATGGCCT GCAGCTGGCC 
GCAGACATAG CCAGCCTCCA GAACCGCATT GACTGGGGTC GAAGCCAGCT CCGGGGACTC 
CAAGAGAAAC TCAAGCAGCT GGAGCCTGGG GCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001308048.1
CDS	104..502
Translation	MGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA

Target ORF information:

RefSeq Version	NM_001321119.1
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001321119.1

ORF Insert Sequence:

ATGGGCGCCA AGTCGGTAGG GCCCCTGCAG TATGCTTCCC ACATGGAGCC CCAGGTCTGC 
CTCCACGCCA GCGAGGCCCA GGAGGGACTC CAGAAGTTCA AGGTGGTGAG AGCTGGTGTC 
CACGCCCCAG AGGAGGTGGG GCCTCGCGAA GCAGGTCTGC GGAGGCGCAA GGGCCCCACT 
AAGACCCCAG AACCGGAGTC CTCTGAGGCC CCTCAGGACC CCCTGAACTG GTTTGGAATC 
CTAGTTCCTC ACAGTCTACG TCAGGCTCAA GCAAGCTTCC GGGATGGCCT GCAGCTGGCC 
GCAGACATAG CCAGCCTCCA GAACCGCATT GACTGGGGTC GAAGCCAGCT CCGGGGACTC 
CAAGAGAAAC TCAAGCAGCT GGAGCCTGGG GCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCDC115 ( NM_001321119.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001308048.2 Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu108775
Clone ID Related Accession (Same CDS sequence)	NM_001321119.2
Accession Version	NM_001321119.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564243200000
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 115 isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC132479.2. On Jul 29, 2019 this sequence version replaced NM_001321119.1. COMPLETENESS: complete on the 3' end.

ATGGCGGCGC TTGACCTGCG AGCGGAGCTG GATTCGCTGG TCCTGCAGCT GCTTGGGGAC 
CTGGAGGAGC TGGAGGGGAA ACGAACGGGC TGGCTCTCGC TCGCCAAGGC TCGCTACGCG 
ATGGGCGCCA AGTCGGTAGG GCCCCTGCAG TATGCTTCCC ACATGGAGCC CCAGGTCTGC 
CTCCACGCCA GCGAGGCCCA GGAGGGACTC CAGAAGTTCA AGGTGGTGAG AGCTGGTGTC 
CACGCCCCAG AGGAGGTGGG GCCTCGCGAA GCAGGTCTGC GGAGGCGCAA GGGCCCCACT 
AAGACCCCAG AACCGGAGTC CTCTGAGGCC CCTCAGGACC CCCTGAACTG GTTTGGAATC 
CTAGTTCCTC ACAGTCTACG TCAGGCTCAA GCAAGCTTCC GGGATGGCCT GCAGCTGGCC 
GCAGACATAG CCAGCCTCCA GAACCGCATT GACTGGGGTC GAAGCCAGCT CCGGGGACTC 
CAAGAGAAAC TCAAGCAGCT GGAGCCTGGG GCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001308048.2
CDS	40..558
Translation	MAALDLRAELDSLVLQLLGDLEELEGKRTGWLSLAKARYAMGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA

Target ORF information:

RefSeq Version	NM_001321119.2
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001321119.2

ORF Insert Sequence:

ATGGCGGCGC TTGACCTGCG AGCGGAGCTG GATTCGCTGG TCCTGCAGCT GCTTGGGGAC 
CTGGAGGAGC TGGAGGGGAA ACGAACGGGC TGGCTCTCGC TCGCCAAGGC TCGCTACGCG 
ATGGGCGCCA AGTCGGTAGG GCCCCTGCAG TATGCTTCCC ACATGGAGCC CCAGGTCTGC 
CTCCACGCCA GCGAGGCCCA GGAGGGACTC CAGAAGTTCA AGGTGGTGAG AGCTGGTGTC 
CACGCCCCAG AGGAGGTGGG GCCTCGCGAA GCAGGTCTGC GGAGGCGCAA GGGCCCCACT 
AAGACCCCAG AACCGGAGTC CTCTGAGGCC CCTCAGGACC CCCTGAACTG GTTTGGAATC 
CTAGTTCCTC ACAGTCTACG TCAGGCTCAA GCAAGCTTCC GGGATGGCCT GCAGCTGGCC 
GCAGACATAG CCAGCCTCCA GAACCGCATT GACTGGGGTC GAAGCCAGCT CCGGGGACTC 
CAAGAGAAAC TCAAGCAGCT GGAGCCTGGG GCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCDC115 ( NM_001321118.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001308047.1 Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu36688
Clone ID Related Accession (Same CDS sequence)	NM_001321118.1
Accession Version	NM_001321118.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1552233600000
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 115 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC340780.1, BC006429.1 and AA831631.1. This sequence is a reference standard in the RefSeqGene project. On Mar 18, 2016 this sequence version replaced XM_005263825.1. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.91207.1, SRR1803612.27259.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAACGC CCCTTGATGG AGGATCTCGT GTGCCTATTG GCTGTCCTGC CAAACTGCGG 
AGGGTGACAA GGAAGAAGGT GGCTCCAGAT CTGGAGGGCT GGCTCTCGCT CGCCAAGGCT 
CGCTACGCGA TGGGCGCCAA GTCGGTAGGG CCCCTGCAGT ATGCTTCCCA CATGGAGCCC 
CAGGTCTGCC TCCACGCCAG CGAGGCCCAG GAGGGACTCC AGAAGTTCAA GGTGGTGAGA 
GCTGGTGTCC ACGCCCCAGA GGAGGTGGGG CCTCGCGAAG CAGGTCTGCG GAGGCGCAAG 
GGCCCCACTA AGACCCCAGA ACCGGAGTCC TCTGAGGCCC CTCAGGACCC CCTGAACTGG 
TTTGGAATCC TAGTTCCTCA CAGTCTACGT CAGGCTCAAG CAAGCTTCCG GGATGGCCTG 
CAGCTGGCCG CAGACATAGC CAGCCTCCAG AACCGCATTG ACTGGGGTCG AAGCCAGCTC 
CGGGGACTCC AAGAGAAACT CAAGCAGCTG GAGCCTGGGG CTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001308047.1
CDS	453..980
Translation	MGTPLDGGSRVPIGCPAKLRRVTRKKVAPDLEGWLSLAKARYAMGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA

Target ORF information:

RefSeq Version	NM_001321118.1
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001321118.1

ORF Insert Sequence:

ATGGGAACGC CCCTTGATGG AGGATCTCGT GTGCCTATTG GCTGTCCTGC CAAACTGCGG 
AGGGTGACAA GGAAGAAGGT GGCTCCAGAT CTGGAGGGCT GGCTCTCGCT CGCCAAGGCT 
CGCTACGCGA TGGGCGCCAA GTCGGTAGGG CCCCTGCAGT ATGCTTCCCA CATGGAGCCC 
CAGGTCTGCC TCCACGCCAG CGAGGCCCAG GAGGGACTCC AGAAGTTCAA GGTGGTGAGA 
GCTGGTGTCC ACGCCCCAGA GGAGGTGGGG CCTCGCGAAG CAGGTCTGCG GAGGCGCAAG 
GGCCCCACTA AGACCCCAGA ACCGGAGTCC TCTGAGGCCC CTCAGGACCC CCTGAACTGG 
TTTGGAATCC TAGTTCCTCA CAGTCTACGT CAGGCTCAAG CAAGCTTCCG GGATGGCCTG 
CAGCTGGCCG CAGACATAGC CAGCCTCCAG AACCGCATTG ACTGGGGTCG AAGCCAGCTC 
CGGGGACTCC AAGAGAAACT CAAGCAGCTG GAGCCTGGGG CTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCDC115 ( NM_032357.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_115733.2 Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04982
Clone ID Related Accession (Same CDS sequence)	NM_032357.4 , NM_032357.3
Accession Version	NM_032357.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1556640000000
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 115 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB025106.1, BC006429.1 and AA831631.1. On Nov 22, 2018 this sequence version replaced NM_032357.3. Transcript Variant: This variant (1) encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.992963.1, SRR3476690.685372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259229.7/ ENSP00000259229.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGC TTGACCTGCG AGCGGAGCTG GATTCGCTGG TCCTGCAGCT GCTTGGGGAC 
CTGGAGGAGC TGGAGGGGAA ACGAACGGTG TTGAACGCCC GGGTGGAGGA GGGCTGGCTC 
TCGCTCGCCA AGGCTCGCTA CGCGATGGGC GCCAAGTCGG TAGGGCCCCT GCAGTATGCT 
TCCCACATGG AGCCCCAGGT CTGCCTCCAC GCCAGCGAGG CCCAGGAGGG ACTCCAGAAG 
TTCAAGGTGG TGAGAGCTGG TGTCCACGCC CCAGAGGAGG TGGGGCCTCG CGAAGCAGGT 
CTGCGGAGGC GCAAGGGCCC CACTAAGACC CCAGAACCGG AGTCCTCTGA GGCCCCTCAG 
GACCCCCTGA ACTGGTTTGG AATCCTAGTT CCTCACAGTC TACGTCAGGC TCAAGCAAGC 
TTCCGGGATG GCCTGCAGCT GGCCGCAGAC ATAGCCAGCC TCCAGAACCG CATTGACTGG 
GGTCGAAGCC AGCTCCGGGG ACTCCAAGAG AAACTCAAGC AGCTGGAGCC TGGGGCTGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115733.2
CDS	40..582
Translation	MAALDLRAELDSLVLQLLGDLEELEGKRTVLNARVEEGWLSLAKARYAMGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA

Target ORF information:

RefSeq Version	NM_032357.4
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032357.4

ORF Insert Sequence:

ATGGCGGCGC TTGACCTGCG AGCGGAGCTG GATTCGCTGG TCCTGCAGCT GCTTGGGGAC 
CTGGAGGAGC TGGAGGGGAA ACGAACGGTG TTGAACGCCC GGGTGGAGGA GGGCTGGCTC 
TCGCTCGCCA AGGCTCGCTA CGCGATGGGC GCCAAGTCGG TAGGGCCCCT GCAGTATGCT 
TCCCACATGG AGCCCCAGGT CTGCCTCCAC GCCAGCGAGG CCCAGGAGGG ACTCCAGAAG 
TTCAAGGTGG TGAGAGCTGG TGTCCACGCC CCAGAGGAGG TGGGGCCTCG CGAAGCAGGT 
CTGCGGAGGC GCAAGGGCCC CACTAAGACC CCAGAACCGG AGTCCTCTGA GGCCCCTCAG 
GACCCCCTGA ACTGGTTTGG AATCCTAGTT CCTCACAGTC TACGTCAGGC TCAAGCAAGC 
TTCCGGGATG GCCTGCAGCT GGCCGCAGAC ATAGCCAGCC TCCAGAACCG CATTGACTGG 
GGTCGAAGCC AGCTCCGGGG ACTCCAAGAG AAACTCAAGC AGCTGGAGCC TGGGGCTGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCDC115 ( NM_032357.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115733.2 Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04982
Clone ID Related Accession (Same CDS sequence)	NM_032357.4 , NM_032357.3
Accession Version	NM_032357.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506873600000
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 115 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB025106.1, BC006429.1 and AA831631.1. On Nov 8, 2013 this sequence version replaced NM_032357.2. Transcript Variant: This variant (1) encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.201112.1, SRR1803617.183802.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC TTGACCTGCG AGCGGAGCTG GATTCGCTGG TCCTGCAGCT GCTTGGGGAC 
CTGGAGGAGC TGGAGGGGAA ACGAACGGTG TTGAACGCCC GGGTGGAGGA GGGCTGGCTC 
TCGCTCGCCA AGGCTCGCTA CGCGATGGGC GCCAAGTCGG TAGGGCCCCT GCAGTATGCT 
TCCCACATGG AGCCCCAGGT CTGCCTCCAC GCCAGCGAGG CCCAGGAGGG ACTCCAGAAG 
TTCAAGGTGG TGAGAGCTGG TGTCCACGCC CCAGAGGAGG TGGGGCCTCG CGAAGCAGGT 
CTGCGGAGGC GCAAGGGCCC CACTAAGACC CCAGAACCGG AGTCCTCTGA GGCCCCTCAG 
GACCCCCTGA ACTGGTTTGG AATCCTAGTT CCTCACAGTC TACGTCAGGC TCAAGCAAGC 
TTCCGGGATG GCCTGCAGCT GGCCGCAGAC ATAGCCAGCC TCCAGAACCG CATTGACTGG 
GGTCGAAGCC AGCTCCGGGG ACTCCAAGAG AAACTCAAGC AGCTGGAGCC TGGGGCTGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115733.2
CDS	259..801
Translation	MAALDLRAELDSLVLQLLGDLEELEGKRTVLNARVEEGWLSLAKARYAMGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA

Target ORF information:

RefSeq Version	NM_032357.3
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032357.3

ORF Insert Sequence:

ATGGCGGCGC TTGACCTGCG AGCGGAGCTG GATTCGCTGG TCCTGCAGCT GCTTGGGGAC 
CTGGAGGAGC TGGAGGGGAA ACGAACGGTG TTGAACGCCC GGGTGGAGGA GGGCTGGCTC 
TCGCTCGCCA AGGCTCGCTA CGCGATGGGC GCCAAGTCGG TAGGGCCCCT GCAGTATGCT 
TCCCACATGG AGCCCCAGGT CTGCCTCCAC GCCAGCGAGG CCCAGGAGGG ACTCCAGAAG 
TTCAAGGTGG TGAGAGCTGG TGTCCACGCC CCAGAGGAGG TGGGGCCTCG CGAAGCAGGT 
CTGCGGAGGC GCAAGGGCCC CACTAAGACC CCAGAACCGG AGTCCTCTGA GGCCCCTCAG 
GACCCCCTGA ACTGGTTTGG AATCCTAGTT CCTCACAGTC TACGTCAGGC TCAAGCAAGC 
TTCCGGGATG GCCTGCAGCT GGCCGCAGAC ATAGCCAGCC TCCAGAACCG CATTGACTGG 
GGTCGAAGCC AGCTCCGGGG ACTCCAAGAG AAACTCAAGC AGCTGGAGCC TGGGGCTGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CCDC115-CDG: A new rare and misleading inherited cause of liver disease.
Molecular genetics and metabolism124(3)228-235(2018 07)
Girard M,Poujois A,Fabre M,Lacaille F,Debray D,Rio M,Fenaille F,Cholet S,Ruel C,Caussé E,Selves J,Bridoux-Henno L,Woimant F,Dupré T,Vuillaumier-Barrot S,Seta N,Alric L,de Lonlay P,Bruneel A

Modifier locus mapping of a transgenic F2 mouse population identifies CCDC115 as a novel aggressive prostate cancer modifier gene in humans.
BMC genomics19(1)450(2018 Jun)
Winter JM,Curry NL,Gildea DM,Williams KA,Lee M,Hu Y,Crawford NPS

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels.
eLife6(2017 03)
Miles AL,Burr SP,Grice GL,Nathan JA

CCDC115 Deficiency Causes a Disorder of Golgi Homeostasis with Abnormal Protein Glycosylation.
American journal of human genetics98(2)310-21(2016 Feb)
Jansen JC,Cirak S,van Scherpenzeel M,Timal S,Reunert J,Rust S,Pérez B,Vicogne D,Krawitz P,Wada Y,Ashikov A,Pérez-Cerdá C,Medrano C,Arnoldy A,Hoischen A,Huijben K,Steenbergen G,Quelhas D,Diogo L,Rymen D,Jaeken J,Guffon N,Cheillan D,van den Heuvel LP,Maeda Y,Kaiser O,Schara U,Gerner P,van den Boogert MA,Holleboom AG,Nassogne MC,Sokal E,Salomon J,van den Bogaart G,Drenth JP,Huynen MA,Veltman JA,Wevers RA,Morava E,Matthijs G,Foulquier F,Marquardt T,Lefeber DJ

Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene.
BMC cancer10657(2010 Nov)
Pellicano F,Thomson RE,Inman GJ,Iwata T

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CCDC115 cDNA ORF clone, Homo sapiens(human)

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