| Gene Symbol | RNASEH2C |
| Entrez Gene ID | 84153 |
| Full Name | ribonuclease H2 subunit C |
| Synonyms | AGS3,AYP1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Aicardi-Goutieres syndrome 3, 610329 (3) |
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RNASEH2C cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following RNASEH2C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNASEH2C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu20612 Clone ID Related Accession (Same CDS sequence) NM_032193.3 , NM_032193.4 Accession Version NM_032193.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 495bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1556812800000 Organism Homo sapiens(human) Product ribonuclease H2 subunit C Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF346606.1, BC023588.2, AP001266.4 and BC000831.1. This sequence is a reference standard in the RefSeqGene project. On Aug 25, 2006 this sequence version replaced NM_032193.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF346606.1, SRR1803613.237853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG
GTGCCCGAGG ACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_115569.2 CDS 181..675 Translation 
Target ORF information:
RefSeq Version NM_032193.3 Organism Homo sapiens(human) Definition Homo sapiens ribonuclease H2 subunit C (RNASEH2C), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_032193.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG
GTGCCCGAGG ACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu20612 Clone ID Related Accession (Same CDS sequence) NM_032193.3 , NM_032193.4 Accession Version NM_032193.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 495bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1575820800000 Organism Homo sapiens(human) Product ribonuclease H2 subunit C Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC023588.2, AP001266.4 and BC000831.1. On Aug 31, 2019 this sequence version replaced NM_032193.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.73915.1, SRR3476690.1048405.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG
GTGCCCGAGG ACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_115569.2 CDS 41..535 Translation
Target ORF information:
RefSeq Version NM_032193.4 Organism Homo sapiens(human) Definition Homo sapiens ribonuclease H2 subunit C (RNASEH2C), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_032193.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG
GTGCCCGAGG ACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer.
PLoS genetics15(5)e1008020(2019 05)
Deasy SK,Uehara R,Vodnala SK,Yang HH,Dass RA,Hu Y,Lee MP,Crouch RJ,Hunter KW
Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Goutières Syndrome and Beyond.
Neuropediatrics47(6)355-360(2016 Dec)
Livingston JH,Crow YJ
Altered spatio-temporal dynamics of RNase H2 complex assembly at replication and repair sites in Aicardi-Goutières syndrome.
Human molecular genetics23(22)5950-60(2014 Nov)
Kind B,Muster B,Staroske W,Herce HD,Sachse R,Rapp A,Schmidt F,Koss S,Cardoso MC,Lee-Kirsch MA
The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects.
The Journal of biological chemistry286(12)10540-50(2011 Mar)
Figiel M,Chon H,Cerritelli SM,Cybulska M,Crouch RJ,Nowotny M
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