FZD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FZD1
Entrez Gene ID	8321
Full Name	frizzled class receptor 1
General protein information	Preferred Names frizzled class receptor 1 Names frizzled-1 Wnt receptor frizzled 1, seven transmembrane spanning receptor frizzled family receptor 1 frizzled homolog 1 frizzled, Drosophila, homolog of, 1 fz-1 fzE1 hFz1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q21.13
Summary	Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008].
Disorder MIM:	603408

mRNA and Protein(s)

mRNA	Protein	Name
NM_003505.1	NP_003496.1	frizzled-1
NM_003505.2	NP_003496.1	frizzled-1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FZD1	XP_519190.2
Macaca mulatta (Rhesus monkey)	FZD1	XP_001092281.1
Rattus norvegicus (Norway rat)	Fzd1	NP_067089.2
Homo sapiens (human)	FZD1	NP_003496.1
Mus musculus (house mouse)	Fzd1	NP_067432.2
Gallus gallus (chicken)	FZD1	NP_001025508.1
Danio rerio (zebrafish)	fzd7a	NP_571214.1
Drosophila melanogaster (fruit fly)	fz	NP_524812.1
Bos taurus (cattle)	FZD1	NP_001094518.1
Canis lupus familiaris (dog)	FZD1	XP_539411.3
Danio rerio (zebrafish)	fzd7b	NP_739569.1

Gene Ontology
Bibliography

Related articles in PubMed

Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis.
Wu F, Jiao J, Liu F, Yang Y, Zhang S, Fang Z, Dai Z, Sun Z
Experimental & molecular medicine51(2)23(2019 02)

Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China.
Wang X, Ning Y, Zhang P, Yang L, Li C, Zhou R, Guo X
Disease markers20193736198(2019)

Overexpression of FZD1 and CAIX are Associated with Invasion, Metastasis, and Poor-Prognosis of the Pancreatic Ductal Adenocarcinoma.
Yang L, Yang Z, Li D, Liu Z, Zou Q, Yuan Y, Xu H
Pathology oncology research : POR24(4)899-906(2018 Oct)

Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation.
Wang YH, Imai Y, Shiseki M, Tanaka J, Motoji T
Leukemia research6799-108(2018 04)

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
Voloshanenko O, Gmach P, Winter J, Kranz D, Boutros M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FZD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FZD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13313	NM_003505.2 Latest version!	Homo sapiens frizzled class receptor 1 (FZD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu13313	NM_003505.1	Homo sapiens frizzled class receptor 1 (FZD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FZD1 ( NM_003505.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_003496.1 Homo sapiens frizzled class receptor 1 (FZD1), mRNA.

Price & Availability↑

CloneID	OHu13313
Clone ID Related Accession (Same CDS sequence)	NM_003505.1 , NM_003505.2
Accession Version	NM_003505.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1944bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1541779200000
Organism	Homo sapiens(human)
Product	frizzled-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB017363.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AB017363.1 [ECO:0000345] ##Evidence-Data-END##

ATGGCTGAGG AGGAGGCGCC TAAGAAGTCC CGGGCCGCCG GCGGTGGCGC GAGCTGGGAA 
CTTTGTGCCG GGGCGCTCTC GGCCCGGCTG GCGGAGGAGG GCAGCGGGGA CGCCGGTGGC 
CGCCGCCGCC CGCCAGTTGA CCCCCGGCGA TTGGCGCGCC AGCTGCTGCT GCTGCTTTGG 
CTGCTGGAGG CTCCGCTGCT GCTGGGGGTC CGGGCCCAGG CGGCGGGCCA GGGGCCAGGC 
CAGGGGCCCG GGCCGGGGCA GCAACCGCCG CCGCCGCCTC AGCAGCAACA GAGCGGGCAG 
CAGTACAACG GCGAGCGGGG CATCTCCGTC CCGGACCACG GCTATTGCCA GCCCATCTCC 
ATCCCGCTGT GCACGGACAT CGCGTACAAC CAGACCATCA TGCCCAACCT GCTGGGCCAC 
ACGAACCAGG AGGACGCGGG CCTGGAGGTG CACCAGTTCT ACCCTCTAGT GAAAGTGCAG 
TGTTCCGCTG AGCTCAAGTT CTTCCTGTGC TCCATGTACG CGCCCGTGTG CACCGTGCTA 
GAGCAGGCGC TGCCGCCCTG CCGCTCCCTG TGCGAGCGCG CGCGCCAGGG CTGCGAGGCG 
CTCATGAACA AGTTCGGCTT CCAGTGGCCA GACACGCTCA AGTGTGAGAA GTTCCCGGTG 
CACGGCGCCG GCGAGCTGTG CGTGGGCCAG AACACGTCCG ACAAGGGCAC CCCGACGCCC 
TCGCTGCTTC CAGAGTTCTG GACCAGCAAC CCTCAGCACG GCGGCGGAGG GCACCGTGGC 
GGCTTCCCGG GGGGCGCCGG CGCGTCGGAG CGAGGCAAGT TCTCCTGCCC GCGCGCCCTC 
AAGGTGCCCT CCTACCTCAA CTACCACTTC CTGGGGGAGA AGGACTGCGG CGCACCTTGT 
GAGCCGACCA AGGTGTATGG GCTCATGTAC TTCGGGCCCG AGGAGCTGCG CTTCTCGCGC 
ACCTGGATTG GCATTTGGTC AGTGCTGTGC TGCGCCTCCA CGCTCTTCAC GGTGCTTACG 
TACCTGGTGG ACATGCGGCG CTTCAGCTAC CCGGAGCGGC CCATCATCTT CTTGTCCGGC 
TGTTACACGG CCGTGGCCGT GGCCTACATC GCCGGCTTCC TCCTGGAAGA CCGAGTGGTG 
TGTAATGACA AGTTCGCCGA GGACGGGGCA CGCACTGTGG CGCAGGGCAC CAAGAAGGAG 
GGCTGCACCA TCCTCTTCAT GATGCTCTAC TTCTTCAGCA TGGCCAGCTC CATCTGGTGG 
GTGATCCTGT CGCTCACCTG GTTCCTGGCG GCTGGCATGA AGTGGGGCCA CGAGGCCATC 
GAAGCCAACT CACAGTATTT TCACCTGGCC GCCTGGGCTG TGCCGGCCAT CAAGACCATC 
ACCATCCTGG CGCTGGGCCA GGTGGACGGC GATGTGCTGA GCGGAGTGTG CTTCGTGGGG 
CTTAACAACG TGGACGCGCT GCGTGGCTTC GTGCTGGCGC CCCTCTTCGT GTACCTGTTT 
ATCGGCACGT CCTTTCTGCT GGCCGGCTTT GTGTCGCTCT TCCGCATCCG CACCATCATG 
AAGCACGATG GCACCAAGAC CGAGAAGCTG GAGAAGCTCA TGGTGCGCAT TGGCGTCTTC 
AGCGTGCTGT ACACTGTGCC AGCCACCATC GTCATCGCCT GCTACTTCTA CGAGCAGGCC 
TTCCGGGACC AGTGGGAACG CAGCTGGGTG GCCCAGAGCT GCAAGAGCTA CGCTATCCCC 
TGCCCTCACC TCCAGGCGGG CGGAGGCGCC CCGCCGCACC CGCCCATGAG CCCGGACTTC 
ACGGTCTTCA TGATTAAGTA CCTTATGACG CTGATCGTGG GCATCACGTC GGGCTTCTGG 
ATCTGGTCCG GCAAGACCCT CAACTCCTGG AGGAAGTTCT ACACGAGGCT CACCAACAGC 
AAACAAGGGG AGACTACAGT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003496.1
CDS	414..2357
Translation	MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV

Target ORF information:

RefSeq Version	NM_003505.1
Organism	Homo sapiens(human)
Definition	Homo sapiens frizzled class receptor 1 (FZD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003505.1

ORF Insert Sequence:

ATGGCTGAGG AGGAGGCGCC TAAGAAGTCC CGGGCCGCCG GCGGTGGCGC GAGCTGGGAA 
CTTTGTGCCG GGGCGCTCTC GGCCCGGCTG GCGGAGGAGG GCAGCGGGGA CGCCGGTGGC 
CGCCGCCGCC CGCCAGTTGA CCCCCGGCGA TTGGCGCGCC AGCTGCTGCT GCTGCTTTGG 
CTGCTGGAGG CTCCGCTGCT GCTGGGGGTC CGGGCCCAGG CGGCGGGCCA GGGGCCAGGC 
CAGGGGCCCG GGCCGGGGCA GCAACCGCCG CCGCCGCCTC AGCAGCAACA GAGCGGGCAG 
CAGTACAACG GCGAGCGGGG CATCTCCGTC CCGGACCACG GCTATTGCCA GCCCATCTCC 
ATCCCGCTGT GCACGGACAT CGCGTACAAC CAGACCATCA TGCCCAACCT GCTGGGCCAC 
ACGAACCAGG AGGACGCGGG CCTGGAGGTG CACCAGTTCT ACCCTCTAGT GAAAGTGCAG 
TGTTCCGCTG AGCTCAAGTT CTTCCTGTGC TCCATGTACG CGCCCGTGTG CACCGTGCTA 
GAGCAGGCGC TGCCGCCCTG CCGCTCCCTG TGCGAGCGCG CGCGCCAGGG CTGCGAGGCG 
CTCATGAACA AGTTCGGCTT CCAGTGGCCA GACACGCTCA AGTGTGAGAA GTTCCCGGTG 
CACGGCGCCG GCGAGCTGTG CGTGGGCCAG AACACGTCCG ACAAGGGCAC CCCGACGCCC 
TCGCTGCTTC CAGAGTTCTG GACCAGCAAC CCTCAGCACG GCGGCGGAGG GCACCGTGGC 
GGCTTCCCGG GGGGCGCCGG CGCGTCGGAG CGAGGCAAGT TCTCCTGCCC GCGCGCCCTC 
AAGGTGCCCT CCTACCTCAA CTACCACTTC CTGGGGGAGA AGGACTGCGG CGCACCTTGT 
GAGCCGACCA AGGTGTATGG GCTCATGTAC TTCGGGCCCG AGGAGCTGCG CTTCTCGCGC 
ACCTGGATTG GCATTTGGTC AGTGCTGTGC TGCGCCTCCA CGCTCTTCAC GGTGCTTACG 
TACCTGGTGG ACATGCGGCG CTTCAGCTAC CCGGAGCGGC CCATCATCTT CTTGTCCGGC 
TGTTACACGG CCGTGGCCGT GGCCTACATC GCCGGCTTCC TCCTGGAAGA CCGAGTGGTG 
TGTAATGACA AGTTCGCCGA GGACGGGGCA CGCACTGTGG CGCAGGGCAC CAAGAAGGAG 
GGCTGCACCA TCCTCTTCAT GATGCTCTAC TTCTTCAGCA TGGCCAGCTC CATCTGGTGG 
GTGATCCTGT CGCTCACCTG GTTCCTGGCG GCTGGCATGA AGTGGGGCCA CGAGGCCATC 
GAAGCCAACT CACAGTATTT TCACCTGGCC GCCTGGGCTG TGCCGGCCAT CAAGACCATC 
ACCATCCTGG CGCTGGGCCA GGTGGACGGC GATGTGCTGA GCGGAGTGTG CTTCGTGGGG 
CTTAACAACG TGGACGCGCT GCGTGGCTTC GTGCTGGCGC CCCTCTTCGT GTACCTGTTT 
ATCGGCACGT CCTTTCTGCT GGCCGGCTTT GTGTCGCTCT TCCGCATCCG CACCATCATG 
AAGCACGATG GCACCAAGAC CGAGAAGCTG GAGAAGCTCA TGGTGCGCAT TGGCGTCTTC 
AGCGTGCTGT ACACTGTGCC AGCCACCATC GTCATCGCCT GCTACTTCTA CGAGCAGGCC 
TTCCGGGACC AGTGGGAACG CAGCTGGGTG GCCCAGAGCT GCAAGAGCTA CGCTATCCCC 
TGCCCTCACC TCCAGGCGGG CGGAGGCGCC CCGCCGCACC CGCCCATGAG CCCGGACTTC 
ACGGTCTTCA TGATTAAGTA CCTTATGACG CTGATCGTGG GCATCACGTC GGGCTTCTGG 
ATCTGGTCCG GCAAGACCCT CAACTCCTGG AGGAAGTTCT ACACGAGGCT CACCAACAGC 
AAACAAGGGG AGACTACAGT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FZD1 ( NM_003505.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003496.1 Homo sapiens frizzled class receptor 1 (FZD1), mRNA.

Price & Availability↑

CloneID	OHu13313
Clone ID Related Accession (Same CDS sequence)	NM_003505.1 , NM_003505.2
Accession Version	NM_003505.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1944bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571500800000
Organism	Homo sapiens(human)
Product	frizzled-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC084381.6 and AB017363.1. On May 17, 2019 this sequence version replaced NM_003505.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AB017363.1, BC051271.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000287934.4/ ENSP00000287934.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCTGAGG AGGAGGCGCC TAAGAAGTCC CGGGCCGCCG GCGGTGGCGC GAGCTGGGAA 
CTTTGTGCCG GGGCGCTCTC GGCCCGGCTG GCGGAGGAGG GCAGCGGGGA CGCCGGTGGC 
CGCCGCCGCC CGCCAGTTGA CCCCCGGCGA TTGGCGCGCC AGCTGCTGCT GCTGCTTTGG 
CTGCTGGAGG CTCCGCTGCT GCTGGGGGTC CGGGCCCAGG CGGCGGGCCA GGGGCCAGGC 
CAGGGGCCCG GGCCGGGGCA GCAACCGCCG CCGCCGCCTC AGCAGCAACA GAGCGGGCAG 
CAGTACAACG GCGAGCGGGG CATCTCCGTC CCGGACCACG GCTATTGCCA GCCCATCTCC 
ATCCCGCTGT GCACGGACAT CGCGTACAAC CAGACCATCA TGCCCAACCT GCTGGGCCAC 
ACGAACCAGG AGGACGCGGG CCTGGAGGTG CACCAGTTCT ACCCTCTAGT GAAAGTGCAG 
TGTTCCGCTG AGCTCAAGTT CTTCCTGTGC TCCATGTACG CGCCCGTGTG CACCGTGCTA 
GAGCAGGCGC TGCCGCCCTG CCGCTCCCTG TGCGAGCGCG CGCGCCAGGG CTGCGAGGCG 
CTCATGAACA AGTTCGGCTT CCAGTGGCCA GACACGCTCA AGTGTGAGAA GTTCCCGGTG 
CACGGCGCCG GCGAGCTGTG CGTGGGCCAG AACACGTCCG ACAAGGGCAC CCCGACGCCC 
TCGCTGCTTC CAGAGTTCTG GACCAGCAAC CCTCAGCACG GCGGCGGAGG GCACCGTGGC 
GGCTTCCCGG GGGGCGCCGG CGCGTCGGAG CGAGGCAAGT TCTCCTGCCC GCGCGCCCTC 
AAGGTGCCCT CCTACCTCAA CTACCACTTC CTGGGGGAGA AGGACTGCGG CGCACCTTGT 
GAGCCGACCA AGGTGTATGG GCTCATGTAC TTCGGGCCCG AGGAGCTGCG CTTCTCGCGC 
ACCTGGATTG GCATTTGGTC AGTGCTGTGC TGCGCCTCCA CGCTCTTCAC GGTGCTTACG 
TACCTGGTGG ACATGCGGCG CTTCAGCTAC CCGGAGCGGC CCATCATCTT CTTGTCCGGC 
TGTTACACGG CCGTGGCCGT GGCCTACATC GCCGGCTTCC TCCTGGAAGA CCGAGTGGTG 
TGTAATGACA AGTTCGCCGA GGACGGGGCA CGCACTGTGG CGCAGGGCAC CAAGAAGGAG 
GGCTGCACCA TCCTCTTCAT GATGCTCTAC TTCTTCAGCA TGGCCAGCTC CATCTGGTGG 
GTGATCCTGT CGCTCACCTG GTTCCTGGCG GCTGGCATGA AGTGGGGCCA CGAGGCCATC 
GAAGCCAACT CACAGTATTT TCACCTGGCC GCCTGGGCTG TGCCGGCCAT CAAGACCATC 
ACCATCCTGG CGCTGGGCCA GGTGGACGGC GATGTGCTGA GCGGAGTGTG CTTCGTGGGG 
CTTAACAACG TGGACGCGCT GCGTGGCTTC GTGCTGGCGC CCCTCTTCGT GTACCTGTTT 
ATCGGCACGT CCTTTCTGCT GGCCGGCTTT GTGTCGCTCT TCCGCATCCG CACCATCATG 
AAGCACGATG GCACCAAGAC CGAGAAGCTG GAGAAGCTCA TGGTGCGCAT TGGCGTCTTC 
AGCGTGCTGT ACACTGTGCC AGCCACCATC GTCATCGCCT GCTACTTCTA CGAGCAGGCC 
TTCCGGGACC AGTGGGAACG CAGCTGGGTG GCCCAGAGCT GCAAGAGCTA CGCTATCCCC 
TGCCCTCACC TCCAGGCGGG CGGAGGCGCC CCGCCGCACC CGCCCATGAG CCCGGACTTC 
ACGGTCTTCA TGATTAAGTA CCTTATGACG CTGATCGTGG GCATCACGTC GGGCTTCTGG 
ATCTGGTCCG GCAAGACCCT CAACTCCTGG AGGAAGTTCT ACACGAGGCT CACCAACAGC 
AAACAAGGGG AGACTACAGT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003496.1
CDS	449..2392
Translation	MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV

Target ORF information:

RefSeq Version	NM_003505.2
Organism	Homo sapiens(human)
Definition	Homo sapiens frizzled class receptor 1 (FZD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003505.2

ORF Insert Sequence:

ATGGCTGAGG AGGAGGCGCC TAAGAAGTCC CGGGCCGCCG GCGGTGGCGC GAGCTGGGAA 
CTTTGTGCCG GGGCGCTCTC GGCCCGGCTG GCGGAGGAGG GCAGCGGGGA CGCCGGTGGC 
CGCCGCCGCC CGCCAGTTGA CCCCCGGCGA TTGGCGCGCC AGCTGCTGCT GCTGCTTTGG 
CTGCTGGAGG CTCCGCTGCT GCTGGGGGTC CGGGCCCAGG CGGCGGGCCA GGGGCCAGGC 
CAGGGGCCCG GGCCGGGGCA GCAACCGCCG CCGCCGCCTC AGCAGCAACA GAGCGGGCAG 
CAGTACAACG GCGAGCGGGG CATCTCCGTC CCGGACCACG GCTATTGCCA GCCCATCTCC 
ATCCCGCTGT GCACGGACAT CGCGTACAAC CAGACCATCA TGCCCAACCT GCTGGGCCAC 
ACGAACCAGG AGGACGCGGG CCTGGAGGTG CACCAGTTCT ACCCTCTAGT GAAAGTGCAG 
TGTTCCGCTG AGCTCAAGTT CTTCCTGTGC TCCATGTACG CGCCCGTGTG CACCGTGCTA 
GAGCAGGCGC TGCCGCCCTG CCGCTCCCTG TGCGAGCGCG CGCGCCAGGG CTGCGAGGCG 
CTCATGAACA AGTTCGGCTT CCAGTGGCCA GACACGCTCA AGTGTGAGAA GTTCCCGGTG 
CACGGCGCCG GCGAGCTGTG CGTGGGCCAG AACACGTCCG ACAAGGGCAC CCCGACGCCC 
TCGCTGCTTC CAGAGTTCTG GACCAGCAAC CCTCAGCACG GCGGCGGAGG GCACCGTGGC 
GGCTTCCCGG GGGGCGCCGG CGCGTCGGAG CGAGGCAAGT TCTCCTGCCC GCGCGCCCTC 
AAGGTGCCCT CCTACCTCAA CTACCACTTC CTGGGGGAGA AGGACTGCGG CGCACCTTGT 
GAGCCGACCA AGGTGTATGG GCTCATGTAC TTCGGGCCCG AGGAGCTGCG CTTCTCGCGC 
ACCTGGATTG GCATTTGGTC AGTGCTGTGC TGCGCCTCCA CGCTCTTCAC GGTGCTTACG 
TACCTGGTGG ACATGCGGCG CTTCAGCTAC CCGGAGCGGC CCATCATCTT CTTGTCCGGC 
TGTTACACGG CCGTGGCCGT GGCCTACATC GCCGGCTTCC TCCTGGAAGA CCGAGTGGTG 
TGTAATGACA AGTTCGCCGA GGACGGGGCA CGCACTGTGG CGCAGGGCAC CAAGAAGGAG 
GGCTGCACCA TCCTCTTCAT GATGCTCTAC TTCTTCAGCA TGGCCAGCTC CATCTGGTGG 
GTGATCCTGT CGCTCACCTG GTTCCTGGCG GCTGGCATGA AGTGGGGCCA CGAGGCCATC 
GAAGCCAACT CACAGTATTT TCACCTGGCC GCCTGGGCTG TGCCGGCCAT CAAGACCATC 
ACCATCCTGG CGCTGGGCCA GGTGGACGGC GATGTGCTGA GCGGAGTGTG CTTCGTGGGG 
CTTAACAACG TGGACGCGCT GCGTGGCTTC GTGCTGGCGC CCCTCTTCGT GTACCTGTTT 
ATCGGCACGT CCTTTCTGCT GGCCGGCTTT GTGTCGCTCT TCCGCATCCG CACCATCATG 
AAGCACGATG GCACCAAGAC CGAGAAGCTG GAGAAGCTCA TGGTGCGCAT TGGCGTCTTC 
AGCGTGCTGT ACACTGTGCC AGCCACCATC GTCATCGCCT GCTACTTCTA CGAGCAGGCC 
TTCCGGGACC AGTGGGAACG CAGCTGGGTG GCCCAGAGCT GCAAGAGCTA CGCTATCCCC 
TGCCCTCACC TCCAGGCGGG CGGAGGCGCC CCGCCGCACC CGCCCATGAG CCCGGACTTC 
ACGGTCTTCA TGATTAAGTA CCTTATGACG CTGATCGTGG GCATCACGTC GGGCTTCTGG 
ATCTGGTCCG GCAAGACCCT CAACTCCTGG AGGAAGTTCT ACACGAGGCT CACCAACAGC 
AAACAAGGGG AGACTACAGT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis.
Experimental & molecular medicine51(2)23(2019 02)
Wu F,Jiao J,Liu F,Yang Y,Zhang S,Fang Z,Dai Z,Sun Z

Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China.
Disease markers20193736198(2019)
Wang X,Ning Y,Zhang P,Yang L,Li C,Zhou R,Guo X

Overexpression of FZD1 and CAIX are Associated with Invasion, Metastasis, and Poor-Prognosis of the Pancreatic Ductal Adenocarcinoma.
Pathology oncology research : POR24(4)899-906(2018 Oct)
Yang L,Yang Z,Li D,Liu Z,Zou Q,Yuan Y,Xu H

Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation.
Leukemia research6799-108(2018 04)
Wang YH,Imai Y,Shiseki M,Tanaka J,Motoji T

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 11)
Voloshanenko O,Gmach P,Winter J,Kranz D,Boutros M

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FZD1 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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