Fzd1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fzd1
Entrez Gene ID	58868
Full Name	frizzled class receptor 1
General protein information	Preferred Names frizzled class receptor 1 Names frizzled-1 Drosophila polarity gene (frizzled) homologue Drosophila polarity gene homolog 1 frizzled family receptor 1 fz-1 rFz1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q13
Summary	G-protein-coupled receptor; may mediate signals required for normal morphogenesis and differentiation; may play a role in bone resorption [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021266.3	NP_067089.2	frizzled-1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FZD1	XP_519190.2
Macaca mulatta (Rhesus monkey)	FZD1	XP_001092281.1
Rattus norvegicus (Norway rat)	Fzd1	NP_067089.2
Homo sapiens (human)	FZD1	NP_003496.1
Mus musculus (house mouse)	Fzd1	NP_067432.2
Gallus gallus (chicken)	FZD1	NP_001025508.1
Danio rerio (zebrafish)	fzd7a	NP_571214.1
Drosophila melanogaster (fruit fly)	fz	NP_524812.1
Bos taurus (cattle)	FZD1	NP_001094518.1
Canis lupus familiaris (dog)	FZD1	XP_539411.3
Danio rerio (zebrafish)	fzd7b	NP_739569.1

Gene Ontology
Bibliography

Related articles in PubMed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
Voloshanenko O, Gmach P, Winter J, Kranz D, Boutros M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 11)

A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons.
Roet KC, Franssen EH, de Bree FM, Essing AH, Zijlstra SJ, Fagoe ND, Eggink HM, Eggers R, Smit AB, van Kesteren RE, Verhaagen J
The Journal of neuroscience : the official journal of the Society for Neuroscience33(27)11116-35(2013 Jul)

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection.
L'episcopo F, Serapide MF, Tirolo C, Testa N, Caniglia S, Morale MC, Pluchino S, Marchetti B
Molecular neurodegeneration649(2011 Jul)

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Kuo JC, Han X, Hsiao CT, Yates JR 3rd, Waterman CM
Nature cell biology13(4)383-93(2011 Apr)

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.
Yu H, Smallwood PM, Wang Y, Vidaltamayo R, Reed R, Nathans J
Development (Cambridge, England)137(21)3707-17(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Fzd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fzd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13718	NM_021266.3 Latest version!	Rattus norvegicus frizzled class receptor 1 (Fzd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fzd1 ( NM_021266.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067089.2 Rattus norvegicus frizzled class receptor 1 (Fzd1), mRNA.

Price & Availability↑

CloneID	ORa13718
Clone ID Related Accession (Same CDS sequence)	NM_021266.3
Accession Version	NM_021266.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1929bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	frizzled-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC111275.4. On Oct 12, 2007 this sequence version replaced NM_021266.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGCTGAGG AGGCGGTGCC TAGCGAGTCC CGGGCCGCCG GCCGGCCGAG CTTGGAACTT 
TGTGCCGTAG CACTCCCCGG CCGGCGGGAG GAGGTGGGGC ACCAGGACAC GGCTGGCCAC 
CGCCGGCCCC GGGCTGACTC CCGGTGCTGG GCTAGAGGGC TACTGCTGCT TCTTTGGCTG 
CTGGAGGCTC CTCTGCTTTT GGGGGTCCGA GCGCAGGCGG CGGGCCAGGT ATCCGGGCCG 
GGCCAGCAAG CTCCGCCGCC GCCCCAGCCA CAGCAGGGCG GGCAGCAGTA CAACGGCGAA 
CGGGGCATCT CCATCCCGGA CCACGGCTAC TGTCAGCCCA TCTCCATCCC GCTGTGCACG 
GACATCGCGT ACAATCAGAC CATCATGCCC AACCTGCTGG GCCACACGAA TCAGGAGGAC 
GCCGGCCTGG AGGTGCACCA GTTCTACCCG TTGGTGAAGG TGCAGTGCTC AGCCGAGCTC 
AAGTTCTTCC TGTGCTCCAT GTACGCGCCT GTGTGCACCG TACTGGAGCA GGCGCTGCCG 
CCCTGCCGCT CCCTGTGCGA GCGCGCGCGC CAGGGCTGCG AGGCACTCAT GAACAAGTTC 
GGCTTCCAGT GGCCAGACAC GCTCAAGTGC GAGAAGTTCC CTGTGCACGG CGCAGGAGAG 
CTGTGCGTGG GCCAGAACAC TTCCGACAAA GGCACCCCGA CTCCCTCCTT GCTGCCGGAG 
TTCTGGACCA GCAATCCGCA GCACGGCGGC GGTGGTTACC GCGGCGGCTA CCCGGGAGGT 
GCCGGCCCCG TGGAGCGGGG AAAGTTCTCC TGCCCGCGCG CCCTCAGGGT GCCTTCCTAC 
CTCAACTATC ACTTTCTGGG GGAGAAGGAC TGCGGCGCGC CCTGCGAACC CACTAAAGTA 
TACGGGCTCA TGTACTTCGG GCCTGAGGAG TTGCGCTTTT CGCGCACCTG GATAGGCATC 
TGGTCGGTGC TGTGCTGCGC CTCCACGCTC TTCACGGTGC TCACGTACCT AGTAGACATG 
CGGCGCTTCA GCTACCCGGA GCGGCCCATT ATTTTCCTGT CCGGCTGTTA CACAGCGGTG 
GCGGTGGCCT ATATCGCCGG CTTTCTGTTG GAGGACCGGG TGGTGTGCAA CGACAAGTTT 
GCAGAGGACG GGGCGCGCAC GGTGGCGCAG GGCACTAAGA AGGAGGGGTG CACCATCCTC 
TTTATGATGC TCTACTTCTT CAGCATGGCC AGCTCCATCT GGTGGGTAAT CCTGTCCCTC 
ACCTGGTTCC TGGCAGCCGG CATGAAGTGG GGCCACGAAG CCATCGAGGC CAACTCACAA 
TATTTTCACC TAGCCGCCTG GGCTGTACCA GCCATTAAAA CTATAACCAT CCTGGCGCTG 
GGCCAAGTGG ATGGCGACGT ACTGAGTGGA GTGTGTTTTG TGGGGCTCAA TAACGTGGAT 
GCTCTGCGGG GCTTTGTGCT GGCGCCGCTC TTCGTCTATC TGTTCATCGG CACCTCTTTC 
CTGCTGGCTG GTTTCGTGTC GCTCTTCCGC ATCCGCACCA TCATGAAGCA TGACGGCACC 
AAGACAGAGA AACTGGAAAA GCTCATGGTG CGCATCGGAG TCTTCAGTGT GCTCTACACC 
GTGCCGGCCA CCATCGTCAT CGCCTGCTAC TTCTATGAGC AGGCCTTTCG GGACCAGTGG 
GAGCGCAGCT GGGTGGCCCA GAGCTGCAAG AGTTATGCCA TCCCTTGCCC TCACCTCCAA 
GGAGGTGGAG GCGTCCCACC ACACCCACCC ATGAGCCCCG ACTTTACAGT CTTCATGATC 
AAGTATCTCA TGACGCTAAT TGTGGGCATC ACATCAGGCT TCTGGATCTG GTCCGGCAAG 
ACACTGAATT CCTGGAGGAA GTTCTACACG AGGCTTACCA ACAGCAAACA GGGGGAGACT 
ACCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067089.2
CDS	413..2341
Translation	MAEEAVPSESRAAGRPSLELCAVALPGRREEVGHQDTAGHRRPRADSRCWARGLLLLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQPQQGGQQYNGERGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGPVERGKFSCPRALRVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV

Target ORF information:

RefSeq Version	NM_021266.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus frizzled class receptor 1 (Fzd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021266.3

ORF Insert Sequence:

ATGGCTGAGG AGGCGGTGCC TAGCGAGTCC CGGGCCGCCG GCCGGCCGAG CTTGGAACTT 
TGTGCCGTAG CACTCCCCGG CCGGCGGGAG GAGGTGGGGC ACCAGGACAC GGCTGGCCAC 
CGCCGGCCCC GGGCTGACTC CCGGTGCTGG GCTAGAGGGC TACTGCTGCT TCTTTGGCTG 
CTGGAGGCTC CTCTGCTTTT GGGGGTCCGA GCGCAGGCGG CGGGCCAGGT ATCCGGGCCG 
GGCCAGCAAG CTCCGCCGCC GCCCCAGCCA CAGCAGGGCG GGCAGCAGTA CAACGGCGAA 
CGGGGCATCT CCATCCCGGA CCACGGCTAC TGTCAGCCCA TCTCCATCCC GCTGTGCACG 
GACATCGCGT ACAATCAGAC CATCATGCCC AACCTGCTGG GCCACACGAA TCAGGAGGAC 
GCCGGCCTGG AGGTGCACCA GTTCTACCCG TTGGTGAAGG TGCAGTGCTC AGCCGAGCTC 
AAGTTCTTCC TGTGCTCCAT GTACGCGCCT GTGTGCACCG TACTGGAGCA GGCGCTGCCG 
CCCTGCCGCT CCCTGTGCGA GCGCGCGCGC CAGGGCTGCG AGGCACTCAT GAACAAGTTC 
GGCTTCCAGT GGCCAGACAC GCTCAAGTGC GAGAAGTTCC CTGTGCACGG CGCAGGAGAG 
CTGTGCGTGG GCCAGAACAC TTCCGACAAA GGCACCCCGA CTCCCTCCTT GCTGCCGGAG 
TTCTGGACCA GCAATCCGCA GCACGGCGGC GGTGGTTACC GCGGCGGCTA CCCGGGAGGT 
GCCGGCCCCG TGGAGCGGGG AAAGTTCTCC TGCCCGCGCG CCCTCAGGGT GCCTTCCTAC 
CTCAACTATC ACTTTCTGGG GGAGAAGGAC TGCGGCGCGC CCTGCGAACC CACTAAAGTA 
TACGGGCTCA TGTACTTCGG GCCTGAGGAG TTGCGCTTTT CGCGCACCTG GATAGGCATC 
TGGTCGGTGC TGTGCTGCGC CTCCACGCTC TTCACGGTGC TCACGTACCT AGTAGACATG 
CGGCGCTTCA GCTACCCGGA GCGGCCCATT ATTTTCCTGT CCGGCTGTTA CACAGCGGTG 
GCGGTGGCCT ATATCGCCGG CTTTCTGTTG GAGGACCGGG TGGTGTGCAA CGACAAGTTT 
GCAGAGGACG GGGCGCGCAC GGTGGCGCAG GGCACTAAGA AGGAGGGGTG CACCATCCTC 
TTTATGATGC TCTACTTCTT CAGCATGGCC AGCTCCATCT GGTGGGTAAT CCTGTCCCTC 
ACCTGGTTCC TGGCAGCCGG CATGAAGTGG GGCCACGAAG CCATCGAGGC CAACTCACAA 
TATTTTCACC TAGCCGCCTG GGCTGTACCA GCCATTAAAA CTATAACCAT CCTGGCGCTG 
GGCCAAGTGG ATGGCGACGT ACTGAGTGGA GTGTGTTTTG TGGGGCTCAA TAACGTGGAT 
GCTCTGCGGG GCTTTGTGCT GGCGCCGCTC TTCGTCTATC TGTTCATCGG CACCTCTTTC 
CTGCTGGCTG GTTTCGTGTC GCTCTTCCGC ATCCGCACCA TCATGAAGCA TGACGGCACC 
AAGACAGAGA AACTGGAAAA GCTCATGGTG CGCATCGGAG TCTTCAGTGT GCTCTACACC 
GTGCCGGCCA CCATCGTCAT CGCCTGCTAC TTCTATGAGC AGGCCTTTCG GGACCAGTGG 
GAGCGCAGCT GGGTGGCCCA GAGCTGCAAG AGTTATGCCA TCCCTTGCCC TCACCTCCAA 
GGAGGTGGAG GCGTCCCACC ACACCCACCC ATGAGCCCCG ACTTTACAGT CTTCATGATC 
AAGTATCTCA TGACGCTAAT TGTGGGCATC ACATCAGGCT TCTGGATCTG GTCCGGCAAG 
ACACTGAATT CCTGGAGGAA GTTCTACACG AGGCTTACCA ACAGCAAACA GGGGGAGACT 
ACCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 11)
Voloshanenko O,Gmach P,Winter J,Kranz D,Boutros M

A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience33(27)11116-35(2013 Jul)
Roet KC,Franssen EH,de Bree FM,Essing AH,Zijlstra SJ,Fagoe ND,Eggink HM,Eggers R,Smit AB,van Kesteren RE,Verhaagen J

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection.
Molecular neurodegeneration649(2011 Jul)
L'episcopo F,Serapide MF,Tirolo C,Testa N,Caniglia S,Morale MC,Pluchino S,Marchetti B

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Nature cell biology13(4)383-93(2011 Apr)
Kuo JC,Han X,Hsiao CT,Yates JR 3rd,Waterman CM

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.
Development (Cambridge, England)137(21)3707-17(2010 Nov)
Yu H,Smallwood PM,Wang Y,Vidaltamayo R,Reed R,Nathans J