| Gene Symbol | UBTD1 |
| Entrez Gene ID | 80019 |
| Full Name | ubiquitin domain containing 1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014]. |
| Disorder MIM: |
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UBTD1 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following UBTD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBTD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu23529 Clone ID Related Accession (Same CDS sequence) NM_024954.5 , NM_024954.4 Accession Version NM_024954.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 684bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1556640000000 Organism Homo sapiens(human) Product ubiquitin domain-containing protein 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM922594.1, BC007331.2, AL359388.32 and CB306542.1. On Nov 23, 2018 this sequence version replaced NM_024954.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.82500.1, SRR3476690.423648.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370664.4/ ENSP00000359698.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661ATGGGCAACT GCGTGGGGAG ACAGCGCCGG GAGAGGCCGG CAGCCCCGGG ACACCCCCGC
AAGCGAGCAG GACGCAATGA GCCCCTGAAG AAAGAGCGGC TTAAGTGGAA GAGCGACTAC
CCCATGACTG ACGGGCAGCT GCGGAGCAAA CGGGATGAGT TCTGGGACAC AGCGCCTGCC
TTCGAGGGCC GCAAGGAGAT CTGGGATGCC CTCAAGGCTG CCGCCTATGC TGCTGAAGCC
AACGACCACG AGCTGGCCCA GGCCATCCTG GATGGAGCCA GCATCACCCT GCCTCATGGC
ACCCTCTGTG AATGCTACGA TGAGCTGGGC AATCGCTACC AGCTGCCCAT CTACTGCCTG
TCACCGCCGG TGAACCTGCT GCTGGAGCAC ACGGAGGAGG AGAGCCTGGA GCCCCCCGAG
CCTCCACCCA GCGTGCGCCG TGAGTTCCCG CTGAAGGTGC GCCTGTCCAC GGGCAAGGAC
GTGAGGCTCA GCGCCAGCCT GCCCGACACA GTGGGGCAGC TCAAGAGGCA GCTGCACGCC
CAGGAGGGCA TCGAGCCATC GTGGCAGCGG TGGTTCTTCT CCGGGAAGCT GCTCACAGAC
CGCACACGGC TCCAGGAGAC CAAGATCCAG AAAGATTTTG TCATCCAGGT CATCATCAAC
CAGCCCCCAC CACCCCAGGA CTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_079230.1 CDS 281..964 Translation 
Target ORF information:
RefSeq Version NM_024954.5 Organism Homo sapiens(human) Definition Homo sapiens ubiquitin domain containing 1 (UBTD1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_024954.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661ATGGGCAACT GCGTGGGGAG ACAGCGCCGG GAGAGGCCGG CAGCCCCGGG ACACCCCCGC
AAGCGAGCAG GACGCAATGA GCCCCTGAAG AAAGAGCGGC TTAAGTGGAA GAGCGACTAC
CCCATGACTG ACGGGCAGCT GCGGAGCAAA CGGGATGAGT TCTGGGACAC AGCGCCTGCC
TTCGAGGGCC GCAAGGAGAT CTGGGATGCC CTCAAGGCTG CCGCCTATGC TGCTGAAGCC
AACGACCACG AGCTGGCCCA GGCCATCCTG GATGGAGCCA GCATCACCCT GCCTCATGGC
ACCCTCTGTG AATGCTACGA TGAGCTGGGC AATCGCTACC AGCTGCCCAT CTACTGCCTG
TCACCGCCGG TGAACCTGCT GCTGGAGCAC ACGGAGGAGG AGAGCCTGGA GCCCCCCGAG
CCTCCACCCA GCGTGCGCCG TGAGTTCCCG CTGAAGGTGC GCCTGTCCAC GGGCAAGGAC
GTGAGGCTCA GCGCCAGCCT GCCCGACACA GTGGGGCAGC TCAAGAGGCA GCTGCACGCC
CAGGAGGGCA TCGAGCCATC GTGGCAGCGG TGGTTCTTCT CCGGGAAGCT GCTCACAGAC
CGCACACGGC TCCAGGAGAC CAAGATCCAG AAAGATTTTG TCATCCAGGT CATCATCAAC
CAGCCCCCAC CACCCCAGGA CTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu23529 Clone ID Related Accession (Same CDS sequence) NM_024954.5 , NM_024954.4 Accession Version NM_024954.4 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 684bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506873600000 Organism Homo sapiens(human) Product ubiquitin domain-containing protein 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM922594.1, AL359388.32, BC007331.2 and CB306542.1. On Mar 29, 2014 this sequence version replaced NM_024954.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: ERR279873.3120.1, BC007331.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661ATGGGCAACT GCGTGGGGAG ACAGCGCCGG GAGAGGCCGG CAGCCCCGGG ACACCCCCGC
AAGCGAGCAG GACGCAATGA GCCCCTGAAG AAAGAGCGGC TTAAGTGGAA GAGCGACTAC
CCCATGACTG ACGGGCAGCT GCGGAGCAAA CGGGATGAGT TCTGGGACAC AGCGCCTGCC
TTCGAGGGCC GCAAGGAGAT CTGGGATGCC CTCAAGGCTG CCGCCTATGC TGCTGAAGCC
AACGACCACG AGCTGGCCCA GGCCATCCTG GATGGAGCCA GCATCACCCT GCCTCATGGC
ACCCTCTGTG AATGCTACGA TGAGCTGGGC AATCGCTACC AGCTGCCCAT CTACTGCCTG
TCACCGCCGG TGAACCTGCT GCTGGAGCAC ACGGAGGAGG AGAGCCTGGA GCCCCCCGAG
CCTCCACCCA GCGTGCGCCG TGAGTTCCCG CTGAAGGTGC GCCTGTCCAC GGGCAAGGAC
GTGAGGCTCA GCGCCAGCCT GCCCGACACA GTGGGGCAGC TCAAGAGGCA GCTGCACGCC
CAGGAGGGCA TCGAGCCATC GTGGCAGCGG TGGTTCTTCT CCGGGAAGCT GCTCACAGAC
CGCACACGGC TCCAGGAGAC CAAGATCCAG AAAGATTTTG TCATCCAGGT CATCATCAAC
CAGCCCCCAC CACCCCAGGA CTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_079230.1 CDS 323..1006 Translation
Target ORF information:
RefSeq Version NM_024954.4 Organism Homo sapiens(human) Definition Homo sapiens ubiquitin domain containing 1 (UBTD1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_024954.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661ATGGGCAACT GCGTGGGGAG ACAGCGCCGG GAGAGGCCGG CAGCCCCGGG ACACCCCCGC
AAGCGAGCAG GACGCAATGA GCCCCTGAAG AAAGAGCGGC TTAAGTGGAA GAGCGACTAC
CCCATGACTG ACGGGCAGCT GCGGAGCAAA CGGGATGAGT TCTGGGACAC AGCGCCTGCC
TTCGAGGGCC GCAAGGAGAT CTGGGATGCC CTCAAGGCTG CCGCCTATGC TGCTGAAGCC
AACGACCACG AGCTGGCCCA GGCCATCCTG GATGGAGCCA GCATCACCCT GCCTCATGGC
ACCCTCTGTG AATGCTACGA TGAGCTGGGC AATCGCTACC AGCTGCCCAT CTACTGCCTG
TCACCGCCGG TGAACCTGCT GCTGGAGCAC ACGGAGGAGG AGAGCCTGGA GCCCCCCGAG
CCTCCACCCA GCGTGCGCCG TGAGTTCCCG CTGAAGGTGC GCCTGTCCAC GGGCAAGGAC
GTGAGGCTCA GCGCCAGCCT GCCCGACACA GTGGGGCAGC TCAAGAGGCA GCTGCACGCC
CAGGAGGGCA TCGAGCCATC GTGGCAGCGG TGGTTCTTCT CCGGGAAGCT GCTCACAGAC
CGCACACGGC TCCAGGAGAC CAAGATCCAG AAAGATTTTG TCATCCAGGT CATCATCAAC
CAGCCCCCAC CACCCCAGGA CTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop.
The Journal of pathology235(4)656-67(2015 Mar)
Zhang XW,Wang XF,Ni SJ,Qin W,Zhao LQ,Hua RX,Lu YW,Li J,Dimri GP,Guo WJ
The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.
Biochemical and biophysical research communications443(1)7-12(2014 Jan)
Uhler JP,Spåhr H,Farge G,Clavel S,Larsson NG,Falkenberg M,Samuelsson T,Gustafsson CM
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
Genome research19(10)1905-11(2009 Oct)
Markson G,Kiel C,Hyde R,Brown S,Charalabous P,Bremm A,Semple J,Woodsmith J,Duley S,Salehi-Ashtiani K,Vidal M,Komander D,Serrano L,Lehner P,Sanderson CM
A germline-specific class of small RNAs binds mammalian Piwi proteins.
Nature442(7099)199-202(2006 Jul)
Girard A,Sachidanandam R,Hannon GJ,Carmell MA
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