ZIC2 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ZIC2
Entrez Gene ID	7546
Full Name	Zic family member 2
Synonyms	HPE5
General protein information	Preferred Names Zic family member 2 Names zinc finger protein ZIC 2 Zic family member 2 (odd-paired homolog, Drosophila) Zinc finger protein of the cerebellum 2
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 13 Map Location: 13q32.3
Summary	This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2016].
Disorder MIM:	603073
Disorder Html:	Holoprosencephaly 5, 609637 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011521110.2	XP_011519412.1	zinc finger protein ZIC 2 isoform X1
NM_007129.4	NP_009060.2	zinc finger protein ZIC 2
NM_007129.5	NP_009060.2	zinc finger protein ZIC 2
NM_007129.3	NP_009060.2	zinc finger protein ZIC 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ZIC2	XP_003314245.1
Mus musculus (house mouse)	Zic2	NP_033600.3
Danio rerio (zebrafish)	zic2a	NP_571633.1
Macaca mulatta (Rhesus monkey)	ZIC2	XP_001093759.2
Homo sapiens (human)	ZIC2	NP_009060.2
Canis lupus familiaris (dog)	ZIC2	XP_542652.2
Xenopus tropicalis (tropical clawed frog)	zic2	NP_001017025.2
Rattus norvegicus (Norway rat)	Zic2	NP_001101862.2
Bos taurus (cattle)	ZIC2	NP_001193295.1
Gallus gallus (chicken)	ZIC2	XP_003640593.2

Gene Ontology
Bibliography

Related articles in PubMed

miR-1284 Inhibits the Growth and Invasion of Breast Cancer Cells by Targeting ZIC2.
Zhang P, Yang F, Luo Q, Yan D, Sun S
Oncology research27(2)253-260(2019 Feb)

miR‑1271‑5p inhibits cell proliferation and induces apoptosis in acute myeloid leukemia by targeting ZIC2.
Chen X, Yang S, Zeng J, Chen M
Molecular medicine reports19(1)508-514(2019 Jan)

The long noncoding RNA lncZic2 drives the self-renewal of liver tumor-initiating cells via the protein kinase C substrates MARCKS and MARCKSL1.
Chen Z, Liu Y, Yao L, Guo S, Gao Y, Zhu P
The Journal of biological chemistry293(21)7982-7992(2018 05)

ZIC2 promotes viability and invasion of human osteosarcoma cells by suppressing SHIP2 expression and activating PI3K/AKT pathways.
Huang S, Jin A
Journal of cellular biochemistry119(2)2248-2257(2018 02)

ZIC2 in Holoprosencephaly.
Barratt KS, Arkell RM
Advances in experimental medicine and biology1046269-299(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ZIC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZIC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu61374	XM_011521110.2 Latest version!	Homo sapiens Zic family member 2 (ZIC2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu23240	NM_007129.5 Latest version!	Homo sapiens Zic family member 2 (ZIC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$314.30 $449.00
View Old Accession Versions >>
OHu23240	NM_007129.4	Homo sapiens Zic family member 2 (ZIC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$314.30 $449.00
OHu23240	NM_007129.3	Homo sapiens Zic family member 2 (ZIC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$314.30 $449.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ZIC2 ( XM_011521110.2 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011519412.1 Homo sapiens Zic family member 2 (ZIC2), transcript variant X1, mRNA.

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CloneID	OHu61374
Clone ID Related Accession (Same CDS sequence)	XM_011521110.2
Accession Version	XM_011521110.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1284bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	zinc finger protein ZIC 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011521110.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCTGG ACGCGGGTCC GCAGTTCCCG GCCATCGGGG TGGGCAGCTT CGCGCGCCAC 
CATCACCACT CCGCCGCGGC GGCGGCGGCG GCTGCCGCCG AGATGCAGGA CCGTGAACTG 
AGCCTGGCGG CGGCGCAGAA CGGCTTCGTT GACTCCGCCG CCGCGCACAT GGGAGCCTTC 
AAGCTCAACC CGGGCGCGCA CGAGCTGTCC CCGGGCCAGA GCTCGGCGTT CACGTCGCAG 
GGCCCCGGCG CCTACCCCGG CTCCGCTGCG GCTGCCGCTG CGGCCGCAGC GCTCGGGCCC 
CACGCCGCGC ACGTTGGCTC CTACTCTGGG CCGCCCTTCA ACTCCACCCG GGACTTCCTG 
TTCCGCAGCC GCGGCTTCGG GGACTCGGCG CCGGGCGGCG GGCAGCACGG GCTGTTCGGG 
CCGGGCGCGG GCGGCCTGCA CCACGCGCAC TCGGACGCGC AGGGCCACCT CCTCTTCCCG 
GGCCTGCCAG AGCAGCACGG GCCGCACGGC TCGCAGAATG TGCTCAACGG GCAGATGCGC 
CTCGGGCTGC CCGGCGAGGT GTTCGGGCGC TCGGAGCAAT ACCGCCAGGT GGCCAGCCCG 
CGGACCGACC CCTACTCGGC GGCGCAACTC CACAACCAGT ACGGCCCCAT GAATATGAAC 
ATGGGTATGA ACATGGCAGC AGCCGCGGCC CACCACCACC ACCACCACCA CCACCACCCC 
GGTGCCTTTT TCCGCTATAT GCGGCAGCAG TGCATCAAGC AGGAGCTAAT CTGCAAGTGG 
ATCGACCCCG AGCAACTGAG CAATCCCAAG AAGAGCTGCA ACAAAACTTT CAGCACCATG 
CACGAGCTGG TGACACACGT CTCGGTGGAG CACGTCGGCG GCCCGGAGCA GAGCAACCAC 
GTCTGCTTCT GGGAGGAGTG TCCGCGCGAG GGCAAGCCCT TCAAGGCCAA ATACAAACTG 
GTCAACCACA TCCGCGTGCA CACAGGCGAG AAACCCTTCC CCTGCCCCTT CCCGGGCTGT 
GGCAAAGTCT TCGCGCGCTC CGAGAACCTC AAGATCCACA AAAGGACCCA CACAGGGGAG 
AAGCCGTTCC AGTGTGAGTT TGAGGGCTGC GACCGGCGCT TCGCCAACAG CAGCGACAGG 
AAGAAGCACA TGCACGTCCA CACCTCCGAT AAGCCCTATC TCTGCAAGAT GTGCGACAAG 
TCCTACACGC ACCCCAGCTC GCTGCGGAAG CACATGAAGT CCCCTCTGGT CCCCCCTCCC 
GGCTTTTGTC TTGCAGGTCC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011519412.1
CDS	65..1348
Translation	MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKSPLVPPPGFCLAGP

Target ORF information:

RefSeq Version	XM_011521110.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Zic family member 2 (ZIC2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521110.2

ORF Insert Sequence:

ATGCTCCTGG ACGCGGGTCC GCAGTTCCCG GCCATCGGGG TGGGCAGCTT CGCGCGCCAC 
CATCACCACT CCGCCGCGGC GGCGGCGGCG GCTGCCGCCG AGATGCAGGA CCGTGAACTG 
AGCCTGGCGG CGGCGCAGAA CGGCTTCGTT GACTCCGCCG CCGCGCACAT GGGAGCCTTC 
AAGCTCAACC CGGGCGCGCA CGAGCTGTCC CCGGGCCAGA GCTCGGCGTT CACGTCGCAG 
GGCCCCGGCG CCTACCCCGG CTCCGCTGCG GCTGCCGCTG CGGCCGCAGC GCTCGGGCCC 
CACGCCGCGC ACGTTGGCTC CTACTCTGGG CCGCCCTTCA ACTCCACCCG GGACTTCCTG 
TTCCGCAGCC GCGGCTTCGG GGACTCGGCG CCGGGCGGCG GGCAGCACGG GCTGTTCGGG 
CCGGGCGCGG GCGGCCTGCA CCACGCGCAC TCGGACGCGC AGGGCCACCT CCTCTTCCCG 
GGCCTGCCAG AGCAGCACGG GCCGCACGGC TCGCAGAATG TGCTCAACGG GCAGATGCGC 
CTCGGGCTGC CCGGCGAGGT GTTCGGGCGC TCGGAGCAAT ACCGCCAGGT GGCCAGCCCG 
CGGACCGACC CCTACTCGGC GGCGCAACTC CACAACCAGT ACGGCCCCAT GAATATGAAC 
ATGGGTATGA ACATGGCAGC AGCCGCGGCC CACCACCACC ACCACCACCA CCACCACCCC 
GGTGCCTTTT TCCGCTATAT GCGGCAGCAG TGCATCAAGC AGGAGCTAAT CTGCAAGTGG 
ATCGACCCCG AGCAACTGAG CAATCCCAAG AAGAGCTGCA ACAAAACTTT CAGCACCATG 
CACGAGCTGG TGACACACGT CTCGGTGGAG CACGTCGGCG GCCCGGAGCA GAGCAACCAC 
GTCTGCTTCT GGGAGGAGTG TCCGCGCGAG GGCAAGCCCT TCAAGGCCAA ATACAAACTG 
GTCAACCACA TCCGCGTGCA CACAGGCGAG AAACCCTTCC CCTGCCCCTT CCCGGGCTGT 
GGCAAAGTCT TCGCGCGCTC CGAGAACCTC AAGATCCACA AAAGGACCCA CACAGGGGAG 
AAGCCGTTCC AGTGTGAGTT TGAGGGCTGC GACCGGCGCT TCGCCAACAG CAGCGACAGG 
AAGAAGCACA TGCACGTCCA CACCTCCGAT AAGCCCTATC TCTGCAAGAT GTGCGACAAG 
TCCTACACGC ACCCCAGCTC GCTGCGGAAG CACATGAAGT CCCCTCTGGT CCCCCCTCCC 
GGCTTTTGTC TTGCAGGTCC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZIC2 ( NM_007129.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_009060.2 Homo sapiens Zic family member 2 (ZIC2), mRNA.

Price & Availability↑

CloneID	OHu23240
Clone ID Related Accession (Same CDS sequence)	NM_007129.4 , NM_007129.5 , NM_007129.3
Accession Version	NM_007129.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1599bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506960000000
Organism	Homo sapiens(human)
Product	zinc finger protein ZIC 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Laure Lemmens. The reference sequence was derived from AL355338.33, AF193855.1 and AA491603.1. This sequence is a reference standard in the RefSeqGene project. On Apr 13, 2017 this sequence version replaced NM_007129.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF193855.1, AF104902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCCTGG ACGCGGGTCC GCAGTTCCCG GCCATCGGGG TGGGCAGCTT CGCGCGCCAC 
CATCACCACT CCGCCGCGGC GGCGGCGGCG GCTGCCGCCG AGATGCAGGA CCGTGAACTG 
AGCCTGGCGG CGGCGCAGAA CGGCTTCGTT GACTCCGCCG CCGCGCACAT GGGAGCCTTC 
AAGCTCAACC CGGGCGCGCA CGAGCTGTCC CCGGGCCAGA GCTCGGCGTT CACGTCGCAG 
GGCCCCGGCG CCTACCCCGG CTCCGCTGCG GCTGCCGCTG CGGCCGCAGC GCTCGGGCCC 
CACGCCGCGC ACGTTGGCTC CTACTCTGGG CCGCCCTTCA ACTCCACCCG GGACTTCCTG 
TTCCGCAGCC GCGGCTTCGG GGACTCGGCG CCGGGCGGCG GGCAGCACGG GCTGTTCGGG 
CCGGGCGCGG GCGGCCTGCA CCACGCGCAC TCGGACGCGC AGGGCCACCT CCTCTTCCCG 
GGCCTGCCAG AGCAGCACGG GCCGCACGGC TCGCAGAATG TGCTCAACGG GCAGATGCGC 
CTCGGGCTGC CCGGCGAGGT GTTCGGGCGC TCGGAGCAAT ACCGCCAGGT GGCCAGCCCG 
CGGACCGACC CCTACTCGGC GGCGCAACTC CACAACCAGT ACGGCCCCAT GAATATGAAC 
ATGGGTATGA ACATGGCAGC AGCCGCGGCC CACCACCACC ACCACCACCA CCACCACCCC 
GGTGCCTTTT TCCGCTATAT GCGGCAGCAG TGCATCAAGC AGGAGCTAAT CTGCAAGTGG 
ATCGACCCCG AGCAACTGAG CAATCCCAAG AAGAGCTGCA ACAAAACTTT CAGCACCATG 
CACGAGCTGG TGACACACGT CTCGGTGGAG CACGTCGGCG GCCCGGAGCA GAGCAACCAC 
GTCTGCTTCT GGGAGGAGTG TCCGCGCGAG GGCAAGCCCT TCAAGGCCAA ATACAAACTG 
GTCAACCACA TCCGCGTGCA CACAGGCGAG AAACCCTTCC CCTGCCCCTT CCCGGGCTGT 
GGCAAAGTCT TCGCGCGCTC CGAGAACCTC AAGATCCACA AAAGGACCCA CACAGGGGAG 
AAGCCGTTCC AGTGTGAGTT TGAGGGCTGC GACCGGCGCT TCGCCAACAG CAGCGACAGG 
AAGAAGCACA TGCACGTCCA CACCTCCGAT AAGCCCTATC TCTGCAAGAT GTGCGACAAG 
TCCTACACGC ACCCCAGCTC GCTGCGGAAG CACATGAAGG TCCATGAGTC CTCCCCGCAG 
GGCTCTGAAT CCTCCCCGGC CGCCAGCTCC GGCTATGAGT CGTCCACGCC CCCGGGGCTG 
GTGTCCCCCA GCGCCGAGCC CCAGAGCAGC TCCAACCTGT CCCCAGCGGC GGCGGCAGCG 
GCGGCGGCGG CTGCGGCGGC GGCGGCCGCG GTGTCCGCGG TGCACCGGGG CGGAGGCTCG 
GGCAGTGGCG GCGCGGGAGG CGGCTCAGGC GGCGGCAGCG GCAGTGGCGG GGGCGGCGGC 
GGGGCGGGCG GCGGGGGCGG CGGCAGCTCT GGCGGGGGCA GCGGGACAGC CGGGGGTCAC 
AGCGGCCTCT CCTCCAACTT CAATGAATGG TACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009060.2
CDS	310..1908
Translation	MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGSGGGGGGAGGGGGGSSGGGSGTAGGHSGLSSNFNEWYV

Target ORF information:

RefSeq Version	NM_007129.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Zic family member 2 (ZIC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007129.4

ORF Insert Sequence:

ATGCTCCTGG ACGCGGGTCC GCAGTTCCCG GCCATCGGGG TGGGCAGCTT CGCGCGCCAC 
CATCACCACT CCGCCGCGGC GGCGGCGGCG GCTGCCGCCG AGATGCAGGA CCGTGAACTG 
AGCCTGGCGG CGGCGCAGAA CGGCTTCGTT GACTCCGCCG CCGCGCACAT GGGAGCCTTC 
AAGCTCAACC CGGGCGCGCA CGAGCTGTCC CCGGGCCAGA GCTCGGCGTT CACGTCGCAG 
GGCCCCGGCG CCTACCCCGG CTCCGCTGCG GCTGCCGCTG CGGCCGCAGC GCTCGGGCCC 
CACGCCGCGC ACGTTGGCTC CTACTCTGGG CCGCCCTTCA ACTCCACCCG GGACTTCCTG 
TTCCGCAGCC GCGGCTTCGG GGACTCGGCG CCGGGCGGCG GGCAGCACGG GCTGTTCGGG 
CCGGGCGCGG GCGGCCTGCA CCACGCGCAC TCGGACGCGC AGGGCCACCT CCTCTTCCCG 
GGCCTGCCAG AGCAGCACGG GCCGCACGGC TCGCAGAATG TGCTCAACGG GCAGATGCGC 
CTCGGGCTGC CCGGCGAGGT GTTCGGGCGC TCGGAGCAAT ACCGCCAGGT GGCCAGCCCG 
CGGACCGACC CCTACTCGGC GGCGCAACTC CACAACCAGT ACGGCCCCAT GAATATGAAC 
ATGGGTATGA ACATGGCAGC AGCCGCGGCC CACCACCACC ACCACCACCA CCACCACCCC 
GGTGCCTTTT TCCGCTATAT GCGGCAGCAG TGCATCAAGC AGGAGCTAAT CTGCAAGTGG 
ATCGACCCCG AGCAACTGAG CAATCCCAAG AAGAGCTGCA ACAAAACTTT CAGCACCATG 
CACGAGCTGG TGACACACGT CTCGGTGGAG CACGTCGGCG GCCCGGAGCA GAGCAACCAC 
GTCTGCTTCT GGGAGGAGTG TCCGCGCGAG GGCAAGCCCT TCAAGGCCAA ATACAAACTG 
GTCAACCACA TCCGCGTGCA CACAGGCGAG AAACCCTTCC CCTGCCCCTT CCCGGGCTGT 
GGCAAAGTCT TCGCGCGCTC CGAGAACCTC AAGATCCACA AAAGGACCCA CACAGGGGAG 
AAGCCGTTCC AGTGTGAGTT TGAGGGCTGC GACCGGCGCT TCGCCAACAG CAGCGACAGG 
AAGAAGCACA TGCACGTCCA CACCTCCGAT AAGCCCTATC TCTGCAAGAT GTGCGACAAG 
TCCTACACGC ACCCCAGCTC GCTGCGGAAG CACATGAAGG TCCATGAGTC CTCCCCGCAG 
GGCTCTGAAT CCTCCCCGGC CGCCAGCTCC GGCTATGAGT CGTCCACGCC CCCGGGGCTG 
GTGTCCCCCA GCGCCGAGCC CCAGAGCAGC TCCAACCTGT CCCCAGCGGC GGCGGCAGCG 
GCGGCGGCGG CTGCGGCGGC GGCGGCCGCG GTGTCCGCGG TGCACCGGGG CGGAGGCTCG 
GGCAGTGGCG GCGCGGGAGG CGGCTCAGGC GGCGGCAGCG GCAGTGGCGG GGGCGGCGGC 
GGGGCGGGCG GCGGGGGCGG CGGCAGCTCT GGCGGGGGCA GCGGGACAGC CGGGGGTCAC 
AGCGGCCTCT CCTCCAACTT CAATGAATGG TACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZIC2 ( NM_007129.5 ) cDNA ORF clone, Homo sapiens(Human) -> NP_009060.2 Homo sapiens Zic family member 2 (ZIC2), mRNA.

Price & Availability↑

CloneID	OHu23240
Clone ID Related Accession (Same CDS sequence)	NM_007129.4 , NM_007129.5 , NM_007129.3
Accession Version	NM_007129.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1599bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573833600000
Organism	Homo sapiens(human)
Product	zinc finger protein ZIC 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Laure Lemmens. The reference sequence was derived from AL355338.33, AF193855.1 and AA491603.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_007129.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF193855.1, AF104902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376335.8/ ENSP00000365514.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCCTGG ACGCGGGTCC GCAGTTCCCG GCCATCGGGG TGGGCAGCTT CGCGCGCCAC 
CATCACCACT CCGCCGCGGC GGCGGCGGCG GCTGCCGCCG AGATGCAGGA CCGTGAACTG 
AGCCTGGCGG CGGCGCAGAA CGGCTTCGTT GACTCCGCCG CCGCGCACAT GGGAGCCTTC 
AAGCTCAACC CGGGCGCGCA CGAGCTGTCC CCGGGCCAGA GCTCGGCGTT CACGTCGCAG 
GGCCCCGGCG CCTACCCCGG CTCCGCTGCG GCTGCCGCTG CGGCCGCAGC GCTCGGGCCC 
CACGCCGCGC ACGTTGGCTC CTACTCTGGG CCGCCCTTCA ACTCCACCCG GGACTTCCTG 
TTCCGCAGCC GCGGCTTCGG GGACTCGGCG CCGGGCGGCG GGCAGCACGG GCTGTTCGGG 
CCGGGCGCGG GCGGCCTGCA CCACGCGCAC TCGGACGCGC AGGGCCACCT CCTCTTCCCG 
GGCCTGCCAG AGCAGCACGG GCCGCACGGC TCGCAGAATG TGCTCAACGG GCAGATGCGC 
CTCGGGCTGC CCGGCGAGGT GTTCGGGCGC TCGGAGCAAT ACCGCCAGGT GGCCAGCCCG 
CGGACCGACC CCTACTCGGC GGCGCAACTC CACAACCAGT ACGGCCCCAT GAATATGAAC 
ATGGGTATGA ACATGGCAGC AGCCGCGGCC CACCACCACC ACCACCACCA CCACCACCCC 
GGTGCCTTTT TCCGCTATAT GCGGCAGCAG TGCATCAAGC AGGAGCTAAT CTGCAAGTGG 
ATCGACCCCG AGCAACTGAG CAATCCCAAG AAGAGCTGCA ACAAAACTTT CAGCACCATG 
CACGAGCTGG TGACACACGT CTCGGTGGAG CACGTCGGCG GCCCGGAGCA GAGCAACCAC 
GTCTGCTTCT GGGAGGAGTG TCCGCGCGAG GGCAAGCCCT TCAAGGCCAA ATACAAACTG 
GTCAACCACA TCCGCGTGCA CACAGGCGAG AAACCCTTCC CCTGCCCCTT CCCGGGCTGT 
GGCAAAGTCT TCGCGCGCTC CGAGAACCTC AAGATCCACA AAAGGACCCA CACAGGGGAG 
AAGCCGTTCC AGTGTGAGTT TGAGGGCTGC GACCGGCGCT TCGCCAACAG CAGCGACAGG 
AAGAAGCACA TGCACGTCCA CACCTCCGAT AAGCCCTATC TCTGCAAGAT GTGCGACAAG 
TCCTACACGC ACCCCAGCTC GCTGCGGAAG CACATGAAGG TCCATGAGTC CTCCCCGCAG 
GGCTCTGAAT CCTCCCCGGC CGCCAGCTCC GGCTATGAGT CGTCCACGCC CCCGGGGCTG 
GTGTCCCCCA GCGCCGAGCC CCAGAGCAGC TCCAACCTGT CCCCAGCGGC GGCGGCAGCG 
GCGGCGGCGG CTGCGGCGGC GGCGGCCGCG GTGTCCGCGG TGCACCGGGG CGGAGGCTCG 
GGCAGTGGCG GCGCGGGAGG CGGCTCAGGC GGCGGCAGCG GCAGTGGCGG GGGCGGCGGC 
GGGGCGGGCG GCGGGGGCGG CGGCAGCTCT GGCGGGGGCA GCGGGACAGC CGGGGGTCAC 
AGCGGCCTCT CCTCCAACTT CAATGAATGG TACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009060.2
CDS	282..1880
Translation	MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGSGGGGGGAGGGGGGSSGGGSGTAGGHSGLSSNFNEWYV

Target ORF information:

RefSeq Version	NM_007129.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Zic family member 2 (ZIC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007129.5

ORF Insert Sequence:

ATGCTCCTGG ACGCGGGTCC GCAGTTCCCG GCCATCGGGG TGGGCAGCTT CGCGCGCCAC 
CATCACCACT CCGCCGCGGC GGCGGCGGCG GCTGCCGCCG AGATGCAGGA CCGTGAACTG 
AGCCTGGCGG CGGCGCAGAA CGGCTTCGTT GACTCCGCCG CCGCGCACAT GGGAGCCTTC 
AAGCTCAACC CGGGCGCGCA CGAGCTGTCC CCGGGCCAGA GCTCGGCGTT CACGTCGCAG 
GGCCCCGGCG CCTACCCCGG CTCCGCTGCG GCTGCCGCTG CGGCCGCAGC GCTCGGGCCC 
CACGCCGCGC ACGTTGGCTC CTACTCTGGG CCGCCCTTCA ACTCCACCCG GGACTTCCTG 
TTCCGCAGCC GCGGCTTCGG GGACTCGGCG CCGGGCGGCG GGCAGCACGG GCTGTTCGGG 
CCGGGCGCGG GCGGCCTGCA CCACGCGCAC TCGGACGCGC AGGGCCACCT CCTCTTCCCG 
GGCCTGCCAG AGCAGCACGG GCCGCACGGC TCGCAGAATG TGCTCAACGG GCAGATGCGC 
CTCGGGCTGC CCGGCGAGGT GTTCGGGCGC TCGGAGCAAT ACCGCCAGGT GGCCAGCCCG 
CGGACCGACC CCTACTCGGC GGCGCAACTC CACAACCAGT ACGGCCCCAT GAATATGAAC 
ATGGGTATGA ACATGGCAGC AGCCGCGGCC CACCACCACC ACCACCACCA CCACCACCCC 
GGTGCCTTTT TCCGCTATAT GCGGCAGCAG TGCATCAAGC AGGAGCTAAT CTGCAAGTGG 
ATCGACCCCG AGCAACTGAG CAATCCCAAG AAGAGCTGCA ACAAAACTTT CAGCACCATG 
CACGAGCTGG TGACACACGT CTCGGTGGAG CACGTCGGCG GCCCGGAGCA GAGCAACCAC 
GTCTGCTTCT GGGAGGAGTG TCCGCGCGAG GGCAAGCCCT TCAAGGCCAA ATACAAACTG 
GTCAACCACA TCCGCGTGCA CACAGGCGAG AAACCCTTCC CCTGCCCCTT CCCGGGCTGT 
GGCAAAGTCT TCGCGCGCTC CGAGAACCTC AAGATCCACA AAAGGACCCA CACAGGGGAG 
AAGCCGTTCC AGTGTGAGTT TGAGGGCTGC GACCGGCGCT TCGCCAACAG CAGCGACAGG 
AAGAAGCACA TGCACGTCCA CACCTCCGAT AAGCCCTATC TCTGCAAGAT GTGCGACAAG 
TCCTACACGC ACCCCAGCTC GCTGCGGAAG CACATGAAGG TCCATGAGTC CTCCCCGCAG 
GGCTCTGAAT CCTCCCCGGC CGCCAGCTCC GGCTATGAGT CGTCCACGCC CCCGGGGCTG 
GTGTCCCCCA GCGCCGAGCC CCAGAGCAGC TCCAACCTGT CCCCAGCGGC GGCGGCAGCG 
GCGGCGGCGG CTGCGGCGGC GGCGGCCGCG GTGTCCGCGG TGCACCGGGG CGGAGGCTCG 
GGCAGTGGCG GCGCGGGAGG CGGCTCAGGC GGCGGCAGCG GCAGTGGCGG GGGCGGCGGC 
GGGGCGGGCG GCGGGGGCGG CGGCAGCTCT GGCGGGGGCA GCGGGACAGC CGGGGGTCAC 
AGCGGCCTCT CCTCCAACTT CAATGAATGG TACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZIC2 ( NM_007129.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_009060.2 Homo sapiens Zic family member 2 (ZIC2), mRNA.

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CloneID	OHu23240
Clone ID Related Accession (Same CDS sequence)	NM_007129.4 , NM_007129.5 , NM_007129.3
Accession Version	NM_007129.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1599bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426262400000
Organism	Homo sapiens(Human)
Product	zinc finger protein ZIC 2
Comment

ATGCTCCTGG ACGCGGGTCC GCAGTTCCCG GCCATCGGGG TGGGCAGCTT CGCGCGCCAC 
CATCACCACT CCGCCGCGGC GGCGGCGGCG GCTGCCGCCG AGATGCAGGA CCGTGAACTG 
AGCCTGGCGG CGGCGCAGAA CGGCTTCGTT GACTCCGCCG CCGCGCACAT GGGAGCCTTC 
AAGCTCAACC CGGGCGCGCA CGAGCTGTCC CCGGGCCAGA GCTCGGCGTT CACGTCGCAG 
GGCCCCGGCG CCTACCCCGG CTCCGCTGCG GCTGCCGCTG CGGCCGCAGC GCTCGGGCCC 
CACGCCGCGC ACGTTGGCTC CTACTCTGGG CCGCCCTTCA ACTCCACCCG GGACTTCCTG 
TTCCGCAGCC GCGGCTTCGG GGACTCGGCG CCGGGCGGCG GGCAGCACGG GCTGTTCGGG 
CCGGGCGCGG GCGGCCTGCA CCACGCGCAC TCGGACGCGC AGGGCCACCT CCTCTTCCCG 
GGCCTGCCAG AGCAGCACGG GCCGCACGGC TCGCAGAATG TGCTCAACGG GCAGATGCGC 
CTCGGGCTGC CCGGCGAGGT GTTCGGGCGC TCGGAGCAAT ACCGCCAGGT GGCCAGCCCG 
CGGACCGACC CCTACTCGGC GGCGCAACTC CACAACCAGT ACGGCCCCAT GAATATGAAC 
ATGGGTATGA ACATGGCAGC AGCCGCGGCC CACCACCACC ACCACCACCA CCACCACCCC 
GGTGCCTTTT TCCGCTATAT GCGGCAGCAG TGCATCAAGC AGGAGCTAAT CTGCAAGTGG 
ATCGACCCCG AGCAACTGAG CAATCCCAAG AAGAGCTGCA ACAAAACTTT CAGCACCATG 
CACGAGCTGG TGACACACGT CTCGGTGGAG CACGTCGGCG GCCCGGAGCA GAGCAACCAC 
GTCTGCTTCT GGGAGGAGTG TCCGCGCGAG GGCAAGCCCT TCAAGGCCAA ATACAAACTG 
GTCAACCACA TCCGCGTGCA CACAGGCGAG AAACCCTTCC CCTGCCCCTT CCCGGGCTGT 
GGCAAAGTCT TCGCGCGCTC CGAGAACCTC AAGATCCACA AAAGGACCCA CACAGGGGAG 
AAGCCGTTCC AGTGTGAGTT TGAGGGCTGC GACCGGCGCT TCGCCAACAG CAGCGACAGG 
AAGAAGCACA TGCACGTCCA CACCTCCGAT AAGCCCTATC TCTGCAAGAT GTGCGACAAG 
TCCTACACGC ACCCCAGCTC GCTGCGGAAG CACATGAAGG TCCATGAGTC CTCCCCGCAG 
GGCTCTGAAT CCTCCCCGGC CGCCAGCTCC GGCTATGAGT CGTCCACGCC CCCGGGGCTG 
GTGTCCCCCA GCGCCGAGCC CCAGAGCAGC TCCAACCTGT CCCCAGCGGC GGCGGCAGCG 
GCGGCGGCGG CTGCGGCGGC GGCGGCCGCG GTGTCCGCGG TGCACCGGGG CGGAGGCTCG 
GGCAGTGGCG GCGCGGGAGG CGGCTCAGGC GGCGGCAGCG GCAGTGGCGG GGGCGGCGGC 
GGGGCGGGCG GCGGGGGCGG CGGCAGCTCT GGCGGGGGCA GCGGGACAGC CGGGGGTCAC 
AGCGGCCTCT CCTCCAACTT CAATGAATGG TACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_009060.2

Translation

MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGSGGGGGGAGGGGGGSSGGGSGTAGGHSGLSSNFNEWYV

Target ORF information:

RefSeq Version	NM_007129.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens Zic family member 2 (ZIC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007129.3

ORF Insert Sequence:

ATGCTCCTGG ACGCGGGTCC GCAGTTCCCG GCCATCGGGG TGGGCAGCTT CGCGCGCCAC 
CATCACCACT CCGCCGCGGC GGCGGCGGCG GCTGCCGCCG AGATGCAGGA CCGTGAACTG 
AGCCTGGCGG CGGCGCAGAA CGGCTTCGTT GACTCCGCCG CCGCGCACAT GGGAGCCTTC 
AAGCTCAACC CGGGCGCGCA CGAGCTGTCC CCGGGCCAGA GCTCGGCGTT CACGTCGCAG 
GGCCCCGGCG CCTACCCCGG CTCCGCTGCG GCTGCCGCTG CGGCCGCAGC GCTCGGGCCC 
CACGCCGCGC ACGTTGGCTC CTACTCTGGG CCGCCCTTCA ACTCCACCCG GGACTTCCTG 
TTCCGCAGCC GCGGCTTCGG GGACTCGGCG CCGGGCGGCG GGCAGCACGG GCTGTTCGGG 
CCGGGCGCGG GCGGCCTGCA CCACGCGCAC TCGGACGCGC AGGGCCACCT CCTCTTCCCG 
GGCCTGCCAG AGCAGCACGG GCCGCACGGC TCGCAGAATG TGCTCAACGG GCAGATGCGC 
CTCGGGCTGC CCGGCGAGGT GTTCGGGCGC TCGGAGCAAT ACCGCCAGGT GGCCAGCCCG 
CGGACCGACC CCTACTCGGC GGCGCAACTC CACAACCAGT ACGGCCCCAT GAATATGAAC 
ATGGGTATGA ACATGGCAGC AGCCGCGGCC CACCACCACC ACCACCACCA CCACCACCCC 
GGTGCCTTTT TCCGCTATAT GCGGCAGCAG TGCATCAAGC AGGAGCTAAT CTGCAAGTGG 
ATCGACCCCG AGCAACTGAG CAATCCCAAG AAGAGCTGCA ACAAAACTTT CAGCACCATG 
CACGAGCTGG TGACACACGT CTCGGTGGAG CACGTCGGCG GCCCGGAGCA GAGCAACCAC 
GTCTGCTTCT GGGAGGAGTG TCCGCGCGAG GGCAAGCCCT TCAAGGCCAA ATACAAACTG 
GTCAACCACA TCCGCGTGCA CACAGGCGAG AAACCCTTCC CCTGCCCCTT CCCGGGCTGT 
GGCAAAGTCT TCGCGCGCTC CGAGAACCTC AAGATCCACA AAAGGACCCA CACAGGGGAG 
AAGCCGTTCC AGTGTGAGTT TGAGGGCTGC GACCGGCGCT TCGCCAACAG CAGCGACAGG 
AAGAAGCACA TGCACGTCCA CACCTCCGAT AAGCCCTATC TCTGCAAGAT GTGCGACAAG 
TCCTACACGC ACCCCAGCTC GCTGCGGAAG CACATGAAGG TCCATGAGTC CTCCCCGCAG 
GGCTCTGAAT CCTCCCCGGC CGCCAGCTCC GGCTATGAGT CGTCCACGCC CCCGGGGCTG 
GTGTCCCCCA GCGCCGAGCC CCAGAGCAGC TCCAACCTGT CCCCAGCGGC GGCGGCAGCG 
GCGGCGGCGG CTGCGGCGGC GGCGGCCGCG GTGTCCGCGG TGCACCGGGG CGGAGGCTCG 
GGCAGTGGCG GCGCGGGAGG CGGCTCAGGC GGCGGCAGCG GCAGTGGCGG GGGCGGCGGC 
GGGGCGGGCG GCGGGGGCGG CGGCAGCTCT GGCGGGGGCA GCGGGACAGC CGGGGGTCAC 
AGCGGCCTCT CCTCCAACTT CAATGAATGG TACGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-1284 Inhibits the Growth and Invasion of Breast Cancer Cells by Targeting ZIC2.
Oncology research27(2)253-260(2019 Feb)
Zhang P,Yang F,Luo Q,Yan D,Sun S

miR‑1271‑5p inhibits cell proliferation and induces apoptosis in acute myeloid leukemia by targeting ZIC2.
Molecular medicine reports19(1)508-514(2019 Jan)
Chen X,Yang S,Zeng J,Chen M

The long noncoding RNA lncZic2 drives the self-renewal of liver tumor-initiating cells via the protein kinase C substrates MARCKS and MARCKSL1.
The Journal of biological chemistry293(21)7982-7992(2018 05)
Chen Z,Liu Y,Yao L,Guo S,Gao Y,Zhu P

ZIC2 promotes viability and invasion of human osteosarcoma cells by suppressing SHIP2 expression and activating PI3K/AKT pathways.
Journal of cellular biochemistry119(2)2248-2257(2018 02)
Huang S,Jin A

ZIC2 in Holoprosencephaly.
Advances in experimental medicine and biology1046269-299(2018)
Barratt KS,Arkell RM

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ZIC2 cDNA ORF clone, Homo sapiens(Human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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