FOXL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FOXL2
Entrez Gene ID	668
Full Name	forkhead box L2
Synonyms	BPES,BPES1,PFRK,PINTO,POF3
General protein information	Preferred Names forkhead box L2 Names forkhead box protein L2 forkhead transcription factor FOXL2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q22.3
Summary	This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jul 2016].
Disorder MIM:	605597
Disorder Html:	Blepharophimosis, epicanthus inversus, and ptosis, type 1, 110100 (3); Blepharophimosis, epicanthus inversus, and ptosis, type 2, 110100 (3); Premature ovarian failure 3, 608996 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_023067.4	NP_075555.1	forkhead box protein L2
NM_023067.3	NP_075555.1	forkhead box protein L2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FOXL2	XP_526323.2
Macaca mulatta (Rhesus monkey)	LOC717906	XP_001109917.2
Homo sapiens (human)	FOXL2	NP_075555.1
Mus musculus (house mouse)	Foxl2	NP_036150.1
Bos taurus (cattle)	FOXL2	NP_001026920.1
Rattus norvegicus (Norway rat)	Foxl2	XP_003750619.1
Danio rerio (zebrafish)	LOC100149117	XP_001922861.1

Gene Ontology
Bibliography

Related articles in PubMed

Screening of a large cohort of blepharophimosis, ptosis, and epicanthus inversus syndrome patients reveals a very strong paternal inheritance bias and a wide spectrum of novel FOXL2 mutations.
Bunyan DJ, Thomas NS
European journal of medical genetics62(7)103668(2019 Jul)

Premature ovarian insufficiency as a variable feature of blepharophimosis, ptosis, and epicanthus inversus syndrome associated with c.223C > T p.(Leu75Phe) FOXL2 mutation: a case report.
Grzechocińska B, Warzecha D, Wypchło M, Ploski R, Wielgoś M
BMC medical genetics20(1)132(2019 07)

Deletion of FOXL2 by CRISPR promotes cell cycle G0/G1 restriction in KGN cells.
Tang B, Zhang Y, Zhang W, Zhu Y, Yuan S
International journal of molecular medicine43(1)567-574(2019 Jan)

Genetic and Functional Analyses of Two Missense Mutations in the Transcription Factor FOXL2 in Two Chinese Families with Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome.
Li H, Gu Y
Genetic testing and molecular biomarkers22(10)585-592(2018 Oct)

[Analysis of FOXL2 gene mutation and genotype-phenotype correlation in a Chinese pedigree affected with blepharophimosis-ptosis-epicanthus inversus syndrome].
Cheng H, Wang T, Wang G, Wang J, Shen L, Han M, Yang S, Shi Y, Wang W, Li H
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics35(4)515-517(2018 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FOXL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20709	NM_023067.4 Latest version!	Homo sapiens forkhead box L2 (FOXL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu20709	NM_023067.3	Homo sapiens forkhead box L2 (FOXL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FOXL2 ( NM_023067.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_075555.1 Homo sapiens forkhead box L2 (FOXL2), mRNA.

Price & Availability↑

CloneID	OHu20709
Clone ID Related Accession (Same CDS sequence)	NM_023067.4 , NM_023067.3
Accession Version	NM_023067.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1131bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	forkhead box protein L2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC062549.1, BF515406.1, BX095729.1 and AC092947.12. This sequence is a reference standard in the RefSeqGene project. On Oct 17, 2018 this sequence version replaced NM_023067.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AF301906.1, DQ089672.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000648323.1/ ENSP00000497217.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGATGGCCA GCTACCCCGA GCCCGAGGAC GCGGCGGGGG CCCTGCTGGC CCCAGAGACC 
GGTCGCACAG TCAAGGAGCC AGAAGGGCCG CCGCCGAGCC CAGGCAAGGG CGGTGGGGGT 
GGCGGCGGGA CAGCCCCGGA GAAGCCGGAC CCGGCGCAGA AGCCCCCGTA CTCGTACGTG 
GCGCTCATCG CCATGGCGAT CCGCGAGAGC GCGGAGAAGA GGCTCACGCT GTCCGGCATC 
TACCAGTACA TCATCGCGAA GTTCCCGTTC TACGAGAAGA ATAAGAAGGG CTGGCAAAAT 
AGCATCCGCC ACAACCTCAG CCTCAACGAG TGCTTCATCA AGGTGCCGCG CGAGGGCGGC 
GGCGAGCGCA AGGGCAACTA CTGGACGCTG GACCCGGCCT GCGAAGACAT GTTCGAGAAG 
GGCAACTACC GGCGCCGCCG CCGCATGAAG AGGCCCTTCC GGCCGCCGCC CGCGCACTTC 
CAGCCCGGCA AGGGGCTCTT CGGGGCCGGA GGCGCCGCAG GCGGGTGCGG CGTGGCGGGC 
GCCGGGGCCG ACGGCTACGG CTACCTGGCG CCCCCCAAGT ACCTGCAGTC TGGCTTCCTC 
AACAACTCGT GGCCGCTACC GCAGCCTCCC TCACCCATGC CCTATGCCTC CTGCCAGATG 
GCGGCAGCCG CAGCGGCTGC AGCAGCTGCG GCTGCAGCCG CGGGCCCCGG TAGCCCTGGC 
GCGGCCGCTG TGGTCAAGGG GCTGGCGGGC CCGGCCGCCT CGTACGGGCC GTACACACGC 
GTGCAGAGCA TGGCGCTGCC CCCCGGCGTA GTGAACTCGT ACAATGGCCT GGGAGGCCCG 
CCGGCCGCAC CCCCGCCTCC GCCGCACCCC CACCCGCATC CGCACGCACA CCATCTGCAC 
GCGGCCGCCG CACCGCCGCC TGCCCCACCG CACCACGGGG CCGCCGCGCC GCCGCCGGGC 
CAGCTCAGCC CTGCCAGCCC AGCCACCGCC GCGCCCCCGG CGCCCGCGCC CACCAGTGCG 
CCGGGCCTGC AGTTCGCTTG TGCCCGGCAG CCCGAGCTCG CCATGATGCA TTGCTCTTAC 
TGGGACCACG ACAGCAAGAC CGGCGCGCTG CATTCGCGCC TCGATCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075555.1
CDS	416..1546
Translation	MMASYPEPEDAAGALLAPETGRTVKEPEGPPPSPGKGGGGGGGTAPEKPDPAQKPPYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGAGGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYASCQMAAAAAAAAAAAAAAGPGSPGAAAVVKGLAGPAASYGPYTRVQSMALPPGVVNSYNGLGGPPAAPPPPPHPHPHPHAHHLHAAAAPPPAPPHHGAAAPPPGQLSPASPATAAPPAPAPTSAPGLQFACARQPELAMMHCSYWDHDSKTGALHSRLDL

Target ORF information:

RefSeq Version	NM_023067.4
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box L2 (FOXL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023067.4

ORF Insert Sequence:

ATGATGGCCA GCTACCCCGA GCCCGAGGAC GCGGCGGGGG CCCTGCTGGC CCCAGAGACC 
GGTCGCACAG TCAAGGAGCC AGAAGGGCCG CCGCCGAGCC CAGGCAAGGG CGGTGGGGGT 
GGCGGCGGGA CAGCCCCGGA GAAGCCGGAC CCGGCGCAGA AGCCCCCGTA CTCGTACGTG 
GCGCTCATCG CCATGGCGAT CCGCGAGAGC GCGGAGAAGA GGCTCACGCT GTCCGGCATC 
TACCAGTACA TCATCGCGAA GTTCCCGTTC TACGAGAAGA ATAAGAAGGG CTGGCAAAAT 
AGCATCCGCC ACAACCTCAG CCTCAACGAG TGCTTCATCA AGGTGCCGCG CGAGGGCGGC 
GGCGAGCGCA AGGGCAACTA CTGGACGCTG GACCCGGCCT GCGAAGACAT GTTCGAGAAG 
GGCAACTACC GGCGCCGCCG CCGCATGAAG AGGCCCTTCC GGCCGCCGCC CGCGCACTTC 
CAGCCCGGCA AGGGGCTCTT CGGGGCCGGA GGCGCCGCAG GCGGGTGCGG CGTGGCGGGC 
GCCGGGGCCG ACGGCTACGG CTACCTGGCG CCCCCCAAGT ACCTGCAGTC TGGCTTCCTC 
AACAACTCGT GGCCGCTACC GCAGCCTCCC TCACCCATGC CCTATGCCTC CTGCCAGATG 
GCGGCAGCCG CAGCGGCTGC AGCAGCTGCG GCTGCAGCCG CGGGCCCCGG TAGCCCTGGC 
GCGGCCGCTG TGGTCAAGGG GCTGGCGGGC CCGGCCGCCT CGTACGGGCC GTACACACGC 
GTGCAGAGCA TGGCGCTGCC CCCCGGCGTA GTGAACTCGT ACAATGGCCT GGGAGGCCCG 
CCGGCCGCAC CCCCGCCTCC GCCGCACCCC CACCCGCATC CGCACGCACA CCATCTGCAC 
GCGGCCGCCG CACCGCCGCC TGCCCCACCG CACCACGGGG CCGCCGCGCC GCCGCCGGGC 
CAGCTCAGCC CTGCCAGCCC AGCCACCGCC GCGCCCCCGG CGCCCGCGCC CACCAGTGCG 
CCGGGCCTGC AGTTCGCTTG TGCCCGGCAG CCCGAGCTCG CCATGATGCA TTGCTCTTAC 
TGGGACCACG ACAGCAAGAC CGGCGCGCTG CATTCGCGCC TCGATCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOXL2 ( NM_023067.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_075555.1 Homo sapiens forkhead box L2 (FOXL2), mRNA.

Price & Availability↑

CloneID	OHu20709
Clone ID Related Accession (Same CDS sequence)	NM_023067.4 , NM_023067.3
Accession Version	NM_023067.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1131bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514217600000
Organism	Homo sapiens(human)
Product	forkhead box protein L2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092947.12. This sequence is a reference standard in the RefSeqGene project. On Jun 10, 2009 this sequence version replaced NM_023067.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGATGGCCA GCTACCCCGA GCCCGAGGAC GCGGCGGGGG CCCTGCTGGC CCCAGAGACC 
GGTCGCACAG TCAAGGAGCC AGAAGGGCCG CCGCCGAGCC CAGGCAAGGG CGGTGGGGGT 
GGCGGCGGGA CAGCCCCGGA GAAGCCGGAC CCGGCGCAGA AGCCCCCGTA CTCGTACGTG 
GCGCTCATCG CCATGGCGAT CCGCGAGAGC GCGGAGAAGA GGCTCACGCT GTCCGGCATC 
TACCAGTACA TCATCGCGAA GTTCCCGTTC TACGAGAAGA ATAAGAAGGG CTGGCAAAAT 
AGCATCCGCC ACAACCTCAG CCTCAACGAG TGCTTCATCA AGGTGCCGCG CGAGGGCGGC 
GGCGAGCGCA AGGGCAACTA CTGGACGCTG GACCCGGCCT GCGAAGACAT GTTCGAGAAG 
GGCAACTACC GGCGCCGCCG CCGCATGAAG AGGCCCTTCC GGCCGCCGCC CGCGCACTTC 
CAGCCCGGCA AGGGGCTCTT CGGGGCCGGA GGCGCCGCAG GCGGGTGCGG CGTGGCGGGC 
GCCGGGGCCG ACGGCTACGG CTACCTGGCG CCCCCCAAGT ACCTGCAGTC TGGCTTCCTC 
AACAACTCGT GGCCGCTACC GCAGCCTCCC TCACCCATGC CCTATGCCTC CTGCCAGATG 
GCGGCAGCCG CAGCGGCTGC AGCAGCTGCG GCTGCAGCCG CGGGCCCCGG TAGCCCTGGC 
GCGGCCGCTG TGGTCAAGGG GCTGGCGGGC CCGGCCGCCT CGTACGGGCC GTACACACGC 
GTGCAGAGCA TGGCGCTGCC CCCCGGCGTA GTGAACTCGT ACAATGGCCT GGGAGGCCCG 
CCGGCCGCAC CCCCGCCTCC GCCGCACCCC CACCCGCATC CGCACGCACA CCATCTGCAC 
GCGGCCGCCG CACCGCCGCC TGCCCCACCG CACCACGGGG CCGCCGCGCC GCCGCCGGGC 
CAGCTCAGCC CTGCCAGCCC AGCCACCGCC GCGCCCCCGG CGCCCGCGCC CACCAGTGCG 
CCGGGCCTGC AGTTCGCTTG TGCCCGGCAG CCCGAGCTCG CCATGATGCA TTGCTCTTAC 
TGGGACCACG ACAGCAAGAC CGGCGCGCTG CATTCGCGCC TCGATCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075555.1
CDS	419..1549
Translation	MMASYPEPEDAAGALLAPETGRTVKEPEGPPPSPGKGGGGGGGTAPEKPDPAQKPPYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGAGGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYASCQMAAAAAAAAAAAAAAGPGSPGAAAVVKGLAGPAASYGPYTRVQSMALPPGVVNSYNGLGGPPAAPPPPPHPHPHPHAHHLHAAAAPPPAPPHHGAAAPPPGQLSPASPATAAPPAPAPTSAPGLQFACARQPELAMMHCSYWDHDSKTGALHSRLDL

Target ORF information:

RefSeq Version	NM_023067.3
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box L2 (FOXL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023067.3

ORF Insert Sequence:

ATGATGGCCA GCTACCCCGA GCCCGAGGAC GCGGCGGGGG CCCTGCTGGC CCCAGAGACC 
GGTCGCACAG TCAAGGAGCC AGAAGGGCCG CCGCCGAGCC CAGGCAAGGG CGGTGGGGGT 
GGCGGCGGGA CAGCCCCGGA GAAGCCGGAC CCGGCGCAGA AGCCCCCGTA CTCGTACGTG 
GCGCTCATCG CCATGGCGAT CCGCGAGAGC GCGGAGAAGA GGCTCACGCT GTCCGGCATC 
TACCAGTACA TCATCGCGAA GTTCCCGTTC TACGAGAAGA ATAAGAAGGG CTGGCAAAAT 
AGCATCCGCC ACAACCTCAG CCTCAACGAG TGCTTCATCA AGGTGCCGCG CGAGGGCGGC 
GGCGAGCGCA AGGGCAACTA CTGGACGCTG GACCCGGCCT GCGAAGACAT GTTCGAGAAG 
GGCAACTACC GGCGCCGCCG CCGCATGAAG AGGCCCTTCC GGCCGCCGCC CGCGCACTTC 
CAGCCCGGCA AGGGGCTCTT CGGGGCCGGA GGCGCCGCAG GCGGGTGCGG CGTGGCGGGC 
GCCGGGGCCG ACGGCTACGG CTACCTGGCG CCCCCCAAGT ACCTGCAGTC TGGCTTCCTC 
AACAACTCGT GGCCGCTACC GCAGCCTCCC TCACCCATGC CCTATGCCTC CTGCCAGATG 
GCGGCAGCCG CAGCGGCTGC AGCAGCTGCG GCTGCAGCCG CGGGCCCCGG TAGCCCTGGC 
GCGGCCGCTG TGGTCAAGGG GCTGGCGGGC CCGGCCGCCT CGTACGGGCC GTACACACGC 
GTGCAGAGCA TGGCGCTGCC CCCCGGCGTA GTGAACTCGT ACAATGGCCT GGGAGGCCCG 
CCGGCCGCAC CCCCGCCTCC GCCGCACCCC CACCCGCATC CGCACGCACA CCATCTGCAC 
GCGGCCGCCG CACCGCCGCC TGCCCCACCG CACCACGGGG CCGCCGCGCC GCCGCCGGGC 
CAGCTCAGCC CTGCCAGCCC AGCCACCGCC GCGCCCCCGG CGCCCGCGCC CACCAGTGCG 
CCGGGCCTGC AGTTCGCTTG TGCCCGGCAG CCCGAGCTCG CCATGATGCA TTGCTCTTAC 
TGGGACCACG ACAGCAAGAC CGGCGCGCTG CATTCGCGCC TCGATCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Screening of a large cohort of blepharophimosis, ptosis, and epicanthus inversus syndrome patients reveals a very strong paternal inheritance bias and a wide spectrum of novel FOXL2 mutations.
European journal of medical genetics62(7)103668(2019 Jul)
Bunyan DJ,Thomas NS

Premature ovarian insufficiency as a variable feature of blepharophimosis, ptosis, and epicanthus inversus syndrome associated with c.223C > T p.(Leu75Phe) FOXL2 mutation: a case report.
BMC medical genetics20(1)132(2019 07)
Grzechocińska B,Warzecha D,Wypchło M,Ploski R,Wielgoś M

Deletion of FOXL2 by CRISPR promotes cell cycle G0/G1 restriction in KGN cells.
International journal of molecular medicine43(1)567-574(2019 Jan)
Tang B,Zhang Y,Zhang W,Zhu Y,Yuan S

Genetic and Functional Analyses of Two Missense Mutations in the Transcription Factor FOXL2 in Two Chinese Families with Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome.
Genetic testing and molecular biomarkers22(10)585-592(2018 Oct)
Li H,Gu Y

[Analysis of FOXL2 gene mutation and genotype-phenotype correlation in a Chinese pedigree affected with blepharophimosis-ptosis-epicanthus inversus syndrome].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics35(4)515-517(2018 Aug)
Cheng H,Wang T,Wang G,Wang J,Shen L,Han M,Yang S,Shi Y,Wang W,Li H

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FOXL2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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