ATG3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATG3
Entrez Gene ID	64422
Full Name	autophagy related 3
Synonyms	APG3,APG3-LIKE,APG3L,PC3-96
General protein information	Preferred Names autophagy related 3 Names ubiquitin-like-conjugating enzyme ATG3 2610016C12Rik APG3 autophagy 3-like ATG3 autophagy related 3 homolog autophagy-related protein 3 hApg3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q13.2
Summary	This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013].
Disorder MIM:	609606

mRNA and Protein(s)

mRNA	Protein	Name
XM_011513074.1	XP_011511376.1	ubiquitin-like-conjugating enzyme ATG3 isoform X1
NM_022488.4	NP_071933.2	ubiquitin-like-conjugating enzyme ATG3 isoform 1
NM_001278712.1	NP_001265641.1	ubiquitin-like-conjugating enzyme ATG3 isoform 2
NM_001278712.2	NP_001265641.1	ubiquitin-like-conjugating enzyme ATG3 isoform 2
NM_022488.5	NP_071933.2	ubiquitin-like-conjugating enzyme ATG3 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ATG3	NP_071933.2
Pan troglodytes (chimpanzee)	ATG3	XP_001155234.1
Danio rerio (zebrafish)	apg3l	NP_956316.1
Rattus norvegicus (Norway rat)	Atg3	NP_599221.1
Drosophila melanogaster (fruit fly)	Aut1	NP_649059.1
Arabidopsis thaliana (thale cress)	ATG3	NP_568934.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011582	XP_309926.3
Bos taurus (cattle)	ATG3	NP_001068832.1
Canis lupus familiaris (dog)	ATG3	XP_535740.3
Xenopus tropicalis (tropical clawed frog)	atg3	NP_001011420.1
Oryza sativa (rice)	Os01g0200000	NP_001042313.1
Macaca mulatta (Rhesus monkey)	ATG3	XP_001104361.1
Mus musculus (house mouse)	Atg3	NP_080678.1
Gallus gallus (chicken)	ATG3	NP_001264999.1
Caenorhabditis elegans (roundworm)	atg-3	NP_500024.1

Gene Ontology
Bibliography

Related articles in PubMed

Long non-coding RNA PVT1 promotes autophagy as ceRNA to target ATG3 by sponging microRNA-365 in hepatocellular carcinoma.
Yang L, Peng X, Jin H, Liu J
Gene69794-102(2019 May)

MicroRNA-1 overexpression increases chemosensitivity of non-small cell lung cancer cells by inhibiting autophagy related 3-mediated autophagy.
Hua L, Zhu G, Wei J
Cell biology international42(9)1240-1249(2018 Sep)

eIF5A is required for autophagy by mediating ATG3 translation.
Lubas M, Harder LM, Kumsta C, Tiessen I, Hansen M, Andersen JS, Lund AH, Frankel LB
EMBO reports19(6)(2018 06)

Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer.
Gu J, Wang Y, Wang X, Zhou D, Wang X, Zhou M, He Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology48(1)194-207(2018)

Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells.
Etna MP, Sinigaglia A, Grassi A, Giacomini E, Romagnoli A, Pardini M, Severa M, Cruciani M, Rizzo F, Anastasiadou E, Di Camillo B, Barzon L, Fimia GM, Manganelli R, Coccia EM
PLoS pathogens14(1)e1006790(2018 01)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ATG3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATG3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12353	NM_022488.5 Latest version!	Homo sapiens autophagy related 3 (ATG3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu11303	NM_001278712.2 Latest version!	Homo sapiens autophagy related 3 (ATG3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu71387	XM_011513074.1 Latest version!	Homo sapiens autophagy related 3 (ATG3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu11303	NM_001278712.1	Homo sapiens autophagy related 3 (ATG3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu12353	NM_022488.4	Homo sapiens autophagy related 3 (ATG3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATG3 ( NM_022488.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071933.2 Homo sapiens autophagy related 3 (ATG3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12353
Clone ID Related Accession (Same CDS sequence)	NM_022488.4 , NM_022488.5
Accession Version	NM_022488.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550851200000
Organism	Homo sapiens(human)
Product	ubiquitin-like-conjugating enzyme ATG3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC311625.1, AC092692.6, AW408464.1 and BC024221.2. On Jul 16, 2013 this sequence version replaced NM_022488.3. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.292476.1, SRR1660803.34387.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGAATG TGATTAATAC TGTGAAGGGA AAGGCACTGG AAGTGGCTGA GTACCTGACC 
CCGGTCCTCA AGGAATCAAA GTTTAAGGAA ACAGGTGTAA TTACCCCAGA AGAGTTTGTG 
GCAGCTGGAG ATCACCTAGT CCACCACTGT CCAACATGGC AATGGGCTAC AGGGGAAGAA 
TTGAAAGTGA AGGCATACCT ACCAACAGGC AAACAATTTT TGGTAACCAA AAATGTGCCG 
TGCTATAAGC GGTGCAAACA GATGGAATAT TCAGATGAAT TGGAAGCTAT CATTGAAGAA 
GATGATGGTG ATGGCGGATG GGTAGATACA TATCACAACA CAGGTATTAC AGGAATAACG 
GAAGCCGTTA AAGAGATCAC ACTGGAAAAT AAGGACAATA TAAGGCTTCA AGATTGCTCA 
GCACTATGTG AAGAGGAAGA AGATGAAGAT GAAGGAGAAG CTGCAGATAT GGAAGAATAT 
GAAGAGAGTG GATTGTTGGA AACAGATGAG GCTACCCTAG ATACAAGGAA AATAGTAGAA 
GCTTGTAAAG CCAAAACTGA TGCTGGCGGT GAAGATGCTA TTTTGCAAAC CAGAACTTAT 
GACCTTTACA TCACTTATGA TAAATATTAC CAGACTCCAC GATTATGGTT GTTTGGCTAT 
GATGAGCAAC GGCAGCCTTT AACAGTTGAG CACATGTATG AAGACATCAG TCAGGATCAT 
GTGAAGAAAA CAGTGACCAT TGAAAATCAC CCTCATCTGC CACCACCTCC CATGTGTTCA 
GTTCACCCAT GCAGGCATGC TGAGGTGATG AAGAAAATCA TTGAGACTGT TGCAGAAGGA 
GGGGGAGAAC TTGGAGTTCA TATGTATCTT CTTATTTTCT TGAAATTTGT ACAAGCTGTC 
ATTCCAACAA TAGAATATGA CTACACAAGA CACTTCACAA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071933.2
CDS	436..1380
Translation	MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAYLPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLENKDNIRLQDCSALCEEEEDEDEGEAADMEEYEESGLLETDEATLDTRKIVEACKAKTDAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKKTVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIEYDYTRHFTM

Target ORF information:

RefSeq Version	NM_022488.4
Organism	Homo sapiens(human)
Definition	Homo sapiens autophagy related 3 (ATG3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022488.4

ORF Insert Sequence:

ATGCAGAATG TGATTAATAC TGTGAAGGGA AAGGCACTGG AAGTGGCTGA GTACCTGACC 
CCGGTCCTCA AGGAATCAAA GTTTAAGGAA ACAGGTGTAA TTACCCCAGA AGAGTTTGTG 
GCAGCTGGAG ATCACCTAGT CCACCACTGT CCAACATGGC AATGGGCTAC AGGGGAAGAA 
TTGAAAGTGA AGGCATACCT ACCAACAGGC AAACAATTTT TGGTAACCAA AAATGTGCCG 
TGCTATAAGC GGTGCAAACA GATGGAATAT TCAGATGAAT TGGAAGCTAT CATTGAAGAA 
GATGATGGTG ATGGCGGATG GGTAGATACA TATCACAACA CAGGTATTAC AGGAATAACG 
GAAGCCGTTA AAGAGATCAC ACTGGAAAAT AAGGACAATA TAAGGCTTCA AGATTGCTCA 
GCACTATGTG AAGAGGAAGA AGATGAAGAT GAAGGAGAAG CTGCAGATAT GGAAGAATAT 
GAAGAGAGTG GATTGTTGGA AACAGATGAG GCTACCCTAG ATACAAGGAA AATAGTAGAA 
GCTTGTAAAG CCAAAACTGA TGCTGGCGGT GAAGATGCTA TTTTGCAAAC CAGAACTTAT 
GACCTTTACA TCACTTATGA TAAATATTAC CAGACTCCAC GATTATGGTT GTTTGGCTAT 
GATGAGCAAC GGCAGCCTTT AACAGTTGAG CACATGTATG AAGACATCAG TCAGGATCAT 
GTGAAGAAAA CAGTGACCAT TGAAAATCAC CCTCATCTGC CACCACCTCC CATGTGTTCA 
GTTCACCCAT GCAGGCATGC TGAGGTGATG AAGAAAATCA TTGAGACTGT TGCAGAAGGA 
GGGGGAGAAC TTGGAGTTCA TATGTATCTT CTTATTTTCT TGAAATTTGT ACAAGCTGTC 
ATTCCAACAA TAGAATATGA CTACACAAGA CACTTCACAA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATG3 ( NM_022488.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_071933.2 Homo sapiens autophagy related 3 (ATG3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12353
Clone ID Related Accession (Same CDS sequence)	NM_022488.4 , NM_022488.5
Accession Version	NM_022488.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573315200000
Organism	Homo sapiens(human)
Product	ubiquitin-like-conjugating enzyme ATG3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC311625.1, AC092692.6, AW408464.1 and BC024221.2. On May 17, 2019 this sequence version replaced NM_022488.4. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.192031.1, AL137515.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000283290.10/ ENSP00000283290.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGAATG TGATTAATAC TGTGAAGGGA AAGGCACTGG AAGTGGCTGA GTACCTGACC 
CCGGTCCTCA AGGAATCAAA GTTTAAGGAA ACAGGTGTAA TTACCCCAGA AGAGTTTGTG 
GCAGCTGGAG ATCACCTAGT CCACCACTGT CCAACATGGC AATGGGCTAC AGGGGAAGAA 
TTGAAAGTGA AGGCATACCT ACCAACAGGC AAACAATTTT TGGTAACCAA AAATGTGCCG 
TGCTATAAGC GGTGCAAACA GATGGAATAT TCAGATGAAT TGGAAGCTAT CATTGAAGAA 
GATGATGGTG ATGGCGGATG GGTAGATACA TATCACAACA CAGGTATTAC AGGAATAACG 
GAAGCCGTTA AAGAGATCAC ACTGGAAAAT AAGGACAATA TAAGGCTTCA AGATTGCTCA 
GCACTATGTG AAGAGGAAGA AGATGAAGAT GAAGGAGAAG CTGCAGATAT GGAAGAATAT 
GAAGAGAGTG GATTGTTGGA AACAGATGAG GCTACCCTAG ATACAAGGAA AATAGTAGAA 
GCTTGTAAAG CCAAAACTGA TGCTGGCGGT GAAGATGCTA TTTTGCAAAC CAGAACTTAT 
GACCTTTACA TCACTTATGA TAAATATTAC CAGACTCCAC GATTATGGTT GTTTGGCTAT 
GATGAGCAAC GGCAGCCTTT AACAGTTGAG CACATGTATG AAGACATCAG TCAGGATCAT 
GTGAAGAAAA CAGTGACCAT TGAAAATCAC CCTCATCTGC CACCACCTCC CATGTGTTCA 
GTTCACCCAT GCAGGCATGC TGAGGTGATG AAGAAAATCA TTGAGACTGT TGCAGAAGGA 
GGGGGAGAAC TTGGAGTTCA TATGTATCTT CTTATTTTCT TGAAATTTGT ACAAGCTGTC 
ATTCCAACAA TAGAATATGA CTACACAAGA CACTTCACAA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071933.2
CDS	435..1379
Translation	MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAYLPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLENKDNIRLQDCSALCEEEEDEDEGEAADMEEYEESGLLETDEATLDTRKIVEACKAKTDAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKKTVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIEYDYTRHFTM

Target ORF information:

RefSeq Version	NM_022488.5
Organism	Homo sapiens(human)
Definition	Homo sapiens autophagy related 3 (ATG3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022488.5

ORF Insert Sequence:

ATGCAGAATG TGATTAATAC TGTGAAGGGA AAGGCACTGG AAGTGGCTGA GTACCTGACC 
CCGGTCCTCA AGGAATCAAA GTTTAAGGAA ACAGGTGTAA TTACCCCAGA AGAGTTTGTG 
GCAGCTGGAG ATCACCTAGT CCACCACTGT CCAACATGGC AATGGGCTAC AGGGGAAGAA 
TTGAAAGTGA AGGCATACCT ACCAACAGGC AAACAATTTT TGGTAACCAA AAATGTGCCG 
TGCTATAAGC GGTGCAAACA GATGGAATAT TCAGATGAAT TGGAAGCTAT CATTGAAGAA 
GATGATGGTG ATGGCGGATG GGTAGATACA TATCACAACA CAGGTATTAC AGGAATAACG 
GAAGCCGTTA AAGAGATCAC ACTGGAAAAT AAGGACAATA TAAGGCTTCA AGATTGCTCA 
GCACTATGTG AAGAGGAAGA AGATGAAGAT GAAGGAGAAG CTGCAGATAT GGAAGAATAT 
GAAGAGAGTG GATTGTTGGA AACAGATGAG GCTACCCTAG ATACAAGGAA AATAGTAGAA 
GCTTGTAAAG CCAAAACTGA TGCTGGCGGT GAAGATGCTA TTTTGCAAAC CAGAACTTAT 
GACCTTTACA TCACTTATGA TAAATATTAC CAGACTCCAC GATTATGGTT GTTTGGCTAT 
GATGAGCAAC GGCAGCCTTT AACAGTTGAG CACATGTATG AAGACATCAG TCAGGATCAT 
GTGAAGAAAA CAGTGACCAT TGAAAATCAC CCTCATCTGC CACCACCTCC CATGTGTTCA 
GTTCACCCAT GCAGGCATGC TGAGGTGATG AAGAAAATCA TTGAGACTGT TGCAGAAGGA 
GGGGGAGAAC TTGGAGTTCA TATGTATCTT CTTATTTTCT TGAAATTTGT ACAAGCTGTC 
ATTCCAACAA TAGAATATGA CTACACAAGA CACTTCACAA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATG3 ( NM_001278712.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265641.1 Homo sapiens autophagy related 3 (ATG3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11303
Clone ID Related Accession (Same CDS sequence)	NM_001278712.1 , NM_001278712.2
Accession Version	NM_001278712.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1537545600000
Organism	Homo sapiens(human)
Product	ubiquitin-like-conjugating enzyme ATG3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092692.6, BC002830.1, AK308919.1, AA448974.1 and AK025778.1. Transcript Variant: This variant (2) contains a 3' terminal exon that extends past a splice site that is used in variant 1 that results in an early stop codon and a different 3' UTR, compared to variant 1. It encodes a protein which is shorter at the C-terminus (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002830.1, SRR1660803.203342.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGAATG TGATTAATAC TGTGAAGGGA AAGGCACTGG AAGTGGCTGA GTACCTGACC 
CCGGTCCTCA AGGAATCAAA GTTTAAGGAA ACAGGTGTAA TTACCCCAGA AGAGTTTGTG 
GCAGCTGGAG ATCACCTAGT CCACCACTGT CCAACATGGC AATGGGCTAC AGGGGAAGAA 
TTGAAAGTGA AGGCATACCT ACCAACAGGC AAACAATTTT TGGTAACCAA AAATGTGCCG 
TGCTATAAGC GGTGCAAACA GATGGAATAT TCAGATGAAT TGGAAGCTAT CATTGAAGAA 
GATGATGGTG ATGGCGGATG GGTAGATACA TATCACAACA CAGGTATTAC AGGAATAACG 
GAAGCCGTTA AAGAGATCAC ACTGGAAAAT AAGGACAATA TAAGGCTTCA AGATTGCTCA 
GCACTATGTG AAGAGGAAGA AGATGAAGAT GAAGGAGAAG CTGCAGATAT GGAAGAATAT 
GAAGAGAGTG GATTGTTGGA AACAGATGAG GCTACCCTAG ATACAAGGAA AATAGTAGAA 
GCTTGTAAAG CCAAAACTGA TGCTGGCGGT GAAGATGCTA TTTTGCAAAC CAGAACTTAT 
GACCTTTACA TCACTTATGA TAAATATTAC CAGACTCCAC GATTATGGTT GTTTGGCTAT 
GATGAGCAAC GGCAGCCTTT AACAGTTGAG CACATGTATG AAGACATCAG TCAGGATCAT 
GTGAAGAAAA CAGTGACCAT TGAAAATCAC CCTCATCTGC CACCACCTCC CATGTGTTCA 
GTTCACCCAT GCAGGCATGC TGAGGTGATG AAGAAAATCA TTGAGACTGT TGCAGAAGGA 
GGGGGAGAAC TTGGAGTTCA TATGTATCCT TCCCTGTATG TAAGATTAGT GGCAAAATGG 
CTGTTAACGA TTTTTTTTTT GAGAAATTTA GTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265641.1
CDS	436..1371
Translation	MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAYLPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLENKDNIRLQDCSALCEEEEDEDEGEAADMEEYEESGLLETDEATLDTRKIVEACKAKTDAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKKTVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYPSLYVRLVAKWLLTIFFLRNLV

Target ORF information:

RefSeq Version	NM_001278712.1
Organism	Homo sapiens(human)
Definition	Homo sapiens autophagy related 3 (ATG3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278712.1

ORF Insert Sequence:

ATGCAGAATG TGATTAATAC TGTGAAGGGA AAGGCACTGG AAGTGGCTGA GTACCTGACC 
CCGGTCCTCA AGGAATCAAA GTTTAAGGAA ACAGGTGTAA TTACCCCAGA AGAGTTTGTG 
GCAGCTGGAG ATCACCTAGT CCACCACTGT CCAACATGGC AATGGGCTAC AGGGGAAGAA 
TTGAAAGTGA AGGCATACCT ACCAACAGGC AAACAATTTT TGGTAACCAA AAATGTGCCG 
TGCTATAAGC GGTGCAAACA GATGGAATAT TCAGATGAAT TGGAAGCTAT CATTGAAGAA 
GATGATGGTG ATGGCGGATG GGTAGATACA TATCACAACA CAGGTATTAC AGGAATAACG 
GAAGCCGTTA AAGAGATCAC ACTGGAAAAT AAGGACAATA TAAGGCTTCA AGATTGCTCA 
GCACTATGTG AAGAGGAAGA AGATGAAGAT GAAGGAGAAG CTGCAGATAT GGAAGAATAT 
GAAGAGAGTG GATTGTTGGA AACAGATGAG GCTACCCTAG ATACAAGGAA AATAGTAGAA 
GCTTGTAAAG CCAAAACTGA TGCTGGCGGT GAAGATGCTA TTTTGCAAAC CAGAACTTAT 
GACCTTTACA TCACTTATGA TAAATATTAC CAGACTCCAC GATTATGGTT GTTTGGCTAT 
GATGAGCAAC GGCAGCCTTT AACAGTTGAG CACATGTATG AAGACATCAG TCAGGATCAT 
GTGAAGAAAA CAGTGACCAT TGAAAATCAC CCTCATCTGC CACCACCTCC CATGTGTTCA 
GTTCACCCAT GCAGGCATGC TGAGGTGATG AAGAAAATCA TTGAGACTGT TGCAGAAGGA 
GGGGGAGAAC TTGGAGTTCA TATGTATCCT TCCCTGTATG TAAGATTAGT GGCAAAATGG 
CTGTTAACGA TTTTTTTTTT GAGAAATTTA GTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATG3 ( NM_001278712.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265641.1 Homo sapiens autophagy related 3 (ATG3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11303
Clone ID Related Accession (Same CDS sequence)	NM_001278712.1 , NM_001278712.2
Accession Version	NM_001278712.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573315200000
Organism	Homo sapiens(human)
Product	ubiquitin-like-conjugating enzyme ATG3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092692.6, BC002830.1, AK308919.1, AA448974.1 and AK025778.1. On May 31, 2019 this sequence version replaced NM_001278712.1. Transcript Variant: This variant (2) contains a 3' terminal exon that extends past a splice site that is used in variant 1 that results in an early stop codon and a different 3' UTR, compared to variant 1. It encodes a protein which is shorter at the C-terminus (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002830.1, SRR1660809.171404.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGAATG TGATTAATAC TGTGAAGGGA AAGGCACTGG AAGTGGCTGA GTACCTGACC 
CCGGTCCTCA AGGAATCAAA GTTTAAGGAA ACAGGTGTAA TTACCCCAGA AGAGTTTGTG 
GCAGCTGGAG ATCACCTAGT CCACCACTGT CCAACATGGC AATGGGCTAC AGGGGAAGAA 
TTGAAAGTGA AGGCATACCT ACCAACAGGC AAACAATTTT TGGTAACCAA AAATGTGCCG 
TGCTATAAGC GGTGCAAACA GATGGAATAT TCAGATGAAT TGGAAGCTAT CATTGAAGAA 
GATGATGGTG ATGGCGGATG GGTAGATACA TATCACAACA CAGGTATTAC AGGAATAACG 
GAAGCCGTTA AAGAGATCAC ACTGGAAAAT AAGGACAATA TAAGGCTTCA AGATTGCTCA 
GCACTATGTG AAGAGGAAGA AGATGAAGAT GAAGGAGAAG CTGCAGATAT GGAAGAATAT 
GAAGAGAGTG GATTGTTGGA AACAGATGAG GCTACCCTAG ATACAAGGAA AATAGTAGAA 
GCTTGTAAAG CCAAAACTGA TGCTGGCGGT GAAGATGCTA TTTTGCAAAC CAGAACTTAT 
GACCTTTACA TCACTTATGA TAAATATTAC CAGACTCCAC GATTATGGTT GTTTGGCTAT 
GATGAGCAAC GGCAGCCTTT AACAGTTGAG CACATGTATG AAGACATCAG TCAGGATCAT 
GTGAAGAAAA CAGTGACCAT TGAAAATCAC CCTCATCTGC CACCACCTCC CATGTGTTCA 
GTTCACCCAT GCAGGCATGC TGAGGTGATG AAGAAAATCA TTGAGACTGT TGCAGAAGGA 
GGGGGAGAAC TTGGAGTTCA TATGTATCCT TCCCTGTATG TAAGATTAGT GGCAAAATGG 
CTGTTAACGA TTTTTTTTTT GAGAAATTTA GTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265641.1
CDS	435..1370
Translation	MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAYLPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLENKDNIRLQDCSALCEEEEDEDEGEAADMEEYEESGLLETDEATLDTRKIVEACKAKTDAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKKTVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYPSLYVRLVAKWLLTIFFLRNLV

Target ORF information:

RefSeq Version	NM_001278712.2
Organism	Homo sapiens(human)
Definition	Homo sapiens autophagy related 3 (ATG3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278712.2

ORF Insert Sequence:

ATGCAGAATG TGATTAATAC TGTGAAGGGA AAGGCACTGG AAGTGGCTGA GTACCTGACC 
CCGGTCCTCA AGGAATCAAA GTTTAAGGAA ACAGGTGTAA TTACCCCAGA AGAGTTTGTG 
GCAGCTGGAG ATCACCTAGT CCACCACTGT CCAACATGGC AATGGGCTAC AGGGGAAGAA 
TTGAAAGTGA AGGCATACCT ACCAACAGGC AAACAATTTT TGGTAACCAA AAATGTGCCG 
TGCTATAAGC GGTGCAAACA GATGGAATAT TCAGATGAAT TGGAAGCTAT CATTGAAGAA 
GATGATGGTG ATGGCGGATG GGTAGATACA TATCACAACA CAGGTATTAC AGGAATAACG 
GAAGCCGTTA AAGAGATCAC ACTGGAAAAT AAGGACAATA TAAGGCTTCA AGATTGCTCA 
GCACTATGTG AAGAGGAAGA AGATGAAGAT GAAGGAGAAG CTGCAGATAT GGAAGAATAT 
GAAGAGAGTG GATTGTTGGA AACAGATGAG GCTACCCTAG ATACAAGGAA AATAGTAGAA 
GCTTGTAAAG CCAAAACTGA TGCTGGCGGT GAAGATGCTA TTTTGCAAAC CAGAACTTAT 
GACCTTTACA TCACTTATGA TAAATATTAC CAGACTCCAC GATTATGGTT GTTTGGCTAT 
GATGAGCAAC GGCAGCCTTT AACAGTTGAG CACATGTATG AAGACATCAG TCAGGATCAT 
GTGAAGAAAA CAGTGACCAT TGAAAATCAC CCTCATCTGC CACCACCTCC CATGTGTTCA 
GTTCACCCAT GCAGGCATGC TGAGGTGATG AAGAAAATCA TTGAGACTGT TGCAGAAGGA 
GGGGGAGAAC TTGGAGTTCA TATGTATCCT TCCCTGTATG TAAGATTAGT GGCAAAATGG 
CTGTTAACGA TTTTTTTTTT GAGAAATTTA GTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATG3 ( XM_011513074.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511376.1 Homo sapiens autophagy related 3 (ATG3), transcript variant X1, mRNA.

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CloneID	OHu71387
Clone ID Related Accession (Same CDS sequence)	XM_011513074.1
Accession Version	XM_011513074.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	ubiquitin-like-conjugating enzyme ATG3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAATATT CAGATGAATT GGAAGCTATC ATTGAAGAAG ATGATGGTGA TGGCGGATGG 
GTAGATACAT ATCACAACAC AGGTATTACA GGAATAACGG AAGCCGTTAA AGAGATCACA 
CTGGAAAATA AGGACAATAT AAGGCTTCAA GATTGCTCAG CACTATGTGA AGAGGAAGAA 
GATGAAGATG AAGGAGAAGC TGCAGATATG GAAGAATATG AAGAGAGTGG ATTGTTGGAA 
ACAGATGAGG CTACCCTAGA TACAAGGAAA ATAGTAGAAG CTTGTAAAGC CAAAACTGAT 
GCTGGCGGTG AAGATGCTAT TTTGCAAACC AGAACTTATG ACCTTTACAT CACTTATGAT 
AAATATTACC AGACTCCACG ATTATGGTTG TTTGGCTATG ATGAGCAACG GCAGCCTTTA 
ACAGTTGAGC ACATGTATGA AGACATCAGT CAGGATCATG TGAAGAAAAC AGTGACCATT 
GAAAATCACC CTCATCTGCC ACCACCTCCC ATGTGTTCAG TTCACCCATG CAGGCATGCT 
GAGGTGATGA AGAAAATCAT TGAGACTGTT GCAGAAGGAG GGGGAGAACT TGGAGTTCAT 
ATGTATCTTC TTATTTTCTT GAAATTTGTA CAAGCTGTCA TTCCAACAAT AGAATATGAC 
TACACAAGAC ACTTCACAAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511376.1
CDS	307..990
Translation	MEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLENKDNIRLQDCSALCEEEEDEDEGEAADMEEYEESGLLETDEATLDTRKIVEACKAKTDAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKKTVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIEYDYTRHFTM

Target ORF information:

RefSeq Version	XM_011513074.1
Organism	Homo sapiens(human)
Definition	Homo sapiens autophagy related 3 (ATG3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513074.1

ORF Insert Sequence:

ATGGAATATT CAGATGAATT GGAAGCTATC ATTGAAGAAG ATGATGGTGA TGGCGGATGG 
GTAGATACAT ATCACAACAC AGGTATTACA GGAATAACGG AAGCCGTTAA AGAGATCACA 
CTGGAAAATA AGGACAATAT AAGGCTTCAA GATTGCTCAG CACTATGTGA AGAGGAAGAA 
GATGAAGATG AAGGAGAAGC TGCAGATATG GAAGAATATG AAGAGAGTGG ATTGTTGGAA 
ACAGATGAGG CTACCCTAGA TACAAGGAAA ATAGTAGAAG CTTGTAAAGC CAAAACTGAT 
GCTGGCGGTG AAGATGCTAT TTTGCAAACC AGAACTTATG ACCTTTACAT CACTTATGAT 
AAATATTACC AGACTCCACG ATTATGGTTG TTTGGCTATG ATGAGCAACG GCAGCCTTTA 
ACAGTTGAGC ACATGTATGA AGACATCAGT CAGGATCATG TGAAGAAAAC AGTGACCATT 
GAAAATCACC CTCATCTGCC ACCACCTCCC ATGTGTTCAG TTCACCCATG CAGGCATGCT 
GAGGTGATGA AGAAAATCAT TGAGACTGTT GCAGAAGGAG GGGGAGAACT TGGAGTTCAT 
ATGTATCTTC TTATTTTCTT GAAATTTGTA CAAGCTGTCA TTCCAACAAT AGAATATGAC 
TACACAAGAC ACTTCACAAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Long non-coding RNA PVT1 promotes autophagy as ceRNA to target ATG3 by sponging microRNA-365 in hepatocellular carcinoma.
Gene69794-102(2019 May)
Yang L,Peng X,Jin H,Liu J

MicroRNA-1 overexpression increases chemosensitivity of non-small cell lung cancer cells by inhibiting autophagy related 3-mediated autophagy.
Cell biology international42(9)1240-1249(2018 Sep)
Hua L,Zhu G,Wei J

eIF5A is required for autophagy by mediating ATG3 translation.
EMBO reports19(6)(2018 06)
Lubas M,Harder LM,Kumsta C,Tiessen I,Hansen M,Andersen JS,Lund AH,Frankel LB

Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology48(1)194-207(2018)
Gu J,Wang Y,Wang X,Zhou D,Wang X,Zhou M,He Z

Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells.
PLoS pathogens14(1)e1006790(2018 01)
Etna MP,Sinigaglia A,Grassi A,Giacomini E,Romagnoli A,Pardini M,Severa M,Cruciani M,Rizzo F,Anastasiadou E,Di Camillo B,Barzon L,Fimia GM,Manganelli R,Coccia EM

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ATG3 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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