ADGRL4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADGRL4
Entrez Gene ID	64123
Full Name	adhesion G protein-coupled receptor L4
Synonyms	ELTD1,ETL,KPG_003
General protein information	Preferred Names adhesion G protein-coupled receptor L4 Names adhesion G protein-coupled receptor L4 EGF, latrophilin and seven transmembrane domain containing 1 EGF, latrophilin and seven transmembrane domain-containing protein 1 EGF-TM7-latrophilin-related protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p31.1
Disorder MIM:	616419

mRNA and Protein(s)

mRNA	Protein	Name
NM_022159.3	NP_071442.2	adhesion G protein-coupled receptor L4 precursor
NM_022159.4	NP_071442.2	adhesion G protein-coupled receptor L4 precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	ELTD1	XP_001100419.1
Gallus gallus (chicken)	ELTD1	XP_004936723.1
Mus musculus (house mouse)	Eltd1	NP_573485.2
Homo sapiens (human)	ELTD1	NP_071442.2
Canis lupus familiaris (dog)	ELTD1	XP_005622081.1
Pan troglodytes (chimpanzee)	ELTD1	XP_001155188.2
Bos taurus (cattle)	ELTD1	NP_001070376.1
Rattus norvegicus (Norway rat)	Eltd1	NP_071630.1
Danio rerio (zebrafish)	eltd1	NP_998532.2
Xenopus tropicalis (tropical clawed frog)	LOC101731473	XP_004913969.1

Gene Ontology
Bibliography

Related articles in PubMed

ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models.
Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, Mallory S, Njoku C, Dong Y, Chen H, Dong J, Lerner M, Mian O, Tummala S, Battiste J, Fung KM, Wren JD, Towner RA
Neuro-oncology19(2)175-185(2017 02)

MicroRNA-139-5p acts as a tumor suppressor by targeting ELTD1 and regulating cell cycle in glioblastoma multiforme.
Dai S, Wang X, Li X, Cao Y
Biochemical and biophysical research communications467(2)204-10(2015 Nov)

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB
Pharmacological reviews67(2)338-67(2015)

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, Mangala LS, Wu SY, Pradeep S, Li D, Han C, Dalton H, Lopez-Berestein G, Tuynman JB, Mortensen N, Li JL, Patient R, Sood AK, Banham AH, Harris AL, Buffa FM
Cancer cell24(2)229-41(2013 Aug)

Microsatellite scanning of the immunogenome associates MAPK14 and ELTD1 with graft-versus-host disease in hematopoietic stem cell transplantation.
Harkensee C, Oka A, Onizuka M, Middleton PG, Inoko H, Nakaoka H, Gennery AR, Ando K, Morishima Y,
Immunogenetics65(6)417-27(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ADGRL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADGRL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03834	NM_022159.4 Latest version!	Homo sapiens adhesion G protein-coupled receptor L4 (ADGRL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$391.30 $559.00
View Old Accession Versions >>
OHu03834	NM_022159.3	Homo sapiens adhesion G protein-coupled receptor L4 (ADGRL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADGRL4 ( NM_022159.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071442.2 Homo sapiens adhesion G protein-coupled receptor L4 (ADGRL4), mRNA.

Price & Availability↑

CloneID	OHu03834
Clone ID Related Accession (Same CDS sequence)	NM_022159.3 , NM_022159.4
Accession Version	NM_022159.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2073bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1505577600000
Organism	Homo sapiens(human)
Product	adhesion G protein-coupled receptor L4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA477962.1, AB032017.1, AK129766.1 and AC099674.2. On or before Jun 15, 2007 this sequence version replaced XM_371262.4, XM_942048.2, NM_022159.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.273173.1, SRR1660803.255079.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAAACGCC TCCCGCTCCT AGTGGTTTTT TCCACTTTGT TGAATTGTTC CTATACTCAA 
AATTGCACCA AGACACCTTG TCTCCCAAAT GCAAAATGTG AAATACGCAA TGGAATTGAA 
GCCTGCTATT GCAACATGGG ATTTTCAGGA AATGGTGTCA CAATTTGTGA AGATGATAAT 
GAATGTGGAA ATTTAACTCA GTCCTGTGGC GAAAATGCTA ATTGCACTAA CACAGAAGGA 
AGTTATTATT GTATGTGTGT ACCTGGCTTC AGATCCAGCA GTAACCAAGA CAGGTTTATC 
ACTAATGATG GAACCGTCTG TATAGAAAAT GTGAATGCAA ACTGCCATTT AGATAATGTC 
TGTATAGCTG CAAATATTAA TAAAACTTTA ACAAAAATCA GATCCATAAA AGAACCTGTG 
GCTTTGCTAC AAGAAGTCTA TAGAAATTCT GTGACAGATC TTTCACCAAC AGATATAATT 
ACATATATAG AAATATTAGC TGAATCATCT TCATTACTAG GTTACAAGAA CAACACTATC 
TCAGCCAAGG ACACCCTTTC TAACTCAACT CTTACTGAAT TTGTAAAAAC CGTGAATAAT 
TTTGTTCAAA GGGATACATT TGTAGTTTGG GACAAGTTAT CTGTGAATCA TAGGAGAACA 
CATCTTACAA AACTCATGCA CACTGTTGAA CAAGCTACTT TAAGGATATC CCAGAGCTTC 
CAAAAGACCA CAGAGTTTGA TACAAATTCA ACGGATATAG CTCTCAAAGT TTTCTTTTTT 
GATTCATATA ACATGAAACA TATTCATCCT CATATGAATA TGGATGGAGA CTACATAAAT 
ATATTTCCAA AGAGAAAAGC TGCATATGAT TCAAATGGCA ATGTTGCAGT TGCATTTGTA 
TATTATAAGA GTATTGGTCC TTTGCTTTCA TCATCTGACA ACTTCTTATT GAAACCTCAA 
AATTATGATA ATTCTGAAGA GGAGGAAAGA GTCATATCTT CAGTAATTTC AGTCTCAATG 
AGCTCAAACC CACCCACATT ATATGAACTT GAAAAAATAA CATTTACATT AAGTCATCGA 
AAGGTCACAG ATAGGTATAG GAGTCTATGT GCATTTTGGA ATTACTCACC TGATACCATG 
AATGGCAGCT GGTCTTCAGA GGGCTGTGAG CTGACATACT CAAATGAGAC CCACACCTCA 
TGCCGCTGTA ATCACCTGAC ACATTTTGCA ATTTTGATGT CCTCTGGTCC TTCCATTGGT 
ATTAAAGATT ATAATATTCT TACAAGGATC ACTCAACTAG GAATAATTAT TTCACTGATT 
TGTCTTGCCA TATGCATTTT TACCTTCTGG TTCTTCAGTG AAATTCAAAG CACCAGGACA 
ACAATTCACA AAAATCTTTG CTGTAGCCTA TTTCTTGCTG AACTTGTTTT TCTTGTTGGG 
ATCAATACAA ATACTAATAA GCTCTTCTGT TCAATCATTG CCGGACTGCT ACACTACTTC 
TTTTTAGCTG CTTTTGCATG GATGTGCATT GAAGGCATAC ATCTCTATCT CATTGTTGTG 
GGTGTCATCT ACAACAAGGG ATTTTTGCAC AAGAATTTTT ATATCTTTGG CTATCTAAGC 
CCAGCCGTGG TAGTTGGATT TTCGGCAGCA CTAGGATACA GATATTATGG CACAACCAAA 
GTATGTTGGC TTAGCACCGA AAACAACTTT ATTTGGAGTT TTATAGGACC AGCATGCCTA 
ATCATTCTTG TTAATCTCTT GGCTTTTGGA GTCATCATAT ACAAAGTTTT TCGTCACACT 
GCAGGGTTGA AACCAGAAGT TAGTTGCTTT GAGAACATAA GGTCTTGTGC AAGAGGAGCC 
CTCGCTCTTC TGTTCCTTCT CGGCACCACC TGGATCTTTG GGGTTCTCCA TGTTGTGCAC 
GCATCAGTGG TTACAGCTTA CCTCTTCACA GTCAGCAATG CTTTCCAGGG GATGTTCATT 
TTTTTATTCC TGTGTGTTTT ATCTAGAAAG ATTCAAGAAG AATATTACAG ATTGTTCAAA 
AATGTCCCCT GTTGTTTTGG ATGTTTAAGG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071442.2
CDS	157..2229
Translation	MKRLPLLVVFSTLLNCSYTQNCTKTPCLPNAKCEIRNGIEACYCNMGFSGNGVTICEDDNECGNLTQSCGENANCTNTEGSYYCMCVPGFRSSSNQDRFITNDGTVCIENVNANCHLDNVCIAANINKTLTKIRSIKEPVALLQEVYRNSVTDLSPTDIITYIEILAESSSLLGYKNNTISAKDTLSNSTLTEFVKTVNNFVQRDTFVVWDKLSVNHRRTHLTKLMHTVEQATLRISQSFQKTTEFDTNSTDIALKVFFFDSYNMKHIHPHMNMDGDYINIFPKRKAAYDSNGNVAVAFVYYKSIGPLLSSSDNFLLKPQNYDNSEEEERVISSVISVSMSSNPPTLYELEKITFTLSHRKVTDRYRSLCAFWNYSPDTMNGSWSSEGCELTYSNETHTSCRCNHLTHFAILMSSGPSIGIKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSAALGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCFENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFGCLR

Target ORF information:

RefSeq Version	NM_022159.3
Organism	Homo sapiens(human)
Definition	Homo sapiens adhesion G protein-coupled receptor L4 (ADGRL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022159.3

ORF Insert Sequence:

ATGAAACGCC TCCCGCTCCT AGTGGTTTTT TCCACTTTGT TGAATTGTTC CTATACTCAA 
AATTGCACCA AGACACCTTG TCTCCCAAAT GCAAAATGTG AAATACGCAA TGGAATTGAA 
GCCTGCTATT GCAACATGGG ATTTTCAGGA AATGGTGTCA CAATTTGTGA AGATGATAAT 
GAATGTGGAA ATTTAACTCA GTCCTGTGGC GAAAATGCTA ATTGCACTAA CACAGAAGGA 
AGTTATTATT GTATGTGTGT ACCTGGCTTC AGATCCAGCA GTAACCAAGA CAGGTTTATC 
ACTAATGATG GAACCGTCTG TATAGAAAAT GTGAATGCAA ACTGCCATTT AGATAATGTC 
TGTATAGCTG CAAATATTAA TAAAACTTTA ACAAAAATCA GATCCATAAA AGAACCTGTG 
GCTTTGCTAC AAGAAGTCTA TAGAAATTCT GTGACAGATC TTTCACCAAC AGATATAATT 
ACATATATAG AAATATTAGC TGAATCATCT TCATTACTAG GTTACAAGAA CAACACTATC 
TCAGCCAAGG ACACCCTTTC TAACTCAACT CTTACTGAAT TTGTAAAAAC CGTGAATAAT 
TTTGTTCAAA GGGATACATT TGTAGTTTGG GACAAGTTAT CTGTGAATCA TAGGAGAACA 
CATCTTACAA AACTCATGCA CACTGTTGAA CAAGCTACTT TAAGGATATC CCAGAGCTTC 
CAAAAGACCA CAGAGTTTGA TACAAATTCA ACGGATATAG CTCTCAAAGT TTTCTTTTTT 
GATTCATATA ACATGAAACA TATTCATCCT CATATGAATA TGGATGGAGA CTACATAAAT 
ATATTTCCAA AGAGAAAAGC TGCATATGAT TCAAATGGCA ATGTTGCAGT TGCATTTGTA 
TATTATAAGA GTATTGGTCC TTTGCTTTCA TCATCTGACA ACTTCTTATT GAAACCTCAA 
AATTATGATA ATTCTGAAGA GGAGGAAAGA GTCATATCTT CAGTAATTTC AGTCTCAATG 
AGCTCAAACC CACCCACATT ATATGAACTT GAAAAAATAA CATTTACATT AAGTCATCGA 
AAGGTCACAG ATAGGTATAG GAGTCTATGT GCATTTTGGA ATTACTCACC TGATACCATG 
AATGGCAGCT GGTCTTCAGA GGGCTGTGAG CTGACATACT CAAATGAGAC CCACACCTCA 
TGCCGCTGTA ATCACCTGAC ACATTTTGCA ATTTTGATGT CCTCTGGTCC TTCCATTGGT 
ATTAAAGATT ATAATATTCT TACAAGGATC ACTCAACTAG GAATAATTAT TTCACTGATT 
TGTCTTGCCA TATGCATTTT TACCTTCTGG TTCTTCAGTG AAATTCAAAG CACCAGGACA 
ACAATTCACA AAAATCTTTG CTGTAGCCTA TTTCTTGCTG AACTTGTTTT TCTTGTTGGG 
ATCAATACAA ATACTAATAA GCTCTTCTGT TCAATCATTG CCGGACTGCT ACACTACTTC 
TTTTTAGCTG CTTTTGCATG GATGTGCATT GAAGGCATAC ATCTCTATCT CATTGTTGTG 
GGTGTCATCT ACAACAAGGG ATTTTTGCAC AAGAATTTTT ATATCTTTGG CTATCTAAGC 
CCAGCCGTGG TAGTTGGATT TTCGGCAGCA CTAGGATACA GATATTATGG CACAACCAAA 
GTATGTTGGC TTAGCACCGA AAACAACTTT ATTTGGAGTT TTATAGGACC AGCATGCCTA 
ATCATTCTTG TTAATCTCTT GGCTTTTGGA GTCATCATAT ACAAAGTTTT TCGTCACACT 
GCAGGGTTGA AACCAGAAGT TAGTTGCTTT GAGAACATAA GGTCTTGTGC AAGAGGAGCC 
CTCGCTCTTC TGTTCCTTCT CGGCACCACC TGGATCTTTG GGGTTCTCCA TGTTGTGCAC 
GCATCAGTGG TTACAGCTTA CCTCTTCACA GTCAGCAATG CTTTCCAGGG GATGTTCATT 
TTTTTATTCC TGTGTGTTTT ATCTAGAAAG ATTCAAGAAG AATATTACAG ATTGTTCAAA 
AATGTCCCCT GTTGTTTTGG ATGTTTAAGG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADGRL4 ( NM_022159.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071442.2 Homo sapiens adhesion G protein-coupled receptor L4 (ADGRL4), mRNA.

Price & Availability↑

CloneID	OHu03834
Clone ID Related Accession (Same CDS sequence)	NM_022159.3 , NM_022159.4
Accession Version	NM_022159.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2073bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1556640000000
Organism	Homo sapiens(human)
Product	adhesion G protein-coupled receptor L4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA477962.1, AB032017.1, AK129766.1 and AC099674.2. On Nov 23, 2018 this sequence version replaced NM_022159.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.273173.1, SRR1660803.255079.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370742.4/ ENSP00000359778.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAACGCC TCCCGCTCCT AGTGGTTTTT TCCACTTTGT TGAATTGTTC CTATACTCAA 
AATTGCACCA AGACACCTTG TCTCCCAAAT GCAAAATGTG AAATACGCAA TGGAATTGAA 
GCCTGCTATT GCAACATGGG ATTTTCAGGA AATGGTGTCA CAATTTGTGA AGATGATAAT 
GAATGTGGAA ATTTAACTCA GTCCTGTGGC GAAAATGCTA ATTGCACTAA CACAGAAGGA 
AGTTATTATT GTATGTGTGT ACCTGGCTTC AGATCCAGCA GTAACCAAGA CAGGTTTATC 
ACTAATGATG GAACCGTCTG TATAGAAAAT GTGAATGCAA ACTGCCATTT AGATAATGTC 
TGTATAGCTG CAAATATTAA TAAAACTTTA ACAAAAATCA GATCCATAAA AGAACCTGTG 
GCTTTGCTAC AAGAAGTCTA TAGAAATTCT GTGACAGATC TTTCACCAAC AGATATAATT 
ACATATATAG AAATATTAGC TGAATCATCT TCATTACTAG GTTACAAGAA CAACACTATC 
TCAGCCAAGG ACACCCTTTC TAACTCAACT CTTACTGAAT TTGTAAAAAC CGTGAATAAT 
TTTGTTCAAA GGGATACATT TGTAGTTTGG GACAAGTTAT CTGTGAATCA TAGGAGAACA 
CATCTTACAA AACTCATGCA CACTGTTGAA CAAGCTACTT TAAGGATATC CCAGAGCTTC 
CAAAAGACCA CAGAGTTTGA TACAAATTCA ACGGATATAG CTCTCAAAGT TTTCTTTTTT 
GATTCATATA ACATGAAACA TATTCATCCT CATATGAATA TGGATGGAGA CTACATAAAT 
ATATTTCCAA AGAGAAAAGC TGCATATGAT TCAAATGGCA ATGTTGCAGT TGCATTTGTA 
TATTATAAGA GTATTGGTCC TTTGCTTTCA TCATCTGACA ACTTCTTATT GAAACCTCAA 
AATTATGATA ATTCTGAAGA GGAGGAAAGA GTCATATCTT CAGTAATTTC AGTCTCAATG 
AGCTCAAACC CACCCACATT ATATGAACTT GAAAAAATAA CATTTACATT AAGTCATCGA 
AAGGTCACAG ATAGGTATAG GAGTCTATGT GCATTTTGGA ATTACTCACC TGATACCATG 
AATGGCAGCT GGTCTTCAGA GGGCTGTGAG CTGACATACT CAAATGAGAC CCACACCTCA 
TGCCGCTGTA ATCACCTGAC ACATTTTGCA ATTTTGATGT CCTCTGGTCC TTCCATTGGT 
ATTAAAGATT ATAATATTCT TACAAGGATC ACTCAACTAG GAATAATTAT TTCACTGATT 
TGTCTTGCCA TATGCATTTT TACCTTCTGG TTCTTCAGTG AAATTCAAAG CACCAGGACA 
ACAATTCACA AAAATCTTTG CTGTAGCCTA TTTCTTGCTG AACTTGTTTT TCTTGTTGGG 
ATCAATACAA ATACTAATAA GCTCTTCTGT TCAATCATTG CCGGACTGCT ACACTACTTC 
TTTTTAGCTG CTTTTGCATG GATGTGCATT GAAGGCATAC ATCTCTATCT CATTGTTGTG 
GGTGTCATCT ACAACAAGGG ATTTTTGCAC AAGAATTTTT ATATCTTTGG CTATCTAAGC 
CCAGCCGTGG TAGTTGGATT TTCGGCAGCA CTAGGATACA GATATTATGG CACAACCAAA 
GTATGTTGGC TTAGCACCGA AAACAACTTT ATTTGGAGTT TTATAGGACC AGCATGCCTA 
ATCATTCTTG TTAATCTCTT GGCTTTTGGA GTCATCATAT ACAAAGTTTT TCGTCACACT 
GCAGGGTTGA AACCAGAAGT TAGTTGCTTT GAGAACATAA GGTCTTGTGC AAGAGGAGCC 
CTCGCTCTTC TGTTCCTTCT CGGCACCACC TGGATCTTTG GGGTTCTCCA TGTTGTGCAC 
GCATCAGTGG TTACAGCTTA CCTCTTCACA GTCAGCAATG CTTTCCAGGG GATGTTCATT 
TTTTTATTCC TGTGTGTTTT ATCTAGAAAG ATTCAAGAAG AATATTACAG ATTGTTCAAA 
AATGTCCCCT GTTGTTTTGG ATGTTTAAGG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071442.2
CDS	77..2149
Translation	MKRLPLLVVFSTLLNCSYTQNCTKTPCLPNAKCEIRNGIEACYCNMGFSGNGVTICEDDNECGNLTQSCGENANCTNTEGSYYCMCVPGFRSSSNQDRFITNDGTVCIENVNANCHLDNVCIAANINKTLTKIRSIKEPVALLQEVYRNSVTDLSPTDIITYIEILAESSSLLGYKNNTISAKDTLSNSTLTEFVKTVNNFVQRDTFVVWDKLSVNHRRTHLTKLMHTVEQATLRISQSFQKTTEFDTNSTDIALKVFFFDSYNMKHIHPHMNMDGDYINIFPKRKAAYDSNGNVAVAFVYYKSIGPLLSSSDNFLLKPQNYDNSEEEERVISSVISVSMSSNPPTLYELEKITFTLSHRKVTDRYRSLCAFWNYSPDTMNGSWSSEGCELTYSNETHTSCRCNHLTHFAILMSSGPSIGIKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSAALGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCFENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFGCLR

Target ORF information:

RefSeq Version	NM_022159.4
Organism	Homo sapiens(human)
Definition	Homo sapiens adhesion G protein-coupled receptor L4 (ADGRL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022159.4

ORF Insert Sequence:

ATGAAACGCC TCCCGCTCCT AGTGGTTTTT TCCACTTTGT TGAATTGTTC CTATACTCAA 
AATTGCACCA AGACACCTTG TCTCCCAAAT GCAAAATGTG AAATACGCAA TGGAATTGAA 
GCCTGCTATT GCAACATGGG ATTTTCAGGA AATGGTGTCA CAATTTGTGA AGATGATAAT 
GAATGTGGAA ATTTAACTCA GTCCTGTGGC GAAAATGCTA ATTGCACTAA CACAGAAGGA 
AGTTATTATT GTATGTGTGT ACCTGGCTTC AGATCCAGCA GTAACCAAGA CAGGTTTATC 
ACTAATGATG GAACCGTCTG TATAGAAAAT GTGAATGCAA ACTGCCATTT AGATAATGTC 
TGTATAGCTG CAAATATTAA TAAAACTTTA ACAAAAATCA GATCCATAAA AGAACCTGTG 
GCTTTGCTAC AAGAAGTCTA TAGAAATTCT GTGACAGATC TTTCACCAAC AGATATAATT 
ACATATATAG AAATATTAGC TGAATCATCT TCATTACTAG GTTACAAGAA CAACACTATC 
TCAGCCAAGG ACACCCTTTC TAACTCAACT CTTACTGAAT TTGTAAAAAC CGTGAATAAT 
TTTGTTCAAA GGGATACATT TGTAGTTTGG GACAAGTTAT CTGTGAATCA TAGGAGAACA 
CATCTTACAA AACTCATGCA CACTGTTGAA CAAGCTACTT TAAGGATATC CCAGAGCTTC 
CAAAAGACCA CAGAGTTTGA TACAAATTCA ACGGATATAG CTCTCAAAGT TTTCTTTTTT 
GATTCATATA ACATGAAACA TATTCATCCT CATATGAATA TGGATGGAGA CTACATAAAT 
ATATTTCCAA AGAGAAAAGC TGCATATGAT TCAAATGGCA ATGTTGCAGT TGCATTTGTA 
TATTATAAGA GTATTGGTCC TTTGCTTTCA TCATCTGACA ACTTCTTATT GAAACCTCAA 
AATTATGATA ATTCTGAAGA GGAGGAAAGA GTCATATCTT CAGTAATTTC AGTCTCAATG 
AGCTCAAACC CACCCACATT ATATGAACTT GAAAAAATAA CATTTACATT AAGTCATCGA 
AAGGTCACAG ATAGGTATAG GAGTCTATGT GCATTTTGGA ATTACTCACC TGATACCATG 
AATGGCAGCT GGTCTTCAGA GGGCTGTGAG CTGACATACT CAAATGAGAC CCACACCTCA 
TGCCGCTGTA ATCACCTGAC ACATTTTGCA ATTTTGATGT CCTCTGGTCC TTCCATTGGT 
ATTAAAGATT ATAATATTCT TACAAGGATC ACTCAACTAG GAATAATTAT TTCACTGATT 
TGTCTTGCCA TATGCATTTT TACCTTCTGG TTCTTCAGTG AAATTCAAAG CACCAGGACA 
ACAATTCACA AAAATCTTTG CTGTAGCCTA TTTCTTGCTG AACTTGTTTT TCTTGTTGGG 
ATCAATACAA ATACTAATAA GCTCTTCTGT TCAATCATTG CCGGACTGCT ACACTACTTC 
TTTTTAGCTG CTTTTGCATG GATGTGCATT GAAGGCATAC ATCTCTATCT CATTGTTGTG 
GGTGTCATCT ACAACAAGGG ATTTTTGCAC AAGAATTTTT ATATCTTTGG CTATCTAAGC 
CCAGCCGTGG TAGTTGGATT TTCGGCAGCA CTAGGATACA GATATTATGG CACAACCAAA 
GTATGTTGGC TTAGCACCGA AAACAACTTT ATTTGGAGTT TTATAGGACC AGCATGCCTA 
ATCATTCTTG TTAATCTCTT GGCTTTTGGA GTCATCATAT ACAAAGTTTT TCGTCACACT 
GCAGGGTTGA AACCAGAAGT TAGTTGCTTT GAGAACATAA GGTCTTGTGC AAGAGGAGCC 
CTCGCTCTTC TGTTCCTTCT CGGCACCACC TGGATCTTTG GGGTTCTCCA TGTTGTGCAC 
GCATCAGTGG TTACAGCTTA CCTCTTCACA GTCAGCAATG CTTTCCAGGG GATGTTCATT 
TTTTTATTCC TGTGTGTTTT ATCTAGAAAG ATTCAAGAAG AATATTACAG ATTGTTCAAA 
AATGTCCCCT GTTGTTTTGG ATGTTTAAGG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models.
Neuro-oncology19(2)175-185(2017 02)
Ziegler J,Pody R,Coutinho de Souza P,Evans B,Saunders D,Smith N,Mallory S,Njoku C,Dong Y,Chen H,Dong J,Lerner M,Mian O,Tummala S,Battiste J,Fung KM,Wren JD,Towner RA

MicroRNA-139-5p acts as a tumor suppressor by targeting ELTD1 and regulating cell cycle in glioblastoma multiforme.
Biochemical and biophysical research communications467(2)204-10(2015 Nov)
Dai S,Wang X,Li X,Cao Y

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Pharmacological reviews67(2)338-67(2015)
Hamann J,Aust G,Araç D,Engel FB,Formstone C,Fredriksson R,Hall RA,Harty BL,Kirchhoff C,Knapp B,Krishnan A,Liebscher I,Lin HH,Martinelli DC,Monk KR,Peeters MC,Piao X,Prömel S,Schöneberg T,Schwartz TW,Singer K,Stacey M,Ushkaryov YA,Vallon M,Wolfrum U,Wright MW,Xu L,Langenhan T,Schiöth HB

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
Cancer cell24(2)229-41(2013 Aug)
Masiero M,Simões FC,Han HD,Snell C,Peterkin T,Bridges E,Mangala LS,Wu SY,Pradeep S,Li D,Han C,Dalton H,Lopez-Berestein G,Tuynman JB,Mortensen N,Li JL,Patient R,Sood AK,Banham AH,Harris AL,Buffa FM

Microsatellite scanning of the immunogenome associates MAPK14 and ELTD1 with graft-versus-host disease in hematopoietic stem cell transplantation.
Immunogenetics65(6)417-27(2013 Jun)
Harkensee C,Oka A,Onizuka M,Middleton PG,Inoko H,Nakaoka H,Gennery AR,Ando K,Morishima Y,

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